Plasma oligomeric alpha-synuclein is associated with glucocerebrosidase activity in Gaucher disease.
Identifieur interne : 000173 ( PubMed/Corpus ); précédent : 000172; suivant : 000174Plasma oligomeric alpha-synuclein is associated with glucocerebrosidase activity in Gaucher disease.
Auteurs : Evgenii Nuzhnyi ; Anton Emelyanov ; Tatyana Boukina ; Tatiana Usenko ; Andrey Yakimovskii ; Ekaterina Zakharova ; Sofya PchelinaSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
The link between Parkinson's disease (PD) and Gaucher disease (GD), the most common lysosomal storage disease associated with loss of glucocerebrosidase (GBA) activity, can be explained by abnormal accumulation of oligomeric alpha-synuclein (α-Syn) species resulting from mutations in the GBA gene. However, in GD, the relationship between GBA activity and α-Syn accumulation in biological fluids has not been investigated.
DOI: 10.1002/mds.26200
PubMed: 25962734
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Plasma oligomeric alpha-synuclein is associated with glucocerebrosidase activity in Gaucher disease.</title><author><name sortKey="Nuzhnyi, Evgenii" sort="Nuzhnyi, Evgenii" uniqKey="Nuzhnyi E" first="Evgenii" last="Nuzhnyi">Evgenii Nuzhnyi</name><affiliation><nlm:affiliation>First Pavlov's State Medical University of Saint-Petersburg, St. Petersburg, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Emelyanov, Anton" sort="Emelyanov, Anton" uniqKey="Emelyanov A" first="Anton" last="Emelyanov">Anton Emelyanov</name><affiliation><nlm:affiliation>First Pavlov's State Medical University of Saint-Petersburg, St. Petersburg, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Boukina, Tatyana" sort="Boukina, Tatyana" uniqKey="Boukina T" first="Tatyana" last="Boukina">Tatyana Boukina</name><affiliation><nlm:affiliation>Medical-genetics Scientific Center, Moscow, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Usenko, Tatiana" sort="Usenko, Tatiana" uniqKey="Usenko T" first="Tatiana" last="Usenko">Tatiana Usenko</name><affiliation><nlm:affiliation>First Pavlov's State Medical University of Saint-Petersburg, St. Petersburg, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Yakimovskii, Andrey" sort="Yakimovskii, Andrey" uniqKey="Yakimovskii A" first="Andrey" last="Yakimovskii">Andrey Yakimovskii</name><affiliation><nlm:affiliation>First Pavlov's State Medical University of Saint-Petersburg, St. Petersburg, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Zakharova, Ekaterina" sort="Zakharova, Ekaterina" uniqKey="Zakharova E" first="Ekaterina" last="Zakharova">Ekaterina Zakharova</name><affiliation><nlm:affiliation>Medical-genetics Scientific Center, Moscow, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Pchelina, Sofya" sort="Pchelina, Sofya" uniqKey="Pchelina S" first="Sofya" last="Pchelina">Sofya Pchelina</name><affiliation><nlm:affiliation>First Pavlov's State Medical University of Saint-Petersburg, St. Petersburg, Russia.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25962734</idno><idno type="pmid">25962734</idno><idno type="doi">10.1002/mds.26200</idno><idno type="wicri:Area/PubMed/Corpus">000173</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Plasma oligomeric alpha-synuclein is associated with glucocerebrosidase activity in Gaucher disease.</title><author><name sortKey="Nuzhnyi, Evgenii" sort="Nuzhnyi, Evgenii" uniqKey="Nuzhnyi E" first="Evgenii" last="Nuzhnyi">Evgenii Nuzhnyi</name><affiliation><nlm:affiliation>First Pavlov's State Medical University of Saint-Petersburg, St. Petersburg, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Emelyanov, Anton" sort="Emelyanov, Anton" uniqKey="Emelyanov A" first="Anton" last="Emelyanov">Anton Emelyanov</name><affiliation><nlm:affiliation>First Pavlov's State Medical University of Saint-Petersburg, St. Petersburg, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Boukina, Tatyana" sort="Boukina, Tatyana" uniqKey="Boukina T" first="Tatyana" last="Boukina">Tatyana Boukina</name><affiliation><nlm:affiliation>Medical-genetics Scientific Center, Moscow, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Usenko, Tatiana" sort="Usenko, Tatiana" uniqKey="Usenko T" first="Tatiana" last="Usenko">Tatiana Usenko</name><affiliation><nlm:affiliation>First Pavlov's State Medical University of Saint-Petersburg, St. Petersburg, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Yakimovskii, Andrey" sort="Yakimovskii, Andrey" uniqKey="Yakimovskii A" first="Andrey" last="Yakimovskii">Andrey Yakimovskii</name><affiliation><nlm:affiliation>First Pavlov's State Medical University of Saint-Petersburg, St. Petersburg, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Zakharova, Ekaterina" sort="Zakharova, Ekaterina" uniqKey="Zakharova E" first="Ekaterina" last="Zakharova">Ekaterina Zakharova</name><affiliation><nlm:affiliation>Medical-genetics Scientific Center, Moscow, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Pchelina, Sofya" sort="Pchelina, Sofya" uniqKey="Pchelina S" first="Sofya" last="Pchelina">Sofya Pchelina</name><affiliation><nlm:affiliation>First Pavlov's State Medical University of Saint-Petersburg, St. Petersburg, Russia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The link between Parkinson's disease (PD) and Gaucher disease (GD), the most common lysosomal storage disease associated with loss of glucocerebrosidase (GBA) activity, can be explained by abnormal accumulation of oligomeric alpha-synuclein (α-Syn) species resulting from mutations in the GBA gene. However, in GD, the relationship between GBA activity and α-Syn accumulation in biological fluids has not been investigated.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="In-Process"><PMID Version="1">25962734</PMID><DateCreated><Year>2015</Year><Month>06</Month><Day>23</Day></DateCreated><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><Issue>7</Issue><PubDate><Year>2015</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Plasma oligomeric alpha-synuclein is associated with glucocerebrosidase activity in Gaucher disease.</ArticleTitle><Pagination><MedlinePgn>989-91</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26200</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The link between Parkinson's disease (PD) and Gaucher disease (GD), the most common lysosomal storage disease associated with loss of glucocerebrosidase (GBA) activity, can be explained by abnormal accumulation of oligomeric alpha-synuclein (α-Syn) species resulting from mutations in the GBA gene. However, in GD, the relationship between GBA activity and α-Syn accumulation in biological fluids has not been investigated.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We analyzed plasma oligomeric α-Syn levels, leucocyte GBA activity, and plasma chitotriosidase activity in 21 patients with GD.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Negative correlation between plasma oligomeric α-Syn levels, and leucocyte GBA activity was observed in patients with GD (R(2) = 0.487; P < 0.001).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The decrease in GBA activity may influence α-Syn oligomerization, explaining the high risk of PD development in GD patients. © 2015 International Parkinson and Movement Disorder Society.</AbstractText><CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nuzhnyi</LastName><ForeName>Evgenii</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>First Pavlov's State Medical University of Saint-Petersburg, St. Petersburg, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Emelyanov</LastName><ForeName>Anton</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>First Pavlov's State Medical University of Saint-Petersburg, St. Petersburg, Russia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Petersburg Nuclear Physics Institute, St. Petersburg, Russia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>St. Petersburg Academic University-Nanothecnology Research and Education Centre, RAS, St. Petersburg, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boukina</LastName><ForeName>Tatyana</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Medical-genetics Scientific Center, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Usenko</LastName><ForeName>Tatiana</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>First Pavlov's State Medical University of Saint-Petersburg, St. Petersburg, Russia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Petersburg Nuclear Physics Institute, St. Petersburg, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yakimovskii</LastName><ForeName>Andrey</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>First Pavlov's State Medical University of Saint-Petersburg, St. Petersburg, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zakharova</LastName><ForeName>Ekaterina</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Medical-genetics Scientific Center, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pchelina</LastName><ForeName>Sofya</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>First Pavlov's State Medical University of Saint-Petersburg, St. Petersburg, Russia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Petersburg Nuclear Physics Institute, St. Petersburg, Russia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>St. Petersburg Academic University-Nanothecnology Research and Education Centre, RAS, St. Petersburg, Russia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>05</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Gaucher disease</Keyword><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">alpha-synuclein</Keyword><Keyword MajorTopicYN="N">glucocerebrosidase</Keyword><Keyword MajorTopicYN="N">oligomerization</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>11</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>1</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>2</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2015</Year><Month>5</Month><Day>12</Day></PubMedPubDate><PubMedPubDate 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