Update on fetal transplantation: the Swedish experience.
Identifieur interne : 004303 ( PubMed/Checkpoint ); précédent : 004302; suivant : 004304Update on fetal transplantation: the Swedish experience.
Auteurs : O. Lindvall [Suède]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1998.
English descriptors
- KwdEn :
- Brain Tissue Transplantation, Clinical Trials as Topic, Corpus Striatum (surgery), Fetal Tissue Transplantation, Follow-Up Studies, Graft Survival (physiology), Humans, Mesencephalon (embryology), Mesencephalon (transplantation), Nerve Regeneration (physiology), Neurologic Examination, Parkinson Disease (surgery).
- MESH :
- embryology : Mesencephalon.
- physiology : Graft Survival, Nerve Regeneration.
- surgery : Corpus Striatum, Parkinson Disease.
- transplantation : Mesencephalon.
- Brain Tissue Transplantation, Clinical Trials as Topic, Fetal Tissue Transplantation, Follow-Up Studies, Humans, Neurologic Examination.
Abstract
We implanted human embryonic mesencephalic tissue into the striatum of 13 patients with idiopathic Parkinson's disease (PD) and three patients with MPTP-induced parkinsonism. Based on our findings so far, as well as data from other groups, the following conclusions can be drawn: First, grafted dopamine (DA) neurons can survive in the human parkinsonian brain and reinnervate part of the host striatum. Second, long-term graft survival, at least up to 6 years after transplantation, is possible in PD despite a progressive degeneration of the patient's own DA neurons. Third, a majority of patients with surviving grafts show long-term improvement of therapeutic value but the symptomatic relief is, in most cases, incomplete. Presently, the most important research strategy to improve the functional recovery after transplantation is to increase the survival of grafted DA neurons and the density and extent of the dopaminergic reinnervation in the striatum.
PubMed: 9613723
Affiliations:
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pubmed:9613723Le document en format XML
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<affiliation wicri:level="1"><nlm:affiliation>Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden.</nlm:affiliation>
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<affiliation wicri:level="1"><nlm:affiliation>Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden.</nlm:affiliation>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain Tissue Transplantation</term>
<term>Clinical Trials as Topic</term>
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<term>Fetal Tissue Transplantation</term>
<term>Follow-Up Studies</term>
<term>Graft Survival (physiology)</term>
<term>Humans</term>
<term>Mesencephalon (embryology)</term>
<term>Mesencephalon (transplantation)</term>
<term>Nerve Regeneration (physiology)</term>
<term>Neurologic Examination</term>
<term>Parkinson Disease (surgery)</term>
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<keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Mesencephalon</term>
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<term>Nerve Regeneration</term>
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<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Corpus Striatum</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Mesencephalon</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Brain Tissue Transplantation</term>
<term>Clinical Trials as Topic</term>
<term>Fetal Tissue Transplantation</term>
<term>Follow-Up Studies</term>
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<front><div type="abstract" xml:lang="en">We implanted human embryonic mesencephalic tissue into the striatum of 13 patients with idiopathic Parkinson's disease (PD) and three patients with MPTP-induced parkinsonism. Based on our findings so far, as well as data from other groups, the following conclusions can be drawn: First, grafted dopamine (DA) neurons can survive in the human parkinsonian brain and reinnervate part of the host striatum. Second, long-term graft survival, at least up to 6 years after transplantation, is possible in PD despite a progressive degeneration of the patient's own DA neurons. Third, a majority of patients with surviving grafts show long-term improvement of therapeutic value but the symptomatic relief is, in most cases, incomplete. Presently, the most important research strategy to improve the functional recovery after transplantation is to increase the survival of grafted DA neurons and the density and extent of the dopaminergic reinnervation in the striatum.</div>
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<Month>08</Month>
<Day>06</Day>
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<DateCompleted><Year>1998</Year>
<Month>08</Month>
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<DateRevised><Year>2007</Year>
<Month>11</Month>
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<JournalIssue CitedMedium="Print"><Volume>13 Suppl 1</Volume>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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<ArticleTitle>Update on fetal transplantation: the Swedish experience.</ArticleTitle>
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<Abstract><AbstractText>We implanted human embryonic mesencephalic tissue into the striatum of 13 patients with idiopathic Parkinson's disease (PD) and three patients with MPTP-induced parkinsonism. Based on our findings so far, as well as data from other groups, the following conclusions can be drawn: First, grafted dopamine (DA) neurons can survive in the human parkinsonian brain and reinnervate part of the host striatum. Second, long-term graft survival, at least up to 6 years after transplantation, is possible in PD despite a progressive degeneration of the patient's own DA neurons. Third, a majority of patients with surviving grafts show long-term improvement of therapeutic value but the symptomatic relief is, in most cases, incomplete. Presently, the most important research strategy to improve the functional recovery after transplantation is to increase the survival of grafted DA neurons and the density and extent of the dopaminergic reinnervation in the striatum.</AbstractText>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D009416">Nerve Regeneration</DescriptorName>
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<NumberOfReferences>24</NumberOfReferences>
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