MovDisordV3, PubMed, Corpus, bibRecord, 000390

Preclinical models: needed in translation? A Pro/Con debate.

Identifieur interne : 000390 ( PubMed/Corpus ); précédent : 000389; suivant : 000391

Preclinical models: needed in translation? A Pro/Con debate.

Auteurs : Thomas Philips ; Jeffrey D. Rothstein ; Mahmoud A. Pouladi

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.

RBID : pubmed:25216370

English descriptors

KwdEn :
- Animals, Disease Models, Animal, Drug Evaluation, Preclinical, Humans, Huntington Disease (genetics), Huntington Disease (therapy), Translational Medical Research (methods).
MESH :
- genetics : Huntington Disease.
- methods : Translational Medical Research.
- therapy : Huntington Disease.
- Animals, Disease Models, Animal, Drug Evaluation, Preclinical, Humans.

Abstract

The discovery of the causative mutations and many of the predisposing risk factors for neurodegenerative disorders such as Amyotrophic Lateral Sclerosis, Alzheimer's, Parkinson's, and Huntington's disease (HD), has led to the development of a large number of genetic animal models of disease. In the case of HD, for example, over 20 different transgenic rodent models have been generated. These models have been of immense value in providing novel insights into mechanisms of disease, with the promise of accelerating the development of therapies that can delay the onset or slow the progression of the disease. Yet, despite extensive use of such models, no effective treatment for HD has been developed. Here, we discuss the value of animal models, highlighting their strengths and shortcomings in the context of translational research for HD.

DOI: 10.1002/mds.26010
PubMed: 25216370

Links to Exploration step

pubmed:25216370

Le document en format XML

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<author><name sortKey="Pouladi, Mahmoud A" sort="Pouladi, Mahmoud A" uniqKey="Pouladi M" first="Mahmoud A" last="Pouladi">Mahmoud A. Pouladi</name>
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<front><div type="abstract" xml:lang="en">The discovery of the causative mutations and many of the predisposing risk factors for neurodegenerative disorders such as Amyotrophic Lateral Sclerosis, Alzheimer's, Parkinson's, and Huntington's disease (HD), has led to the development of a large number of genetic animal models of disease. In the case of HD, for example, over 20 different transgenic rodent models have been generated. These models have been of immense value in providing novel insights into mechanisms of disease, with the promise of accelerating the development of therapies that can delay the onset or slow the progression of the disease. Yet, despite extensive use of such models, no effective treatment for HD has been developed. Here, we discuss the value of animal models, highlighting their strengths and shortcomings in the context of translational research for HD.</div>
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Movement Disorders (revue)

Preclinical models: needed in translation? A Pro/Con debate.

Preclinical models: needed in translation? A Pro/Con debate.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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