The motor inhibition system in Parkinson's disease with levodopa-induced dyskinesias.
Identifieur interne : 000059 ( PubMed/Corpus ); précédent : 000058; suivant : 000060The motor inhibition system in Parkinson's disease with levodopa-induced dyskinesias.
Auteurs : Antonio Cerasa ; Giulia Donzuso ; Maurizio Morelli ; Graziella Mangone ; Maria Salsone ; Luca Passamonti ; Antonio Augimeri ; Gennarina Arabia ; Aldo QuattroneSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
Parkinson's disease is primarily a disorder of response initiation characterized by an excessive motor inhibition, whereas levodopa-induced dyskinesias are clearly a clinical expression of disinhibition of movements.
DOI: 10.1002/mds.26378
PubMed: 26275050
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The motor inhibition system in Parkinson's disease with levodopa-induced dyskinesias.</title><author><name sortKey="Cerasa, Antonio" sort="Cerasa, Antonio" uniqKey="Cerasa A" first="Antonio" last="Cerasa">Antonio Cerasa</name><affiliation><nlm:affiliation>Consiglio Nazionale delle Ricerche, IBFM, Catanzaro, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Donzuso, Giulia" sort="Donzuso, Giulia" uniqKey="Donzuso G" first="Giulia" last="Donzuso">Giulia Donzuso</name><affiliation><nlm:affiliation>Consiglio Nazionale delle Ricerche, IBFM, Catanzaro, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Morelli, Maurizio" sort="Morelli, Maurizio" uniqKey="Morelli M" first="Maurizio" last="Morelli">Maurizio Morelli</name><affiliation><nlm:affiliation>Università degli studi "Magna Graecia", Clinica Neurologica, Catanzaro, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Mangone, Graziella" sort="Mangone, Graziella" uniqKey="Mangone G" first="Graziella" last="Mangone">Graziella Mangone</name><affiliation><nlm:affiliation>Consiglio Nazionale delle Ricerche, IBFM, Catanzaro, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Salsone, Maria" sort="Salsone, Maria" uniqKey="Salsone M" first="Maria" last="Salsone">Maria Salsone</name><affiliation><nlm:affiliation>Consiglio Nazionale delle Ricerche, IBFM, Catanzaro, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Passamonti, Luca" sort="Passamonti, Luca" uniqKey="Passamonti L" first="Luca" last="Passamonti">Luca Passamonti</name><affiliation><nlm:affiliation>Consiglio Nazionale delle Ricerche, IBFM, Catanzaro, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Augimeri, Antonio" sort="Augimeri, Antonio" uniqKey="Augimeri A" first="Antonio" last="Augimeri">Antonio Augimeri</name><affiliation><nlm:affiliation>Consiglio Nazionale delle Ricerche, IBFM, Catanzaro, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Arabia, Gennarina" sort="Arabia, Gennarina" uniqKey="Arabia G" first="Gennarina" last="Arabia">Gennarina Arabia</name><affiliation><nlm:affiliation>Università degli studi "Magna Graecia", Clinica Neurologica, Catanzaro, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation><nlm:affiliation>Consiglio Nazionale delle Ricerche, IBFM, Catanzaro, Italy.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="doi">10.1002/mds.26378</idno><idno type="RBID">pubmed:26275050</idno><idno type="pmid">26275050</idno><idno type="wicri:Area/PubMed/Corpus">000059</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The motor inhibition system in Parkinson's disease with levodopa-induced dyskinesias.</title><author><name sortKey="Cerasa, Antonio" sort="Cerasa, Antonio" uniqKey="Cerasa A" first="Antonio" last="Cerasa">Antonio Cerasa</name><affiliation><nlm:affiliation>Consiglio Nazionale delle Ricerche, IBFM, Catanzaro, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Donzuso, Giulia" sort="Donzuso, Giulia" uniqKey="Donzuso G" first="Giulia" last="Donzuso">Giulia Donzuso</name><affiliation><nlm:affiliation>Consiglio Nazionale delle Ricerche, IBFM, Catanzaro, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Morelli, Maurizio" sort="Morelli, Maurizio" uniqKey="Morelli M" first="Maurizio" last="Morelli">Maurizio Morelli</name><affiliation><nlm:affiliation>Università degli studi "Magna Graecia", Clinica Neurologica, Catanzaro, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Mangone, Graziella" sort="Mangone, Graziella" uniqKey="Mangone G" first="Graziella" last="Mangone">Graziella Mangone</name><affiliation><nlm:affiliation>Consiglio Nazionale delle Ricerche, IBFM, Catanzaro, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Salsone, Maria" sort="Salsone, Maria" uniqKey="Salsone M" first="Maria" last="Salsone">Maria Salsone</name><affiliation><nlm:affiliation>Consiglio Nazionale delle Ricerche, IBFM, Catanzaro, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Passamonti, Luca" sort="Passamonti, Luca" uniqKey="Passamonti L" first="Luca" last="Passamonti">Luca Passamonti</name><affiliation><nlm:affiliation>Consiglio Nazionale delle Ricerche, IBFM, Catanzaro, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Augimeri, Antonio" sort="Augimeri, Antonio" uniqKey="Augimeri A" first="Antonio" last="Augimeri">Antonio Augimeri</name><affiliation><nlm:affiliation>Consiglio Nazionale delle Ricerche, IBFM, Catanzaro, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Arabia, Gennarina" sort="Arabia, Gennarina" uniqKey="Arabia G" first="Gennarina" last="Arabia">Gennarina Arabia</name><affiliation><nlm:affiliation>Università degli studi "Magna Graecia", Clinica Neurologica, Catanzaro, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation><nlm:affiliation>Consiglio Nazionale delle Ricerche, IBFM, Catanzaro, Italy.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease is primarily a disorder of response initiation characterized by an excessive motor inhibition, whereas levodopa-induced dyskinesias are clearly a clinical expression of disinhibition of movements.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">26275050</PMID><DateCreated><Year>2015</Year><Month>8</Month><Day>14</Day></DateCreated><DateRevised><Year>2015</Year><Month>8</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2015</Year><Month>Aug</Month><Day>14</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>The motor inhibition system in Parkinson's disease with levodopa-induced dyskinesias.</ArticleTitle><Pagination><MedlinePgn></MedlinePgn></Pagination><ELocationID EIdType="doi">10.1002/mds.26378</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Parkinson's disease is primarily a disorder of response initiation characterized by an excessive motor inhibition, whereas levodopa-induced dyskinesias are clearly a clinical expression of disinhibition of movements.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">That levodopa-induced dyskinesias are linked to dysfunctions of inhibitory brain network has recently been proposed, but no investigation of behavioral performance during action inhibition task in these patients has been published.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Twenty-four Parkinson's disease patients with or without levodopa-induced dyskinesias tested on or off their medications underwent functional magnetic resonance imaging investigation during the execution of a stop-signal inhibition task. In particular, we were interested in evaluating the neural correlates of stop-related conditions: StopInhibit task (in which patients had to successfully inhibit their responses) and StopRespond task (Stop trials with erroneous button press). Both tasks were compared against Go trials.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Levodopa intake in dyskinetic patients tended to worsen inhibitory control during the StopInhibit task, while significantly affecting the ability to monitor motor responses when patients failed to stop (StopRespond task). Functional analysis showed that, during the StopInhibit task, dyskinetic patients were characterized by decreased activity of the right inferior frontal cortex after levodopa intake, whereas patients without dyskinesias showed a reverse effect. A similar group × levodopa interaction effect was detected in the medial frontal cortex during the execution of the StopRespond task, in which dyskinetic patients showed increased activity after dopaminergic therapy CONCLUSIONS: Our study demonstrated that levodopa intake in dyskinetic patients tends to alter the functioning of some parts of the neural network involved in motor inhibition. © 2015 International Parkinson and Movement Disorder Society.</AbstractText><CopyrightInformation>© 2015 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList><Author><LastName>Cerasa</LastName><ForeName>Antonio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Consiglio Nazionale delle Ricerche, IBFM, Catanzaro, Italy.</Affiliation></AffiliationInfo></Author><Author><LastName>Donzuso</LastName><ForeName>Giulia</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Consiglio Nazionale delle Ricerche, IBFM, Catanzaro, Italy.</Affiliation></AffiliationInfo></Author><Author><LastName>Morelli</LastName><ForeName>Maurizio</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Università degli studi "Magna Graecia", Clinica Neurologica, Catanzaro, Italy.</Affiliation></AffiliationInfo></Author><Author><LastName>Mangone</LastName><ForeName>Graziella</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Consiglio Nazionale delle Ricerche, IBFM, Catanzaro, Italy.</Affiliation></AffiliationInfo></Author><Author><LastName>Salsone</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Consiglio Nazionale delle Ricerche, IBFM, Catanzaro, Italy.</Affiliation></AffiliationInfo></Author><Author><LastName>Passamonti</LastName><ForeName>Luca</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Consiglio Nazionale delle Ricerche, IBFM, Catanzaro, Italy.</Affiliation></AffiliationInfo></Author><Author><LastName>Augimeri</LastName><ForeName>Antonio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Consiglio Nazionale delle Ricerche, IBFM, Catanzaro, Italy.</Affiliation></AffiliationInfo></Author><Author><LastName>Arabia</LastName><ForeName>Gennarina</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Università degli studi "Magna Graecia", Clinica Neurologica, Catanzaro, Italy.</Affiliation></AffiliationInfo></Author><Author><LastName>Quattrone</LastName><ForeName>Aldo</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Consiglio Nazionale delle Ricerche, IBFM, Catanzaro, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Università degli studi "Magna Graecia", Clinica Neurologica, Catanzaro, Italy.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="">JOURNAL ARTICLE</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>8</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">inferior frontal cortex</Keyword><Keyword MajorTopicYN="N">levodopa-induced dyskinesias</Keyword><Keyword MajorTopicYN="N">medial frontal cortex</Keyword><Keyword MajorTopicYN="N">motor inhibition</Keyword><Keyword MajorTopicYN="N">stop-signal reaction time</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>3</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>7</Month><Day>9</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>7</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>8</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>8</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>8</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.26378</ArticleId><ArticleId IdType="pubmed">26275050</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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