Common variation in the LRRK2 gene is a risk factor for Parkinson's disease.
Identifieur interne : 000B84 ( PubMed/Corpus ); précédent : 000B83; suivant : 000B85Common variation in the LRRK2 gene is a risk factor for Parkinson's disease.
Auteurs : Ignacio F. Mata ; Harvey Checkoway ; Carolyn M. Hutter ; Ali Samii ; John W. Roberts ; Hojoong M. Kim ; Pinky Agarwal ; Victoria Alvarez ; Renee Ribacoba ; Pau Pastor ; Oswaldo Lorenzo-Betancor ; Jon Infante ; María Sierra ; Pilar G Mez-Garre ; Pablo Mir ; Beate Ritz ; Shannon L. Rhodes ; Amy Colcher ; Vivianna Van Deerlin ; Kathryn A. Chung ; Joseph F. Quinn ; Dora Yearout ; Erica Martinez ; Federico M. Farin ; Jia Y. Wan ; Karen L. Edwards ; Cyrus P. ZabetianSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Protein-Serine-Threonine Kinases.
- geographic : Spain, United States.
- genetics : Genetic Predisposition to Disease, Parkinson Disease, Polymorphism, Single Nucleotide.
- methods : Genetic Testing.
- Aged, Female, Genotype, Humans, Male, Middle Aged, Risk Factors.
Abstract
Common variants in the LRRK2 gene influence the risk of Parkinson's disease (PD) in Asians, but whether the same is true in European-derived populations is less clear.
DOI: 10.1002/mds.25226
PubMed: 23115130
Links to Exploration step
pubmed:23115130Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Common variation in the LRRK2 gene is a risk factor for Parkinson's disease.</title><author><name sortKey="Mata, Ignacio F" sort="Mata, Ignacio F" uniqKey="Mata I" first="Ignacio F" last="Mata">Ignacio F. Mata</name><affiliation><nlm:affiliation>Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA. nachofm@u.washington.edu</nlm:affiliation></affiliation></author><author><name sortKey="Checkoway, Harvey" sort="Checkoway, Harvey" uniqKey="Checkoway H" first="Harvey" last="Checkoway">Harvey Checkoway</name></author><author><name sortKey="Hutter, Carolyn M" sort="Hutter, Carolyn M" uniqKey="Hutter C" first="Carolyn M" last="Hutter">Carolyn M. Hutter</name></author><author><name sortKey="Samii, Ali" sort="Samii, Ali" uniqKey="Samii A" first="Ali" last="Samii">Ali Samii</name></author><author><name sortKey="Roberts, John W" sort="Roberts, John W" uniqKey="Roberts J" first="John W" last="Roberts">John W. Roberts</name></author><author><name sortKey="Kim, Hojoong M" sort="Kim, Hojoong M" uniqKey="Kim H" first="Hojoong M" last="Kim">Hojoong M. Kim</name></author><author><name sortKey="Agarwal, Pinky" sort="Agarwal, Pinky" uniqKey="Agarwal P" first="Pinky" last="Agarwal">Pinky Agarwal</name></author><author><name sortKey="Alvarez, Victoria" sort="Alvarez, Victoria" uniqKey="Alvarez V" first="Victoria" last="Alvarez">Victoria Alvarez</name></author><author><name sortKey="Ribacoba, Renee" sort="Ribacoba, Renee" uniqKey="Ribacoba R" first="Renee" last="Ribacoba">Renee Ribacoba</name></author><author><name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name></author><author><name sortKey="Lorenzo Betancor, Oswaldo" sort="Lorenzo Betancor, Oswaldo" uniqKey="Lorenzo Betancor O" first="Oswaldo" last="Lorenzo-Betancor">Oswaldo Lorenzo-Betancor</name></author><author><name sortKey="Infante, Jon" sort="Infante, Jon" uniqKey="Infante J" first="Jon" last="Infante">Jon Infante</name></author><author><name sortKey="Sierra, Maria" sort="Sierra, Maria" uniqKey="Sierra M" first="María" last="Sierra">María Sierra</name></author><author><name sortKey="G Mez Garre, Pilar" sort="G Mez Garre, Pilar" uniqKey="G Mez Garre P" first="Pilar" last="G Mez-Garre">Pilar G Mez-Garre</name></author><author><name sortKey="Mir, Pablo" sort="Mir, Pablo" uniqKey="Mir P" first="Pablo" last="Mir">Pablo Mir</name></author><author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name></author><author><name sortKey="Rhodes, Shannon L" sort="Rhodes, Shannon L" uniqKey="Rhodes S" first="Shannon L" last="Rhodes">Shannon L. 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Quinn</name></author><author><name sortKey="Yearout, Dora" sort="Yearout, Dora" uniqKey="Yearout D" first="Dora" last="Yearout">Dora Yearout</name></author><author><name sortKey="Martinez, Erica" sort="Martinez, Erica" uniqKey="Martinez E" first="Erica" last="Martinez">Erica Martinez</name></author><author><name sortKey="Farin, Federico M" sort="Farin, Federico M" uniqKey="Farin F" first="Federico M" last="Farin">Federico M. Farin</name></author><author><name sortKey="Wan, Jia Y" sort="Wan, Jia Y" uniqKey="Wan J" first="Jia Y" last="Wan">Jia Y. Wan</name></author><author><name sortKey="Edwards, Karen L" sort="Edwards, Karen L" uniqKey="Edwards K" first="Karen L" last="Edwards">Karen L. Edwards</name></author><author><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P" last="Zabetian">Cyrus P. Zabetian</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1002/mds.25226</idno><idno type="RBID">pubmed:23115130</idno><idno type="pmid">23115130</idno><idno type="wicri:Area/PubMed/Corpus">000B84</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Common variation in the LRRK2 gene is a risk factor for Parkinson's disease.</title><author><name sortKey="Mata, Ignacio F" sort="Mata, Ignacio F" uniqKey="Mata I" first="Ignacio F" last="Mata">Ignacio F. Mata</name><affiliation><nlm:affiliation>Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA. nachofm@u.washington.edu</nlm:affiliation></affiliation></author><author><name sortKey="Checkoway, Harvey" sort="Checkoway, Harvey" uniqKey="Checkoway H" first="Harvey" last="Checkoway">Harvey Checkoway</name></author><author><name sortKey="Hutter, Carolyn M" sort="Hutter, Carolyn M" uniqKey="Hutter C" first="Carolyn M" last="Hutter">Carolyn M. Hutter</name></author><author><name sortKey="Samii, Ali" sort="Samii, Ali" uniqKey="Samii A" first="Ali" last="Samii">Ali Samii</name></author><author><name sortKey="Roberts, John W" sort="Roberts, John W" uniqKey="Roberts J" first="John W" last="Roberts">John W. Roberts</name></author><author><name sortKey="Kim, Hojoong M" sort="Kim, Hojoong M" uniqKey="Kim H" first="Hojoong M" last="Kim">Hojoong M. Kim</name></author><author><name sortKey="Agarwal, Pinky" sort="Agarwal, Pinky" uniqKey="Agarwal P" first="Pinky" last="Agarwal">Pinky Agarwal</name></author><author><name sortKey="Alvarez, Victoria" sort="Alvarez, Victoria" uniqKey="Alvarez V" first="Victoria" last="Alvarez">Victoria Alvarez</name></author><author><name sortKey="Ribacoba, Renee" sort="Ribacoba, Renee" uniqKey="Ribacoba R" first="Renee" last="Ribacoba">Renee Ribacoba</name></author><author><name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name></author><author><name sortKey="Lorenzo Betancor, Oswaldo" sort="Lorenzo Betancor, Oswaldo" uniqKey="Lorenzo Betancor O" first="Oswaldo" last="Lorenzo-Betancor">Oswaldo Lorenzo-Betancor</name></author><author><name sortKey="Infante, Jon" sort="Infante, Jon" uniqKey="Infante J" first="Jon" last="Infante">Jon Infante</name></author><author><name sortKey="Sierra, Maria" sort="Sierra, Maria" uniqKey="Sierra M" first="María" last="Sierra">María Sierra</name></author><author><name sortKey="G Mez Garre, Pilar" sort="G Mez Garre, Pilar" uniqKey="G Mez Garre P" first="Pilar" last="G Mez-Garre">Pilar G Mez-Garre</name></author><author><name sortKey="Mir, Pablo" sort="Mir, Pablo" uniqKey="Mir P" first="Pablo" last="Mir">Pablo Mir</name></author><author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name></author><author><name sortKey="Rhodes, Shannon L" sort="Rhodes, Shannon L" uniqKey="Rhodes S" first="Shannon L" last="Rhodes">Shannon L. Rhodes</name></author><author><name sortKey="Colcher, Amy" sort="Colcher, Amy" uniqKey="Colcher A" first="Amy" last="Colcher">Amy Colcher</name></author><author><name sortKey="Van Deerlin, Vivianna" sort="Van Deerlin, Vivianna" uniqKey="Van Deerlin V" first="Vivianna" last="Van Deerlin">Vivianna Van Deerlin</name></author><author><name sortKey="Chung, Kathryn A" sort="Chung, Kathryn A" uniqKey="Chung K" first="Kathryn A" last="Chung">Kathryn A. Chung</name></author><author><name sortKey="Quinn, Joseph F" sort="Quinn, Joseph F" uniqKey="Quinn J" first="Joseph F" last="Quinn">Joseph F. Quinn</name></author><author><name sortKey="Yearout, Dora" sort="Yearout, Dora" uniqKey="Yearout D" first="Dora" last="Yearout">Dora Yearout</name></author><author><name sortKey="Martinez, Erica" sort="Martinez, Erica" uniqKey="Martinez E" first="Erica" last="Martinez">Erica Martinez</name></author><author><name sortKey="Farin, Federico M" sort="Farin, Federico M" uniqKey="Farin F" first="Federico M" last="Farin">Federico M. Farin</name></author><author><name sortKey="Wan, Jia Y" sort="Wan, Jia Y" uniqKey="Wan J" first="Jia Y" last="Wan">Jia Y. Wan</name></author><author><name sortKey="Edwards, Karen L" sort="Edwards, Karen L" uniqKey="Edwards K" first="Karen L" last="Edwards">Karen L. Edwards</name></author><author><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P" last="Zabetian">Cyrus P. Zabetian</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Female</term><term>Genetic Predisposition to Disease (genetics)</term><term>Genetic Testing (methods)</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (genetics)</term><term>Polymorphism, Single Nucleotide (genetics)</term><term>Protein-Serine-Threonine Kinases (genetics)</term><term>Risk Factors</term><term>Spain</term><term>United States</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Protein-Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Spain</term><term>United States</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genetic Predisposition to Disease</term><term>Parkinson Disease</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Genetic Testing</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Common variants in the LRRK2 gene influence the risk of Parkinson's disease (PD) in Asians, but whether the same is true in European-derived populations is less clear.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">23115130</PMID><DateCreated><Year>2013</Year><Month>01</Month><Day>03</Day></DateCreated><DateCompleted><Year>2013</Year><Month>08</Month><Day>07</Day></DateCompleted><DateRevised><Year>2015</Year><Month>09</Month><Day>29</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>27</Volume><Issue>14</Issue><PubDate><Year>2012</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Common variation in the LRRK2 gene is a risk factor for Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>1822-5</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.25226</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Common variants in the LRRK2 gene influence the risk of Parkinson's disease (PD) in Asians, but whether the same is true in European-derived populations is less clear.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We genotyped 66 LRRK2 tagging single-nucleotide polymorphisms (SNPs) in 575 PD patients and 689 controls from the northwestern United States (tier 1). PD-associated SNPs (P < .05) were then genotyped in an independent sample of 3617 cases and 2512 controls from the United States and Spain (tier 2). Logistic regression was used to model additive SNP genotype effects adjusted for age and sex among white individuals.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Two regions showed independent association with PD in tier 1, and SNPs in both regions were successfully replicated in tier 2 (rs10878226, combined odds ratio [OR], 1.20; 95% confidence interval [CI], 1.08-1.33; P = 6.3 × 10(-4); rs11176013, OR, 0.89; CI, 0.83-0.95; P = 4.6 × 10(-4)).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our data suggest that common variation within LRRK2 conveys susceptibility for PD in individuals of European ancestry.</AbstractText><CopyrightInformation>Copyright © 2012 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mata</LastName><ForeName>Ignacio F</ForeName><Initials>IF</Initials><AffiliationInfo><Affiliation>Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA. nachofm@u.washington.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Checkoway</LastName><ForeName>Harvey</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Hutter</LastName><ForeName>Carolyn M</ForeName><Initials>CM</Initials></Author><Author ValidYN="Y"><LastName>Samii</LastName><ForeName>Ali</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Roberts</LastName><ForeName>John W</ForeName><Initials>JW</Initials></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Hojoong M</ForeName><Initials>HM</Initials></Author><Author ValidYN="Y"><LastName>Agarwal</LastName><ForeName>Pinky</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Alvarez</LastName><ForeName>Victoria</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Ribacoba</LastName><ForeName>Renee</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Pastor</LastName><ForeName>Pau</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Lorenzo-Betancor</LastName><ForeName>Oswaldo</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Infante</LastName><ForeName>Jon</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Sierra</LastName><ForeName>María</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Gómez-Garre</LastName><ForeName>Pilar</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Mir</LastName><ForeName>Pablo</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Ritz</LastName><ForeName>Beate</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Rhodes</LastName><ForeName>Shannon L</ForeName><Initials>SL</Initials></Author><Author ValidYN="Y"><LastName>Colcher</LastName><ForeName>Amy</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Van Deerlin</LastName><ForeName>Vivianna</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Chung</LastName><ForeName>Kathryn A</ForeName><Initials>KA</Initials></Author><Author ValidYN="Y"><LastName>Quinn</LastName><ForeName>Joseph F</ForeName><Initials>JF</Initials></Author><Author ValidYN="Y"><LastName>Yearout</LastName><ForeName>Dora</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Martinez</LastName><ForeName>Erica</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Farin</LastName><ForeName>Federico M</ForeName><Initials>FM</Initials></Author><Author ValidYN="Y"><LastName>Wan</LastName><ForeName>Jia Y</ForeName><Initials>JY</Initials></Author><Author ValidYN="Y"><LastName>Edwards</LastName><ForeName>Karen L</ForeName><Initials>KL</Initials></Author><Author ValidYN="Y"><LastName>Zabetian</LastName><ForeName>Cyrus P</ForeName><Initials>CP</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>I01 BX000531</GrantID><Acronym>BX</Acronym><Agency>BLRD VA</Agency><Country>United States</Country></Grant><Grant><GrantID>P01 ES016732</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 AG008017</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P50 NS053488</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P50 NS062684</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 ES010544</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 NS065070</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>10</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="C495280">LRRK2 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="D017346">Protein-Serine-Threonine Kinases</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Am J Epidemiol. 2002 Apr 15;155(8):732-8</RefSource><PMID Version="1">11943691</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurol Neurosurg Psychiatry. 1988 Jun;51(6):745-52</RefSource><PMID Version="1">2841426</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet Neurol. 2011 Oct;10(10):898-908</RefSource><PMID Version="1">21885347</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Genet. 2011 Jun;7(6):e1002141</RefSource><PMID Version="1">21738487</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parkinsonism Relat Disord. 2012 Jul;18(6):722-30</RefSource><PMID Version="1">22575234</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Genet. 2012;8(3):e1002548</RefSource><PMID Version="1">22438815</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2005 Sep;20(9):1133-42</RefSource><PMID Version="1">15954133</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2005 Sep 13;65(5):741-4</RefSource><PMID Version="1">16157909</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2005 Dec;58(6):905-8</RefSource><PMID Version="1">16254973</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurogenetics. 2006 Jul;7(3):133-8</RefSource><PMID Version="1">16633828</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Mutat. 2008 Apr;29(4):485-90</RefSource><PMID Version="1">18213618</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2008 Jul;64(1):88-92</RefSource><PMID Version="1">18412265</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2009 May 15;24(7):1034-41</RefSource><PMID Version="1">19343804</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2009 Dec;41(12):1308-12</RefSource><PMID Version="1">19915575</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Hum Genet. 2010 Mar;74(2):97-109</RefSource><PMID Version="1">20070850</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Mutat. 2010 May;31(5):561-8</RefSource><PMID Version="1">20186690</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2010 Sep;42(9):781-5</RefSource><PMID Version="1">20711177</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Mol Genet. 2011 Jan 15;20(2):345-53</RefSource><PMID Version="1">21044948</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2011 Feb 19;377(9766):641-9</RefSource><PMID Version="1">21292315</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Hum Genet. 2011 Jun;19(6):655-61</RefSource><PMID Version="1">21248740</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" 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UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020641">Polymorphism, Single Nucleotide</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017346">Protein-Serine-Threonine Kinases</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012307">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" Type="Geographic" UI="D013030">Spain</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" Type="Geographic" UI="D014481">United States</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS407662</OtherID><OtherID Source="NLM">PMC3536918</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>6</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2012</Year><Month>8</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>9</Month><Day>6</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2012</Year><Month>10</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>11</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>11</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>8</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.25226</ArticleId><ArticleId IdType="pubmed">23115130</ArticleId><ArticleId IdType="pmc">PMC3536918</ArticleId><ArticleId 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