Impact of Parkinson's disease risk loci on age at onset.
Identifieur interne : 000178 ( PubMed/Corpus ); précédent : 000177; suivant : 000179Impact of Parkinson's disease risk loci on age at onset.
Auteurs : Christina M. Lill ; Johnni Hansen ; J Rgen H. Olsen ; Harald Binder ; Beate Ritz ; Lars BertramSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
The aim of this study was to assess whether recently identified Parkinson's disease (PD) risk genes also influence age at onset in PD.
DOI: 10.1002/mds.26237
PubMed: 25914293
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impact of Parkinson's disease risk loci on age at onset.</title><author><name sortKey="Lill, Christina M" sort="Lill, Christina M" uniqKey="Lill C" first="Christina M" last="Lill">Christina M. Lill</name><affiliation><nlm:affiliation>Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hansen, Johnni" sort="Hansen, Johnni" uniqKey="Hansen J" first="Johnni" last="Hansen">Johnni Hansen</name><affiliation><nlm:affiliation>Institute of Cancer Epidemiology, Danish Cancer Society Research Center, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Olsen, J Rgen H" sort="Olsen, J Rgen H" uniqKey="Olsen J" first="J Rgen H" last="Olsen">J Rgen H. Olsen</name><affiliation><nlm:affiliation>Institute of Cancer Epidemiology, Danish Cancer Society Research Center, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Binder, Harald" sort="Binder, Harald" uniqKey="Binder H" first="Harald" last="Binder">Harald Binder</name><affiliation><nlm:affiliation>Institute for Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center Mainz, Mainz, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name><affiliation><nlm:affiliation>Department of Epidemiology and Environmental Sciences, School of Public Health, University of California, Los Angeles, California, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bertram, Lars" sort="Bertram, Lars" uniqKey="Bertram L" first="Lars" last="Bertram">Lars Bertram</name><affiliation><nlm:affiliation>Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25914293</idno><idno type="pmid">25914293</idno><idno type="doi">10.1002/mds.26237</idno><idno type="wicri:Area/PubMed/Corpus">000178</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Impact of Parkinson's disease risk loci on age at onset.</title><author><name sortKey="Lill, Christina M" sort="Lill, Christina M" uniqKey="Lill C" first="Christina M" last="Lill">Christina M. Lill</name><affiliation><nlm:affiliation>Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hansen, Johnni" sort="Hansen, Johnni" uniqKey="Hansen J" first="Johnni" last="Hansen">Johnni Hansen</name><affiliation><nlm:affiliation>Institute of Cancer Epidemiology, Danish Cancer Society Research Center, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Olsen, J Rgen H" sort="Olsen, J Rgen H" uniqKey="Olsen J" first="J Rgen H" last="Olsen">J Rgen H. Olsen</name><affiliation><nlm:affiliation>Institute of Cancer Epidemiology, Danish Cancer Society Research Center, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Binder, Harald" sort="Binder, Harald" uniqKey="Binder H" first="Harald" last="Binder">Harald Binder</name><affiliation><nlm:affiliation>Institute for Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center Mainz, Mainz, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name><affiliation><nlm:affiliation>Department of Epidemiology and Environmental Sciences, School of Public Health, University of California, Los Angeles, California, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bertram, Lars" sort="Bertram, Lars" uniqKey="Bertram L" first="Lars" last="Bertram">Lars Bertram</name><affiliation><nlm:affiliation>Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this study was to assess whether recently identified Parkinson's disease (PD) risk genes also influence age at onset in PD.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="In-Process"><PMID Version="1">25914293</PMID><DateCreated><Year>2015</Year><Month>05</Month><Day>20</Day></DateCreated><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><Issue>6</Issue><PubDate><Year>2015</Year><Month>May</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Impact of Parkinson's disease risk loci on age at onset.</ArticleTitle><Pagination><MedlinePgn>847-50</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26237</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The aim of this study was to assess whether recently identified Parkinson's disease (PD) risk genes also influence age at onset in PD.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We genotyped 23 single-nucleotide polymorphisms in 1,526 Danish PD patients and performed linear regression analyses with age at onset. The combined impact of PD risk loci on age at onset was assessed by linear regression analyses using a weighted genetic risk score.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The strongest effects were observed with rs12726330 in GBA (beta = -3.63, P = 2.0 × 10(-5) ) and rs34311866 in TMEM175/GAK (beta = -1.19, P = 4.0 × 10(-3) ), corresponding to a 3.6-y and 1.2-y decrease of age at onset per risk allele, respectively. The weighted genetic risk score yielded significant association with reduced onset age (P = 3.98 × 10(-3) ), although the variance explained was small (0.6%), and the effect was mostly driven by polymorphisms in GBA and TMEM175/GAK.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Overall, our study indicates that GBA and TMEM175/GAK significantly alter age at onset in PD.</AbstractText><CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lill</LastName><ForeName>Christina M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hansen</LastName><ForeName>Johnni</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute of Cancer Epidemiology, Danish Cancer Society Research Center, Copenhagen, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology and Environmental Sciences, School of Public Health, University of California, Los Angeles, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olsen</LastName><ForeName>Jørgen H</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Institute of Cancer Epidemiology, Danish Cancer Society Research Center, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Binder</LastName><ForeName>Harald</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Institute for Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center Mainz, Mainz, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ritz</LastName><ForeName>Beate</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Environmental Sciences, School of Public Health, University of California, Los Angeles, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bertram</LastName><ForeName>Lars</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Public Health, Faculty of Medicine, The Imperial College of Science, Technology, and Medicine, London, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01ES013717</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>04</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">DGKQ</Keyword><Keyword MajorTopicYN="N">GAK</Keyword><Keyword MajorTopicYN="N">GBA</Keyword><Keyword MajorTopicYN="N">N370S</Keyword><Keyword MajorTopicYN="N">Parkinson's disease, PD</Keyword><Keyword MajorTopicYN="N">age at onset</Keyword><Keyword MajorTopicYN="N">genetic association</Keyword><Keyword MajorTopicYN="N">genetic risk score</Keyword><Keyword MajorTopicYN="N">genome-wide association study, GWAS</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>2</Month><Day>3</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>3</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>3</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2015</Year><Month>4</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>4</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>4</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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