Ventricular enlargement and mild cognitive impairment in early Parkinson's disease.
Identifieur interne : 001389 ( PubMed/Corpus ); précédent : 001388; suivant : 001390Ventricular enlargement and mild cognitive impairment in early Parkinson's disease.
Auteurs : Turi O. Dalaker ; Robert Zivadinov ; Deepa Preeti Ramasamy ; Mona K. Beyer ; Guido Alves ; Kolbjorn S. Bronnick ; Ole-Bjorn Tysnes ; Dag Aarsland ; Jan P. LarsenSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2011.
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Cognition Disorders (pathology), Cognition Disorders (physiopathology), Disease Progression, Female, Humans, Image Processing, Computer-Assisted, Lateral Ventricles (pathology), Lateral Ventricles (physiopathology), Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (pathology), Parkinson Disease (physiopathology), Severity of Illness Index, Third Ventricle (pathology), Third Ventricle (physiopathology).
- MESH :
- pathology : Cognition Disorders, Lateral Ventricles, Parkinson Disease, Third Ventricle.
- physiopathology : Cognition Disorders, Lateral Ventricles, Parkinson Disease, Third Ventricle.
- Aged, Analysis of Variance, Disease Progression, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Severity of Illness Index.
Abstract
Mild cognitive impairment (MCI) may predict future development of dementia in Parkinson's disease (PD). We aimed to examine the extent of subcortical brain atrophy in patients with early PD with and without MCI compared to normal controls (NC). Participating in a population-based study were 43 early, drug-naïve PD patients and 41 NC. Eleven patients were classified with MCI (MCI PD) and 32 patients without (non-MCI PD). Volumetric segmentation of 3D-T1 weighted brain MRI was performed using FreeSurfer. Groups were compared applying MANCOVA corrected for total intracranial volume, age, and sex. Results showed that left inferior lateral ventricle and third ventricle volumes were significantly larger in MCI PD than in non-MCI PD and NC. Fourth ventricular size in MCI PD was significantly different from NC and highly correlated with memory performance in MCI PD patients. This suggests that cognitive dysfunction in early PD may be associated with ventricular enlargement.
DOI: 10.1002/mds.23443
PubMed: 21412836
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pubmed:21412836Le document en format XML
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Beyer</name></author><author><name sortKey="Alves, Guido" sort="Alves, Guido" uniqKey="Alves G" first="Guido" last="Alves">Guido Alves</name></author><author><name sortKey="Bronnick, Kolbjorn S" sort="Bronnick, Kolbjorn S" uniqKey="Bronnick K" first="Kolbjorn S" last="Bronnick">Kolbjorn S. Bronnick</name></author><author><name sortKey="Tysnes, Ole Bjorn" sort="Tysnes, Ole Bjorn" uniqKey="Tysnes O" first="Ole-Bjorn" last="Tysnes">Ole-Bjorn Tysnes</name></author><author><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name></author><author><name sortKey="Larsen, Jan P" sort="Larsen, Jan P" uniqKey="Larsen J" first="Jan P" last="Larsen">Jan P. Larsen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="doi">10.1002/mds.23443</idno><idno type="RBID">pubmed:21412836</idno><idno type="pmid">21412836</idno><idno type="wicri:Area/PubMed/Corpus">001389</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Ventricular enlargement and mild cognitive impairment in early Parkinson's disease.</title><author><name sortKey="Dalaker, Turi O" sort="Dalaker, Turi O" uniqKey="Dalaker T" first="Turi O" last="Dalaker">Turi O. Dalaker</name><affiliation><nlm:affiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway. datu@sus.no</nlm:affiliation></affiliation></author><author><name sortKey="Zivadinov, Robert" sort="Zivadinov, Robert" uniqKey="Zivadinov R" first="Robert" last="Zivadinov">Robert Zivadinov</name></author><author><name sortKey="Ramasamy, Deepa Preeti" sort="Ramasamy, Deepa Preeti" uniqKey="Ramasamy D" first="Deepa Preeti" last="Ramasamy">Deepa Preeti Ramasamy</name></author><author><name sortKey="Beyer, Mona K" sort="Beyer, Mona K" uniqKey="Beyer M" first="Mona K" last="Beyer">Mona K. Beyer</name></author><author><name sortKey="Alves, Guido" sort="Alves, Guido" uniqKey="Alves G" first="Guido" last="Alves">Guido Alves</name></author><author><name sortKey="Bronnick, Kolbjorn S" sort="Bronnick, Kolbjorn S" uniqKey="Bronnick K" first="Kolbjorn S" last="Bronnick">Kolbjorn S. Bronnick</name></author><author><name sortKey="Tysnes, Ole Bjorn" sort="Tysnes, Ole Bjorn" uniqKey="Tysnes O" first="Ole-Bjorn" last="Tysnes">Ole-Bjorn Tysnes</name></author><author><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name></author><author><name sortKey="Larsen, Jan P" sort="Larsen, Jan P" uniqKey="Larsen J" first="Jan P" last="Larsen">Jan P. Larsen</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Cognition Disorders (pathology)</term><term>Cognition Disorders (physiopathology)</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Lateral Ventricles (pathology)</term><term>Lateral Ventricles (physiopathology)</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Severity of Illness Index</term><term>Third Ventricle (pathology)</term><term>Third Ventricle (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cognition Disorders</term><term>Lateral Ventricles</term><term>Parkinson Disease</term><term>Third Ventricle</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cognition Disorders</term><term>Lateral Ventricles</term><term>Parkinson Disease</term><term>Third Ventricle</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mild cognitive impairment (MCI) may predict future development of dementia in Parkinson's disease (PD). We aimed to examine the extent of subcortical brain atrophy in patients with early PD with and without MCI compared to normal controls (NC). Participating in a population-based study were 43 early, drug-naïve PD patients and 41 NC. Eleven patients were classified with MCI (MCI PD) and 32 patients without (non-MCI PD). Volumetric segmentation of 3D-T1 weighted brain MRI was performed using FreeSurfer. Groups were compared applying MANCOVA corrected for total intracranial volume, age, and sex. Results showed that left inferior lateral ventricle and third ventricle volumes were significantly larger in MCI PD than in non-MCI PD and NC. Fourth ventricular size in MCI PD was significantly different from NC and highly correlated with memory performance in MCI PD patients. This suggests that cognitive dysfunction in early PD may be associated with ventricular enlargement.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">21412836</PMID><DateCreated><Year>2011</Year><Month>03</Month><Day>17</Day></DateCreated><DateCompleted><Year>2011</Year><Month>07</Month><Day>25</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>2</Issue><PubDate><Year>2011</Year><Month>Feb</Month><Day>1</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Ventricular enlargement and mild cognitive impairment in early Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>297-301</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.23443</ELocationID><Abstract><AbstractText>Mild cognitive impairment (MCI) may predict future development of dementia in Parkinson's disease (PD). We aimed to examine the extent of subcortical brain atrophy in patients with early PD with and without MCI compared to normal controls (NC). Participating in a population-based study were 43 early, drug-naïve PD patients and 41 NC. Eleven patients were classified with MCI (MCI PD) and 32 patients without (non-MCI PD). Volumetric segmentation of 3D-T1 weighted brain MRI was performed using FreeSurfer. Groups were compared applying MANCOVA corrected for total intracranial volume, age, and sex. Results showed that left inferior lateral ventricle and third ventricle volumes were significantly larger in MCI PD than in non-MCI PD and NC. Fourth ventricular size in MCI PD was significantly different from NC and highly correlated with memory performance in MCI PD patients. This suggests that cognitive dysfunction in early PD may be associated with ventricular enlargement.</AbstractText><CopyrightInformation>Copyright © 2010 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dalaker</LastName><ForeName>Turi O</ForeName><Initials>TO</Initials><AffiliationInfo><Affiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway. datu@sus.no</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zivadinov</LastName><ForeName>Robert</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Ramasamy</LastName><ForeName>Deepa Preeti</ForeName><Initials>DP</Initials></Author><Author ValidYN="Y"><LastName>Beyer</LastName><ForeName>Mona K</ForeName><Initials>MK</Initials></Author><Author ValidYN="Y"><LastName>Alves</LastName><ForeName>Guido</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Bronnick</LastName><ForeName>Kolbjorn S</ForeName><Initials>KS</Initials></Author><Author ValidYN="Y"><LastName>Tysnes</LastName><ForeName>Ole-Bjorn</ForeName><Initials>OB</Initials></Author><Author ValidYN="Y"><LastName>Aarsland</LastName><ForeName>Dag</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Larsen</LastName><ForeName>Jan P</ForeName><Initials>JP</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>12</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" 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UI="Q000473">pathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008279">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009483">Neuropsychological Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012720">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020542">Third 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