Predictors of cognitive impairment in an early stage Parkinson's disease cohort.
Identifieur interne : 000616 ( PubMed/Corpus ); précédent : 000615; suivant : 000617Predictors of cognitive impairment in an early stage Parkinson's disease cohort.
Auteurs : Michele T M. Hu ; Konrad Szewczyk-Kr Likowski ; Paul Tomlinson ; Kannan Nithi ; Michal Rolinski ; Clara Murray ; Kevin Talbot ; Klaus P. Ebmeier ; Clare E. Mackay ; Yoav Ben-ShlomoSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Alzheimer Disease (complications), Alzheimer Disease (diagnosis), Cohort Studies, Female, Humans, Male, Middle Aged, Mild Cognitive Impairment (complications), Mild Cognitive Impairment (diagnosis), Mild Cognitive Impairment (physiopathology), Motor Activity, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Predictive Value of Tests.
- MESH :
- complications : Alzheimer Disease, Mild Cognitive Impairment, Parkinson Disease.
- diagnosis : Alzheimer Disease, Mild Cognitive Impairment, Parkinson Disease.
- physiopathology : Mild Cognitive Impairment, Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Cohort Studies, Female, Humans, Male, Middle Aged, Motor Activity, Neuropsychological Tests, Predictive Value of Tests.
Abstract
The impact of Parkinson's disease (PD) dementia is substantial and has major functional and socioeconomic consequences. Early prediction of future cognitive impairment would help target future interventions. The Montreal Cognitive Assessment (MoCA), the Mini-Mental State Examination (MMSE), and fluency tests were administered to 486 patients with PD within 3.5 years of diagnosis, and the results were compared with those from 141 controls correcting for age, sex, and educational years. Eighteen-month longitudinal assessments were performed in 155 patients with PD. The proportion of patients classified with normal cognition, mild cognitive impairment (MCI), and dementia varied considerably, depending on the MoCA and MMSE thresholds used. With the MoCA total score at screening threshold, 47.7%, 40.5%, and 11.7% of patients with PD were classified with normal cognition, MCI, and dementia, respectively; by comparison, 78.7% and 21.3% of controls had normal cognition and MCI, respectively. Cognitive impairment was predicted by lower education, increased age, male sex, and quantitative motor and non-motor (smell, depression, and anxiety) measures. Longitudinal data from 155 patients with PD over 18 months showed significant reductions in MoCA scores, but not in MMSE scores, with 21.3% of patients moving from normal cognition to MCI and 4.5% moving from MCI to dementia, although 13.5% moved from MCI to normal; however, none of the patients with dementia changed their classification. The MoCA may be more sensitive than the MMSE in detecting early baseline and longitudinal cognitive impairment in PD, because it identified 25.8% of those who experienced significant cognitive decline over 18 months. Cognitive decline was associated with worse motor and non-motor features, suggesting that this reflects a faster progressive phenotype.
DOI: 10.1002/mds.25748
PubMed: 24395708
Links to Exploration step
pubmed:24395708Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Predictors of cognitive impairment in an early stage Parkinson's disease cohort.</title><author><name sortKey="Hu, Michele T M" sort="Hu, Michele T M" uniqKey="Hu M" first="Michele T M" last="Hu">Michele T M. Hu</name><affiliation><nlm:affiliation>Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, University of Oxford, Oxford, United Kingdom; Department of Clinical Neurology, John Radcliffe Hospital, Oxford, United Kingdom; Oxford Parkinson's Disease Centre, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Szewczyk Kr Likowski, Konrad" sort="Szewczyk Kr Likowski, Konrad" uniqKey="Szewczyk Kr Likowski K" first="Konrad" last="Szewczyk-Kr Likowski">Konrad Szewczyk-Kr Likowski</name></author><author><name sortKey="Tomlinson, Paul" sort="Tomlinson, Paul" uniqKey="Tomlinson P" first="Paul" last="Tomlinson">Paul Tomlinson</name></author><author><name sortKey="Nithi, Kannan" sort="Nithi, Kannan" uniqKey="Nithi K" first="Kannan" last="Nithi">Kannan Nithi</name></author><author><name sortKey="Rolinski, Michal" sort="Rolinski, Michal" uniqKey="Rolinski M" first="Michal" last="Rolinski">Michal Rolinski</name></author><author><name sortKey="Murray, Clara" sort="Murray, Clara" uniqKey="Murray C" first="Clara" last="Murray">Clara Murray</name></author><author><name sortKey="Talbot, Kevin" sort="Talbot, Kevin" uniqKey="Talbot K" first="Kevin" last="Talbot">Kevin Talbot</name></author><author><name sortKey="Ebmeier, Klaus P" sort="Ebmeier, Klaus P" uniqKey="Ebmeier K" first="Klaus P" last="Ebmeier">Klaus P. Ebmeier</name></author><author><name sortKey="Mackay, Clare E" sort="Mackay, Clare E" uniqKey="Mackay C" first="Clare E" last="Mackay">Clare E. Mackay</name></author><author><name sortKey="Ben Shlomo, Yoav" sort="Ben Shlomo, Yoav" uniqKey="Ben Shlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24395708</idno><idno type="pmid">24395708</idno><idno type="doi">10.1002/mds.25748</idno><idno type="wicri:Area/PubMed/Corpus">000616</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Predictors of cognitive impairment in an early stage Parkinson's disease cohort.</title><author><name sortKey="Hu, Michele T M" sort="Hu, Michele T M" uniqKey="Hu M" first="Michele T M" last="Hu">Michele T M. Hu</name><affiliation><nlm:affiliation>Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, University of Oxford, Oxford, United Kingdom; Department of Clinical Neurology, John Radcliffe Hospital, Oxford, United Kingdom; Oxford Parkinson's Disease Centre, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Szewczyk Kr Likowski, Konrad" sort="Szewczyk Kr Likowski, Konrad" uniqKey="Szewczyk Kr Likowski K" first="Konrad" last="Szewczyk-Kr Likowski">Konrad Szewczyk-Kr Likowski</name></author><author><name sortKey="Tomlinson, Paul" sort="Tomlinson, Paul" uniqKey="Tomlinson P" first="Paul" last="Tomlinson">Paul Tomlinson</name></author><author><name sortKey="Nithi, Kannan" sort="Nithi, Kannan" uniqKey="Nithi K" first="Kannan" last="Nithi">Kannan Nithi</name></author><author><name sortKey="Rolinski, Michal" sort="Rolinski, Michal" uniqKey="Rolinski M" first="Michal" last="Rolinski">Michal Rolinski</name></author><author><name sortKey="Murray, Clara" sort="Murray, Clara" uniqKey="Murray C" first="Clara" last="Murray">Clara Murray</name></author><author><name sortKey="Talbot, Kevin" sort="Talbot, Kevin" uniqKey="Talbot K" first="Kevin" last="Talbot">Kevin Talbot</name></author><author><name sortKey="Ebmeier, Klaus P" sort="Ebmeier, Klaus P" uniqKey="Ebmeier K" first="Klaus P" last="Ebmeier">Klaus P. Ebmeier</name></author><author><name sortKey="Mackay, Clare E" sort="Mackay, Clare E" uniqKey="Mackay C" first="Clare E" last="Mackay">Clare E. Mackay</name></author><author><name sortKey="Ben Shlomo, Yoav" sort="Ben Shlomo, Yoav" uniqKey="Ben Shlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Alzheimer Disease (complications)</term><term>Alzheimer Disease (diagnosis)</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Mild Cognitive Impairment (complications)</term><term>Mild Cognitive Impairment (diagnosis)</term><term>Mild Cognitive Impairment (physiopathology)</term><term>Motor Activity</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Predictive Value of Tests</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Alzheimer Disease</term><term>Mild Cognitive Impairment</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Alzheimer Disease</term><term>Mild Cognitive Impairment</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Mild Cognitive Impairment</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Activity</term><term>Neuropsychological Tests</term><term>Predictive Value of Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The impact of Parkinson's disease (PD) dementia is substantial and has major functional and socioeconomic consequences. Early prediction of future cognitive impairment would help target future interventions. The Montreal Cognitive Assessment (MoCA), the Mini-Mental State Examination (MMSE), and fluency tests were administered to 486 patients with PD within 3.5 years of diagnosis, and the results were compared with those from 141 controls correcting for age, sex, and educational years. Eighteen-month longitudinal assessments were performed in 155 patients with PD. The proportion of patients classified with normal cognition, mild cognitive impairment (MCI), and dementia varied considerably, depending on the MoCA and MMSE thresholds used. With the MoCA total score at screening threshold, 47.7%, 40.5%, and 11.7% of patients with PD were classified with normal cognition, MCI, and dementia, respectively; by comparison, 78.7% and 21.3% of controls had normal cognition and MCI, respectively. Cognitive impairment was predicted by lower education, increased age, male sex, and quantitative motor and non-motor (smell, depression, and anxiety) measures. Longitudinal data from 155 patients with PD over 18 months showed significant reductions in MoCA scores, but not in MMSE scores, with 21.3% of patients moving from normal cognition to MCI and 4.5% moving from MCI to dementia, although 13.5% moved from MCI to normal; however, none of the patients with dementia changed their classification. The MoCA may be more sensitive than the MMSE in detecting early baseline and longitudinal cognitive impairment in PD, because it identified 25.8% of those who experienced significant cognitive decline over 18 months. Cognitive decline was associated with worse motor and non-motor features, suggesting that this reflects a faster progressive phenotype.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">24395708</PMID><DateCreated><Year>2014</Year><Month>03</Month><Day>18</Day></DateCreated><DateCompleted><Year>2014</Year><Month>12</Month><Day>01</Day></DateCompleted><DateRevised><Year>2015</Year><Month>01</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>29</Volume><Issue>3</Issue><PubDate><Year>2014</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Predictors of cognitive impairment in an early stage Parkinson's disease cohort.</ArticleTitle><Pagination><MedlinePgn>351-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.25748</ELocationID><Abstract><AbstractText>The impact of Parkinson's disease (PD) dementia is substantial and has major functional and socioeconomic consequences. Early prediction of future cognitive impairment would help target future interventions. The Montreal Cognitive Assessment (MoCA), the Mini-Mental State Examination (MMSE), and fluency tests were administered to 486 patients with PD within 3.5 years of diagnosis, and the results were compared with those from 141 controls correcting for age, sex, and educational years. Eighteen-month longitudinal assessments were performed in 155 patients with PD. The proportion of patients classified with normal cognition, mild cognitive impairment (MCI), and dementia varied considerably, depending on the MoCA and MMSE thresholds used. With the MoCA total score at screening threshold, 47.7%, 40.5%, and 11.7% of patients with PD were classified with normal cognition, MCI, and dementia, respectively; by comparison, 78.7% and 21.3% of controls had normal cognition and MCI, respectively. Cognitive impairment was predicted by lower education, increased age, male sex, and quantitative motor and non-motor (smell, depression, and anxiety) measures. Longitudinal data from 155 patients with PD over 18 months showed significant reductions in MoCA scores, but not in MMSE scores, with 21.3% of patients moving from normal cognition to MCI and 4.5% moving from MCI to dementia, although 13.5% moved from MCI to normal; however, none of the patients with dementia changed their classification. The MoCA may be more sensitive than the MMSE in detecting early baseline and longitudinal cognitive impairment in PD, because it identified 25.8% of those who experienced significant cognitive decline over 18 months. Cognitive decline was associated with worse motor and non-motor features, suggesting that this reflects a faster progressive phenotype.</AbstractText><CopyrightInformation>© 2014 The Authors. International Parkinson and Movement Disorder Society published by Wiley Periodicals, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Michele T M</ForeName><Initials>MT</Initials><AffiliationInfo><Affiliation>Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, University of Oxford, Oxford, United Kingdom; Department of Clinical Neurology, John Radcliffe Hospital, Oxford, United Kingdom; Oxford Parkinson's Disease Centre, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Szewczyk-Królikowski</LastName><ForeName>Konrad</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Tomlinson</LastName><ForeName>Paul</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Nithi</LastName><ForeName>Kannan</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Rolinski</LastName><ForeName>Michal</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Murray</LastName><ForeName>Clara</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Talbot</LastName><ForeName>Kevin</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Ebmeier</LastName><ForeName>Klaus P</ForeName><Initials>KP</Initials></Author><Author ValidYN="Y"><LastName>Mackay</LastName><ForeName>Clare E</ForeName><Initials>CE</Initials></Author><Author ValidYN="Y"><LastName>Ben-Shlomo</LastName><ForeName>Yoav</ForeName><Initials>Y</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>G1001354</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>J-0901</GrantID><Agency>Parkinson's UK</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal 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UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D060825">Mild Cognitive Impairment</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009043">Motor Activity</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009483">Neuropsychological Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011237">Predictive Value of Tests</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4235340</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Mini-Mental State Examination</Keyword><Keyword MajorTopicYN="N">Montreal Cognitive Assessment</Keyword><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">dementia</Keyword><Keyword MajorTopicYN="N">mild cognitive impairment</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>3</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2013</Year><Month>10</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>10</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2014</Year><Month>1</Month><Day>6</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>1</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>1</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24395708</ArticleId><ArticleId IdType="doi">10.1002/mds.25748</ArticleId><ArticleId IdType="pmc">PMC4235340</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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