The NINDS Parkinson's disease biomarkers program.
Identifieur interne : 000020 ( PubMed/Corpus ); précédent : 000019; suivant : 000021The NINDS Parkinson's disease biomarkers program.
Auteurs : Liana S. Rosenthal ; Daniel Drake ; Roy N. Alcalay ; Debra Babcock ; F Dubois Bowman ; Alice Chen-Plotkin ; Ted M. Dawson ; Richard B. Dewey ; Dwight C. German ; Xuemei Huang ; Barry Landin ; Matthew Mcauliffe ; Vladislav A. Petyuk ; Clemens R. Scherzer ; Coryse St Hillaire-Clarke ; Beth-Anne Sieber ; Margaret Sutherland ; Chi Tarn ; Andrew West ; David Vaillancourt ; Jing Zhang ; Katrina GwinnSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
Neuroprotection for Parkinson's disease (PD) remains elusive. Biomarkers hold the promise of removing roadblocks to therapy development. The National Institute of Neurological Disorders and Stroke has therefore established the Parkinson's Disease Biomarkers Program to promote discovery of PD biomarkers for use in phase II and III clinical trials.
DOI: 10.1002/mds.26438
PubMed: 26442452
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Rosenthal</name><affiliation><nlm:affiliation>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Drake, Daniel" sort="Drake, Daniel" uniqKey="Drake D" first="Daniel" last="Drake">Daniel Drake</name><affiliation><nlm:affiliation>Department of Biostatistics, Columbia University, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Alcalay, Roy N" sort="Alcalay, Roy N" uniqKey="Alcalay R" first="Roy N" last="Alcalay">Roy N. Alcalay</name><affiliation><nlm:affiliation>Department of Neurology, Columbia University, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Babcock, Debra" sort="Babcock, Debra" uniqKey="Babcock D" first="Debra" last="Babcock">Debra Babcock</name><affiliation><nlm:affiliation>National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bowman, F Dubois" sort="Bowman, F Dubois" uniqKey="Bowman F" first="F Dubois" last="Bowman">F Dubois Bowman</name><affiliation><nlm:affiliation>Department of Biostatistics, Columbia University, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chen Plotkin, Alice" sort="Chen Plotkin, Alice" uniqKey="Chen Plotkin A" first="Alice" last="Chen-Plotkin">Alice Chen-Plotkin</name><affiliation><nlm:affiliation>Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Dawson, Ted M" sort="Dawson, Ted M" uniqKey="Dawson T" first="Ted M" last="Dawson">Ted M. Dawson</name><affiliation><nlm:affiliation>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Dewey, Richard B" sort="Dewey, Richard B" uniqKey="Dewey R" first="Richard B" last="Dewey">Richard B. Dewey</name><affiliation><nlm:affiliation>Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="German, Dwight C" sort="German, Dwight C" uniqKey="German D" first="Dwight C" last="German">Dwight C. German</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Xuemei" sort="Huang, Xuemei" uniqKey="Huang X" first="Xuemei" last="Huang">Xuemei Huang</name><affiliation><nlm:affiliation>Department of Neurology, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Landin, Barry" sort="Landin, Barry" uniqKey="Landin B" first="Barry" last="Landin">Barry Landin</name><affiliation><nlm:affiliation>Center for Information Technology, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mcauliffe, Matthew" sort="Mcauliffe, Matthew" uniqKey="Mcauliffe M" first="Matthew" last="Mcauliffe">Matthew Mcauliffe</name><affiliation><nlm:affiliation>Center for Information Technology, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Petyuk, Vladislav A" sort="Petyuk, Vladislav A" uniqKey="Petyuk V" first="Vladislav A" last="Petyuk">Vladislav A. Petyuk</name><affiliation><nlm:affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R" last="Scherzer">Clemens R. Scherzer</name><affiliation><nlm:affiliation>Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Cambridge, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hillaire Clarke, Coryse St" sort="Hillaire Clarke, Coryse St" uniqKey="Hillaire Clarke C" first="Coryse St" last="Hillaire-Clarke">Coryse St Hillaire-Clarke</name><affiliation><nlm:affiliation>National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sieber, Beth Anne" sort="Sieber, Beth Anne" uniqKey="Sieber B" first="Beth-Anne" last="Sieber">Beth-Anne Sieber</name><affiliation><nlm:affiliation>National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sutherland, Margaret" sort="Sutherland, Margaret" uniqKey="Sutherland M" first="Margaret" last="Sutherland">Margaret Sutherland</name><affiliation><nlm:affiliation>National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Tarn, Chi" sort="Tarn, Chi" uniqKey="Tarn C" first="Chi" last="Tarn">Chi Tarn</name><affiliation><nlm:affiliation>Coriell Institute for Medical Research, Camden, New Jersey, USA.</nlm:affiliation></affiliation></author><author><name sortKey="West, Andrew" sort="West, Andrew" uniqKey="West A" first="Andrew" last="West">Andrew West</name><affiliation><nlm:affiliation>Department of Neurology, University of Alabama at Birmingham, Birmingham, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Vaillancourt, David" sort="Vaillancourt, David" uniqKey="Vaillancourt D" first="David" last="Vaillancourt">David Vaillancourt</name><affiliation><nlm:affiliation>Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Jing" sort="Zhang, Jing" uniqKey="Zhang J" first="Jing" last="Zhang">Jing Zhang</name><affiliation><nlm:affiliation>Department of Pathology, University of Washington, Seattle, Washington, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gwinn, Katrina" sort="Gwinn, Katrina" uniqKey="Gwinn K" first="Katrina" last="Gwinn">Katrina Gwinn</name><affiliation><nlm:affiliation>National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Neuroprotection for Parkinson's disease (PD) remains elusive. Biomarkers hold the promise of removing roadblocks to therapy development. The National Institute of Neurological Disorders and Stroke has therefore established the Parkinson's Disease Biomarkers Program to promote discovery of PD biomarkers for use in phase II and III clinical trials.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">26442452</PMID><DateCreated><Year>2015</Year><Month>10</Month><Day>7</Day></DateCreated><DateRevised><Year>2015</Year><Month>10</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2015</Year><Month>Oct</Month><Day>7</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>The NINDS Parkinson's disease biomarkers program.</ArticleTitle><Pagination><MedlinePgn></MedlinePgn></Pagination><ELocationID EIdType="doi">10.1002/mds.26438</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Neuroprotection for Parkinson's disease (PD) remains elusive. Biomarkers hold the promise of removing roadblocks to therapy development. The National Institute of Neurological Disorders and Stroke has therefore established the Parkinson's Disease Biomarkers Program to promote discovery of PD biomarkers for use in phase II and III clinical trials.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Using a novel consortium design, the Parkinson's Disease Biomarker Program is focused on the development of clinical and laboratory-based biomarkers for PD diagnosis, progression, and prognosis. Standardized operating procedures and pooled reference samples were created to allow cross-project comparisons and assessment of batch effects. A web-based Data Management Resource facilitates rapid sharing of data and biosamples across the research community for additional biomarker projects.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Eleven consortium projects are ongoing, seven of which recruit participants and obtain biosamples. As of October 2014, 1,082 participants have enrolled (620 PD, 101 with other causes of parkinsonism, 23 essential tremor, and 338 controls), 1,040 of whom have at least one biosample. Six thousand eight hundred ninety-eight total biosamples are available from baseline, 6-, 12-, and 18-month visits: 1,006 DNA, 1,661 RNA, 1,419 whole blood, 1,382 plasma, 1,200 serum, and 230 cerebrospinal fluid (CSF). Quality control analysis of plasma, serum, and CSF samples indicates that almost all samples are high quality (24 of 2,812 samples exceed acceptable hemoglobin levels).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">By making samples and data widely available, using stringent operating procedures based on existing standards, hypothesis testing for biomarker discovery, and providing a resource that complements existing programs, the Parkinson's Disease Biomarker Program will accelerate the pace of PD biomarker research. © 2015 International Parkinson and Movement Disorder Society.</AbstractText><CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList><Author><LastName>Rosenthal</LastName><ForeName>Liana S</ForeName><Initials>LS</Initials><AffiliationInfo><Affiliation>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Drake</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, Columbia University, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Alcalay</LastName><ForeName>Roy N</ForeName><Initials>RN</Initials><AffiliationInfo><Affiliation>Department of Neurology, Columbia University, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Babcock</LastName><ForeName>Debra</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Bowman</LastName><ForeName>F DuBois</ForeName><Initials>FD</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, Columbia University, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Chen-Plotkin</LastName><ForeName>Alice</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Dawson</LastName><ForeName>Ted M</ForeName><Initials>TM</Initials><AffiliationInfo><Affiliation>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Solomon H. Snyder Department of Neuroscience, Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Dewey</LastName><ForeName>Richard B</ForeName><Initials>RB</Initials><Suffix>Jr</Suffix><AffiliationInfo><Affiliation>Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>German</LastName><ForeName>Dwight C</ForeName><Initials>DC</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Huang</LastName><ForeName>Xuemei</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Neurology, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Landin</LastName><ForeName>Barry</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Center for Information Technology, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>McAuliffe</LastName><ForeName>Matthew</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Center for Information Technology, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Petyuk</LastName><ForeName>Vladislav A</ForeName><Initials>VA</Initials><AffiliationInfo><Affiliation>Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Scherzer</LastName><ForeName>Clemens R</ForeName><Initials>CR</Initials><AffiliationInfo><Affiliation>Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Cambridge, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Hillaire-Clarke</LastName><ForeName>Coryse St</ForeName><Initials>CS</Initials><AffiliationInfo><Affiliation>National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Sieber</LastName><ForeName>Beth-Anne</ForeName><Initials>BA</Initials><AffiliationInfo><Affiliation>National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Sutherland</LastName><ForeName>Margaret</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Tarn</LastName><ForeName>Chi</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Coriell Institute for Medical Research, Camden, New Jersey, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>West</LastName><ForeName>Andrew</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Alabama at Birmingham, Birmingham, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Vaillancourt</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Zhang</LastName><ForeName>Jing</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, Washington, USA.</Affiliation></AffiliationInfo></Author><Author><LastName>Gwinn</LastName><ForeName>Katrina</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author><CollectiveName>PDBP consortium</CollectiveName></Author></AuthorList><Language>ENG</Language><GrantList><Grant><GrantID>U01 NS082133</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="">JOURNAL ARTICLE</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>10</Month><Day>7</Day></ArticleDate></Article><MedlineJournalInfo><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Parkinsonism</Keyword><Keyword MajorTopicYN="N">biofluids</Keyword><Keyword MajorTopicYN="N">data management</Keyword><Keyword MajorTopicYN="N">disease-modifying strategies</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>1</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>8</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>8</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>10</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>10</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>10</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId 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