A unique retinal epitheliopathy is associated with amyotrophic lateral sclerosis/Parkinsonism-Dementia complex of Guam.
Identifieur interne : 000126 ( PubMed/Corpus ); précédent : 000125; suivant : 000127A unique retinal epitheliopathy is associated with amyotrophic lateral sclerosis/Parkinsonism-Dementia complex of Guam.
Auteurs : John C. Steele ; Robert Wresch ; Samuel D. Hanlon ; Jay Keystone ; Yoav Ben-ShlomoSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
The aim of this work was to examine whether a linear retinal pigment epitheliopathy is associated with the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam.
DOI: 10.1002/mds.26264
PubMed: 26153661
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A unique retinal epitheliopathy is associated with amyotrophic lateral sclerosis/Parkinsonism-Dementia complex of Guam.</title><author><name sortKey="Steele, John C" sort="Steele, John C" uniqKey="Steele J" first="John C" last="Steele">John C. Steele</name><affiliation><nlm:affiliation>Guam Memorial Hospital, Tamuning, Guam.</nlm:affiliation></affiliation></author><author><name sortKey="Wresch, Robert" sort="Wresch, Robert" uniqKey="Wresch R" first="Robert" last="Wresch">Robert Wresch</name><affiliation><nlm:affiliation>Seventh-day Adventist Guam Clinic; Guam Memorial Hospital; and Loma Linda University, Loma Linda, California, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hanlon, Samuel D" sort="Hanlon, Samuel D" uniqKey="Hanlon S" first="Samuel D" last="Hanlon">Samuel D. Hanlon</name><affiliation><nlm:affiliation>University Eye Institute, University of Houston, Houston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Keystone, Jay" sort="Keystone, Jay" uniqKey="Keystone J" first="Jay" last="Keystone">Jay Keystone</name><affiliation><nlm:affiliation>Tropical Disease Unit, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Ben Shlomo, Yoav" sort="Ben Shlomo, Yoav" uniqKey="Ben Shlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name><affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26153661</idno><idno type="pmid">26153661</idno><idno type="doi">10.1002/mds.26264</idno><idno type="wicri:Area/PubMed/Corpus">000126</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A unique retinal epitheliopathy is associated with amyotrophic lateral sclerosis/Parkinsonism-Dementia complex of Guam.</title><author><name sortKey="Steele, John C" sort="Steele, John C" uniqKey="Steele J" first="John C" last="Steele">John C. Steele</name><affiliation><nlm:affiliation>Guam Memorial Hospital, Tamuning, Guam.</nlm:affiliation></affiliation></author><author><name sortKey="Wresch, Robert" sort="Wresch, Robert" uniqKey="Wresch R" first="Robert" last="Wresch">Robert Wresch</name><affiliation><nlm:affiliation>Seventh-day Adventist Guam Clinic; Guam Memorial Hospital; and Loma Linda University, Loma Linda, California, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hanlon, Samuel D" sort="Hanlon, Samuel D" uniqKey="Hanlon S" first="Samuel D" last="Hanlon">Samuel D. Hanlon</name><affiliation><nlm:affiliation>University Eye Institute, University of Houston, Houston, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Keystone, Jay" sort="Keystone, Jay" uniqKey="Keystone J" first="Jay" last="Keystone">Jay Keystone</name><affiliation><nlm:affiliation>Tropical Disease Unit, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Ben Shlomo, Yoav" sort="Ben Shlomo, Yoav" uniqKey="Ben Shlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name><affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this work was to examine whether a linear retinal pigment epitheliopathy is associated with the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="In-Process"><PMID Version="1">26153661</PMID><DateCreated><Year>2015</Year><Month>09</Month><Day>21</Day></DateCreated><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><Issue>9</Issue><PubDate><Year>2015</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>A unique retinal epitheliopathy is associated with amyotrophic lateral sclerosis/Parkinsonism-Dementia complex of Guam.</ArticleTitle><Pagination><MedlinePgn>1271-5</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26264</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The aim of this work was to examine whether a linear retinal pigment epitheliopathy is associated with the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A total of 918 Guamanian Chamorros, with and without amyotrophic lateral sclerosis/parkinsonism-dementia complex, were examined cross-sectionally for linear retinal pigment epitheliopathy (LRPE). Overall, 239 Guamanians, who were neurologically asymptomatic, were followed for up to 20 years to determine the risk of developing amyotrophic lateral sclerosis/parkinsonism-dementia complex.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The epitheliopathy was present in 59.7% (117 of 196) patients with amyotrophic lateral sclerosis/parkinsonism-dementia complex, but in only 24.7% (178 of 722) of subjects who were neurologically asymptomatic (age- and sex-adjusted risk difference: 35.0%; 95% confidence interval [CI]: 27.5-42.6; p < 0.0001). Prospectively, 15 of 50 cases with epitheliopathy developed amyotrophic lateral sclerosis/parkinsonism-dementia complex, compared to 4 of 189 cases without epitheliopathy (age- and sex-adjusted hazard ratio: 13.1; 95% CI: 4.0-43.1; P < 0.0001).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Amyotrophic lateral sclerosis/parkinsonism-dementia complex is associated with an LRPE and predicts future neurological disease. Identifying the cause of this retinopathy could provide an understanding about the pathogenesis of amyotrophic lateral sclerosis/parkinsonism-dementia complex and related diseases.</AbstractText><CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Steele</LastName><ForeName>John C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Guam Memorial Hospital, Tamuning, Guam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wresch</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Seventh-day Adventist Guam Clinic; Guam Memorial Hospital; and Loma Linda University, Loma Linda, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hanlon</LastName><ForeName>Samuel D</ForeName><Initials>SD</Initials><AffiliationInfo><Affiliation>University Eye Institute, University of Houston, Houston, Texas, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Keystone</LastName><ForeName>Jay</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Tropical Disease Unit, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ben-Shlomo</LastName><ForeName>Yoav</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>07</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Guam</Keyword><Keyword MajorTopicYN="N">Parkinson's disease with dementia</Keyword><Keyword MajorTopicYN="N">amyotrophic lateral sclerosis</Keyword><Keyword MajorTopicYN="N">neuroepidemiology</Keyword><Keyword MajorTopicYN="N">parkinsonism</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>3</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>3</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>4</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2015</Year><Month>7</Month><Day>7</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>7</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>7</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>7</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26153661</ArticleId><ArticleId IdType="doi">10.1002/mds.26264</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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