MovDisordV3, PubMed, Corpus, bibRecord, 000E48

Intrathecal application of autologous bone marrow cell preparations in Parkinsonian syndromes.

Identifieur interne : 000E48 ( PubMed/Corpus ); précédent : 000E47; suivant : 000E49

Intrathecal application of autologous bone marrow cell preparations in Parkinsonian syndromes.

Auteurs : Alexander Storch ; Ilona Csoti ; Karla Eggert ; Tove Henriksen ; Annika Plate ; Michael Lorrain ; Wolfgang H. Oertel ; Angelo Antonini

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.

RBID : pubmed:22362657

English descriptors

KwdEn :
- Adult, Aged, Bone Marrow Cells (physiology), Bone Marrow Transplantation (methods), Female, Humans, Injections, Spinal, Male, Middle Aged, Parkinsonian Disorders (surgery), Retrospective Studies, Treatment Outcome.
MESH :
- methods : Bone Marrow Transplantation.
- physiology : Bone Marrow Cells.
- surgery : Parkinsonian Disorders.
- Adult, Aged, Female, Humans, Injections, Spinal, Male, Middle Aged, Retrospective Studies, Treatment Outcome.

Abstract

A growing number of patients is treated with intrathecal application of autologous bone marrow cells (aBMCs), but clinical data are completely lacking in movement disorders. We provide first clinical data on efficacy and safety of this highly experimental treatment approach in parkinsonian syndromes.

DOI: 10.1002/mds.24920
PubMed: 22362657

Links to Exploration step

pubmed:22362657

Le document en format XML

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<author><name sortKey="Storch, Alexander" sort="Storch, Alexander" uniqKey="Storch A" first="Alexander" last="Storch">Alexander Storch</name>
<affiliation><nlm:affiliation>Division of Neurodegenerative Diseases, Department of Neurology, Dresden University of Technology, Dresden, Germany. alexander.storch@neuro.med.tu-dresden.de</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Csoti, Ilona" sort="Csoti, Ilona" uniqKey="Csoti I" first="Ilona" last="Csoti">Ilona Csoti</name>
</author>
<author><name sortKey="Eggert, Karla" sort="Eggert, Karla" uniqKey="Eggert K" first="Karla" last="Eggert">Karla Eggert</name>
</author>
<author><name sortKey="Henriksen, Tove" sort="Henriksen, Tove" uniqKey="Henriksen T" first="Tove" last="Henriksen">Tove Henriksen</name>
</author>
<author><name sortKey="Plate, Annika" sort="Plate, Annika" uniqKey="Plate A" first="Annika" last="Plate">Annika Plate</name>
</author>
<author><name sortKey="Lorrain, Michael" sort="Lorrain, Michael" uniqKey="Lorrain M" first="Michael" last="Lorrain">Michael Lorrain</name>
</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H" last="Oertel">Wolfgang H. Oertel</name>
</author>
<author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name>
</author>
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<idno type="doi">10.1002/mds.24920</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Intrathecal application of autologous bone marrow cell preparations in Parkinsonian syndromes.</title>
<author><name sortKey="Storch, Alexander" sort="Storch, Alexander" uniqKey="Storch A" first="Alexander" last="Storch">Alexander Storch</name>
<affiliation><nlm:affiliation>Division of Neurodegenerative Diseases, Department of Neurology, Dresden University of Technology, Dresden, Germany. alexander.storch@neuro.med.tu-dresden.de</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Csoti, Ilona" sort="Csoti, Ilona" uniqKey="Csoti I" first="Ilona" last="Csoti">Ilona Csoti</name>
</author>
<author><name sortKey="Eggert, Karla" sort="Eggert, Karla" uniqKey="Eggert K" first="Karla" last="Eggert">Karla Eggert</name>
</author>
<author><name sortKey="Henriksen, Tove" sort="Henriksen, Tove" uniqKey="Henriksen T" first="Tove" last="Henriksen">Tove Henriksen</name>
</author>
<author><name sortKey="Plate, Annika" sort="Plate, Annika" uniqKey="Plate A" first="Annika" last="Plate">Annika Plate</name>
</author>
<author><name sortKey="Lorrain, Michael" sort="Lorrain, Michael" uniqKey="Lorrain M" first="Michael" last="Lorrain">Michael Lorrain</name>
</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H" last="Oertel">Wolfgang H. Oertel</name>
</author>
<author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2012" type="published">2012</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Bone Marrow Cells (physiology)</term>
<term>Bone Marrow Transplantation (methods)</term>
<term>Female</term>
<term>Humans</term>
<term>Injections, Spinal</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinsonian Disorders (surgery)</term>
<term>Retrospective Studies</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Bone Marrow Transplantation</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Bone Marrow Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinsonian Disorders</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Injections, Spinal</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Retrospective Studies</term>
<term>Treatment Outcome</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en">A growing number of patients is treated with intrathecal application of autologous bone marrow cells (aBMCs), but clinical data are completely lacking in movement disorders. We provide first clinical data on efficacy and safety of this highly experimental treatment approach in parkinsonian syndromes.</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">22362657</PMID>
<DateCreated><Year>2012</Year>
<Month>10</Month>
<Day>19</Day>
</DateCreated>
<DateCompleted><Year>2013</Year>
<Month>04</Month>
<Day>18</Day>
</DateCompleted>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>27</Volume>
<Issue>12</Issue>
<PubDate><Year>2012</Year>
<Month>Oct</Month>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>Intrathecal application of autologous bone marrow cell preparations in Parkinsonian syndromes.</ArticleTitle>
<Pagination><MedlinePgn>1552-5</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.24920</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">A growing number of patients is treated with intrathecal application of autologous bone marrow cells (aBMCs), but clinical data are completely lacking in movement disorders. We provide first clinical data on efficacy and safety of this highly experimental treatment approach in parkinsonian syndromes.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Retrospective data collection from patients with parkinsonism who spontaneously sought cell treatment. The application procedure was neither recommended nor performed by the authors.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">We report 17 patients with parkinsonian syndromes (Parkinson's disease [PD], n = 7; multiple system atrophy [MSA], n = 7; various, n = 3) who received intrathecal application of aBMCs. We did not observe any changes in motor function, activities of daily living, global clinical impression, or antiparkinsonian medication after a median observation period of 10 months. Two patients reported a worsening of parkinsonian symptoms, but the intervention was otherwise safe and well-tolerated.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Intrathecal application of aBMCs in uncontrolled conditions produces no clinical benefit in parkinsonian syndromes.</AbstractText>
<CopyrightInformation>Copyright © 2012 Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Storch</LastName>
<ForeName>Alexander</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Division of Neurodegenerative Diseases, Department of Neurology, Dresden University of Technology, Dresden, Germany. alexander.storch@neuro.med.tu-dresden.de</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Csoti</LastName>
<ForeName>Ilona</ForeName>
<Initials>I</Initials>
</Author>
<Author ValidYN="Y"><LastName>Eggert</LastName>
<ForeName>Karla</ForeName>
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<Author ValidYN="Y"><LastName>Henriksen</LastName>
<ForeName>Tove</ForeName>
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<Author ValidYN="Y"><LastName>Plate</LastName>
<ForeName>Annika</ForeName>
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<Author ValidYN="Y"><LastName>Lorrain</LastName>
<ForeName>Michael</ForeName>
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<Author ValidYN="Y"><LastName>Oertel</LastName>
<ForeName>Wolfgang H</ForeName>
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<Author ValidYN="Y"><LastName>Antonini</LastName>
<ForeName>Angelo</ForeName>
<Initials>A</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2012</Year>
<Month>02</Month>
<Day>23</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Mov Disord</MedlineTA>
<NlmUniqueID>8610688</NlmUniqueID>
<ISSNLinking>0885-3185</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Mov Disord. 2012 Oct;27(12):1475-7</RefSource>
<PMID Version="1">23032987</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D001854">Bone Marrow Cells</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D016026">Bone Marrow Transplantation</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000379">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D007278">Injections, Spinal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D020734">Parkinsonian Disorders</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000601">surgery</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D012189">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D016896">Treatment Outcome</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year>
<Month>5</Month>
<Day>12</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2011</Year>
<Month>12</Month>
<Day>23</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2012</Year>
<Month>1</Month>
<Day>1</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="aheadofprint"><Year>2012</Year>
<Month>2</Month>
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<PubMedPubDate PubStatus="medline"><Year>2013</Year>
<Month>4</Month>
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</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="doi">10.1002/mds.24920</ArticleId>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Intrathecal application of autologous bone marrow cell preparations in Parkinsonian syndromes.

Intrathecal application of autologous bone marrow cell preparations in Parkinsonian syndromes.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki