Movement Disorders (revue)

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I finally see what you see: Parkinson's disease visual hallucinations captured with functional neuroimaging.

Identifieur interne : 000847 ( PubMed/Corpus ); précédent : 000846; suivant : 000848

I finally see what you see: Parkinson's disease visual hallucinations captured with functional neuroimaging.

Auteurs : Christopher G. Goetz ; Christina L. Vaughan ; Jennifer G. Goldman ; Glenn T. Stebbins

Source :

RBID : pubmed:23843193

English descriptors

Abstract

Functional neuroimaging studies have described alterations in neural activation in PD patients with chronic hallucinations. These studies have not, however, captured neural activation patterns during an actual hallucinatory event. The objective of this work was to investigate neuroanatomical substrates active during visual hallucinations in a patient with Parkinson's disease (PD).

DOI: 10.1002/mds.25554
PubMed: 23843193

Links to Exploration step

pubmed:23843193

Le document en format XML

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<title xml:lang="en">I finally see what you see: Parkinson's disease visual hallucinations captured with functional neuroimaging.</title>
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<name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher G" last="Goetz">Christopher G. Goetz</name>
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<nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.</nlm:affiliation>
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<name sortKey="Vaughan, Christina L" sort="Vaughan, Christina L" uniqKey="Vaughan C" first="Christina L" last="Vaughan">Christina L. Vaughan</name>
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<name sortKey="Goldman, Jennifer G" sort="Goldman, Jennifer G" uniqKey="Goldman J" first="Jennifer G" last="Goldman">Jennifer G. Goldman</name>
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<name sortKey="Stebbins, Glenn T" sort="Stebbins, Glenn T" uniqKey="Stebbins G" first="Glenn T" last="Stebbins">Glenn T. Stebbins</name>
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<name sortKey="Vaughan, Christina L" sort="Vaughan, Christina L" uniqKey="Vaughan C" first="Christina L" last="Vaughan">Christina L. Vaughan</name>
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<name sortKey="Goldman, Jennifer G" sort="Goldman, Jennifer G" uniqKey="Goldman J" first="Jennifer G" last="Goldman">Jennifer G. Goldman</name>
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<term>Hallucinations (complications)</term>
<term>Hallucinations (physiopathology)</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (physiopathology)</term>
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<term>Hallucinations</term>
<term>Parkinson Disease</term>
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<div type="abstract" xml:lang="en">Functional neuroimaging studies have described alterations in neural activation in PD patients with chronic hallucinations. These studies have not, however, captured neural activation patterns during an actual hallucinatory event. The objective of this work was to investigate neuroanatomical substrates active during visual hallucinations in a patient with Parkinson's disease (PD).</div>
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<Month>09</Month>
<Day>19</Day>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
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<ArticleTitle>I finally see what you see: Parkinson's disease visual hallucinations captured with functional neuroimaging.</ArticleTitle>
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<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Functional neuroimaging studies have described alterations in neural activation in PD patients with chronic hallucinations. These studies have not, however, captured neural activation patterns during an actual hallucinatory event. The objective of this work was to investigate neuroanatomical substrates active during visual hallucinations in a patient with Parkinson's disease (PD).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We conducted an event-related functional magnetic resonance imaging (fMRI) case-study examination of a 66-year-old male PD patient with stereotypic, chronic, and frequent visual hallucinations.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The patient reported 16 hallucinations during the fMRI scan. Increased activation during hallucinations was found in the cingulate, insula, frontal lobe, thalamus, and brain stem. Decreased activation was found in the lingual and fusiform gyri, inferior occipital gyrus, and middle frontal and superior temporal lobes.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">To our knowledge, this report is the first published case documenting the cortical activation patterns using fMRI techniques in a PD patient during active hallucinations. Our results suggest that during a visual hallucination, a marked desynchronization occurs between posterior and anterior cortical areas involved in visual processing.</AbstractText>
<CopyrightInformation>Copyright © 2013 Movement Disorder Society.</CopyrightInformation>
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