Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease.
Identifieur interne : 000609 ( PubMed/Corpus ); précédent : 000608; suivant : 000610Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease.
Auteurs : Lucilla Parnetti ; Davide Chiasserini ; Emanuele Persichetti ; Paolo Eusebi ; Shiji Varghese ; Mohammad M. Qureshi ; Andrea Dardis ; Marta Deganuto ; Claudia De Carlo ; Anna Castrioto ; Chiara Balducci ; Silvia Paciotti ; Nicola Tambasco ; Bruno Bembi ; Laura Bonanni ; Marco Onofrj ; Aroldo Rossi ; Tommaso Beccari ; Omar El-Agnaf ; Paolo CalabresiSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- Adult, Aged, Female, Genotype, Glucosylceramidase (cerebrospinal fluid), Glucosylceramidase (genetics), Glycoside Hydrolases (cerebrospinal fluid), Humans, Immunoassay, Male, Middle Aged, Mutation (genetics), Parkinson Disease (cerebrospinal fluid), Parkinson Disease (genetics), Prospective Studies, alpha-Synuclein (cerebrospinal fluid), tau Proteins (cerebrospinal fluid).
- MESH :
- chemical , cerebrospinal fluid : Glucosylceramidase, Glycoside Hydrolases, alpha-Synuclein, tau Proteins.
- chemical , genetics : Glucosylceramidase.
- cerebrospinal fluid : Parkinson Disease.
- genetics : Mutation, Parkinson Disease.
- Adult, Aged, Female, Genotype, Humans, Immunoassay, Male, Middle Aged, Prospective Studies.
Abstract
To assess the discriminating power of multiple cerebrospinal fluid (CSF) biomarkers for Parkinson's disease (PD), we measured several proteins playing an important role in the disease pathogenesis. The activities of β-glucocerebrosidase and other lysosomal enzymes, together with total and oligomeric α-synuclein, and total and phosphorylated tau, were thus assessed in CSF of 71 PD patients and compared to 45 neurological controls. Activities of β-glucocerebrosidase, β-mannosidase, β-hexosaminidase, and β-galactosidase were measured with established enzymatic assays, while α-synuclein and tau biomarkers were evaluated with immunoassays. A subset of PD patients (n = 44) was also screened for mutations in the β-glucocerebrosidase-encoding gene (GBA1). In the PD group, β-glucocerebrosidase activity was reduced (P < 0.05) and patients at earlier stages showed lower enzymatic activity (P < 0.05); conversely, β-hexosaminidase activity was significantly increased (P < 0.05). Eight PD patients (18%) presented GBA1 sequence variations; 3 of them were heterozygous for the N370S mutation. Levels of total α-synuclein were significantly reduced (P < 0.05) in PD, in contrast to increased levels of α-synuclein oligomers, with a higher oligomeric/total α-synuclein ratio in PD patients when compared with controls (P < 0.001). A combination of β-glucocerebrosidase activity, oligomeric/total α-synuclein ratio, and age gave the best performance in discriminating PD from neurological controls (sensitivity 82%; specificity 71%, area under the receiver operating characteristic curve = 0.87). These results demonstrate the possibility of detecting lysosomal dysfunction in CSF and further support the need to combine different biomarkers for improving the diagnostic accuracy of PD.
DOI: 10.1002/mds.25772
PubMed: 24436092
Links to Exploration step
pubmed:24436092Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease.</title><author><name sortKey="Parnetti, Lucilla" sort="Parnetti, Lucilla" uniqKey="Parnetti L" first="Lucilla" last="Parnetti">Lucilla Parnetti</name><affiliation><nlm:affiliation>Clinica Neurologica, Università degli Studi di Perugia, Perugia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Chiasserini, Davide" sort="Chiasserini, Davide" uniqKey="Chiasserini D" first="Davide" last="Chiasserini">Davide Chiasserini</name></author><author><name sortKey="Persichetti, Emanuele" sort="Persichetti, Emanuele" uniqKey="Persichetti E" first="Emanuele" last="Persichetti">Emanuele Persichetti</name></author><author><name sortKey="Eusebi, Paolo" sort="Eusebi, Paolo" uniqKey="Eusebi P" first="Paolo" last="Eusebi">Paolo Eusebi</name></author><author><name sortKey="Varghese, Shiji" sort="Varghese, Shiji" uniqKey="Varghese S" first="Shiji" last="Varghese">Shiji Varghese</name></author><author><name sortKey="Qureshi, Mohammad M" sort="Qureshi, Mohammad M" uniqKey="Qureshi M" first="Mohammad M" last="Qureshi">Mohammad M. Qureshi</name></author><author><name sortKey="Dardis, Andrea" sort="Dardis, Andrea" uniqKey="Dardis A" first="Andrea" last="Dardis">Andrea Dardis</name></author><author><name sortKey="Deganuto, Marta" sort="Deganuto, Marta" uniqKey="Deganuto M" first="Marta" last="Deganuto">Marta Deganuto</name></author><author><name sortKey="De Carlo, Claudia" sort="De Carlo, Claudia" uniqKey="De Carlo C" first="Claudia" last="De Carlo">Claudia De Carlo</name></author><author><name sortKey="Castrioto, Anna" sort="Castrioto, Anna" uniqKey="Castrioto A" first="Anna" last="Castrioto">Anna Castrioto</name></author><author><name sortKey="Balducci, Chiara" sort="Balducci, Chiara" uniqKey="Balducci C" first="Chiara" last="Balducci">Chiara Balducci</name></author><author><name sortKey="Paciotti, Silvia" sort="Paciotti, Silvia" uniqKey="Paciotti S" first="Silvia" last="Paciotti">Silvia Paciotti</name></author><author><name sortKey="Tambasco, Nicola" sort="Tambasco, Nicola" uniqKey="Tambasco N" first="Nicola" last="Tambasco">Nicola Tambasco</name></author><author><name sortKey="Bembi, Bruno" sort="Bembi, Bruno" uniqKey="Bembi B" first="Bruno" last="Bembi">Bruno Bembi</name></author><author><name sortKey="Bonanni, Laura" sort="Bonanni, Laura" uniqKey="Bonanni L" first="Laura" last="Bonanni">Laura Bonanni</name></author><author><name sortKey="Onofrj, Marco" sort="Onofrj, Marco" uniqKey="Onofrj M" first="Marco" last="Onofrj">Marco Onofrj</name></author><author><name sortKey="Rossi, Aroldo" sort="Rossi, Aroldo" uniqKey="Rossi A" first="Aroldo" last="Rossi">Aroldo Rossi</name></author><author><name sortKey="Beccari, Tommaso" sort="Beccari, Tommaso" uniqKey="Beccari T" first="Tommaso" last="Beccari">Tommaso Beccari</name></author><author><name sortKey="El Agnaf, Omar" sort="El Agnaf, Omar" uniqKey="El Agnaf O" first="Omar" last="El-Agnaf">Omar El-Agnaf</name></author><author><name sortKey="Calabresi, Paolo" sort="Calabresi, Paolo" uniqKey="Calabresi P" first="Paolo" last="Calabresi">Paolo Calabresi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24436092</idno><idno type="pmid">24436092</idno><idno type="doi">10.1002/mds.25772</idno><idno type="wicri:Area/PubMed/Corpus">000609</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease.</title><author><name sortKey="Parnetti, Lucilla" sort="Parnetti, Lucilla" uniqKey="Parnetti L" first="Lucilla" last="Parnetti">Lucilla Parnetti</name><affiliation><nlm:affiliation>Clinica Neurologica, Università degli Studi di Perugia, Perugia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Chiasserini, Davide" sort="Chiasserini, Davide" uniqKey="Chiasserini D" first="Davide" last="Chiasserini">Davide Chiasserini</name></author><author><name sortKey="Persichetti, Emanuele" sort="Persichetti, Emanuele" uniqKey="Persichetti E" first="Emanuele" last="Persichetti">Emanuele Persichetti</name></author><author><name sortKey="Eusebi, Paolo" sort="Eusebi, Paolo" uniqKey="Eusebi P" first="Paolo" last="Eusebi">Paolo Eusebi</name></author><author><name sortKey="Varghese, Shiji" sort="Varghese, Shiji" uniqKey="Varghese S" first="Shiji" last="Varghese">Shiji Varghese</name></author><author><name sortKey="Qureshi, Mohammad M" sort="Qureshi, Mohammad M" uniqKey="Qureshi M" first="Mohammad M" last="Qureshi">Mohammad M. Qureshi</name></author><author><name sortKey="Dardis, Andrea" sort="Dardis, Andrea" uniqKey="Dardis A" first="Andrea" last="Dardis">Andrea Dardis</name></author><author><name sortKey="Deganuto, Marta" sort="Deganuto, Marta" uniqKey="Deganuto M" first="Marta" last="Deganuto">Marta Deganuto</name></author><author><name sortKey="De Carlo, Claudia" sort="De Carlo, Claudia" uniqKey="De Carlo C" first="Claudia" last="De Carlo">Claudia De Carlo</name></author><author><name sortKey="Castrioto, Anna" sort="Castrioto, Anna" uniqKey="Castrioto A" first="Anna" last="Castrioto">Anna Castrioto</name></author><author><name sortKey="Balducci, Chiara" sort="Balducci, Chiara" uniqKey="Balducci C" first="Chiara" last="Balducci">Chiara Balducci</name></author><author><name sortKey="Paciotti, Silvia" sort="Paciotti, Silvia" uniqKey="Paciotti S" first="Silvia" last="Paciotti">Silvia Paciotti</name></author><author><name sortKey="Tambasco, Nicola" sort="Tambasco, Nicola" uniqKey="Tambasco N" first="Nicola" last="Tambasco">Nicola Tambasco</name></author><author><name sortKey="Bembi, Bruno" sort="Bembi, Bruno" uniqKey="Bembi B" first="Bruno" last="Bembi">Bruno Bembi</name></author><author><name sortKey="Bonanni, Laura" sort="Bonanni, Laura" uniqKey="Bonanni L" first="Laura" last="Bonanni">Laura Bonanni</name></author><author><name sortKey="Onofrj, Marco" sort="Onofrj, Marco" uniqKey="Onofrj M" first="Marco" last="Onofrj">Marco Onofrj</name></author><author><name sortKey="Rossi, Aroldo" sort="Rossi, Aroldo" uniqKey="Rossi A" first="Aroldo" last="Rossi">Aroldo Rossi</name></author><author><name sortKey="Beccari, Tommaso" sort="Beccari, Tommaso" uniqKey="Beccari T" first="Tommaso" last="Beccari">Tommaso Beccari</name></author><author><name sortKey="El Agnaf, Omar" sort="El Agnaf, Omar" uniqKey="El Agnaf O" first="Omar" last="El-Agnaf">Omar El-Agnaf</name></author><author><name sortKey="Calabresi, Paolo" sort="Calabresi, Paolo" uniqKey="Calabresi P" first="Paolo" last="Calabresi">Paolo Calabresi</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Genotype</term><term>Glucosylceramidase (cerebrospinal fluid)</term><term>Glucosylceramidase (genetics)</term><term>Glycoside Hydrolases (cerebrospinal fluid)</term><term>Humans</term><term>Immunoassay</term><term>Male</term><term>Middle Aged</term><term>Mutation (genetics)</term><term>Parkinson Disease (cerebrospinal fluid)</term><term>Parkinson Disease (genetics)</term><term>Prospective Studies</term><term>alpha-Synuclein (cerebrospinal fluid)</term><term>tau Proteins (cerebrospinal fluid)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Glucosylceramidase</term><term>Glycoside Hydrolases</term><term>alpha-Synuclein</term><term>tau Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Glucosylceramidase</term></keywords><keywords scheme="MESH" qualifier="cerebrospinal fluid" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Mutation</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Immunoassay</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To assess the discriminating power of multiple cerebrospinal fluid (CSF) biomarkers for Parkinson's disease (PD), we measured several proteins playing an important role in the disease pathogenesis. The activities of β-glucocerebrosidase and other lysosomal enzymes, together with total and oligomeric α-synuclein, and total and phosphorylated tau, were thus assessed in CSF of 71 PD patients and compared to 45 neurological controls. Activities of β-glucocerebrosidase, β-mannosidase, β-hexosaminidase, and β-galactosidase were measured with established enzymatic assays, while α-synuclein and tau biomarkers were evaluated with immunoassays. A subset of PD patients (n = 44) was also screened for mutations in the β-glucocerebrosidase-encoding gene (GBA1). In the PD group, β-glucocerebrosidase activity was reduced (P < 0.05) and patients at earlier stages showed lower enzymatic activity (P < 0.05); conversely, β-hexosaminidase activity was significantly increased (P < 0.05). Eight PD patients (18%) presented GBA1 sequence variations; 3 of them were heterozygous for the N370S mutation. Levels of total α-synuclein were significantly reduced (P < 0.05) in PD, in contrast to increased levels of α-synuclein oligomers, with a higher oligomeric/total α-synuclein ratio in PD patients when compared with controls (P < 0.001). A combination of β-glucocerebrosidase activity, oligomeric/total α-synuclein ratio, and age gave the best performance in discriminating PD from neurological controls (sensitivity 82%; specificity 71%, area under the receiver operating characteristic curve = 0.87). These results demonstrate the possibility of detecting lysosomal dysfunction in CSF and further support the need to combine different biomarkers for improving the diagnostic accuracy of PD.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">24436092</PMID><DateCreated><Year>2014</Year><Month>07</Month><Day>21</Day></DateCreated><DateCompleted><Year>2015</Year><Month>03</Month><Day>30</Day></DateCompleted><DateRevised><Year>2015</Year><Month>01</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>29</Volume><Issue>8</Issue><PubDate><Year>2014</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>1019-27</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.25772</ELocationID><Abstract><AbstractText>To assess the discriminating power of multiple cerebrospinal fluid (CSF) biomarkers for Parkinson's disease (PD), we measured several proteins playing an important role in the disease pathogenesis. The activities of β-glucocerebrosidase and other lysosomal enzymes, together with total and oligomeric α-synuclein, and total and phosphorylated tau, were thus assessed in CSF of 71 PD patients and compared to 45 neurological controls. Activities of β-glucocerebrosidase, β-mannosidase, β-hexosaminidase, and β-galactosidase were measured with established enzymatic assays, while α-synuclein and tau biomarkers were evaluated with immunoassays. A subset of PD patients (n = 44) was also screened for mutations in the β-glucocerebrosidase-encoding gene (GBA1). In the PD group, β-glucocerebrosidase activity was reduced (P < 0.05) and patients at earlier stages showed lower enzymatic activity (P < 0.05); conversely, β-hexosaminidase activity was significantly increased (P < 0.05). Eight PD patients (18%) presented GBA1 sequence variations; 3 of them were heterozygous for the N370S mutation. Levels of total α-synuclein were significantly reduced (P < 0.05) in PD, in contrast to increased levels of α-synuclein oligomers, with a higher oligomeric/total α-synuclein ratio in PD patients when compared with controls (P < 0.001). A combination of β-glucocerebrosidase activity, oligomeric/total α-synuclein ratio, and age gave the best performance in discriminating PD from neurological controls (sensitivity 82%; specificity 71%, area under the receiver operating characteristic curve = 0.87). These results demonstrate the possibility of detecting lysosomal dysfunction in CSF and further support the need to combine different biomarkers for improving the diagnostic accuracy of PD.</AbstractText><CopyrightInformation>© 2014 The Authors. International Parkinson and Movement Disorder Society published by Wiley Periodicals, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Parnetti</LastName><ForeName>Lucilla</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Clinica Neurologica, Università degli Studi di Perugia, Perugia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chiasserini</LastName><ForeName>Davide</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Persichetti</LastName><ForeName>Emanuele</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Eusebi</LastName><ForeName>Paolo</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Varghese</LastName><ForeName>Shiji</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Qureshi</LastName><ForeName>Mohammad M</ForeName><Initials>MM</Initials></Author><Author ValidYN="Y"><LastName>Dardis</LastName><ForeName>Andrea</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Deganuto</LastName><ForeName>Marta</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>De Carlo</LastName><ForeName>Claudia</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Castrioto</LastName><ForeName>Anna</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Balducci</LastName><ForeName>Chiara</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Paciotti</LastName><ForeName>Silvia</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Tambasco</LastName><ForeName>Nicola</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Bembi</LastName><ForeName>Bruno</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Bonanni</LastName><ForeName>Laura</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Onofrj</LastName><ForeName>Marco</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Rossi</LastName><ForeName>Aroldo</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Beccari</LastName><ForeName>Tommaso</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>El-Agnaf</LastName><ForeName>Omar</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Calabresi</LastName><ForeName>Paolo</ForeName><Initials>P</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>01</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051844">alpha-Synuclein</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016875">tau Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.2.1.-</RegistryNumber><NameOfSubstance UI="D006026">Glycoside Hydrolases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.2.1.45</RegistryNumber><NameOfSubstance UI="D005962">Glucosylceramidase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Acta Neuropathol. 2007 Nov;114(5):481-9</RefSource><PMID Version="1">17653558</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 2008 Aug;131(Pt 8):1969-78</RefSource><PMID Version="1">18187492</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2008 Aug 29;283(35):23542-56</RefSource><PMID Version="1">18566453</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Exp Neurol. 2008 Oct;213(2):315-25</RefSource><PMID Version="1">18625222</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2008 Oct 4;372(9645):1263-71</RefSource><PMID Version="1">19094956</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurosci Lett. 2009 Mar 13;452(2):87-9</RefSource><PMID Version="1">19383421</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurobiol Dis. 2009 Jun;34(3):484-6</RefSource><PMID Version="1">19303930</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>EMBO J. 2009 Oct 21;28(20):3256-68</RefSource><PMID Version="1">19745811</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2009 Oct 22;361(17):1651-61</RefSource><PMID Version="1">19846850</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2009 Dec 1;73(22):1914-22</RefSource><PMID Version="1">19949037</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2010 Jun 15;25(8):1005-11</RefSource><PMID Version="1">20131388</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 2010 Mar;133(Pt 3):713-26</RefSource><PMID Version="1">20157014</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Mol Biol. 2010 Mar 19;397(1):202-18</RefSource><PMID Version="1">20114052</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2010 Nov 16;75(20):1766-72</RefSource><PMID Version="1">20962290</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Mol Genet. 2011 Jan 1;20(1):202-10</RefSource><PMID Version="1">20947659</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet Neurol. 2011 Mar;10(3):230-40</RefSource><PMID Version="1">21317042</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet Neurol. 2011 Mar;10(3):203-5</RefSource><PMID Version="1">21317043</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4194-9</RefSource><PMID Version="1">21325059</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2011 Mar;69(3):570-80</RefSource><PMID Version="1">21400565</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2011 Jun;69(6):940-53</RefSource><PMID Version="1">21472771</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2011 Jul 8;146(1):37-52</RefSource><PMID Version="1">21700325</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2011 Aug 2;77(5):510; author reply 510-1</RefSource><PMID Version="1">21810701</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2011 Jul;26(8):1428-35</RefSource><PMID Version="1">21469206</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parkinsonism Relat Disord. 2012 Feb;18(2):185-90</RefSource><PMID Version="1">22001711</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2012 Feb 7;78(6):417-20</RefSource><PMID Version="1">22282650</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2012 Sep;72(3):455-63</RefSource><PMID Version="1">23034917</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2013;8(4):e60674</RefSource><PMID Version="1">23580063</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2013 Jun;28(6):747-54</RefSource><PMID Version="1">23712522</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Neurol. 2014 Mar;21(3):388-94</RefSource><PMID Version="1">23631635</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):571-6</RefSource><PMID Version="1">10639120</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Hum Genet. 2000 Jun;66(6):1777-86</RefSource><PMID Version="1">10796875</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2003 Jul 4;278(27):25009-13</RefSource><PMID Version="1">12719433</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Epidemiol. 2003 Nov;56(11):1129-35</RefSource><PMID Version="1">14615004</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Genet Metab. 2004 Jan;81(1):70-3</RefSource><PMID Version="1">14728994</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2004 Feb 25;24(8):1888-96</RefSource><PMID Version="1">14985429</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 2004 Aug 27;305(5688):1292-5</RefSource><PMID Version="1">15333840</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Chim Acta. 1991 Nov 9;203(1):17-22</RefSource><PMID Version="1">1837502</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>QJM. 1996 Sep;89(9):691-4</RefSource><PMID Version="1">8917744</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 1997 Aug 28;388(6645):839-40</RefSource><PMID Version="1">9278044</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 1998 Feb;55(2):151-2</RefSource><PMID Version="1">9482355</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2005 Oct;20(10):1366-9</RefSource><PMID Version="1">15986423</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochem Biophys Res Commun. 2006 Oct 13;349(1):162-6</RefSource><PMID Version="1">16930553</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Genet Metab. 2007 Jun;91(2):195-200</RefSource><PMID Version="1">17462935</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2007 Jul 30;22(10):1481-4</RefSource><PMID Version="1">17546678</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2007 Sep 18;69(12):1270-7</RefSource><PMID Version="1">17875915</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Mov Disord. 2014 Sep;29(10):1328-9</RefSource><PMID Version="1">25130999</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005838">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005962">Glucosylceramidase</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000134">cerebrospinal fluid</QualifierName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006026">Glycoside Hydrolases</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000134">cerebrospinal fluid</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007118">Immunoassay</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009154">Mutation</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000134">cerebrospinal fluid</QualifierName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011446">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D051844">alpha-Synuclein</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000134">cerebrospinal fluid</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016875">tau Proteins</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000134">cerebrospinal fluid</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4282452</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">CSF biomarkers</Keyword><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">alpha-synuclein</Keyword><Keyword MajorTopicYN="N">beta-glucocerebrosidase</Keyword><Keyword MajorTopicYN="N">lysosomal enzymes</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>2</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2013</Year><Month>11</Month><Day>4</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>11</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2014</Year><Month>1</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>1</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>1</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>3</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24436092</ArticleId><ArticleId IdType="doi">10.1002/mds.25772</ArticleId><ArticleId IdType="pmc">PMC4282452</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000609 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000609 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:24436092
|texte= Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:24436092" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |