Light pigmentation phenotype is correlated with increased substantia nigra echogenicity.
Identifieur interne : 000026 ( PubMed/Corpus ); précédent : 000025; suivant : 000027Light pigmentation phenotype is correlated with increased substantia nigra echogenicity.
Auteurs : Jost-Julian Rumpf ; Maria Schirmer ; Christopher Fricke ; David Weise ; Justinus Aspasios Wagner ; Jan Simon ; Joseph ClassenSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
This study was undertaken to address the question of whether pigmentation may be mechanistically linked with Parkinson's disease.
DOI: 10.1002/mds.26427
PubMed: 26395561
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Light pigmentation phenotype is correlated with increased substantia nigra echogenicity.</title><author><name sortKey="Rumpf, Jost Julian" sort="Rumpf, Jost Julian" uniqKey="Rumpf J" first="Jost-Julian" last="Rumpf">Jost-Julian Rumpf</name><affiliation><nlm:affiliation>Department of Neurology, University of Leipzig, Leipzig, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schirmer, Maria" sort="Schirmer, Maria" uniqKey="Schirmer M" first="Maria" last="Schirmer">Maria Schirmer</name><affiliation><nlm:affiliation>Department of Neurology, University of Leipzig, Leipzig, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Fricke, Christopher" sort="Fricke, Christopher" uniqKey="Fricke C" first="Christopher" last="Fricke">Christopher Fricke</name><affiliation><nlm:affiliation>Department of Neurology, University of Leipzig, Leipzig, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Weise, David" sort="Weise, David" uniqKey="Weise D" first="David" last="Weise">David Weise</name><affiliation><nlm:affiliation>Department of Neurology, University of Leipzig, Leipzig, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Wagner, Justinus Aspasios" sort="Wagner, Justinus Aspasios" uniqKey="Wagner J" first="Justinus Aspasios" last="Wagner">Justinus Aspasios Wagner</name><affiliation><nlm:affiliation>Department of Dermatology and Venereology, University of Leipzig, Leipzig, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Simon, Jan" sort="Simon, Jan" uniqKey="Simon J" first="Jan" last="Simon">Jan Simon</name><affiliation><nlm:affiliation>Department of Dermatology and Venereology, University of Leipzig, Leipzig, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Classen, Joseph" sort="Classen, Joseph" uniqKey="Classen J" first="Joseph" last="Classen">Joseph Classen</name><affiliation><nlm:affiliation>Department of Neurology, University of Leipzig, Leipzig, Germany.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="doi">10.1002/mds.26427</idno><idno type="RBID">pubmed:26395561</idno><idno type="pmid">26395561</idno><idno type="wicri:Area/PubMed/Corpus">000026</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Light pigmentation phenotype is correlated with increased substantia nigra echogenicity.</title><author><name sortKey="Rumpf, Jost Julian" sort="Rumpf, Jost Julian" uniqKey="Rumpf J" first="Jost-Julian" last="Rumpf">Jost-Julian Rumpf</name><affiliation><nlm:affiliation>Department of Neurology, University of Leipzig, Leipzig, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schirmer, Maria" sort="Schirmer, Maria" uniqKey="Schirmer M" first="Maria" last="Schirmer">Maria Schirmer</name><affiliation><nlm:affiliation>Department of Neurology, University of Leipzig, Leipzig, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Fricke, Christopher" sort="Fricke, Christopher" uniqKey="Fricke C" first="Christopher" last="Fricke">Christopher Fricke</name><affiliation><nlm:affiliation>Department of Neurology, University of Leipzig, Leipzig, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Weise, David" sort="Weise, David" uniqKey="Weise D" first="David" last="Weise">David Weise</name><affiliation><nlm:affiliation>Department of Neurology, University of Leipzig, Leipzig, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Wagner, Justinus Aspasios" sort="Wagner, Justinus Aspasios" uniqKey="Wagner J" first="Justinus Aspasios" last="Wagner">Justinus Aspasios Wagner</name><affiliation><nlm:affiliation>Department of Dermatology and Venereology, University of Leipzig, Leipzig, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Simon, Jan" sort="Simon, Jan" uniqKey="Simon J" first="Jan" last="Simon">Jan Simon</name><affiliation><nlm:affiliation>Department of Dermatology and Venereology, University of Leipzig, Leipzig, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Classen, Joseph" sort="Classen, Joseph" uniqKey="Classen J" first="Joseph" last="Classen">Joseph Classen</name><affiliation><nlm:affiliation>Department of Neurology, University of Leipzig, Leipzig, Germany.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study was undertaken to address the question of whether pigmentation may be mechanistically linked with Parkinson's disease.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">26395561</PMID><DateCreated><Year>2015</Year><Month>9</Month><Day>23</Day></DateCreated><DateRevised><Year>2015</Year><Month>9</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2015</Year><Month>Sep</Month><Day>23</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Light pigmentation phenotype is correlated with increased substantia nigra echogenicity.</ArticleTitle><Pagination><MedlinePgn></MedlinePgn></Pagination><ELocationID EIdType="doi">10.1002/mds.26427</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">This study was undertaken to address the question of whether pigmentation may be mechanistically linked with Parkinson's disease.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">In a cross-sectional, observational study, 116 healthy subjects received transcranial sonography of the substantia nigra. Pigmentation phenotype was assessed using the Fitzpatrick skin phototype classification, and five additional phenotypic pigmentation traits as well as a photographic method (Melanin index) in a subgroup of 46 subjects.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Lighter skin phototype was associated with larger echogenic substantia nigra area and increased prevalence of abnormally enlarged echogenic substantia nigra area. The strongest association of substantia nigra echogenicity and phenotypic pigmentation traits was found for hair color and facial tanning.</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">Findings suggest an increasing prevalence of structural abnormality of substantia nigra with decreasing darkness of skin and thus may provide additional evidence in favor of a pathogenic link of pigmentation and Parkinson's disease. © 2015 International Parkinson and Movement Disorder Society.</AbstractText><CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList><Author><LastName>Rumpf</LastName><ForeName>Jost-Julian</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Leipzig, Leipzig, Germany.</Affiliation></AffiliationInfo></Author><Author><LastName>Schirmer</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Leipzig, Leipzig, Germany.</Affiliation></AffiliationInfo></Author><Author><LastName>Fricke</LastName><ForeName>Christopher</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Leipzig, Leipzig, Germany.</Affiliation></AffiliationInfo></Author><Author><LastName>Weise</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Leipzig, Leipzig, Germany.</Affiliation></AffiliationInfo></Author><Author><LastName>Wagner</LastName><ForeName>Justinus Aspasios</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Department of Dermatology and Venereology, University of Leipzig, Leipzig, Germany.</Affiliation></AffiliationInfo></Author><Author><LastName>Simon</LastName><ForeName>Jan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Dermatology and Venereology, University of Leipzig, Leipzig, Germany.</Affiliation></AffiliationInfo></Author><Author><LastName>Classen</LastName><ForeName>Joseph</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Leipzig, Leipzig, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="">JOURNAL ARTICLE</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>9</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">pigmentation</Keyword><Keyword MajorTopicYN="N">substantia nigra hyperechogenicity</Keyword><Keyword MajorTopicYN="N">transcranial sonography</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>4</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>7</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>8</Month><Day>6</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>9</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>9</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>9</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.26427</ArticleId><ArticleId IdType="pubmed">26395561</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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