Direct visualization of Parkinson's disease by in vivo human brain imaging using 7.0T magnetic resonance imaging.
Identifieur interne : 001273 ( PubMed/Corpus ); précédent : 001272; suivant : 001274Direct visualization of Parkinson's disease by in vivo human brain imaging using 7.0T magnetic resonance imaging.
Auteurs : Zang-Hee Cho ; Se-Hong Oh ; Jong-Min Kim ; Sung-Yeon Park ; Dae-Hyuk Kwon ; Hye-Jin Jeong ; Young-Bo Kim ; Je-Geun Chi ; Chan-Woong Park ; John Huston ; Kendall H. Lee ; Beom S. JeonSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2011.
English descriptors
- KwdEn :
- MESH :
- methods : Image Processing, Computer-Assisted.
- pathology : Parkinson Disease, Substantia Nigra.
- Adult, Aged, Brain Mapping, Case-Control Studies, Female, Functional Laterality, Humans, Magnetic Resonance Imaging, Male, Middle Aged.
Abstract
Parkinson's disease (PD) is a neurodegenerative disorder resulting from progressive loss of dopaminergic neurons in the substantia nigra (SN) pars compacta. Therefore, imaging of the SN has been regarded to hold greatest potential for use in the diagnosis of PD. At the 7.0T magnetic resonance imaging (MRI), it is now possible to delineate clearly the shapes and boundaries of the SN. We scanned eight early and two advanced PD patients, along with nine age-matched control subjects, using a 7.0T MRI in an attempt to directly visualize the SN and quantify the differences in shape and boundaries of SN between PD subjects in comparison with the normal control subjects. In the normal controls, the boundaries between the SN and crus cerebri appear smooth, and clean "arch" shapes that stretch ventrally from posterior to anterior. In contrast, these smooth and clean arch-like boundaries were lost in PD subjects. The measured correlation analyses show that, in PD patients, there is age-dependent correlation and substantially stronger UPDRS motor score-dependent correlation. These results suggest that, by using 7.0T MRI, it appears possible to use these visible and distinctive changes in morphology as a diagnostic marker of PD.
DOI: 10.1002/mds.23465
PubMed: 21506148
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pubmed:21506148Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Direct visualization of Parkinson's disease by in vivo human brain imaging using 7.0T magnetic resonance imaging.</title><author><name sortKey="Cho, Zang Hee" sort="Cho, Zang Hee" uniqKey="Cho Z" first="Zang-Hee" last="Cho">Zang-Hee Cho</name><affiliation><nlm:affiliation>Neuroscience Research Institute, Gachon University of Medicine and Science, Namdong-gu, Incheon, South Korea. zcho@gachon.ac.kr</nlm:affiliation></affiliation></author><author><name sortKey="Oh, Se Hong" sort="Oh, Se Hong" uniqKey="Oh S" first="Se-Hong" last="Oh">Se-Hong Oh</name></author><author><name sortKey="Kim, Jong Min" sort="Kim, Jong Min" uniqKey="Kim J" first="Jong-Min" last="Kim">Jong-Min Kim</name></author><author><name sortKey="Park, Sung Yeon" sort="Park, Sung Yeon" uniqKey="Park S" first="Sung-Yeon" last="Park">Sung-Yeon Park</name></author><author><name sortKey="Kwon, Dae Hyuk" sort="Kwon, Dae Hyuk" uniqKey="Kwon D" first="Dae-Hyuk" last="Kwon">Dae-Hyuk Kwon</name></author><author><name sortKey="Jeong, Hye Jin" sort="Jeong, Hye Jin" uniqKey="Jeong H" first="Hye-Jin" last="Jeong">Hye-Jin Jeong</name></author><author><name sortKey="Kim, Young Bo" sort="Kim, Young Bo" uniqKey="Kim Y" first="Young-Bo" last="Kim">Young-Bo Kim</name></author><author><name sortKey="Chi, Je Geun" sort="Chi, Je Geun" uniqKey="Chi J" first="Je-Geun" last="Chi">Je-Geun Chi</name></author><author><name sortKey="Park, Chan Woong" sort="Park, Chan Woong" uniqKey="Park C" first="Chan-Woong" last="Park">Chan-Woong Park</name></author><author><name sortKey="Huston, John" sort="Huston, John" uniqKey="Huston J" first="John" last="Huston">John Huston</name></author><author><name sortKey="Lee, Kendall H" sort="Lee, Kendall H" uniqKey="Lee K" first="Kendall H" last="Lee">Kendall H. Lee</name></author><author><name sortKey="Jeon, Beom S" sort="Jeon, Beom S" uniqKey="Jeon B" first="Beom S" last="Jeon">Beom S. Jeon</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="doi">10.1002/mds.23465</idno><idno type="RBID">pubmed:21506148</idno><idno type="pmid">21506148</idno><idno type="wicri:Area/PubMed/Corpus">001273</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Direct visualization of Parkinson's disease by in vivo human brain imaging using 7.0T magnetic resonance imaging.</title><author><name sortKey="Cho, Zang Hee" sort="Cho, Zang Hee" uniqKey="Cho Z" first="Zang-Hee" last="Cho">Zang-Hee Cho</name><affiliation><nlm:affiliation>Neuroscience Research Institute, Gachon University of Medicine and Science, Namdong-gu, Incheon, South Korea. zcho@gachon.ac.kr</nlm:affiliation></affiliation></author><author><name sortKey="Oh, Se Hong" sort="Oh, Se Hong" uniqKey="Oh S" first="Se-Hong" last="Oh">Se-Hong Oh</name></author><author><name sortKey="Kim, Jong Min" sort="Kim, Jong Min" uniqKey="Kim J" first="Jong-Min" last="Kim">Jong-Min Kim</name></author><author><name sortKey="Park, Sung Yeon" sort="Park, Sung Yeon" uniqKey="Park S" first="Sung-Yeon" last="Park">Sung-Yeon Park</name></author><author><name sortKey="Kwon, Dae Hyuk" sort="Kwon, Dae Hyuk" uniqKey="Kwon D" first="Dae-Hyuk" last="Kwon">Dae-Hyuk Kwon</name></author><author><name sortKey="Jeong, Hye Jin" sort="Jeong, Hye Jin" uniqKey="Jeong H" first="Hye-Jin" last="Jeong">Hye-Jin Jeong</name></author><author><name sortKey="Kim, Young Bo" sort="Kim, Young Bo" uniqKey="Kim Y" first="Young-Bo" last="Kim">Young-Bo Kim</name></author><author><name sortKey="Chi, Je Geun" sort="Chi, Je Geun" uniqKey="Chi J" first="Je-Geun" last="Chi">Je-Geun Chi</name></author><author><name sortKey="Park, Chan Woong" sort="Park, Chan Woong" uniqKey="Park C" first="Chan-Woong" last="Park">Chan-Woong Park</name></author><author><name sortKey="Huston, John" sort="Huston, John" uniqKey="Huston J" first="John" last="Huston">John Huston</name></author><author><name sortKey="Lee, Kendall H" sort="Lee, Kendall H" uniqKey="Lee K" first="Kendall H" last="Lee">Kendall H. Lee</name></author><author><name sortKey="Jeon, Beom S" sort="Jeon, Beom S" uniqKey="Jeon B" first="Beom S" last="Jeon">Beom S. Jeon</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Brain Mapping</term><term>Case-Control Studies</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Image Processing, Computer-Assisted (methods)</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (pathology)</term><term>Substantia Nigra (pathology)</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Image Processing, Computer-Assisted</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Brain Mapping</term><term>Case-Control Studies</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is a neurodegenerative disorder resulting from progressive loss of dopaminergic neurons in the substantia nigra (SN) pars compacta. Therefore, imaging of the SN has been regarded to hold greatest potential for use in the diagnosis of PD. At the 7.0T magnetic resonance imaging (MRI), it is now possible to delineate clearly the shapes and boundaries of the SN. We scanned eight early and two advanced PD patients, along with nine age-matched control subjects, using a 7.0T MRI in an attempt to directly visualize the SN and quantify the differences in shape and boundaries of SN between PD subjects in comparison with the normal control subjects. In the normal controls, the boundaries between the SN and crus cerebri appear smooth, and clean "arch" shapes that stretch ventrally from posterior to anterior. In contrast, these smooth and clean arch-like boundaries were lost in PD subjects. The measured correlation analyses show that, in PD patients, there is age-dependent correlation and substantially stronger UPDRS motor score-dependent correlation. These results suggest that, by using 7.0T MRI, it appears possible to use these visible and distinctive changes in morphology as a diagnostic marker of PD.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">21506148</PMID><DateCreated><Year>2011</Year><Month>04</Month><Day>20</Day></DateCreated><DateCompleted><Year>2011</Year><Month>08</Month><Day>15</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>4</Issue><PubDate><Year>2011</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Direct visualization of Parkinson's disease by in vivo human brain imaging using 7.0T magnetic resonance imaging.</ArticleTitle><Pagination><MedlinePgn>713-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.23465</ELocationID><Abstract><AbstractText>Parkinson's disease (PD) is a neurodegenerative disorder resulting from progressive loss of dopaminergic neurons in the substantia nigra (SN) pars compacta. Therefore, imaging of the SN has been regarded to hold greatest potential for use in the diagnosis of PD. At the 7.0T magnetic resonance imaging (MRI), it is now possible to delineate clearly the shapes and boundaries of the SN. We scanned eight early and two advanced PD patients, along with nine age-matched control subjects, using a 7.0T MRI in an attempt to directly visualize the SN and quantify the differences in shape and boundaries of SN between PD subjects in comparison with the normal control subjects. In the normal controls, the boundaries between the SN and crus cerebri appear smooth, and clean "arch" shapes that stretch ventrally from posterior to anterior. In contrast, these smooth and clean arch-like boundaries were lost in PD subjects. The measured correlation analyses show that, in PD patients, there is age-dependent correlation and substantially stronger UPDRS motor score-dependent correlation. These results suggest that, by using 7.0T MRI, it appears possible to use these visible and distinctive changes in morphology as a diagnostic marker of PD.</AbstractText><CopyrightInformation>Copyright © 2011 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cho</LastName><ForeName>Zang-Hee</ForeName><Initials>ZH</Initials><AffiliationInfo><Affiliation>Neuroscience Research Institute, Gachon University of Medicine and Science, Namdong-gu, Incheon, South Korea. zcho@gachon.ac.kr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oh</LastName><ForeName>Se-Hong</ForeName><Initials>SH</Initials></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Jong-Min</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Sung-Yeon</ForeName><Initials>SY</Initials></Author><Author ValidYN="Y"><LastName>Kwon</LastName><ForeName>Dae-Hyuk</ForeName><Initials>DH</Initials></Author><Author ValidYN="Y"><LastName>Jeong</LastName><ForeName>Hye-Jin</ForeName><Initials>HJ</Initials></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Young-Bo</ForeName><Initials>YB</Initials></Author><Author ValidYN="Y"><LastName>Chi</LastName><ForeName>Je-Geun</ForeName><Initials>JG</Initials></Author><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Chan-Woong</ForeName><Initials>CW</Initials></Author><Author ValidYN="Y"><LastName>Huston</LastName><ForeName>John</ForeName><Initials>J</Initials><Suffix>3rd</Suffix></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Kendall H</ForeName><Initials>KH</Initials></Author><Author ValidYN="Y"><LastName>Jeon</LastName><ForeName>Beom S</ForeName><Initials>BS</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>01</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001931">Brain Mapping</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016022">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007839">Functional Laterality</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007091">Image Processing, Computer-Assisted</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D008279">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013378">Substantia Nigra</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year><Month>3</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2010</Year><Month>7</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2010</Year><Month>9</Month><Day>9</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2011</Year><Month>1</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>4</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>4</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>8</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.23465</ArticleId><ArticleId IdType="pubmed">21506148</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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