Movement Disorders (revue)

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The pattern of cortical atrophy in patients with Parkinson's disease according to cognitive status.

Identifieur interne : 001428 ( PubMed/Corpus ); précédent : 001427; suivant : 001429

The pattern of cortical atrophy in patients with Parkinson's disease according to cognitive status.

Auteurs : Sook K. Song ; Ji E. Lee ; Hae-Jeong Park ; Young H. Sohn ; Jong Doo Lee ; Phil Hyu Lee

Source :

RBID : pubmed:21370255

English descriptors

Abstract

Cognitive dysfunction is common in Parkinson's disease (PD), and along with PD with dementia (PDD), the concept of mild cognitive impairment in PD (PD-MCI) has been introduced.

DOI: 10.1002/mds.23477
PubMed: 21370255

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pubmed:21370255

Le document en format XML

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<title xml:lang="en">The pattern of cortical atrophy in patients with Parkinson's disease according to cognitive status.</title>
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<name sortKey="Song, Sook K" sort="Song, Sook K" uniqKey="Song S" first="Sook K" last="Song">Sook K. Song</name>
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<nlm:affiliation>Department of Neurology, Jeju University College of Medicine, Jeju, Korea.</nlm:affiliation>
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<name sortKey="Lee, Ji E" sort="Lee, Ji E" uniqKey="Lee J" first="Ji E" last="Lee">Ji E. Lee</name>
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<name sortKey="Park, Hae Jeong" sort="Park, Hae Jeong" uniqKey="Park H" first="Hae-Jeong" last="Park">Hae-Jeong Park</name>
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<name sortKey="Sohn, Young H" sort="Sohn, Young H" uniqKey="Sohn Y" first="Young H" last="Sohn">Young H. Sohn</name>
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<name sortKey="Lee, Jong Doo" sort="Lee, Jong Doo" uniqKey="Lee J" first="Jong Doo" last="Lee">Jong Doo Lee</name>
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<name sortKey="Lee, Phil Hyu" sort="Lee, Phil Hyu" uniqKey="Lee P" first="Phil Hyu" last="Lee">Phil Hyu Lee</name>
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<title xml:lang="en">The pattern of cortical atrophy in patients with Parkinson's disease according to cognitive status.</title>
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<nlm:affiliation>Department of Neurology, Jeju University College of Medicine, Jeju, Korea.</nlm:affiliation>
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<name sortKey="Lee, Ji E" sort="Lee, Ji E" uniqKey="Lee J" first="Ji E" last="Lee">Ji E. Lee</name>
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<name sortKey="Park, Hae Jeong" sort="Park, Hae Jeong" uniqKey="Park H" first="Hae-Jeong" last="Park">Hae-Jeong Park</name>
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<name sortKey="Sohn, Young H" sort="Sohn, Young H" uniqKey="Sohn Y" first="Young H" last="Sohn">Young H. Sohn</name>
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<title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
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<keywords scheme="KwdEn" xml:lang="en">
<term>Atrophy (pathology)</term>
<term>Atrophy (psychology)</term>
<term>Cerebral Cortex (pathology)</term>
<term>Cognition (physiology)</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Nerve Fibers, Unmyelinated (pathology)</term>
<term>Neurons (pathology)</term>
<term>Neuropsychological Tests</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (psychology)</term>
<term>Prospective Studies</term>
<term>Statistics, Nonparametric</term>
</keywords>
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<term>Atrophy</term>
<term>Cerebral Cortex</term>
<term>Nerve Fibers, Unmyelinated</term>
<term>Neurons</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en">
<term>Cognition</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en">
<term>Atrophy</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Neuropsychological Tests</term>
<term>Prospective Studies</term>
<term>Statistics, Nonparametric</term>
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<div type="abstract" xml:lang="en">Cognitive dysfunction is common in Parkinson's disease (PD), and along with PD with dementia (PDD), the concept of mild cognitive impairment in PD (PD-MCI) has been introduced.</div>
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<Year>2011</Year>
<Month>03</Month>
<Day>17</Day>
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<Year>2011</Year>
<Month>07</Month>
<Day>25</Day>
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<Journal>
<ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>26</Volume>
<Issue>2</Issue>
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<Year>2011</Year>
<Month>Feb</Month>
<Day>1</Day>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
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<ArticleTitle>The pattern of cortical atrophy in patients with Parkinson's disease according to cognitive status.</ArticleTitle>
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<ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.23477</ELocationID>
<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Cognitive dysfunction is common in Parkinson's disease (PD), and along with PD with dementia (PDD), the concept of mild cognitive impairment in PD (PD-MCI) has been introduced.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">To identify structural candidates according to cognitive status in PD, we compared gray matter (GM) density across PD-intact cognition (PD-IC, n = 23), PD-MCI (n = 27), and PDD (n = 18) using voxel-based morphometry.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The demographic data among PD subjects were similar, however, general cognition and disease duration were more severe in PD-MCI and PDD than in PD-IC. Compared with controls, GM density was significantly decreased in the left occipital area in PD-IC; the bilateral temporal, left prefrontal and insular, and right occipital areas in PD-MCI; and in widespread brain areas in PDD. Compared with PD-IC, patients with PD-MCI had significantly decreased GM density in the right middle frontal area, and those with PDD had decreased GM density in the right parietal, middle frontal, insular, and lentiform areas. GM density in patients with PDD was significantly decreased in the bilateral middle temporal, right inferior temporal, and left middle and superior prefrontal areas. PDD patients with shorter disease duration before dementia (<5 year) showed greater GM atrophy in the posterior cingulate area than did those with longer disease duration (≥5 year).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These data suggest that cortical atrophy in PD exhibits a greater extent with increasing levels of cognitive impairment, and different anatomical substrates would correspond to each cognitive status.</AbstractText>
<CopyrightInformation>Copyright © 2011 Movement Disorder Society.</CopyrightInformation>
</Abstract>
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<LastName>Song</LastName>
<ForeName>Sook K</ForeName>
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