MovDisordV3, PubMed, Corpus, bibRecord, 000257

A randomized, placebo-controlled trial of AFQ056 for the treatment of chorea in Huntington's disease.

Identifieur interne : 000257 ( PubMed/Corpus ); précédent : 000256; suivant : 000258

A randomized, placebo-controlled trial of AFQ056 for the treatment of chorea in Huntington's disease.

Auteurs : Ralf Reilmann ; Marie-Laure Rouzade-Dominguez ; Carsten Saft ; Sigurd D. Süssmuth ; Josef Priller ; Anne Rosser ; Hugh Rickards ; Ludger Schöls ; Nicole Pezous ; Fabrizio Gasparini ; Donald Johns ; Georg Bernhard Landwehrmeyer ; Baltazar Gomez-Mancilla

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.

RBID : pubmed:25689146

Abstract

This study investigated the hypothesis that AFQ056 (mavoglurant), a selective metabotropic glutamate receptor 5 antagonist, reduces chorea in Huntington's disease (HD).

DOI: 10.1002/mds.26174
PubMed: 25689146

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pubmed:25689146

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A randomized, placebo-controlled trial of AFQ056 for the treatment of chorea in Huntington's disease.</title>
<author><name sortKey="Reilmann, Ralf" sort="Reilmann, Ralf" uniqKey="Reilmann R" first="Ralf" last="Reilmann">Ralf Reilmann</name>
<affiliation><nlm:affiliation>George-Huntington-Institute, Münster, Germany; Institute for Clinical Radiology, University of Münster, Münster, Germany; Department of Neurodegenerative Diseases and Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rouzade Dominguez, Marie Laure" sort="Rouzade Dominguez, Marie Laure" uniqKey="Rouzade Dominguez M" first="Marie-Laure" last="Rouzade-Dominguez">Marie-Laure Rouzade-Dominguez</name>
</author>
<author><name sortKey="Saft, Carsten" sort="Saft, Carsten" uniqKey="Saft C" first="Carsten" last="Saft">Carsten Saft</name>
</author>
<author><name sortKey="Sussmuth, Sigurd D" sort="Sussmuth, Sigurd D" uniqKey="Sussmuth S" first="Sigurd D" last="Süssmuth">Sigurd D. Süssmuth</name>
</author>
<author><name sortKey="Priller, Josef" sort="Priller, Josef" uniqKey="Priller J" first="Josef" last="Priller">Josef Priller</name>
</author>
<author><name sortKey="Rosser, Anne" sort="Rosser, Anne" uniqKey="Rosser A" first="Anne" last="Rosser">Anne Rosser</name>
</author>
<author><name sortKey="Rickards, Hugh" sort="Rickards, Hugh" uniqKey="Rickards H" first="Hugh" last="Rickards">Hugh Rickards</name>
</author>
<author><name sortKey="Schols, Ludger" sort="Schols, Ludger" uniqKey="Schols L" first="Ludger" last="Schöls">Ludger Schöls</name>
</author>
<author><name sortKey="Pezous, Nicole" sort="Pezous, Nicole" uniqKey="Pezous N" first="Nicole" last="Pezous">Nicole Pezous</name>
</author>
<author><name sortKey="Gasparini, Fabrizio" sort="Gasparini, Fabrizio" uniqKey="Gasparini F" first="Fabrizio" last="Gasparini">Fabrizio Gasparini</name>
</author>
<author><name sortKey="Johns, Donald" sort="Johns, Donald" uniqKey="Johns D" first="Donald" last="Johns">Donald Johns</name>
</author>
<author><name sortKey="Landwehrmeyer, Georg Bernhard" sort="Landwehrmeyer, Georg Bernhard" uniqKey="Landwehrmeyer G" first="Georg Bernhard" last="Landwehrmeyer">Georg Bernhard Landwehrmeyer</name>
</author>
<author><name sortKey="Gomez Mancilla, Baltazar" sort="Gomez Mancilla, Baltazar" uniqKey="Gomez Mancilla B" first="Baltazar" last="Gomez-Mancilla">Baltazar Gomez-Mancilla</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">A randomized, placebo-controlled trial of AFQ056 for the treatment of chorea in Huntington's disease.</title>
<author><name sortKey="Reilmann, Ralf" sort="Reilmann, Ralf" uniqKey="Reilmann R" first="Ralf" last="Reilmann">Ralf Reilmann</name>
<affiliation><nlm:affiliation>George-Huntington-Institute, Münster, Germany; Institute for Clinical Radiology, University of Münster, Münster, Germany; Department of Neurodegenerative Diseases and Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rouzade Dominguez, Marie Laure" sort="Rouzade Dominguez, Marie Laure" uniqKey="Rouzade Dominguez M" first="Marie-Laure" last="Rouzade-Dominguez">Marie-Laure Rouzade-Dominguez</name>
</author>
<author><name sortKey="Saft, Carsten" sort="Saft, Carsten" uniqKey="Saft C" first="Carsten" last="Saft">Carsten Saft</name>
</author>
<author><name sortKey="Sussmuth, Sigurd D" sort="Sussmuth, Sigurd D" uniqKey="Sussmuth S" first="Sigurd D" last="Süssmuth">Sigurd D. Süssmuth</name>
</author>
<author><name sortKey="Priller, Josef" sort="Priller, Josef" uniqKey="Priller J" first="Josef" last="Priller">Josef Priller</name>
</author>
<author><name sortKey="Rosser, Anne" sort="Rosser, Anne" uniqKey="Rosser A" first="Anne" last="Rosser">Anne Rosser</name>
</author>
<author><name sortKey="Rickards, Hugh" sort="Rickards, Hugh" uniqKey="Rickards H" first="Hugh" last="Rickards">Hugh Rickards</name>
</author>
<author><name sortKey="Schols, Ludger" sort="Schols, Ludger" uniqKey="Schols L" first="Ludger" last="Schöls">Ludger Schöls</name>
</author>
<author><name sortKey="Pezous, Nicole" sort="Pezous, Nicole" uniqKey="Pezous N" first="Nicole" last="Pezous">Nicole Pezous</name>
</author>
<author><name sortKey="Gasparini, Fabrizio" sort="Gasparini, Fabrizio" uniqKey="Gasparini F" first="Fabrizio" last="Gasparini">Fabrizio Gasparini</name>
</author>
<author><name sortKey="Johns, Donald" sort="Johns, Donald" uniqKey="Johns D" first="Donald" last="Johns">Donald Johns</name>
</author>
<author><name sortKey="Landwehrmeyer, Georg Bernhard" sort="Landwehrmeyer, Georg Bernhard" uniqKey="Landwehrmeyer G" first="Georg Bernhard" last="Landwehrmeyer">Georg Bernhard Landwehrmeyer</name>
</author>
<author><name sortKey="Gomez Mancilla, Baltazar" sort="Gomez Mancilla, Baltazar" uniqKey="Gomez Mancilla B" first="Baltazar" last="Gomez-Mancilla">Baltazar Gomez-Mancilla</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2015" type="published">2015</date>
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<front><div type="abstract" xml:lang="en">This study investigated the hypothesis that AFQ056 (mavoglurant), a selective metabotropic glutamate receptor 5 antagonist, reduces chorea in Huntington's disease (HD).</div>
</front>
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<pubmed><MedlineCitation Owner="NLM" Status="In-Process"><PMID Version="1">25689146</PMID>
<DateCreated><Year>2015</Year>
<Month>03</Month>
<Day>11</Day>
</DateCreated>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>30</Volume>
<Issue>3</Issue>
<PubDate><Year>2015</Year>
<Month>Mar</Month>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>A randomized, placebo-controlled trial of AFQ056 for the treatment of chorea in Huntington's disease.</ArticleTitle>
<Pagination><MedlinePgn>427-31</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26174</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">This study investigated the hypothesis that AFQ056 (mavoglurant), a selective metabotropic glutamate receptor 5 antagonist, reduces chorea in Huntington's disease (HD).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">This 32-day randomized, double-blind, parallel-group, proof-of-concept study investigated AFQ056 (25-150 mg [incremental doses], twice-daily) versus placebo in patients with HD. Primary efficacy assessments were the chorea-sum score and orientation index (nondominant hand) from the quantitative motor (Q-Motor) grasping task at day 28. Key secondary efficacy assessments included finger-tapping in the Unified Huntington's Disease Rating Scale-Total Motor Score and Q-Motor measures. Safety and tolerability were assessed.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Overall, 42 patients were randomized. At day 28, no improvement was observed on the primary efficacy assessments (P > 0.10) with AFQ056 versus placebo. The Q-Motor speeded-tapping interonset interval variability was reduced with AFQ056 versus placebo for the nondominant hand (P = 0.01). The incidence of adverse events was 66.7% with AFQ056 and 57.1% with placebo.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">AFQ056 did not reduce choreatic movements in HD, but was well tolerated. The clinical relevance of the Q-Motor findings (speeded-tapping) are unknown and may warrant further investigation.</AbstractText>
<CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Reilmann</LastName>
<ForeName>Ralf</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>George-Huntington-Institute, Münster, Germany; Institute for Clinical Radiology, University of Münster, Münster, Germany; Department of Neurodegenerative Diseases and Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</Affiliation>
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<Author ValidYN="Y"><LastName>Rouzade-Dominguez</LastName>
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<Author ValidYN="Y"><LastName>Süssmuth</LastName>
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<Author ValidYN="Y"><LastName>Johns</LastName>
<ForeName>Donald</ForeName>
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<Author ValidYN="Y"><LastName>Landwehrmeyer</LastName>
<ForeName>Georg Bernhard</ForeName>
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<Author ValidYN="Y"><LastName>Gomez-Mancilla</LastName>
<ForeName>Baltazar</ForeName>
<Initials>B</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName>
<AccessionNumberList><AccessionNumber>NCT01019473</AccessionNumber>
</AccessionNumberList>
</DataBank>
<DataBank><DataBankName>EudraCT</DataBankName>
<AccessionNumberList><AccessionNumber>200901174339</AccessionNumber>
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<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>02</Month>
<Day>17</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Mov Disord</MedlineTA>
<NlmUniqueID>8610688</NlmUniqueID>
<ISSNLinking>0885-3185</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">AFQ056</Keyword>
<Keyword MajorTopicYN="N">Huntington's disease</Keyword>
<Keyword MajorTopicYN="N">chorea</Keyword>
<Keyword MajorTopicYN="N">mGluR5 antagonist</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year>
<Month>6</Month>
<Day>26</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2015</Year>
<Month>1</Month>
<Day>13</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2015</Year>
<Month>1</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="aheadofprint"><Year>2015</Year>
<Month>2</Month>
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	Movement Disorders (revue)
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Movement Disorders (revue)

A randomized, placebo-controlled trial of AFQ056 for the treatment of chorea in Huntington's disease.

A randomized, placebo-controlled trial of AFQ056 for the treatment of chorea in Huntington's disease.

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Abstract

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