Electrophysiological observations in hereditary parkinsonism-dementia with Lewy body pathology.
Identifieur interne : 003F90 ( PubMed/Checkpoint ); précédent : 003F89; suivant : 003F91Electrophysiological observations in hereditary parkinsonism-dementia with Lewy body pathology.
Auteurs : J N Caviness [États-Unis] ; K. Gwinn-Hardy ; C H Adler ; M D MuenterSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2000.
English descriptors
- KwdEn :
- Adult, Brain Mapping, Cerebral Cortex (pathology), Cerebral Cortex (physiopathology), Dementia (genetics), Dementia (pathology), Dementia (physiopathology), Electroencephalography, Electromyography, Evoked Potentials, Somatosensory (physiology), Female, Functional Laterality (physiology), Humans, Lewy Bodies (pathology), Lewy Body Disease (genetics), Lewy Body Disease (pathology), Lewy Body Disease (physiopathology), Male, Motor Neurons (pathology), Motor Neurons (physiology), Muscle, Skeletal (innervation), Parkinson Disease (genetics), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Reaction Time (physiology), Tremor (genetics), Tremor (pathology), Tremor (physiopathology).
- MESH :
- genetics : Dementia, Lewy Body Disease, Parkinson Disease, Tremor.
- innervation : Muscle, Skeletal.
- pathology : Cerebral Cortex, Dementia, Lewy Bodies, Lewy Body Disease, Motor Neurons, Parkinson Disease, Tremor.
- physiology : Evoked Potentials, Somatosensory, Functional Laterality, Motor Neurons, Reaction Time.
- physiopathology : Cerebral Cortex, Dementia, Lewy Body Disease, Parkinson Disease, Tremor.
- Adult, Brain Mapping, Electroencephalography, Electromyography, Female, Humans, Male.
Abstract
We studied the only two living affected individuals who are part of a previously reported kindred that expresses a hereditary parkinsonism-dementia syndrome with Lewy body pathology. The electrophysiological characteristics of the hyperkinetic movement disorders in these patients were examined to provide physiological insights into the clinical phenotype of this syndrome. Evaluation of both patients showed 7-9 Hz electromyographic discharges in upper extremity muscles during postural activation, and one patient showed a 4-5 Hz discharge pattern correlating to a rest tremor. Brief (<50 ms) myoclonic electromyographic discharges were seen in both patients, and a time-locked relationship to a focal cortical premovement electroencephalographic potential was elicited in one patient. Somatosensory evoked potentials were not enlarged and long latency reflexes were not enhanced. Electroencephalography was normal in one patient but showed pathologic slow frequencies in the other. The electrophysiological findings show evolution which correlates with an apparent characteristic evolution of hyperkinetic movement disorders that accompanies the severe progression of parkinsonism-dementia in this kindred. These results have implications for the future study of this and similar syndromes.
PubMed: 10634254
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Gwinn-Hardy</name></author><author><name sortKey="Adler, C H" sort="Adler, C H" uniqKey="Adler C" first="C H" last="Adler">C H Adler</name></author><author><name sortKey="Muenter, M D" sort="Muenter, M D" uniqKey="Muenter M" first="M D" last="Muenter">M D Muenter</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2000">2000</date><idno type="RBID">pubmed:10634254</idno><idno type="pmid">10634254</idno><idno type="wicri:Area/PubMed/Corpus">004049</idno><idno type="wicri:Area/PubMed/Curation">004049</idno><idno type="wicri:Area/PubMed/Checkpoint">003F90</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Electrophysiological observations in hereditary parkinsonism-dementia with Lewy body pathology.</title><author><name sortKey="Caviness, J N" sort="Caviness, J N" uniqKey="Caviness J" first="J N" last="Caviness">J N Caviness</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Mayo Clinic, Scottsdale, Arizona 85259, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Scottsdale, Arizona 85259</wicri:regionArea><wicri:noRegion>Arizona 85259</wicri:noRegion></affiliation></author><author><name sortKey="Gwinn Hardy, K" sort="Gwinn Hardy, K" uniqKey="Gwinn Hardy K" first="K" last="Gwinn-Hardy">K. Gwinn-Hardy</name></author><author><name sortKey="Adler, C H" sort="Adler, C H" uniqKey="Adler C" first="C H" last="Adler">C H Adler</name></author><author><name sortKey="Muenter, M D" sort="Muenter, M D" uniqKey="Muenter M" first="M D" last="Muenter">M D Muenter</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Brain Mapping</term><term>Cerebral Cortex (pathology)</term><term>Cerebral Cortex (physiopathology)</term><term>Dementia (genetics)</term><term>Dementia (pathology)</term><term>Dementia (physiopathology)</term><term>Electroencephalography</term><term>Electromyography</term><term>Evoked Potentials, Somatosensory (physiology)</term><term>Female</term><term>Functional Laterality (physiology)</term><term>Humans</term><term>Lewy Bodies (pathology)</term><term>Lewy Body Disease (genetics)</term><term>Lewy Body Disease (pathology)</term><term>Lewy Body Disease (physiopathology)</term><term>Male</term><term>Motor Neurons (pathology)</term><term>Motor Neurons (physiology)</term><term>Muscle, Skeletal (innervation)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Reaction Time (physiology)</term><term>Tremor (genetics)</term><term>Tremor (pathology)</term><term>Tremor (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Dementia</term><term>Lewy Body Disease</term><term>Parkinson Disease</term><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cerebral Cortex</term><term>Dementia</term><term>Lewy Bodies</term><term>Lewy Body Disease</term><term>Motor Neurons</term><term>Parkinson Disease</term><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials, Somatosensory</term><term>Functional Laterality</term><term>Motor Neurons</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebral Cortex</term><term>Dementia</term><term>Lewy Body Disease</term><term>Parkinson Disease</term><term>Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Brain Mapping</term><term>Electroencephalography</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied the only two living affected individuals who are part of a previously reported kindred that expresses a hereditary parkinsonism-dementia syndrome with Lewy body pathology. The electrophysiological characteristics of the hyperkinetic movement disorders in these patients were examined to provide physiological insights into the clinical phenotype of this syndrome. Evaluation of both patients showed 7-9 Hz electromyographic discharges in upper extremity muscles during postural activation, and one patient showed a 4-5 Hz discharge pattern correlating to a rest tremor. Brief (<50 ms) myoclonic electromyographic discharges were seen in both patients, and a time-locked relationship to a focal cortical premovement electroencephalographic potential was elicited in one patient. Somatosensory evoked potentials were not enlarged and long latency reflexes were not enhanced. Electroencephalography was normal in one patient but showed pathologic slow frequencies in the other. The electrophysiological findings show evolution which correlates with an apparent characteristic evolution of hyperkinetic movement disorders that accompanies the severe progression of parkinsonism-dementia in this kindred. These results have implications for the future study of this and similar syndromes.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">10634254</PMID><DateCreated><Year>2000</Year><Month>02</Month><Day>10</Day></DateCreated><DateCompleted><Year>2000</Year><Month>02</Month><Day>10</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>15</Volume><Issue>1</Issue><PubDate><Year>2000</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Electrophysiological observations in hereditary parkinsonism-dementia with Lewy body pathology.</ArticleTitle><Pagination><MedlinePgn>140-5</MedlinePgn></Pagination><Abstract><AbstractText>We studied the only two living affected individuals who are part of a previously reported kindred that expresses a hereditary parkinsonism-dementia syndrome with Lewy body pathology. The electrophysiological characteristics of the hyperkinetic movement disorders in these patients were examined to provide physiological insights into the clinical phenotype of this syndrome. Evaluation of both patients showed 7-9 Hz electromyographic discharges in upper extremity muscles during postural activation, and one patient showed a 4-5 Hz discharge pattern correlating to a rest tremor. Brief (<50 ms) myoclonic electromyographic discharges were seen in both patients, and a time-locked relationship to a focal cortical premovement electroencephalographic potential was elicited in one patient. Somatosensory evoked potentials were not enlarged and long latency reflexes were not enhanced. Electroencephalography was normal in one patient but showed pathologic slow frequencies in the other. The electrophysiological findings show evolution which correlates with an apparent characteristic evolution of hyperkinetic movement disorders that accompanies the severe progression of parkinsonism-dementia in this kindred. These results have implications for the future study of this and similar syndromes.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Caviness</LastName><ForeName>J N</ForeName><Initials>JN</Initials><AffiliationInfo><Affiliation>Department of Neurology, Mayo Clinic, Scottsdale, Arizona 85259, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gwinn-Hardy</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Adler</LastName><ForeName>C H</ForeName><Initials>CH</Initials></Author><Author ValidYN="Y"><LastName>Muenter</LastName><ForeName>M D</ForeName><Initials>MD</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>UNITED STATES</Country><MedlineTA>Mov 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UI="D004569">Electroencephalography</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D004576">Electromyography</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005073">Evoked Potentials, Somatosensory</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007839">Functional Laterality</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016631">Lewy Bodies</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020961">Lewy Body Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009046">Motor Neurons</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018482">Muscle, Skeletal</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000294">innervation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011930">Reaction Time</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014202">Tremor</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2000</Year><Month>1</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2000</Year><Month>1</Month><Day>14</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2000</Year><Month>1</Month><Day>14</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">10634254</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Adler, C H" sort="Adler, C H" uniqKey="Adler C" first="C H" last="Adler">C H Adler</name><name sortKey="Gwinn Hardy, K" sort="Gwinn Hardy, K" uniqKey="Gwinn Hardy K" first="K" last="Gwinn-Hardy">K. Gwinn-Hardy</name><name sortKey="Muenter, M D" sort="Muenter, M D" uniqKey="Muenter M" first="M D" last="Muenter">M D Muenter</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Caviness, J N" sort="Caviness, J N" uniqKey="Caviness J" first="J N" last="Caviness">J N Caviness</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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