Cerebral perfusion and cortical thickness indicate cortical involvement in mild Parkinson's disease.
Identifieur interne : 000237 ( PubMed/Corpus ); précédent : 000236; suivant : 000238Cerebral perfusion and cortical thickness indicate cortical involvement in mild Parkinson's disease.
Auteurs : Tara M. Madhyastha ; Mary K. Askren ; Peter Boord ; Jing Zhang ; James B. Leverenz ; Thomas J. GrabowskiSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
Cortical dysfunction in Parkinson's disease (PD) may be caused by disruption to ascending systems or by intrinsic cortical neuropathology. We introduce and conduct a joint analysis of metabolism and atrophy capable of identifying whether metabolic disruption occurs in mild PD without cortical atrophy, to determine the extent and spatial pattern of cortical involvement in mild PD. The design was observational, studying 23 cognitively normal participants with mild PD (mean Hoehn & Yahr stage 2) and 21 healthy controls. Cortical thickness (obtained from analysis of structural magnetic resonance imaging [MRI] with FreeSurfer) and cerebral perfusion measures (obtained from arterial spin labeling [ASL]) analyzed independently and then together in a joint multiple factorial analysis to identify spatial patterns of perfusion and cortical thickness. We identify a pattern of changes in perfusion and cortical thickness characterized by symmetric parietal cortical thinning and reduced precuneus perfusion, with relative preservation of thickness and perfusion in the anterior cingulate cortex (ACC), right prefrontal gyrus, and medial frontal gyrus. The expression of this pattern is correlated with motor system symptoms and speed of processing. A spatial pattern of joint parietal cortical thinning and disproportionate reduction in perfusion occurs in our nondemented PD sample. We found no PD-related components of reduced perfusion without cortical thinning. This suggests that PD affects the cortex itself, even when symptoms are relatively mild. © 2015 International Parkinson and Movement Disorder Society.
DOI: 10.1002/mds.26128
PubMed: 25759166
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Leverenz</name></author><author><name sortKey="Grabowski, Thomas J" sort="Grabowski, Thomas J" uniqKey="Grabowski T" first="Thomas J" last="Grabowski">Thomas J. Grabowski</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="doi">10.1002/mds.26128</idno><idno type="RBID">pubmed:25759166</idno><idno type="pmid">25759166</idno><idno type="wicri:Area/PubMed/Corpus">000237</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cerebral perfusion and cortical thickness indicate cortical involvement in mild Parkinson's disease.</title><author><name sortKey="Madhyastha, Tara M" sort="Madhyastha, Tara M" uniqKey="Madhyastha T" first="Tara M" last="Madhyastha">Tara M. Madhyastha</name><affiliation><nlm:affiliation>Department of Radiology, University of Washington, Seattle, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Askren, Mary K" sort="Askren, Mary K" uniqKey="Askren M" first="Mary K" last="Askren">Mary K. Askren</name></author><author><name sortKey="Boord, Peter" sort="Boord, Peter" uniqKey="Boord P" first="Peter" last="Boord">Peter Boord</name></author><author><name sortKey="Zhang, Jing" sort="Zhang, Jing" uniqKey="Zhang J" first="Jing" last="Zhang">Jing Zhang</name></author><author><name sortKey="Leverenz, James B" sort="Leverenz, James B" uniqKey="Leverenz J" first="James B" last="Leverenz">James B. Leverenz</name></author><author><name sortKey="Grabowski, Thomas J" sort="Grabowski, Thomas J" uniqKey="Grabowski T" first="Thomas J" last="Grabowski">Thomas J. Grabowski</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cortical dysfunction in Parkinson's disease (PD) may be caused by disruption to ascending systems or by intrinsic cortical neuropathology. We introduce and conduct a joint analysis of metabolism and atrophy capable of identifying whether metabolic disruption occurs in mild PD without cortical atrophy, to determine the extent and spatial pattern of cortical involvement in mild PD. The design was observational, studying 23 cognitively normal participants with mild PD (mean Hoehn & Yahr stage 2) and 21 healthy controls. Cortical thickness (obtained from analysis of structural magnetic resonance imaging [MRI] with FreeSurfer) and cerebral perfusion measures (obtained from arterial spin labeling [ASL]) analyzed independently and then together in a joint multiple factorial analysis to identify spatial patterns of perfusion and cortical thickness. We identify a pattern of changes in perfusion and cortical thickness characterized by symmetric parietal cortical thinning and reduced precuneus perfusion, with relative preservation of thickness and perfusion in the anterior cingulate cortex (ACC), right prefrontal gyrus, and medial frontal gyrus. The expression of this pattern is correlated with motor system symptoms and speed of processing. A spatial pattern of joint parietal cortical thinning and disproportionate reduction in perfusion occurs in our nondemented PD sample. We found no PD-related components of reduced perfusion without cortical thinning. This suggests that PD affects the cortex itself, even when symptoms are relatively mild. © 2015 International Parkinson and Movement Disorder Society.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">25759166</PMID><DateCreated><Year>2015</Year><Month>3</Month><Day>11</Day></DateCreated><DateRevised><Year>2015</Year><Month>9</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2015</Year><Month>Mar</Month><Day>11</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Cerebral perfusion and cortical thickness indicate cortical involvement in mild Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn></MedlinePgn></Pagination><ELocationID EIdType="doi">10.1002/mds.26128</ELocationID><Abstract><AbstractText NlmCategory="UNASSIGNED">Cortical dysfunction in Parkinson's disease (PD) may be caused by disruption to ascending systems or by intrinsic cortical neuropathology. We introduce and conduct a joint analysis of metabolism and atrophy capable of identifying whether metabolic disruption occurs in mild PD without cortical atrophy, to determine the extent and spatial pattern of cortical involvement in mild PD. The design was observational, studying 23 cognitively normal participants with mild PD (mean Hoehn & Yahr stage 2) and 21 healthy controls. Cortical thickness (obtained from analysis of structural magnetic resonance imaging [MRI] with FreeSurfer) and cerebral perfusion measures (obtained from arterial spin labeling [ASL]) analyzed independently and then together in a joint multiple factorial analysis to identify spatial patterns of perfusion and cortical thickness. We identify a pattern of changes in perfusion and cortical thickness characterized by symmetric parietal cortical thinning and reduced precuneus perfusion, with relative preservation of thickness and perfusion in the anterior cingulate cortex (ACC), right prefrontal gyrus, and medial frontal gyrus. The expression of this pattern is correlated with motor system symptoms and speed of processing. A spatial pattern of joint parietal cortical thinning and disproportionate reduction in perfusion occurs in our nondemented PD sample. We found no PD-related components of reduced perfusion without cortical thinning. This suggests that PD affects the cortex itself, even when symptoms are relatively mild. © 2015 International Parkinson and Movement Disorder Society.</AbstractText><CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList><Author><LastName>Madhyastha</LastName><ForeName>Tara M</ForeName><Initials>TM</Initials><AffiliationInfo><Affiliation>Department of Radiology, University of Washington, Seattle, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Askren</LastName><ForeName>Mary K</ForeName><Initials>MK</Initials></Author><Author><LastName>Boord</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author><LastName>Zhang</LastName><ForeName>Jing</ForeName><Initials>J</Initials></Author><Author><LastName>Leverenz</LastName><ForeName>James B</ForeName><Initials>JB</Initials></Author><Author><LastName>Grabowski</LastName><ForeName>Thomas J</ForeName><Initials>TJ</Initials></Author></AuthorList><Language>ENG</Language><GrantList><Grant><GrantID>P50 NS062684</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>RC4 NS073008</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="">JOURNAL ARTICLE</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>3</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">cerebral perfusion</Keyword><Keyword MajorTopicYN="N">cortical thickness</Keyword><Keyword MajorTopicYN="N">joint analysis</Keyword><Keyword MajorTopicYN="N">multiple factor analysis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>7</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>10</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>11</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>3</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>3</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>3</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pmc-release"><Year>2016</Year><Month>9</Month><Day>11</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.26128</ArticleId><ArticleId IdType="pubmed">25759166</ArticleId><ArticleId IdType="pmc">PMC4567553</ArticleId><ArticleId IdType="mid">NIHMS647355</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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