Update on fetal transplantation: the Swedish experience.
Identifieur interne : 004303 ( PubMed/Checkpoint ); précédent : 004302; suivant : 004304Update on fetal transplantation: the Swedish experience.
Auteurs : O. Lindvall [Suède]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1998.
English descriptors
- KwdEn :
- Brain Tissue Transplantation, Clinical Trials as Topic, Corpus Striatum (surgery), Fetal Tissue Transplantation, Follow-Up Studies, Graft Survival (physiology), Humans, Mesencephalon (embryology), Mesencephalon (transplantation), Nerve Regeneration (physiology), Neurologic Examination, Parkinson Disease (surgery).
- MESH :
- embryology : Mesencephalon.
- physiology : Graft Survival, Nerve Regeneration.
- surgery : Corpus Striatum, Parkinson Disease.
- transplantation : Mesencephalon.
- Brain Tissue Transplantation, Clinical Trials as Topic, Fetal Tissue Transplantation, Follow-Up Studies, Humans, Neurologic Examination.
Abstract
We implanted human embryonic mesencephalic tissue into the striatum of 13 patients with idiopathic Parkinson's disease (PD) and three patients with MPTP-induced parkinsonism. Based on our findings so far, as well as data from other groups, the following conclusions can be drawn: First, grafted dopamine (DA) neurons can survive in the human parkinsonian brain and reinnervate part of the host striatum. Second, long-term graft survival, at least up to 6 years after transplantation, is possible in PD despite a progressive degeneration of the patient's own DA neurons. Third, a majority of patients with surviving grafts show long-term improvement of therapeutic value but the symptomatic relief is, in most cases, incomplete. Presently, the most important research strategy to improve the functional recovery after transplantation is to increase the survival of grafted DA neurons and the density and extent of the dopaminergic reinnervation in the striatum.
PubMed: 9613723
Affiliations:
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Lindvall</name><affiliation wicri:level="1"><nlm:affiliation>Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1998">1998</date><idno type="RBID">pubmed:9613723</idno><idno type="pmid">9613723</idno><idno type="wicri:Area/PubMed/Corpus">004438</idno><idno type="wicri:Area/PubMed/Curation">004438</idno><idno type="wicri:Area/PubMed/Checkpoint">004303</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Update on fetal transplantation: the Swedish experience.</title><author><name sortKey="Lindvall, O" sort="Lindvall, O" uniqKey="Lindvall O" first="O" last="Lindvall">O. Lindvall</name><affiliation wicri:level="1"><nlm:affiliation>Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1998" type="published">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain Tissue Transplantation</term><term>Clinical Trials as Topic</term><term>Corpus Striatum (surgery)</term><term>Fetal Tissue Transplantation</term><term>Follow-Up Studies</term><term>Graft Survival (physiology)</term><term>Humans</term><term>Mesencephalon (embryology)</term><term>Mesencephalon (transplantation)</term><term>Nerve Regeneration (physiology)</term><term>Neurologic Examination</term><term>Parkinson Disease (surgery)</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Mesencephalon</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Graft Survival</term><term>Nerve Regeneration</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Corpus Striatum</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Mesencephalon</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Brain Tissue Transplantation</term><term>Clinical Trials as Topic</term><term>Fetal Tissue Transplantation</term><term>Follow-Up Studies</term><term>Humans</term><term>Neurologic Examination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We implanted human embryonic mesencephalic tissue into the striatum of 13 patients with idiopathic Parkinson's disease (PD) and three patients with MPTP-induced parkinsonism. Based on our findings so far, as well as data from other groups, the following conclusions can be drawn: First, grafted dopamine (DA) neurons can survive in the human parkinsonian brain and reinnervate part of the host striatum. Second, long-term graft survival, at least up to 6 years after transplantation, is possible in PD despite a progressive degeneration of the patient's own DA neurons. Third, a majority of patients with surviving grafts show long-term improvement of therapeutic value but the symptomatic relief is, in most cases, incomplete. Presently, the most important research strategy to improve the functional recovery after transplantation is to increase the survival of grafted DA neurons and the density and extent of the dopaminergic reinnervation in the striatum.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">9613723</PMID><DateCreated><Year>1998</Year><Month>08</Month><Day>06</Day></DateCreated><DateCompleted><Year>1998</Year><Month>08</Month><Day>06</Day></DateCompleted><DateRevised><Year>2007</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>13 Suppl 1</Volume><PubDate><Year>1998</Year></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Update on fetal transplantation: the Swedish experience.</ArticleTitle><Pagination><MedlinePgn>83-7</MedlinePgn></Pagination><Abstract><AbstractText>We implanted human embryonic mesencephalic tissue into the striatum of 13 patients with idiopathic Parkinson's disease (PD) and three patients with MPTP-induced parkinsonism. Based on our findings so far, as well as data from other groups, the following conclusions can be drawn: First, grafted dopamine (DA) neurons can survive in the human parkinsonian brain and reinnervate part of the host striatum. Second, long-term graft survival, at least up to 6 years after transplantation, is possible in PD despite a progressive degeneration of the patient's own DA neurons. Third, a majority of patients with surviving grafts show long-term improvement of therapeutic value but the symptomatic relief is, in most cases, incomplete. Presently, the most important research strategy to improve the functional recovery after transplantation is to increase the survival of grafted DA neurons and the density and extent of the dopaminergic reinnervation in the striatum.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lindvall</LastName><ForeName>O</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>UNITED STATES</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D016380">Brain Tissue Transplantation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002986">Clinical Trials as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003342">Corpus Striatum</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000601">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D016332">Fetal Tissue Transplantation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005500">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006085">Graft Survival</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008636">Mesencephalon</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000196">embryology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000637">transplantation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009416">Nerve Regeneration</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009460">Neurologic Examination</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000601">surgery</QualifierName></MeshHeading></MeshHeadingList><NumberOfReferences>24</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1998</Year><Month>6</Month><Day>5</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1998</Year><Month>6</Month><Day>5</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1998</Year><Month>6</Month><Day>5</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9613723</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Suède</li></country></list><tree><country name="Suède"><noRegion><name sortKey="Lindvall, O" sort="Lindvall, O" uniqKey="Lindvall O" first="O" last="Lindvall">O. 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