Spontaneous orofacial dyskinesias in a captive cynomolgus monkey: implications for tardive dyskinesia.
Identifieur interne : 004E76 ( PubMed/Checkpoint ); précédent : 004E75; suivant : 004E77Spontaneous orofacial dyskinesias in a captive cynomolgus monkey: implications for tardive dyskinesia.
Auteurs : N M Rupniak [Royaume-Uni] ; S J Tye ; M J Steventon ; S. Boyce ; S D IversenSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1990.
English descriptors
- KwdEn :
- Animals, Benzazepines (pharmacology), Disease Models, Animal, Dose-Response Relationship, Drug, Dyskinesia, Drug-Induced (physiopathology), Facial Expression, Facial Muscles (physiopathology), Haloperidol (pharmacology), Macaca fascicularis (physiology), Mastication (physiology), Movement Disorders (physiopathology), Physostigmine (pharmacology), Scopolamine Hydrobromide (pharmacology), Stereotyped Behavior (physiology).
- MESH :
- chemical , pharmacology : Benzazepines, Haloperidol, Physostigmine, Scopolamine Hydrobromide.
- physiology : Macaca fascicularis, Mastication, Stereotyped Behavior.
- physiopathology : Dyskinesia, Drug-Induced, Facial Muscles, Movement Disorders.
- Animals, Disease Models, Animal, Dose-Response Relationship, Drug, Facial Expression.
Abstract
We describe a syndrome of spontaneous orofacial dyskinesias and cage stereotypies in a singly housed adult cynomolgus monkey never previously exposed to neuroleptic drugs. Abnormal movements were readily suppressed by acute treatment with haloperidol (0.03-0.24 mg/kg i.m.) or SCH23390 (0.05-0.2 mg/kg i.m.) but not by physostigmine (0.005-0.04 mg/kg i.m.) or scopolamine (0.0025-0.04 mg/kg i.m.). The symptomatology and response to pharmacological manipulations was indistinguishable from that previously attributed to chronic neuroleptic treatment in primates. Our findings indicate that neuroleptic-induced tardive dyskinesias in most primate studies have not been clearly demonstrated.
DOI: 10.1002/mds.870050410
PubMed: 2259355
Affiliations:
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pubmed:2259355Le document en format XML
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Abnormal movements were readily suppressed by acute treatment with haloperidol (0.03-0.24 mg/kg i.m.) or SCH23390 (0.05-0.2 mg/kg i.m.) but not by physostigmine (0.005-0.04 mg/kg i.m.) or scopolamine (0.0025-0.04 mg/kg i.m.). The symptomatology and response to pharmacological manipulations was indistinguishable from that previously attributed to chronic neuroleptic treatment in primates. Our findings indicate that neuroleptic-induced tardive dyskinesias in most primate studies have not been clearly demonstrated.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">2259355</PMID><DateCreated><Year>1991</Year><Month>01</Month><Day>28</Day></DateCreated><DateCompleted><Year>1991</Year><Month>01</Month><Day>28</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>5</Volume><Issue>4</Issue><PubDate><Year>1990</Year></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Spontaneous orofacial dyskinesias in a captive cynomolgus monkey: implications for tardive dyskinesia.</ArticleTitle><Pagination><MedlinePgn>314-8</MedlinePgn></Pagination><Abstract><AbstractText>We describe a syndrome of spontaneous orofacial dyskinesias and cage stereotypies in a singly housed adult cynomolgus monkey never previously exposed to neuroleptic drugs. Abnormal movements were readily suppressed by acute treatment with haloperidol (0.03-0.24 mg/kg i.m.) or SCH23390 (0.05-0.2 mg/kg i.m.) but not by physostigmine (0.005-0.04 mg/kg i.m.) or scopolamine (0.0025-0.04 mg/kg i.m.). The symptomatology and response to pharmacological manipulations was indistinguishable from that previously attributed to chronic neuroleptic treatment in primates. 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Boyce</name><name sortKey="Iversen, S D" sort="Iversen, S D" uniqKey="Iversen S" first="S D" last="Iversen">S D Iversen</name><name sortKey="Steventon, M J" sort="Steventon, M J" uniqKey="Steventon M" first="M J" last="Steventon">M J Steventon</name><name sortKey="Tye, S J" sort="Tye, S J" uniqKey="Tye S" first="S J" last="Tye">S J Tye</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Rupniak, N M" sort="Rupniak, N M" uniqKey="Rupniak N" first="N M" last="Rupniak">N M Rupniak</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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