Central oscillators in a patient with neuropathic tremor: evidence from intraoperative local field potential recordings.
Identifieur interne : 001512 ( PubMed/Corpus ); précédent : 001511; suivant : 001513Central oscillators in a patient with neuropathic tremor: evidence from intraoperative local field potential recordings.
Auteurs : Daniel Weiss ; Rathinaswamy B. Govindan ; Albrecht Rilk ; Tobias W Chter ; Sorin Breit ; Leopold Zizlsperger ; Thomas Haarmeier ; Christian Plewnia ; Rejko Krüger ; Alireza GharabaghiSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2011.
English descriptors
- KwdEn :
- Aged, Biological Clocks (physiology), Brain (physiopathology), Brain (surgery), Deep Brain Stimulation, Electroencephalography, Electromyography, Female, Humans, Muscle, Skeletal (physiopathology), Neurons (physiology), Paraproteinemias (complications), Paraproteinemias (physiopathology), Tremor (etiology), Tremor (physiopathology), Tremor (therapy).
- MESH :
- complications : Paraproteinemias.
- etiology : Tremor.
- physiology : Biological Clocks, Neurons.
- physiopathology : Brain, Muscle, Skeletal, Paraproteinemias, Tremor.
- surgery : Brain.
- therapy : Tremor.
- Aged, Deep Brain Stimulation, Electroencephalography, Electromyography, Female, Humans.
Abstract
Present pathophysiological concepts of neuropathic tremor assume mistimed and defective afferent input resulting in deregulation of cerebello-thalamo-cortical motor networks. Here, we provide direct evidence of central tremor processing in a 76-year-old female who underwent bilateral deep brain stimulation of the ventral intermedial nucleus of the thalamus (Vim-DBS) because of neuropathic tremor associated with IgM paraproteinemia. Electrophysiological recordings of EEG and EMG were performed in three perioperative sessions: (1) preoperatively, (2) intraoperatively, and (3) 4 days after surgery in both rest and postural tremor conditions. Tremor-related synchronization (coherence) between motor cortex (M1) and muscles (M. extensor digitorum, M. flexor digitorum) was assessed, and additional intraoperative local field potential (LFP) recordings from Vim allowed comprehensive coherence mapping in thalamo-cortico-muscular networks. Directionality of information flow was determined by directed transfer function (DTF) and phase analyses. Stimulation effects on tremor and corticomuscular coherence were assessed and the patient was followed for 12 months on clinical outcome measures (Tremor Rating Scale, CADET-Score). Vim-DBS reduced tremor (59%) and improved motor functionality in daily activities (31%, CADET-A) after 12 months. Intraoperative recordings demonstrated significant coherence in the tremor frequency (4 Hz) between M1 and contralateral muscle, Vim and ipsilateral M1, Vim and contralateral muscle, but not between Vim and contralateral M1. Information flow was directed from M1 to Vim and bidirectional between M1 and muscle and between Vim and muscle, respectively. Corticomuscular coherence at tremor frequency was completely suppressed by Vim-DBS. Our case study demonstrates central oscillators underlying neuropathic tremor and implies a strong pathophysiological rationale for Vim-DBS.
DOI: 10.1002/mds.23374
PubMed: 20945432
Links to Exploration step
pubmed:20945432Le document en format XML
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Govindan</name></author><author><name sortKey="Rilk, Albrecht" sort="Rilk, Albrecht" uniqKey="Rilk A" first="Albrecht" last="Rilk">Albrecht Rilk</name></author><author><name sortKey="W Chter, Tobias" sort="W Chter, Tobias" uniqKey="W Chter T" first="Tobias" last="W Chter">Tobias W Chter</name></author><author><name sortKey="Breit, Sorin" sort="Breit, Sorin" uniqKey="Breit S" first="Sorin" last="Breit">Sorin Breit</name></author><author><name sortKey="Zizlsperger, Leopold" sort="Zizlsperger, Leopold" uniqKey="Zizlsperger L" first="Leopold" last="Zizlsperger">Leopold Zizlsperger</name></author><author><name sortKey="Haarmeier, Thomas" sort="Haarmeier, Thomas" uniqKey="Haarmeier T" first="Thomas" last="Haarmeier">Thomas Haarmeier</name></author><author><name sortKey="Plewnia, Christian" sort="Plewnia, Christian" uniqKey="Plewnia C" first="Christian" last="Plewnia">Christian Plewnia</name></author><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name></author><author><name sortKey="Gharabaghi, Alireza" sort="Gharabaghi, Alireza" uniqKey="Gharabaghi A" first="Alireza" last="Gharabaghi">Alireza Gharabaghi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="doi">10.1002/mds.23374</idno><idno type="RBID">pubmed:20945432</idno><idno type="pmid">20945432</idno><idno type="wicri:Area/PubMed/Corpus">001512</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Central oscillators in a patient with neuropathic tremor: evidence from intraoperative local field potential recordings.</title><author><name sortKey="Weiss, Daniel" sort="Weiss, Daniel" uniqKey="Weiss D" first="Daniel" last="Weiss">Daniel Weiss</name><affiliation><nlm:affiliation>Center of Neurology and Hertie Institute for Clinical Brain Research, and German Center for Neurodegenerative Diseases, University of Tübingen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Govindan, Rathinaswamy B" sort="Govindan, Rathinaswamy B" uniqKey="Govindan R" first="Rathinaswamy B" last="Govindan">Rathinaswamy B. Govindan</name></author><author><name sortKey="Rilk, Albrecht" sort="Rilk, Albrecht" uniqKey="Rilk A" first="Albrecht" last="Rilk">Albrecht Rilk</name></author><author><name sortKey="W Chter, Tobias" sort="W Chter, Tobias" uniqKey="W Chter T" first="Tobias" last="W Chter">Tobias W Chter</name></author><author><name sortKey="Breit, Sorin" sort="Breit, Sorin" uniqKey="Breit S" first="Sorin" last="Breit">Sorin Breit</name></author><author><name sortKey="Zizlsperger, Leopold" sort="Zizlsperger, Leopold" uniqKey="Zizlsperger L" first="Leopold" last="Zizlsperger">Leopold Zizlsperger</name></author><author><name sortKey="Haarmeier, Thomas" sort="Haarmeier, Thomas" uniqKey="Haarmeier T" first="Thomas" last="Haarmeier">Thomas Haarmeier</name></author><author><name sortKey="Plewnia, Christian" sort="Plewnia, Christian" uniqKey="Plewnia C" first="Christian" last="Plewnia">Christian Plewnia</name></author><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name></author><author><name sortKey="Gharabaghi, Alireza" sort="Gharabaghi, Alireza" uniqKey="Gharabaghi A" first="Alireza" last="Gharabaghi">Alireza Gharabaghi</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Biological Clocks (physiology)</term><term>Brain (physiopathology)</term><term>Brain (surgery)</term><term>Deep Brain Stimulation</term><term>Electroencephalography</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Muscle, Skeletal (physiopathology)</term><term>Neurons (physiology)</term><term>Paraproteinemias (complications)</term><term>Paraproteinemias (physiopathology)</term><term>Tremor (etiology)</term><term>Tremor (physiopathology)</term><term>Tremor (therapy)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Paraproteinemias</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Biological Clocks</term><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term><term>Muscle, Skeletal</term><term>Paraproteinemias</term><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Deep Brain Stimulation</term><term>Electroencephalography</term><term>Electromyography</term><term>Female</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Present pathophysiological concepts of neuropathic tremor assume mistimed and defective afferent input resulting in deregulation of cerebello-thalamo-cortical motor networks. Here, we provide direct evidence of central tremor processing in a 76-year-old female who underwent bilateral deep brain stimulation of the ventral intermedial nucleus of the thalamus (Vim-DBS) because of neuropathic tremor associated with IgM paraproteinemia. Electrophysiological recordings of EEG and EMG were performed in three perioperative sessions: (1) preoperatively, (2) intraoperatively, and (3) 4 days after surgery in both rest and postural tremor conditions. Tremor-related synchronization (coherence) between motor cortex (M1) and muscles (M. extensor digitorum, M. flexor digitorum) was assessed, and additional intraoperative local field potential (LFP) recordings from Vim allowed comprehensive coherence mapping in thalamo-cortico-muscular networks. Directionality of information flow was determined by directed transfer function (DTF) and phase analyses. Stimulation effects on tremor and corticomuscular coherence were assessed and the patient was followed for 12 months on clinical outcome measures (Tremor Rating Scale, CADET-Score). Vim-DBS reduced tremor (59%) and improved motor functionality in daily activities (31%, CADET-A) after 12 months. Intraoperative recordings demonstrated significant coherence in the tremor frequency (4 Hz) between M1 and contralateral muscle, Vim and ipsilateral M1, Vim and contralateral muscle, but not between Vim and contralateral M1. Information flow was directed from M1 to Vim and bidirectional between M1 and muscle and between Vim and muscle, respectively. Corticomuscular coherence at tremor frequency was completely suppressed by Vim-DBS. Our case study demonstrates central oscillators underlying neuropathic tremor and implies a strong pathophysiological rationale for Vim-DBS.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20945432</PMID><DateCreated><Year>2011</Year><Month>03</Month><Day>17</Day></DateCreated><DateCompleted><Year>2011</Year><Month>07</Month><Day>25</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>2</Issue><PubDate><Year>2011</Year><Month>Feb</Month><Day>1</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Central oscillators in a patient with neuropathic tremor: evidence from intraoperative local field potential recordings.</ArticleTitle><Pagination><MedlinePgn>323-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.23374</ELocationID><Abstract><AbstractText>Present pathophysiological concepts of neuropathic tremor assume mistimed and defective afferent input resulting in deregulation of cerebello-thalamo-cortical motor networks. Here, we provide direct evidence of central tremor processing in a 76-year-old female who underwent bilateral deep brain stimulation of the ventral intermedial nucleus of the thalamus (Vim-DBS) because of neuropathic tremor associated with IgM paraproteinemia. Electrophysiological recordings of EEG and EMG were performed in three perioperative sessions: (1) preoperatively, (2) intraoperatively, and (3) 4 days after surgery in both rest and postural tremor conditions. Tremor-related synchronization (coherence) between motor cortex (M1) and muscles (M. extensor digitorum, M. flexor digitorum) was assessed, and additional intraoperative local field potential (LFP) recordings from Vim allowed comprehensive coherence mapping in thalamo-cortico-muscular networks. Directionality of information flow was determined by directed transfer function (DTF) and phase analyses. Stimulation effects on tremor and corticomuscular coherence were assessed and the patient was followed for 12 months on clinical outcome measures (Tremor Rating Scale, CADET-Score). Vim-DBS reduced tremor (59%) and improved motor functionality in daily activities (31%, CADET-A) after 12 months. Intraoperative recordings demonstrated significant coherence in the tremor frequency (4 Hz) between M1 and contralateral muscle, Vim and ipsilateral M1, Vim and contralateral muscle, but not between Vim and contralateral M1. Information flow was directed from M1 to Vim and bidirectional between M1 and muscle and between Vim and muscle, respectively. Corticomuscular coherence at tremor frequency was completely suppressed by Vim-DBS. Our case study demonstrates central oscillators underlying neuropathic tremor and implies a strong pathophysiological rationale for Vim-DBS.</AbstractText><CopyrightInformation>Copyright © 2010 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Weiss</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Center of Neurology and Hertie Institute for Clinical Brain Research, and German Center for Neurodegenerative Diseases, University of Tübingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Govindan</LastName><ForeName>Rathinaswamy B</ForeName><Initials>RB</Initials></Author><Author ValidYN="Y"><LastName>Rilk</LastName><ForeName>Albrecht</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Wächter</LastName><ForeName>Tobias</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Breit</LastName><ForeName>Sorin</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Zizlsperger</LastName><ForeName>Leopold</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Haarmeier</LastName><ForeName>Thomas</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Plewnia</LastName><ForeName>Christian</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Krüger</LastName><ForeName>Rejko</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Gharabaghi</LastName><ForeName>Alireza</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>10</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001683">Biological Clocks</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001921">Brain</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000601">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D046690">Deep Brain Stimulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004569">Electroencephalography</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004576">Electromyography</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018482">Muscle, Skeletal</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009474">Neurons</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010265">Paraproteinemias</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014202">Tremor</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000209">etiology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000628">therapy</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year><Month>4</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2010</Year><Month>6</Month><Day>9</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2010</Year><Month>7</Month><Day>6</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2010</Year><Month>10</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>10</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>10</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>7</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.23374</ArticleId><ArticleId IdType="pubmed">20945432</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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