Dysfunction of Ib (autogenic) spinal inhibition in patients with progressive supranuclear palsy.
Identifieur interne : 004452 ( PubMed/Checkpoint ); précédent : 004451; suivant : 004453Dysfunction of Ib (autogenic) spinal inhibition in patients with progressive supranuclear palsy.
Auteurs : E J Fine [États-Unis] ; M. Hallett ; I. Litvan ; N. Tresser ; D. KatzSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1998.
English descriptors
- KwdEn :
- Afferent Pathways (pathology), Afferent Pathways (physiopathology), Aged, Aged, 80 and over, Brain Mapping, Electric Stimulation, Female, H-Reflex (physiology), Humans, Immunoenzyme Techniques, Interneurons (pathology), Interneurons (physiology), Male, Mechanoreceptors (pathology), Mechanoreceptors (physiopathology), Middle Aged, Muscle, Skeletal (innervation), Neural Inhibition (physiology), Reaction Time (physiology), Reticular Formation (pathology), Reticular Formation (physiopathology), Spinal Cord (pathology), Spinal Cord (physiopathology), Supranuclear Palsy, Progressive (diagnosis), Supranuclear Palsy, Progressive (pathology), Supranuclear Palsy, Progressive (physiopathology).
- MESH :
- diagnosis : Supranuclear Palsy, Progressive.
- innervation : Muscle, Skeletal.
- pathology : Afferent Pathways, Interneurons, Mechanoreceptors, Reticular Formation, Spinal Cord, Supranuclear Palsy, Progressive.
- physiology : H-Reflex, Interneurons, Neural Inhibition, Reaction Time.
- physiopathology : Afferent Pathways, Mechanoreceptors, Reticular Formation, Spinal Cord, Supranuclear Palsy, Progressive.
- Aged, Aged, 80 and over, Brain Mapping, Electric Stimulation, Female, Humans, Immunoenzyme Techniques, Male, Middle Aged.
Abstract
We compared the activity of Ib spinal interneurons in five patients with progressive supranuclear palsy (PSP) with six age-matched control subjects. Stimulation of the medial gastrocnemius nerve at motor threshold intensity activated Ib afferents that in turn inhibit H reflexes from the soleus muscle. Maximum inhibition occurred at interstimulus intervals of 6 and 8 ms for both control subjects and PSP patients and was significantly greater in the PSP patients. Increased Ib activity of PSP patients may be caused by loss of inhibition of Ib interneurons through degeneration of the medullary reticulospinal pathway. The corticospinal pathways, unopposed by the medullary reticulospinal tract, may excessively activate Ib interneurons.
DOI: 10.1002/mds.870130410
PubMed: 9686772
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dysfunction of Ib (autogenic) spinal inhibition in patients with progressive supranuclear palsy.</title><author><name sortKey="Fine, E J" sort="Fine, E J" uniqKey="Fine E" first="E J" last="Fine">E J Fine</name><affiliation wicri:level="1"><nlm:affiliation>Neurology Service, Department of Veterans' Affairs Medical Center, State University of New York at Buffalo, 14215, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurology Service, Department of Veterans' Affairs Medical Center, State University of New York at Buffalo, 14215</wicri:regionArea><wicri:noRegion>14215</wicri:noRegion></affiliation></author><author><name sortKey="Hallett, M" sort="Hallett, M" uniqKey="Hallett M" first="M" last="Hallett">M. Hallett</name></author><author><name sortKey="Litvan, I" sort="Litvan, I" uniqKey="Litvan I" first="I" last="Litvan">I. Litvan</name></author><author><name sortKey="Tresser, N" sort="Tresser, N" uniqKey="Tresser N" first="N" last="Tresser">N. Tresser</name></author><author><name sortKey="Katz, D" sort="Katz, D" uniqKey="Katz D" first="D" last="Katz">D. Katz</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1998">1998</date><idno type="RBID">pubmed:9686772</idno><idno type="pmid">9686772</idno><idno type="doi">10.1002/mds.870130410</idno><idno type="wicri:Area/PubMed/Corpus">004378</idno><idno type="wicri:Area/PubMed/Curation">004378</idno><idno type="wicri:Area/PubMed/Checkpoint">004452</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Dysfunction of Ib (autogenic) spinal inhibition in patients with progressive supranuclear palsy.</title><author><name sortKey="Fine, E J" sort="Fine, E J" uniqKey="Fine E" first="E J" last="Fine">E J Fine</name><affiliation wicri:level="1"><nlm:affiliation>Neurology Service, Department of Veterans' Affairs Medical Center, State University of New York at Buffalo, 14215, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurology Service, Department of Veterans' Affairs Medical Center, State University of New York at Buffalo, 14215</wicri:regionArea><wicri:noRegion>14215</wicri:noRegion></affiliation></author><author><name sortKey="Hallett, M" sort="Hallett, M" uniqKey="Hallett M" first="M" last="Hallett">M. Hallett</name></author><author><name sortKey="Litvan, I" sort="Litvan, I" uniqKey="Litvan I" first="I" last="Litvan">I. Litvan</name></author><author><name sortKey="Tresser, N" sort="Tresser, N" uniqKey="Tresser N" first="N" last="Tresser">N. Tresser</name></author><author><name sortKey="Katz, D" sort="Katz, D" uniqKey="Katz D" first="D" last="Katz">D. Katz</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1998" type="published">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Afferent Pathways (pathology)</term><term>Afferent Pathways (physiopathology)</term><term>Aged</term><term>Aged, 80 and over</term><term>Brain Mapping</term><term>Electric Stimulation</term><term>Female</term><term>H-Reflex (physiology)</term><term>Humans</term><term>Immunoenzyme Techniques</term><term>Interneurons (pathology)</term><term>Interneurons (physiology)</term><term>Male</term><term>Mechanoreceptors (pathology)</term><term>Mechanoreceptors (physiopathology)</term><term>Middle Aged</term><term>Muscle, Skeletal (innervation)</term><term>Neural Inhibition (physiology)</term><term>Reaction Time (physiology)</term><term>Reticular Formation (pathology)</term><term>Reticular Formation (physiopathology)</term><term>Spinal Cord (pathology)</term><term>Spinal Cord (physiopathology)</term><term>Supranuclear Palsy, Progressive (diagnosis)</term><term>Supranuclear Palsy, Progressive (pathology)</term><term>Supranuclear Palsy, Progressive (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Afferent Pathways</term><term>Interneurons</term><term>Mechanoreceptors</term><term>Reticular Formation</term><term>Spinal Cord</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>H-Reflex</term><term>Interneurons</term><term>Neural Inhibition</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Afferent Pathways</term><term>Mechanoreceptors</term><term>Reticular Formation</term><term>Spinal Cord</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Brain Mapping</term><term>Electric Stimulation</term><term>Female</term><term>Humans</term><term>Immunoenzyme Techniques</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We compared the activity of Ib spinal interneurons in five patients with progressive supranuclear palsy (PSP) with six age-matched control subjects. Stimulation of the medial gastrocnemius nerve at motor threshold intensity activated Ib afferents that in turn inhibit H reflexes from the soleus muscle. Maximum inhibition occurred at interstimulus intervals of 6 and 8 ms for both control subjects and PSP patients and was significantly greater in the PSP patients. Increased Ib activity of PSP patients may be caused by loss of inhibition of Ib interneurons through degeneration of the medullary reticulospinal pathway. The corticospinal pathways, unopposed by the medullary reticulospinal tract, may excessively activate Ib interneurons.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">9686772</PMID><DateCreated><Year>1998</Year><Month>10</Month><Day>28</Day></DateCreated><DateCompleted><Year>1998</Year><Month>10</Month><Day>28</Day></DateCompleted><DateRevised><Year>2004</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>13</Volume><Issue>4</Issue><PubDate><Year>1998</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Dysfunction of Ib (autogenic) spinal inhibition in patients with progressive supranuclear palsy.</ArticleTitle><Pagination><MedlinePgn>668-72</MedlinePgn></Pagination><Abstract><AbstractText>We compared the activity of Ib spinal interneurons in five patients with progressive supranuclear palsy (PSP) with six age-matched control subjects. Stimulation of the medial gastrocnemius nerve at motor threshold intensity activated Ib afferents that in turn inhibit H reflexes from the soleus muscle. Maximum inhibition occurred at interstimulus intervals of 6 and 8 ms for both control subjects and PSP patients and was significantly greater in the PSP patients. Increased Ib activity of PSP patients may be caused by loss of inhibition of Ib interneurons through degeneration of the medullary reticulospinal pathway. The corticospinal pathways, unopposed by the medullary reticulospinal tract, may excessively activate Ib interneurons.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fine</LastName><ForeName>E J</ForeName><Initials>EJ</Initials><AffiliationInfo><Affiliation>Neurology Service, Department of Veterans' Affairs Medical Center, State University of New York at Buffalo, 14215, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hallett</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Litvan</LastName><ForeName>I</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Tresser</LastName><ForeName>N</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Katz</LastName><ForeName>D</ForeName><Initials>D</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>UNITED STATES</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000344">Afferent Pathways</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001931">Brain Mapping</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004558">Electric Stimulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006181">H-Reflex</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007124">Immunoenzyme Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007395">Interneurons</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008465">Mechanoreceptors</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018482">Muscle, Skeletal</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000294">innervation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009433">Neural Inhibition</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011930">Reaction Time</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012154">Reticular Formation</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013116">Spinal Cord</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013494">Supranuclear Palsy, Progressive</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1998</Year><Month>8</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1998</Year><Month>8</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1998</Year><Month>8</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9686772</ArticleId><ArticleId IdType="doi">10.1002/mds.870130410</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Hallett, M" sort="Hallett, M" uniqKey="Hallett M" first="M" last="Hallett">M. Hallett</name><name sortKey="Katz, D" sort="Katz, D" uniqKey="Katz D" first="D" last="Katz">D. Katz</name><name sortKey="Litvan, I" sort="Litvan, I" uniqKey="Litvan I" first="I" last="Litvan">I. Litvan</name><name sortKey="Tresser, N" sort="Tresser, N" uniqKey="Tresser N" first="N" last="Tresser">N. Tresser</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Fine, E J" sort="Fine, E J" uniqKey="Fine E" first="E J" last="Fine">E J Fine</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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