MovDisordV3, PubMed, Corpus, bibRecord, 000757

Specific splice variants are associated with Parkinson's disease.

Identifieur interne : 000757 ( PubMed/Corpus ); précédent : 000756; suivant : 000758

Specific splice variants are associated with Parkinson's disease.

Auteurs : Jose A. Santiago ; Clemens R. Scherzer ; Judith A. Potashkin

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.

RBID : pubmed:24108702

English descriptors

KwdEn :
- Aged, Biological Markers (blood), Female, Humans, Male, Middle Aged, Parkinson Disease (blood), Parkinson Disease (diagnosis), Protein Isoforms (blood).
MESH :
- chemical , blood : Biological Markers, Protein Isoforms.
- blood : Parkinson Disease.
- diagnosis : Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged.

Abstract

Diagnosis of Parkinson's disease (PD) currently relies on assessment of motor symptoms. Recently, sensitive, specific, and readily available splice variant-specific biomarkers were identified in peripheral blood from participants in the Diagnostic and Prognostic Biomarkers in Parkinson Disease study.

DOI: 10.1002/mds.25635
PubMed: 24108702

Links to Exploration step

pubmed:24108702

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Specific splice variants are associated with Parkinson's disease.</title>
<author><name sortKey="Santiago, Jose A" sort="Santiago, Jose A" uniqKey="Santiago J" first="Jose A" last="Santiago">Jose A. Santiago</name>
<affiliation><nlm:affiliation>Department of Cellular and Molecular Pharmacology, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R" last="Scherzer">Clemens R. Scherzer</name>
</author>
<author><name sortKey="Potashkin, Judith A" sort="Potashkin, Judith A" uniqKey="Potashkin J" first="Judith A" last="Potashkin">Judith A. Potashkin</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2013">2013</date>
<idno type="RBID">pubmed:24108702</idno>
<idno type="pmid">24108702</idno>
<idno type="doi">10.1002/mds.25635</idno>
<idno type="wicri:Area/PubMed/Corpus">000757</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Specific splice variants are associated with Parkinson's disease.</title>
<author><name sortKey="Santiago, Jose A" sort="Santiago, Jose A" uniqKey="Santiago J" first="Jose A" last="Santiago">Jose A. Santiago</name>
<affiliation><nlm:affiliation>Department of Cellular and Molecular Pharmacology, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R" last="Scherzer">Clemens R. Scherzer</name>
</author>
<author><name sortKey="Potashkin, Judith A" sort="Potashkin, Judith A" uniqKey="Potashkin J" first="Judith A" last="Potashkin">Judith A. Potashkin</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2013" type="published">2013</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Biological Markers (blood)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (blood)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Protein Isoforms (blood)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biological Markers</term>
<term>Protein Isoforms</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">Diagnosis of Parkinson's disease (PD) currently relies on assessment of motor symptoms. Recently, sensitive, specific, and readily available splice variant-specific biomarkers were identified in peripheral blood from participants in the Diagnostic and Prognostic Biomarkers in Parkinson Disease study.</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">24108702</PMID>
<DateCreated><Year>2013</Year>
<Month>10</Month>
<Day>29</Day>
</DateCreated>
<DateCompleted><Year>2014</Year>
<Month>06</Month>
<Day>20</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>06</Month>
<Day>15</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>28</Volume>
<Issue>12</Issue>
<PubDate><Year>2013</Year>
<Month>Oct</Month>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>Specific splice variants are associated with Parkinson's disease.</ArticleTitle>
<Pagination><MedlinePgn>1724-7</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.25635</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Diagnosis of Parkinson's disease (PD) currently relies on assessment of motor symptoms. Recently, sensitive, specific, and readily available splice variant-specific biomarkers were identified in peripheral blood from participants in the Diagnostic and Prognostic Biomarkers in Parkinson Disease study.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Here we test for an association between candidate splice variant biomarkers and PD in blood of an independent population of cases and controls nested in the Harvard NeuroDiscovery Center Biomarker Study.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Expression of 7 out of 13 candidate biomarkers was dysregulated in whole cellular blood of patients with PD.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These results support the view that differential expression of a subset of splice-variant markers in blood is associated with PD. Further evaluation in untreated, de novo patients and at-risk subjects is warranted.</AbstractText>
<CopyrightInformation>© 2013 Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Santiago</LastName>
<ForeName>Jose A</ForeName>
<Initials>JA</Initials>
<AffiliationInfo><Affiliation>Department of Cellular and Molecular Pharmacology, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Scherzer</LastName>
<ForeName>Clemens R</ForeName>
<Initials>CR</Initials>
</Author>
<Author ValidYN="Y"><CollectiveName>Harvard Biomarker Study</CollectiveName>
</Author>
<Author ValidYN="Y"><LastName>Potashkin</LastName>
<ForeName>Judith A</ForeName>
<Initials>JA</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>P01 NS058793</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 AG044113</GrantID>
<Acronym>AG</Acronym>
<Agency>NIA NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 NS064155</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 NS064155</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U01 AT000613</GrantID>
<Acronym>AT</Acronym>
<Agency>NCCIH NIH HHS</Agency>
<Country>United States</Country>
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<Grant><GrantID>U01 NS082080</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U01 NS082157</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U01 NS082157</GrantID>
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<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
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<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
<PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2013</Year>
<Month>09</Month>
<Day>20</Day>
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</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Mov Disord</MedlineTA>
<NlmUniqueID>8610688</NlmUniqueID>
<ISSNLinking>0885-3185</ISSNLinking>
</MedlineJournalInfo>
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<NameOfSubstance UI="D015415">Biological Markers</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D020033">Protein Isoforms</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2010 Jul;38(Web Server issue):W214-20</RefSource>
<PMID Version="1">20576703</PMID>
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<CommentsCorrections RefType="Cites"><RefSource>Science. 2013 Jan 11;339(6116):218-22</RefSource>
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<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2005 May 10;102(19):6931-5</RefSource>
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<PMID Version="1">17215369</PMID>
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<CommentsCorrections RefType="Cites"><RefSource>Eur J Neurosci. 2009 Mar;29(5):954-63</RefSource>
<PMID Version="1">19245367</PMID>
</CommentsCorrections>
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<MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D015415">Biological Markers</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName>
</MeshHeading>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName>
<QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D020033">Protein Isoforms</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000097">blood</QualifierName>
</MeshHeading>
</MeshHeadingList>
<OtherID Source="NLM">NIHMS509649</OtherID>
<OtherID Source="NLM">PMC3812386</OtherID>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Parkinson's disease</Keyword>
<Keyword MajorTopicYN="N">biomarker</Keyword>
<Keyword MajorTopicYN="N">gene expression</Keyword>
<Keyword MajorTopicYN="N">neurodegeneration</Keyword>
<Keyword MajorTopicYN="N">splicing</Keyword>
</KeywordList>
</MedlineCitation>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Specific splice variants are associated with Parkinson's disease.

Specific splice variants are associated with Parkinson's disease.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki