Does abnormal interhemispheric inhibition play a role in mirror dystonia?
Identifieur interne : 000650 ( PubMed/Corpus ); précédent : 000649; suivant : 000651Does abnormal interhemispheric inhibition play a role in mirror dystonia?
Auteurs : Virginie Sattler ; Maya Dickler ; Martin Michaud ; Sabine Meunier ; Marion Simonetta-MoreauSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Dystonia (etiology), Dystonic Disorders (complications), Electromyography, Evoked Potentials, Motor (physiology), Female, Functional Laterality (physiology), Humans, Male, Middle Aged, Motor Cortex (physiopathology), Neural Inhibition (physiology), Time Factors, Transcranial Magnetic Stimulation, Wrist (innervation), Young Adult.
- MESH :
- complications : Dystonic Disorders.
- etiology : Dystonia.
- innervation : Wrist.
- physiology : Evoked Potentials, Motor, Functional Laterality, Neural Inhibition.
- physiopathology : Motor Cortex.
- Adolescent, Adult, Aged, Electromyography, Female, Humans, Male, Middle Aged, Time Factors, Transcranial Magnetic Stimulation, Young Adult.
Abstract
The presence of mirror dystonia (dystonic movement induced by a specific task performed by the unaffected hand) in the dominant hand of writer's cramp patients when the nondominant hand is moved suggests an abnormal interaction between the 2 hemispheres. In this study we compare the level of interhemispheric inhibition (IHI) in 2 groups of patients with writer's cramp, one with the presence of a mirror dystonia and the other without as well as a control group. The level of bidirectional IHI was measured in wrist muscles with dual-site transcranial magnetic stimulation with a 10-millisecond (short IHI) and a 40-millisecond (long IHI) interstimulus interval during rest and while holding a pen in 9 patients with mirror dystonia 7 without mirror dystonia, and 13 controls. The group of patients without mirror dystonia did not differ from the controls in their IHI level. In contrast, IHI was significantly decreased in the group of patients with mirror dystonia in comparison with the group without mirror dystonia and the controls in both wrist muscles of both the dystonic and unaffected hand whatever the resting or active condition (P = 0.001). The decrease of IHI level in the group of patients with mirror dystonia was negatively correlated with the severity and the duration of the disease: the weaker the level of IHI, the more severe was the disease and the longer its duration. Interhemispheric inhibition disturbances are most likely involved in the occurrence of mirror dystonia. This bilateral deficient inhibition further suggests the involvement of the unaffected hemisphere in the pathophysiology of unilateral dystonia.
DOI: 10.1002/mds.25768
PubMed: 24352854
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Does abnormal interhemispheric inhibition play a role in mirror dystonia?</title><author><name sortKey="Sattler, Virginie" sort="Sattler, Virginie" uniqKey="Sattler V" first="Virginie" last="Sattler">Virginie Sattler</name><affiliation><nlm:affiliation>Centre Hospitalier Universitaire de Toulouse, Pôle Neurosciences, CHU Purpan, Place du Dr Baylac, F-31059 Toulouse Cedex 9, France; Inserm; Imagerie cérébrale et handicaps neurologiques, UMR 825, CHU Purpan, Pavillon Baudot, Toulouse, France.</nlm:affiliation></affiliation></author><author><name sortKey="Dickler, Maya" sort="Dickler, Maya" uniqKey="Dickler M" first="Maya" last="Dickler">Maya Dickler</name></author><author><name sortKey="Michaud, Martin" sort="Michaud, Martin" uniqKey="Michaud M" first="Martin" last="Michaud">Martin Michaud</name></author><author><name sortKey="Meunier, Sabine" sort="Meunier, Sabine" uniqKey="Meunier S" first="Sabine" last="Meunier">Sabine Meunier</name></author><author><name sortKey="Simonetta Moreau, Marion" sort="Simonetta Moreau, Marion" uniqKey="Simonetta Moreau M" first="Marion" last="Simonetta-Moreau">Marion Simonetta-Moreau</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24352854</idno><idno type="pmid">24352854</idno><idno type="doi">10.1002/mds.25768</idno><idno type="wicri:Area/PubMed/Corpus">000650</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Does abnormal interhemispheric inhibition play a role in mirror dystonia?</title><author><name sortKey="Sattler, Virginie" sort="Sattler, Virginie" uniqKey="Sattler V" first="Virginie" last="Sattler">Virginie Sattler</name><affiliation><nlm:affiliation>Centre Hospitalier Universitaire de Toulouse, Pôle Neurosciences, CHU Purpan, Place du Dr Baylac, F-31059 Toulouse Cedex 9, France; Inserm; Imagerie cérébrale et handicaps neurologiques, UMR 825, CHU Purpan, Pavillon Baudot, Toulouse, France.</nlm:affiliation></affiliation></author><author><name sortKey="Dickler, Maya" sort="Dickler, Maya" uniqKey="Dickler M" first="Maya" last="Dickler">Maya Dickler</name></author><author><name sortKey="Michaud, Martin" sort="Michaud, Martin" uniqKey="Michaud M" first="Martin" last="Michaud">Martin Michaud</name></author><author><name sortKey="Meunier, Sabine" sort="Meunier, Sabine" uniqKey="Meunier S" first="Sabine" last="Meunier">Sabine Meunier</name></author><author><name sortKey="Simonetta Moreau, Marion" sort="Simonetta Moreau, Marion" uniqKey="Simonetta Moreau M" first="Marion" last="Simonetta-Moreau">Marion Simonetta-Moreau</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Dystonia (etiology)</term><term>Dystonic Disorders (complications)</term><term>Electromyography</term><term>Evoked Potentials, Motor (physiology)</term><term>Female</term><term>Functional Laterality (physiology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (physiopathology)</term><term>Neural Inhibition (physiology)</term><term>Time Factors</term><term>Transcranial Magnetic Stimulation</term><term>Wrist (innervation)</term><term>Young Adult</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Dystonic Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dystonia</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Wrist</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials, Motor</term><term>Functional Laterality</term><term>Neural Inhibition</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Motor Cortex</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Time Factors</term><term>Transcranial Magnetic Stimulation</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The presence of mirror dystonia (dystonic movement induced by a specific task performed by the unaffected hand) in the dominant hand of writer's cramp patients when the nondominant hand is moved suggests an abnormal interaction between the 2 hemispheres. In this study we compare the level of interhemispheric inhibition (IHI) in 2 groups of patients with writer's cramp, one with the presence of a mirror dystonia and the other without as well as a control group. The level of bidirectional IHI was measured in wrist muscles with dual-site transcranial magnetic stimulation with a 10-millisecond (short IHI) and a 40-millisecond (long IHI) interstimulus interval during rest and while holding a pen in 9 patients with mirror dystonia 7 without mirror dystonia, and 13 controls. The group of patients without mirror dystonia did not differ from the controls in their IHI level. In contrast, IHI was significantly decreased in the group of patients with mirror dystonia in comparison with the group without mirror dystonia and the controls in both wrist muscles of both the dystonic and unaffected hand whatever the resting or active condition (P = 0.001). The decrease of IHI level in the group of patients with mirror dystonia was negatively correlated with the severity and the duration of the disease: the weaker the level of IHI, the more severe was the disease and the longer its duration. Interhemispheric inhibition disturbances are most likely involved in the occurrence of mirror dystonia. This bilateral deficient inhibition further suggests the involvement of the unaffected hemisphere in the pathophysiology of unilateral dystonia.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">24352854</PMID><DateCreated><Year>2014</Year><Month>05</Month><Day>06</Day></DateCreated><DateCompleted><Year>2014</Year><Month>12</Month><Day>19</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>29</Volume><Issue>6</Issue><PubDate><Year>2014</Year><Month>May</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Does abnormal interhemispheric inhibition play a role in mirror dystonia?</ArticleTitle><Pagination><MedlinePgn>787-96</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.25768</ELocationID><Abstract><AbstractText>The presence of mirror dystonia (dystonic movement induced by a specific task performed by the unaffected hand) in the dominant hand of writer's cramp patients when the nondominant hand is moved suggests an abnormal interaction between the 2 hemispheres. In this study we compare the level of interhemispheric inhibition (IHI) in 2 groups of patients with writer's cramp, one with the presence of a mirror dystonia and the other without as well as a control group. The level of bidirectional IHI was measured in wrist muscles with dual-site transcranial magnetic stimulation with a 10-millisecond (short IHI) and a 40-millisecond (long IHI) interstimulus interval during rest and while holding a pen in 9 patients with mirror dystonia 7 without mirror dystonia, and 13 controls. The group of patients without mirror dystonia did not differ from the controls in their IHI level. In contrast, IHI was significantly decreased in the group of patients with mirror dystonia in comparison with the group without mirror dystonia and the controls in both wrist muscles of both the dystonic and unaffected hand whatever the resting or active condition (P = 0.001). The decrease of IHI level in the group of patients with mirror dystonia was negatively correlated with the severity and the duration of the disease: the weaker the level of IHI, the more severe was the disease and the longer its duration. Interhemispheric inhibition disturbances are most likely involved in the occurrence of mirror dystonia. This bilateral deficient inhibition further suggests the involvement of the unaffected hemisphere in the pathophysiology of unilateral dystonia.</AbstractText><CopyrightInformation>© 2013 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sattler</LastName><ForeName>Virginie</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Centre Hospitalier Universitaire de Toulouse, Pôle Neurosciences, CHU Purpan, Place du Dr Baylac, F-31059 Toulouse Cedex 9, France; Inserm; Imagerie cérébrale et handicaps neurologiques, UMR 825, CHU Purpan, Pavillon Baudot, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dickler</LastName><ForeName>Maya</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Michaud</LastName><ForeName>Martin</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Meunier</LastName><ForeName>Sabine</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Simonetta-Moreau</LastName><ForeName>Marion</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>12</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000293">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" 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MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009044">Motor Cortex</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009433">Neural Inhibition</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013997">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D050781">Transcranial Magnetic Stimulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014953">Wrist</DescriptorName><QualifierName MajorTopicYN="N" 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