Further studies on periodic limb movement disorder and restless legs syndrome in children with attention-deficit hyperactivity disorder.
Identifieur interne : 004205 ( PubMed/Checkpoint ); précédent : 004204; suivant : 004206Further studies on periodic limb movement disorder and restless legs syndrome in children with attention-deficit hyperactivity disorder.
Auteurs : D L Picchietti [États-Unis] ; D J Underwood ; W A Farris ; A S Walters ; M M Shah ; R E Dahl ; L J Trubnick ; M A Bertocci ; M. Wagner ; W A HeningSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1999.
English descriptors
- KwdEn :
- Arousal, Attention Deficit Disorder with Hyperactivity (diagnosis), Attention Deficit Disorder with Hyperactivity (genetics), Child, Child, Preschool, Female, Genetic Predisposition to Disease (genetics), Humans, Male, Nocturnal Myoclonus Syndrome (diagnosis), Nocturnal Myoclonus Syndrome (genetics), Polysomnography, Restless Legs Syndrome (diagnosis), Restless Legs Syndrome (genetics).
- MESH :
- diagnosis : Attention Deficit Disorder with Hyperactivity, Nocturnal Myoclonus Syndrome, Restless Legs Syndrome.
- genetics : Attention Deficit Disorder with Hyperactivity, Genetic Predisposition to Disease, Nocturnal Myoclonus Syndrome, Restless Legs Syndrome.
- Arousal, Child, Child, Preschool, Female, Humans, Male, Polysomnography.
Abstract
Fourteen consecutive children who were newly diagnosed with attention-deficit hyperactivity disorder (ADHD) and who had never been exposed to stimulants and 10 control children without ADHD underwent polysomnographic studies to quantify Periodic Limb Movements in Sleep (PLMS) and arousals. Parents commonly gave both false-negative and false-positive reports of PLMS in their children, and a sleep study was necessary to confirm their presence or absence. The prevalence of PLMS on polysomnography was higher in the children with ADHD than in the control subjects. Nine of 14 (64%) children with ADHD had PLMS at a rate of >5 per hour of sleep compared with none of the control children (p <0.0015). Three of 14 children with ADHD (21%) had PLMS at a rate of >20 per hour of sleep. Many of the PLMS in the children with ADHD were associated with arousals. Historical sleep times were less for children with ADHD. The children with ADHD who had PLMS chronically got 43 minutes less sleep at home than the control subjects (p = 0.0091). All nine children with ADHD who had a PLMS index of >5 per hour of sleep had a long-standing clinical history of sleep onset problems (>30 minutes) and/or maintenance problems (more than two full awakenings nightly) thus meeting the criteria for Periodic Limb Movement Disorder (PLMD). None of the control children had a clinical history of sleep onset or maintenance problems. The parents of the children with ADHD were more likely to have restless legs syndrome (RLS) than the parents of the control children. Twenty-five of 28 biologic parents of the children with ADHD and all of the biologic parents of the control children were reached for interview. Eight of twenty-five parents of the children with ADHD (32%) had symptoms of RLS as opposed to none of the control parents (p = 0.011). PLMS may directly lead to symptoms of ADHD through the mechanism of sleep disruption. Alternative explanations for the association between ADHD and RLS/PLMS are that they are genetically linked, they share a common dopaminergic deficit, or both.
PubMed: 10584676
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Further studies on periodic limb movement disorder and restless legs syndrome in children with attention-deficit hyperactivity disorder.</title><author><name sortKey="Picchietti, D L" sort="Picchietti, D L" uniqKey="Picchietti D" first="D L" last="Picchietti">D L Picchietti</name><affiliation wicri:level="2"><nlm:affiliation>Pediatric Neurology, Carle Clinic, Urbana, Illinois, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pediatric Neurology, Carle Clinic, Urbana, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Underwood, D J" sort="Underwood, D J" uniqKey="Underwood D" first="D J" last="Underwood">D J Underwood</name></author><author><name sortKey="Farris, W A" sort="Farris, W A" uniqKey="Farris W" first="W A" last="Farris">W A Farris</name></author><author><name sortKey="Walters, A S" sort="Walters, A S" uniqKey="Walters A" first="A S" last="Walters">A S Walters</name></author><author><name sortKey="Shah, M M" sort="Shah, M M" uniqKey="Shah M" first="M M" last="Shah">M M Shah</name></author><author><name sortKey="Dahl, R E" sort="Dahl, R E" uniqKey="Dahl R" first="R E" last="Dahl">R E Dahl</name></author><author><name sortKey="Trubnick, L J" sort="Trubnick, L J" uniqKey="Trubnick L" first="L J" last="Trubnick">L J Trubnick</name></author><author><name sortKey="Bertocci, M A" sort="Bertocci, M A" uniqKey="Bertocci M" first="M A" last="Bertocci">M A Bertocci</name></author><author><name sortKey="Wagner, M" sort="Wagner, M" uniqKey="Wagner M" first="M" last="Wagner">M. Wagner</name></author><author><name sortKey="Hening, W A" sort="Hening, W A" uniqKey="Hening W" first="W A" last="Hening">W A Hening</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1999">1999</date><idno type="RBID">pubmed:10584676</idno><idno type="pmid">10584676</idno><idno type="wicri:Area/PubMed/Corpus">004089</idno><idno type="wicri:Area/PubMed/Curation">004089</idno><idno type="wicri:Area/PubMed/Checkpoint">004205</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Further studies on periodic limb movement disorder and restless legs syndrome in children with attention-deficit hyperactivity disorder.</title><author><name sortKey="Picchietti, D L" sort="Picchietti, D L" uniqKey="Picchietti D" first="D L" last="Picchietti">D L Picchietti</name><affiliation wicri:level="2"><nlm:affiliation>Pediatric Neurology, Carle Clinic, Urbana, Illinois, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pediatric Neurology, Carle Clinic, Urbana, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Underwood, D J" sort="Underwood, D J" uniqKey="Underwood D" first="D J" last="Underwood">D J Underwood</name></author><author><name sortKey="Farris, W A" sort="Farris, W A" uniqKey="Farris W" first="W A" last="Farris">W A Farris</name></author><author><name sortKey="Walters, A S" sort="Walters, A S" uniqKey="Walters A" first="A S" last="Walters">A S Walters</name></author><author><name sortKey="Shah, M M" sort="Shah, M M" uniqKey="Shah M" first="M M" last="Shah">M M Shah</name></author><author><name sortKey="Dahl, R E" sort="Dahl, R E" uniqKey="Dahl R" first="R E" last="Dahl">R E Dahl</name></author><author><name sortKey="Trubnick, L J" sort="Trubnick, L J" uniqKey="Trubnick L" first="L J" last="Trubnick">L J Trubnick</name></author><author><name sortKey="Bertocci, M A" sort="Bertocci, M A" uniqKey="Bertocci M" first="M A" last="Bertocci">M A Bertocci</name></author><author><name sortKey="Wagner, M" sort="Wagner, M" uniqKey="Wagner M" first="M" last="Wagner">M. Wagner</name></author><author><name sortKey="Hening, W A" sort="Hening, W A" uniqKey="Hening W" first="W A" last="Hening">W A Hening</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arousal</term><term>Attention Deficit Disorder with Hyperactivity (diagnosis)</term><term>Attention Deficit Disorder with Hyperactivity (genetics)</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Genetic Predisposition to Disease (genetics)</term><term>Humans</term><term>Male</term><term>Nocturnal Myoclonus Syndrome (diagnosis)</term><term>Nocturnal Myoclonus Syndrome (genetics)</term><term>Polysomnography</term><term>Restless Legs Syndrome (diagnosis)</term><term>Restless Legs Syndrome (genetics)</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Attention Deficit Disorder with Hyperactivity</term><term>Nocturnal Myoclonus Syndrome</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Attention Deficit Disorder with Hyperactivity</term><term>Genetic Predisposition to Disease</term><term>Nocturnal Myoclonus Syndrome</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Arousal</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Male</term><term>Polysomnography</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Fourteen consecutive children who were newly diagnosed with attention-deficit hyperactivity disorder (ADHD) and who had never been exposed to stimulants and 10 control children without ADHD underwent polysomnographic studies to quantify Periodic Limb Movements in Sleep (PLMS) and arousals. Parents commonly gave both false-negative and false-positive reports of PLMS in their children, and a sleep study was necessary to confirm their presence or absence. The prevalence of PLMS on polysomnography was higher in the children with ADHD than in the control subjects. Nine of 14 (64%) children with ADHD had PLMS at a rate of >5 per hour of sleep compared with none of the control children (p <0.0015). Three of 14 children with ADHD (21%) had PLMS at a rate of >20 per hour of sleep. Many of the PLMS in the children with ADHD were associated with arousals. Historical sleep times were less for children with ADHD. The children with ADHD who had PLMS chronically got 43 minutes less sleep at home than the control subjects (p = 0.0091). All nine children with ADHD who had a PLMS index of >5 per hour of sleep had a long-standing clinical history of sleep onset problems (>30 minutes) and/or maintenance problems (more than two full awakenings nightly) thus meeting the criteria for Periodic Limb Movement Disorder (PLMD). None of the control children had a clinical history of sleep onset or maintenance problems. The parents of the children with ADHD were more likely to have restless legs syndrome (RLS) than the parents of the control children. Twenty-five of 28 biologic parents of the children with ADHD and all of the biologic parents of the control children were reached for interview. Eight of twenty-five parents of the children with ADHD (32%) had symptoms of RLS as opposed to none of the control parents (p = 0.011). PLMS may directly lead to symptoms of ADHD through the mechanism of sleep disruption. Alternative explanations for the association between ADHD and RLS/PLMS are that they are genetically linked, they share a common dopaminergic deficit, or both.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">10584676</PMID><DateCreated><Year>2000</Year><Month>01</Month><Day>20</Day></DateCreated><DateCompleted><Year>2000</Year><Month>01</Month><Day>20</Day></DateCompleted><DateRevised><Year>2007</Year><Month>11</Month><Day>14</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>14</Volume><Issue>6</Issue><PubDate><Year>1999</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Further studies on periodic limb movement disorder and restless legs syndrome in children with attention-deficit hyperactivity disorder.</ArticleTitle><Pagination><MedlinePgn>1000-7</MedlinePgn></Pagination><Abstract><AbstractText>Fourteen consecutive children who were newly diagnosed with attention-deficit hyperactivity disorder (ADHD) and who had never been exposed to stimulants and 10 control children without ADHD underwent polysomnographic studies to quantify Periodic Limb Movements in Sleep (PLMS) and arousals. Parents commonly gave both false-negative and false-positive reports of PLMS in their children, and a sleep study was necessary to confirm their presence or absence. The prevalence of PLMS on polysomnography was higher in the children with ADHD than in the control subjects. Nine of 14 (64%) children with ADHD had PLMS at a rate of >5 per hour of sleep compared with none of the control children (p <0.0015). Three of 14 children with ADHD (21%) had PLMS at a rate of >20 per hour of sleep. Many of the PLMS in the children with ADHD were associated with arousals. Historical sleep times were less for children with ADHD. The children with ADHD who had PLMS chronically got 43 minutes less sleep at home than the control subjects (p = 0.0091). All nine children with ADHD who had a PLMS index of >5 per hour of sleep had a long-standing clinical history of sleep onset problems (>30 minutes) and/or maintenance problems (more than two full awakenings nightly) thus meeting the criteria for Periodic Limb Movement Disorder (PLMD). None of the control children had a clinical history of sleep onset or maintenance problems. The parents of the children with ADHD were more likely to have restless legs syndrome (RLS) than the parents of the control children. Twenty-five of 28 biologic parents of the children with ADHD and all of the biologic parents of the control children were reached for interview. Eight of twenty-five parents of the children with ADHD (32%) had symptoms of RLS as opposed to none of the control parents (p = 0.011). PLMS may directly lead to symptoms of ADHD through the mechanism of sleep disruption. Alternative explanations for the association between ADHD and RLS/PLMS are that they are genetically linked, they share a common dopaminergic deficit, or both.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Picchietti</LastName><ForeName>D L</ForeName><Initials>DL</Initials><AffiliationInfo><Affiliation>Pediatric Neurology, Carle Clinic, Urbana, Illinois, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Underwood</LastName><ForeName>D J</ForeName><Initials>DJ</Initials></Author><Author ValidYN="Y"><LastName>Farris</LastName><ForeName>W A</ForeName><Initials>WA</Initials></Author><Author ValidYN="Y"><LastName>Walters</LastName><ForeName>A S</ForeName><Initials>AS</Initials></Author><Author ValidYN="Y"><LastName>Shah</LastName><ForeName>M M</ForeName><Initials>MM</Initials></Author><Author ValidYN="Y"><LastName>Dahl</LastName><ForeName>R E</ForeName><Initials>RE</Initials></Author><Author ValidYN="Y"><LastName>Trubnick</LastName><ForeName>L J</ForeName><Initials>LJ</Initials></Author><Author ValidYN="Y"><LastName>Bertocci</LastName><ForeName>M A</ForeName><Initials>MA</Initials></Author><Author ValidYN="Y"><LastName>Wagner</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Hening</LastName><ForeName>W A</ForeName><Initials>WA</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>MH 41712</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>UNITED STATES</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001143">Arousal</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001289">Attention Deficit Disorder with Hyperactivity</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002648">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002675">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020022">Genetic Predisposition to Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020189">Nocturnal Myoclonus Syndrome</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017286">Polysomnography</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012148">Restless Legs Syndrome</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1999</Year><Month>12</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1999</Year><Month>12</Month><Day>10</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1999</Year><Month>12</Month><Day>10</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">10584676</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li></region></list><tree><noCountry><name sortKey="Bertocci, M A" sort="Bertocci, M A" uniqKey="Bertocci M" first="M A" last="Bertocci">M A Bertocci</name><name sortKey="Dahl, R E" sort="Dahl, R E" uniqKey="Dahl R" first="R E" last="Dahl">R E Dahl</name><name sortKey="Farris, W A" sort="Farris, W A" uniqKey="Farris W" first="W A" last="Farris">W A Farris</name><name sortKey="Hening, W A" sort="Hening, W A" uniqKey="Hening W" first="W A" last="Hening">W A Hening</name><name sortKey="Shah, M M" sort="Shah, M M" uniqKey="Shah M" first="M M" last="Shah">M M Shah</name><name sortKey="Trubnick, L J" sort="Trubnick, L J" uniqKey="Trubnick L" first="L J" last="Trubnick">L J Trubnick</name><name sortKey="Underwood, D J" sort="Underwood, D J" uniqKey="Underwood D" first="D J" last="Underwood">D J Underwood</name><name sortKey="Wagner, M" sort="Wagner, M" uniqKey="Wagner M" first="M" last="Wagner">M. Wagner</name><name sortKey="Walters, A S" sort="Walters, A S" uniqKey="Walters A" first="A S" last="Walters">A S Walters</name></noCountry><country name="États-Unis"><region name="Illinois"><name sortKey="Picchietti, D L" sort="Picchietti, D L" uniqKey="Picchietti D" first="D L" last="Picchietti">D L Picchietti</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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