MovDisordV3, PubMed, Corpus, bibRecord, 000996

The inferior olivary nucleus: a postmortem study of essential tremor cases versus controls.

Identifieur interne : 000996 ( PubMed/Corpus ); précédent : 000995; suivant : 000997

The inferior olivary nucleus: a postmortem study of essential tremor cases versus controls.

Auteurs : Elan D. Louis ; Rachel Babij ; Etty Cortés ; Jean-Paul G. Vonsattel ; Phyllis L. Faust

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.

RBID : pubmed:23483605

English descriptors

KwdEn :
- Age Factors, Aged, Aged, 80 and over, Essential Tremor (pathology), Female, Humans, Male, Neuroglia (pathology), Neurons (pathology), Olivary Nucleus (pathology), Postmortem Changes.
MESH :
- pathology : Essential Tremor, Neuroglia, Neurons, Olivary Nucleus.
- Age Factors, Aged, Aged, 80 and over, Female, Humans, Male, Postmortem Changes.

Abstract

The pathogenesis of essential tremor is poorly understood. Historically, it has been hypothesized that the inferior olivary nucleus plays an important role in the generation of tremor in essential tremor, yet a detailed, controlled, anatomic-pathological study of that brain region has yet to be conducted. A detailed postmortem study was undertaken of the microscopic changes in the inferior olivary nucleus of 14 essential tremor cases versus 15 age-matched controls at the Essential Tremor Centralized Brain Repository. A series of metrics was used to quantify microscopic neuronal and glial changes in the inferior olivary nucleus and its input and output tracts. Olivary linear neuronal density also was assessed. Cases and controls did not differ from one another with respect to any of the assessed metrics (P values ranged from 0.23 to 1.0). Olivary linear neuronal density also was similar in cases and controls (P = 0.62). Paddle-shaped neurons, a morphologic shape change in olivary neurons, which, to our knowledge, have not been previously recognized, occurred to an equal degree in essential tremor cases and controls (P = 0.89) and were correlated with several markers of neuronal loss and gliosis. A systematic postmortem study of the microscopic changes in the inferior olivary nucleus did not detect any differences between cases and controls. These data, along with positron emission tomography data, which have failed to identify any metabolic abnormality of the olive, indicate that, if the olive is involved in essential tremor, then there is no clearly identifiable structural or metabolic correlate.

DOI: 10.1002/mds.25400
PubMed: 23483605

Links to Exploration step

pubmed:23483605

Le document en format XML

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<author><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D" last="Louis">Elan D. Louis</name>
<affiliation><nlm:affiliation>G H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Babij, Rachel" sort="Babij, Rachel" uniqKey="Babij R" first="Rachel" last="Babij">Rachel Babij</name>
</author>
<author><name sortKey="Cortes, Etty" sort="Cortes, Etty" uniqKey="Cortes E" first="Etty" last="Cortés">Etty Cortés</name>
</author>
<author><name sortKey="Vonsattel, Jean Paul G" sort="Vonsattel, Jean Paul G" uniqKey="Vonsattel J" first="Jean-Paul G" last="Vonsattel">Jean-Paul G. Vonsattel</name>
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<author><name sortKey="Faust, Phyllis L" sort="Faust, Phyllis L" uniqKey="Faust P" first="Phyllis L" last="Faust">Phyllis L. Faust</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">The inferior olivary nucleus: a postmortem study of essential tremor cases versus controls.</title>
<author><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D" last="Louis">Elan D. Louis</name>
<affiliation><nlm:affiliation>G H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA.</nlm:affiliation>
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<author><name sortKey="Babij, Rachel" sort="Babij, Rachel" uniqKey="Babij R" first="Rachel" last="Babij">Rachel Babij</name>
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<author><name sortKey="Vonsattel, Jean Paul G" sort="Vonsattel, Jean Paul G" uniqKey="Vonsattel J" first="Jean-Paul G" last="Vonsattel">Jean-Paul G. Vonsattel</name>
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<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Neuroglia (pathology)</term>
<term>Neurons (pathology)</term>
<term>Olivary Nucleus (pathology)</term>
<term>Postmortem Changes</term>
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<term>Aged</term>
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<front><div type="abstract" xml:lang="en">The pathogenesis of essential tremor is poorly understood. Historically, it has been hypothesized that the inferior olivary nucleus plays an important role in the generation of tremor in essential tremor, yet a detailed, controlled, anatomic-pathological study of that brain region has yet to be conducted. A detailed postmortem study was undertaken of the microscopic changes in the inferior olivary nucleus of 14 essential tremor cases versus 15 age-matched controls at the Essential Tremor Centralized Brain Repository. A series of metrics was used to quantify microscopic neuronal and glial changes in the inferior olivary nucleus and its input and output tracts. Olivary linear neuronal density also was assessed. Cases and controls did not differ from one another with respect to any of the assessed metrics (P values ranged from 0.23 to 1.0). Olivary linear neuronal density also was similar in cases and controls (P = 0.62). Paddle-shaped neurons, a morphologic shape change in olivary neurons, which, to our knowledge, have not been previously recognized, occurred to an equal degree in essential tremor cases and controls (P = 0.89) and were correlated with several markers of neuronal loss and gliosis. A systematic postmortem study of the microscopic changes in the inferior olivary nucleus did not detect any differences between cases and controls. These data, along with positron emission tomography data, which have failed to identify any metabolic abnormality of the olive, indicate that, if the olive is involved in essential tremor, then there is no clearly identifiable structural or metabolic correlate.</div>
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<CopyrightInformation>Copyright © 2013 Movement Disorder Society.</CopyrightInformation>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Louis</LastName>
<ForeName>Elan D</ForeName>
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<AffiliationInfo><Affiliation>G H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA.</Affiliation>
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	Movement Disorders (revue)
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Movement Disorders (revue)

The inferior olivary nucleus: a postmortem study of essential tremor cases versus controls.

The inferior olivary nucleus: a postmortem study of essential tremor cases versus controls.

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Abstract

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