Brain alterations with deep brain stimulation: New insight from a neuropathological case series.
Identifieur interne : 000159 ( PubMed/Corpus ); précédent : 000158; suivant : 000160Brain alterations with deep brain stimulation: New insight from a neuropathological case series.
Auteurs : Martin Kronenbuerger ; Kay Wilhelm Nolte ; Volker Arnd Coenen ; Jean-Marc Burgunder ; Joachim K. Krauss ; Joachim WeisSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
Previous studies on human brain tissue alterations caused by deep brain stimulation described glial and reactive inflammatory changes. In the current pathoanatomical study, we extended the analysis to signs of axonal changes and the influence of concomitant disease.
DOI: 10.1002/mds.26247
PubMed: 26011773
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Brain alterations with deep brain stimulation: New insight from a neuropathological case series.</title><author><name sortKey="Kronenbuerger, Martin" sort="Kronenbuerger, Martin" uniqKey="Kronenbuerger M" first="Martin" last="Kronenbuerger">Martin Kronenbuerger</name><affiliation><nlm:affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Nolte, Kay Wilhelm" sort="Nolte, Kay Wilhelm" uniqKey="Nolte K" first="Kay Wilhelm" last="Nolte">Kay Wilhelm Nolte</name><affiliation><nlm:affiliation>Institute of Neuropathology, RWTH Aachen University Hospital, Aachen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Coenen, Volker Arnd" sort="Coenen, Volker Arnd" uniqKey="Coenen V" first="Volker Arnd" last="Coenen">Volker Arnd Coenen</name><affiliation><nlm:affiliation>Department of Stereotactic and Functional Neurosurgery, Freiburg University Medical Center, Freiburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Burgunder, Jean Marc" sort="Burgunder, Jean Marc" uniqKey="Burgunder J" first="Jean-Marc" last="Burgunder">Jean-Marc Burgunder</name><affiliation><nlm:affiliation>Department of Neurology, University of Berne, Inselspital, Berne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Krauss, Joachim K" sort="Krauss, Joachim K" uniqKey="Krauss J" first="Joachim K" last="Krauss">Joachim K. Krauss</name><affiliation><nlm:affiliation>Department of Neurosurgery, Medical School Hannover (MHH), Hannover, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Weis, Joachim" sort="Weis, Joachim" uniqKey="Weis J" first="Joachim" last="Weis">Joachim Weis</name><affiliation><nlm:affiliation>Institute of Neuropathology, RWTH Aachen University Hospital, Aachen, Germany.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26011773</idno><idno type="pmid">26011773</idno><idno type="doi">10.1002/mds.26247</idno><idno type="wicri:Area/PubMed/Corpus">000159</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Brain alterations with deep brain stimulation: New insight from a neuropathological case series.</title><author><name sortKey="Kronenbuerger, Martin" sort="Kronenbuerger, Martin" uniqKey="Kronenbuerger M" first="Martin" last="Kronenbuerger">Martin Kronenbuerger</name><affiliation><nlm:affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Nolte, Kay Wilhelm" sort="Nolte, Kay Wilhelm" uniqKey="Nolte K" first="Kay Wilhelm" last="Nolte">Kay Wilhelm Nolte</name><affiliation><nlm:affiliation>Institute of Neuropathology, RWTH Aachen University Hospital, Aachen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Coenen, Volker Arnd" sort="Coenen, Volker Arnd" uniqKey="Coenen V" first="Volker Arnd" last="Coenen">Volker Arnd Coenen</name><affiliation><nlm:affiliation>Department of Stereotactic and Functional Neurosurgery, Freiburg University Medical Center, Freiburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Burgunder, Jean Marc" sort="Burgunder, Jean Marc" uniqKey="Burgunder J" first="Jean-Marc" last="Burgunder">Jean-Marc Burgunder</name><affiliation><nlm:affiliation>Department of Neurology, University of Berne, Inselspital, Berne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Krauss, Joachim K" sort="Krauss, Joachim K" uniqKey="Krauss J" first="Joachim K" last="Krauss">Joachim K. Krauss</name><affiliation><nlm:affiliation>Department of Neurosurgery, Medical School Hannover (MHH), Hannover, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Weis, Joachim" sort="Weis, Joachim" uniqKey="Weis J" first="Joachim" last="Weis">Joachim Weis</name><affiliation><nlm:affiliation>Institute of Neuropathology, RWTH Aachen University Hospital, Aachen, Germany.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previous studies on human brain tissue alterations caused by deep brain stimulation described glial and reactive inflammatory changes. In the current pathoanatomical study, we extended the analysis to signs of axonal changes and the influence of concomitant disease.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="In-Process"><PMID Version="1">26011773</PMID><DateCreated><Year>2015</Year><Month>07</Month><Day>16</Day></DateCreated><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><Issue>8</Issue><PubDate><Year>2015</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Brain alterations with deep brain stimulation: New insight from a neuropathological case series.</ArticleTitle><Pagination><MedlinePgn>1125-30</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26247</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Previous studies on human brain tissue alterations caused by deep brain stimulation described glial and reactive inflammatory changes. In the current pathoanatomical study, we extended the analysis to signs of axonal changes and the influence of concomitant disease.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Brains of 10 patients with Parkinson's disease or essential tremor and a total of 18 electrodes were systematically examined up to 7.5 y after surgery.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In general, tissue that had long-term contact with the electrode material exhibited astrogliosis in all, T-lymphocytes in 93%, and multinucleated giant cells in 68% of patients. Immunohistochemistry showed an increase in amyloid precursor protein immunoreactive axonal swellings in the brain at the electrically active parts of the electrodes. Patients who died of septicemia showed a more severe astrogliosis and giant cell reaction than patients who died of cardiovascular events. Parkinson's disease or essential tremor did not differentially produce histopathological changes around the electrodes.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Long-term electrical stimulation by deep brain stimulation causes minor axonal changes. The cause of death, but not the underlying neurological disease, affects the histopathological changes around the electrode. The findings need to be reproduced by examining larger patient subgroups.</AbstractText><CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kronenbuerger</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurology, RWTH Aachen University Hospital, Aachen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nolte</LastName><ForeName>Kay Wilhelm</ForeName><Initials>KW</Initials><AffiliationInfo><Affiliation>Institute of Neuropathology, RWTH Aachen University Hospital, Aachen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coenen</LastName><ForeName>Volker Arnd</ForeName><Initials>VA</Initials><AffiliationInfo><Affiliation>Department of Stereotactic and Functional Neurosurgery, Freiburg University Medical Center, Freiburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burgunder</LastName><ForeName>Jean-Marc</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Berne, Inselspital, Berne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krauss</LastName><ForeName>Joachim K</ForeName><Initials>JK</Initials><AffiliationInfo><Affiliation>Department of Neurosurgery, Medical School Hannover (MHH), Hannover, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weis</LastName><ForeName>Joachim</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute of Neuropathology, RWTH Aachen University Hospital, Aachen, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>05</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">axonal lesions</Keyword><Keyword MajorTopicYN="N">deep brain stimulation</Keyword><Keyword MajorTopicYN="N">gliosis</Keyword><Keyword MajorTopicYN="N">inflammation</Keyword><Keyword MajorTopicYN="N">post-mortem analysis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>6</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>3</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>3</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2015</Year><Month>5</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>5</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>5</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>5</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26011773</ArticleId><ArticleId IdType="doi">10.1002/mds.26247</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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