Action-effect binding is decreased in motor conversion disorder: implications for sense of agency.
Identifieur interne : 000987 ( PubMed/Corpus ); précédent : 000986; suivant : 000988Action-effect binding is decreased in motor conversion disorder: implications for sense of agency.
Auteurs : Sarah M. Kranick ; James W. Moore ; Nadia Yusuf ; Valeria T. Martinez ; Kathrin Lafaver ; Mark J. Edwards ; Arpan R. Mehta ; Phoebe Collins ; Neil A. Harrison ; Patrick Haggard ; Mark Hallett ; Valerie VoonSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- complications : Conversion Disorder.
- etiology : Mood Disorders.
- psychology : Conversion Disorder.
- Adult, Aged, Awareness, Case-Control Studies, Cooperative Behavior, Dyskinesias, Female, Humans, Male, Middle Aged, Psychomotor Performance, Regression Analysis, Young Adult.
Abstract
The abnormal movements seen in motor conversion disorder are affected by distraction and entrainment, similar to voluntary movement. Unlike voluntary movement, however, patients lack a sense of control for the abnormal movements, a failure of "self-agency." The action-effect binding paradigm has been used to quantify the sense of self-agency, because subjective contraction of time between an action and its effect only occurs if the patient feels that they are the agent responsible for the action. We used this paradigm, coupled with emotional stimuli, to investigate the sense of agency with voluntary movements in patients with motor conversion disorder. Twenty patients with motor conversion disorder and 20 age-matched and sex-matched healthy volunteers used a rotating clock to judge the time of their own voluntary key presses (action) and a subsequent auditory tone (effect) after they completed conditioning blocks in which high, medium, and low tones were coupled to images of happy, fearful, and neutral faces. The results replicated those produced previously: it was reported that an effect after a voluntary action occurred earlier, and the preceding action occurred later, compared with trials that used only key presses or tones. Patients had reduced overall binding scores relative to healthy volunteers, suggesting a reduced sense of agency. There was no effect of the emotional stimuli (faces) or other interaction effects. Healthy volunteers with subclinical depressive symptoms had higher overall binding scores. We demonstrate that patients with motor conversion disorder have decreased action-effect binding for normal voluntary movements compared with healthy volunteers, consistent with the greater experience of lack of control.
DOI: 10.1002/mds.25408
PubMed: 23494975
Links to Exploration step
pubmed:23494975Le document en format XML
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Martinez</name></author><author><name sortKey="Lafaver, Kathrin" sort="Lafaver, Kathrin" uniqKey="Lafaver K" first="Kathrin" last="Lafaver">Kathrin Lafaver</name></author><author><name sortKey="Edwards, Mark J" sort="Edwards, Mark J" uniqKey="Edwards M" first="Mark J" last="Edwards">Mark J. Edwards</name></author><author><name sortKey="Mehta, Arpan R" sort="Mehta, Arpan R" uniqKey="Mehta A" first="Arpan R" last="Mehta">Arpan R. Mehta</name></author><author><name sortKey="Collins, Phoebe" sort="Collins, Phoebe" uniqKey="Collins P" first="Phoebe" last="Collins">Phoebe Collins</name></author><author><name sortKey="Harrison, Neil A" sort="Harrison, Neil A" uniqKey="Harrison N" first="Neil A" last="Harrison">Neil A. 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Kranick</name><affiliation><nlm:affiliation>Human Motor Control Section, Medical Neurology Branch, National Institutes of Neurological Disease and Stroke, National Institutes of Health, Bethesda Maryland, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Moore, James W" sort="Moore, James W" uniqKey="Moore J" first="James W" last="Moore">James W. Moore</name></author><author><name sortKey="Yusuf, Nadia" sort="Yusuf, Nadia" uniqKey="Yusuf N" first="Nadia" last="Yusuf">Nadia Yusuf</name></author><author><name sortKey="Martinez, Valeria T" sort="Martinez, Valeria T" uniqKey="Martinez V" first="Valeria T" last="Martinez">Valeria T. Martinez</name></author><author><name sortKey="Lafaver, Kathrin" sort="Lafaver, Kathrin" uniqKey="Lafaver K" first="Kathrin" last="Lafaver">Kathrin Lafaver</name></author><author><name sortKey="Edwards, Mark J" sort="Edwards, Mark J" uniqKey="Edwards M" first="Mark J" last="Edwards">Mark J. Edwards</name></author><author><name sortKey="Mehta, Arpan R" sort="Mehta, Arpan R" uniqKey="Mehta A" first="Arpan R" last="Mehta">Arpan R. Mehta</name></author><author><name sortKey="Collins, Phoebe" sort="Collins, Phoebe" uniqKey="Collins P" first="Phoebe" last="Collins">Phoebe Collins</name></author><author><name sortKey="Harrison, Neil A" sort="Harrison, Neil A" uniqKey="Harrison N" first="Neil A" last="Harrison">Neil A. Harrison</name></author><author><name sortKey="Haggard, Patrick" sort="Haggard, Patrick" uniqKey="Haggard P" first="Patrick" last="Haggard">Patrick Haggard</name></author><author><name sortKey="Hallett, Mark" sort="Hallett, Mark" uniqKey="Hallett M" first="Mark" last="Hallett">Mark Hallett</name></author><author><name sortKey="Voon, Valerie" sort="Voon, Valerie" uniqKey="Voon V" first="Valerie" last="Voon">Valerie Voon</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Awareness</term><term>Case-Control Studies</term><term>Conversion Disorder (complications)</term><term>Conversion Disorder (psychology)</term><term>Cooperative Behavior</term><term>Dyskinesias</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Mood Disorders (etiology)</term><term>Psychomotor Performance</term><term>Regression Analysis</term><term>Young Adult</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Conversion Disorder</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Mood Disorders</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Conversion Disorder</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Awareness</term><term>Case-Control Studies</term><term>Cooperative Behavior</term><term>Dyskinesias</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Psychomotor Performance</term><term>Regression Analysis</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The abnormal movements seen in motor conversion disorder are affected by distraction and entrainment, similar to voluntary movement. Unlike voluntary movement, however, patients lack a sense of control for the abnormal movements, a failure of "self-agency." The action-effect binding paradigm has been used to quantify the sense of self-agency, because subjective contraction of time between an action and its effect only occurs if the patient feels that they are the agent responsible for the action. We used this paradigm, coupled with emotional stimuli, to investigate the sense of agency with voluntary movements in patients with motor conversion disorder. Twenty patients with motor conversion disorder and 20 age-matched and sex-matched healthy volunteers used a rotating clock to judge the time of their own voluntary key presses (action) and a subsequent auditory tone (effect) after they completed conditioning blocks in which high, medium, and low tones were coupled to images of happy, fearful, and neutral faces. The results replicated those produced previously: it was reported that an effect after a voluntary action occurred earlier, and the preceding action occurred later, compared with trials that used only key presses or tones. Patients had reduced overall binding scores relative to healthy volunteers, suggesting a reduced sense of agency. There was no effect of the emotional stimuli (faces) or other interaction effects. Healthy volunteers with subclinical depressive symptoms had higher overall binding scores. We demonstrate that patients with motor conversion disorder have decreased action-effect binding for normal voluntary movements compared with healthy volunteers, consistent with the greater experience of lack of control.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">23494975</PMID><DateCreated><Year>2013</Year><Month>08</Month><Day>13</Day></DateCreated><DateCompleted><Year>2014</Year><Month>03</Month><Day>06</Day></DateCompleted><DateRevised><Year>2015</Year><Month>03</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>28</Volume><Issue>8</Issue><PubDate><Year>2013</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Action-effect binding is decreased in motor conversion disorder: implications for sense of agency.</ArticleTitle><Pagination><MedlinePgn>1110-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.25408</ELocationID><Abstract><AbstractText>The abnormal movements seen in motor conversion disorder are affected by distraction and entrainment, similar to voluntary movement. Unlike voluntary movement, however, patients lack a sense of control for the abnormal movements, a failure of "self-agency." The action-effect binding paradigm has been used to quantify the sense of self-agency, because subjective contraction of time between an action and its effect only occurs if the patient feels that they are the agent responsible for the action. We used this paradigm, coupled with emotional stimuli, to investigate the sense of agency with voluntary movements in patients with motor conversion disorder. Twenty patients with motor conversion disorder and 20 age-matched and sex-matched healthy volunteers used a rotating clock to judge the time of their own voluntary key presses (action) and a subsequent auditory tone (effect) after they completed conditioning blocks in which high, medium, and low tones were coupled to images of happy, fearful, and neutral faces. The results replicated those produced previously: it was reported that an effect after a voluntary action occurred earlier, and the preceding action occurred later, compared with trials that used only key presses or tones. Patients had reduced overall binding scores relative to healthy volunteers, suggesting a reduced sense of agency. There was no effect of the emotional stimuli (faces) or other interaction effects. Healthy volunteers with subclinical depressive symptoms had higher overall binding scores. We demonstrate that patients with motor conversion disorder have decreased action-effect binding for normal voluntary movements compared with healthy volunteers, consistent with the greater experience of lack of control.</AbstractText><CopyrightInformation>Copyright © 2013 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kranick</LastName><ForeName>Sarah M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Human Motor Control Section, Medical Neurology Branch, National Institutes of Neurological Disease and Stroke, National Institutes of Health, Bethesda Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moore</LastName><ForeName>James W</ForeName><Initials>JW</Initials></Author><Author ValidYN="Y"><LastName>Yusuf</LastName><ForeName>Nadia</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Martinez</LastName><ForeName>Valeria T</ForeName><Initials>VT</Initials></Author><Author ValidYN="Y"><LastName>LaFaver</LastName><ForeName>Kathrin</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Edwards</LastName><ForeName>Mark J</ForeName><Initials>MJ</Initials></Author><Author ValidYN="Y"><LastName>Mehta</LastName><ForeName>Arpan R</ForeName><Initials>AR</Initials></Author><Author ValidYN="Y"><LastName>Collins</LastName><ForeName>Phoebe</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Harrison</LastName><ForeName>Neil A</ForeName><Initials>NA</Initials></Author><Author ValidYN="Y"><LastName>Haggard</LastName><ForeName>Patrick</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Hallett</LastName><ForeName>Mark</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Voon</LastName><ForeName>Valerie</ForeName><Initials>V</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>Z99 NS999999</GrantID><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052060">Research Support, N.I.H., Intramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>03</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Nat Neurosci. 2002 Apr;5(4):382-5</RefSource><PMID Version="1">11896397</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Exp Brain Res. 2003 Apr;149(4):439-46</RefSource><PMID Version="1">12677324</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Conscious Cogn. 2003 Dec;12(4):695-707</RefSource><PMID Version="1">14656511</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 1983 Sep;106 (Pt 3):623-42</RefSource><PMID Version="1">6640273</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Adv Neurol. 1988;50:431-55</RefSource><PMID Version="1">3400501</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Gen Psychiatry. 1961 Jun;4:561-71</RefSource><PMID Version="1">13688369</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Conscious Cogn. 2009 Dec;18(4):1056-64</RefSource><PMID Version="1">19515577</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2010 Jan 19;74(3):223-8</RefSource><PMID Version="1">20083798</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 2010 May;133(Pt 5):1526-36</RefSource><PMID Version="1">20371508</PMID></CommentsCorrections><CommentsCorrections 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Behavior</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020820">Dyskinesias</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019964">Mood Disorders</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000209">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011597">Psychomotor Performance</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012044">Regression Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D055815">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS442539</OtherID><OtherID Source="NLM">PMC3701023</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">action-effect binding</Keyword><Keyword MajorTopicYN="N">agency</Keyword><Keyword MajorTopicYN="N">conversion disorder</Keyword><Keyword MajorTopicYN="N">forward model</Keyword><Keyword MajorTopicYN="N">psychogenic movement disorder</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>9</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2012</Year><Month>12</Month><Day>4</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>1</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2013</Year><Month>3</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>3</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>3</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>3</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23494975</ArticleId><ArticleId IdType="doi">10.1002/mds.25408</ArticleId><ArticleId IdType="pmc">PMC3701023</ArticleId><ArticleId IdType="mid">NIHMS442539</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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