CSF dopamine, serotonin, and biopterin metabolites in patients with restless legs syndrome.
Identifieur interne : 003E03 ( PubMed/Checkpoint ); précédent : 003E02; suivant : 003E04CSF dopamine, serotonin, and biopterin metabolites in patients with restless legs syndrome.
Auteurs : C J Earley [États-Unis] ; K. Hyland ; R P AllenSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2001.
English descriptors
- KwdEn :
- Age Factors, Biopterin (analogs & derivatives), Biopterin (cerebrospinal fluid), Brain (metabolism), Dopamine (cerebrospinal fluid), Female, Homovanillic Acid (cerebrospinal fluid), Humans, Hydroxyindoleacetic Acid (cerebrospinal fluid), Male, Middle Aged, Neopterin (cerebrospinal fluid), Restless Legs Syndrome (cerebrospinal fluid), Serotonin (cerebrospinal fluid), Spinal Cord (metabolism).
- MESH :
- chemical , analogs & derivatives : Biopterin.
- chemical , cerebrospinal fluid : Biopterin, Dopamine, Homovanillic Acid, Hydroxyindoleacetic Acid, Neopterin, Serotonin.
- cerebrospinal fluid : Restless Legs Syndrome.
- metabolism : Brain, Spinal Cord.
- Age Factors, Female, Humans, Male, Middle Aged.
Abstract
To evaluate the role of CNS dopaminergic systems in Restless Legs Syndrome (RLS), homovanillic acid (HVA), tetrahydrobiopterin (BH4), and neopterin (NEOP), were assayed in CSF from RLS patients. The serotonin metabolite, 5-hydroxyindoleacetic acid (5-HIAA), was also measured.
PubMed: 11215576
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">CSF dopamine, serotonin, and biopterin metabolites in patients with restless legs syndrome.</title><author><name sortKey="Earley, C J" sort="Earley, C J" uniqKey="Earley C" first="C J" last="Earley">C J Earley</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224</wicri:regionArea><wicri:noRegion>Maryland 21224</wicri:noRegion></affiliation></author><author><name sortKey="Hyland, K" sort="Hyland, K" uniqKey="Hyland K" first="K" last="Hyland">K. Hyland</name></author><author><name sortKey="Allen, R P" sort="Allen, R P" uniqKey="Allen R" first="R P" last="Allen">R P Allen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2001">2001</date><idno type="RBID">pubmed:11215576</idno><idno type="pmid">11215576</idno><idno type="wicri:Area/PubMed/Corpus">003E19</idno><idno type="wicri:Area/PubMed/Curation">003E19</idno><idno type="wicri:Area/PubMed/Checkpoint">003E03</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">CSF dopamine, serotonin, and biopterin metabolites in patients with restless legs syndrome.</title><author><name sortKey="Earley, C J" sort="Earley, C J" uniqKey="Earley C" first="C J" last="Earley">C J Earley</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224</wicri:regionArea><wicri:noRegion>Maryland 21224</wicri:noRegion></affiliation></author><author><name sortKey="Hyland, K" sort="Hyland, K" uniqKey="Hyland K" first="K" last="Hyland">K. Hyland</name></author><author><name sortKey="Allen, R P" sort="Allen, R P" uniqKey="Allen R" first="R P" last="Allen">R P Allen</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term><term>Biopterin (analogs & derivatives)</term><term>Biopterin (cerebrospinal fluid)</term><term>Brain (metabolism)</term><term>Dopamine (cerebrospinal fluid)</term><term>Female</term><term>Homovanillic Acid (cerebrospinal fluid)</term><term>Humans</term><term>Hydroxyindoleacetic Acid (cerebrospinal fluid)</term><term>Male</term><term>Middle Aged</term><term>Neopterin (cerebrospinal fluid)</term><term>Restless Legs Syndrome (cerebrospinal fluid)</term><term>Serotonin (cerebrospinal fluid)</term><term>Spinal Cord (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Biopterin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Biopterin</term><term>Dopamine</term><term>Homovanillic Acid</term><term>Hydroxyindoleacetic Acid</term><term>Neopterin</term><term>Serotonin</term></keywords><keywords scheme="MESH" qualifier="cerebrospinal fluid" xml:lang="en"><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term><term>Spinal Cord</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To evaluate the role of CNS dopaminergic systems in Restless Legs Syndrome (RLS), homovanillic acid (HVA), tetrahydrobiopterin (BH4), and neopterin (NEOP), were assayed in CSF from RLS patients. The serotonin metabolite, 5-hydroxyindoleacetic acid (5-HIAA), was also measured.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">11215576</PMID><DateCreated><Year>2001</Year><Month>02</Month><Day>15</Day></DateCreated><DateCompleted><Year>2001</Year><Month>06</Month><Day>14</Day></DateCompleted><DateRevised><Year>2014</Year><Month>11</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>16</Volume><Issue>1</Issue><PubDate><Year>2001</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>CSF dopamine, serotonin, and biopterin metabolites in patients with restless legs syndrome.</ArticleTitle><Pagination><MedlinePgn>144-9</MedlinePgn></Pagination><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">To evaluate the role of CNS dopaminergic systems in Restless Legs Syndrome (RLS), homovanillic acid (HVA), tetrahydrobiopterin (BH4), and neopterin (NEOP), were assayed in CSF from RLS patients. The serotonin metabolite, 5-hydroxyindoleacetic acid (5-HIAA), was also measured.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">CSF was taken from 16 RLS patients after 2 weeks off medication and from 14 control subjects. The CSF metabolites were determined using HPLC techniques.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">There was no significant difference in HVA or 5-HIAA, but NEOP and BH4 were higher in RLS patients. The RLS group was significantly older than the control group (64.2 +/- 9.2 years vs. 51.4 +/- 6.3 years; P < 0.001). A multiple regression analysis showed a strong correlation between age and 5-HIAA (r = 0.46, P = 0.04) and between age and NEOP (r = 0.61, P < 0.01). To eliminate the potential error created by the age difference between groups, an age-adjusted subgroup of RLS and control subjects were compared. There was still no difference found for HVA; however, 5-HIAA was now significantly lower (P < 0.01) in the RLS subgroup. Age-adjustment eliminated the differences previously found for NEOP, (P = 0.12), but BH4 continued to remain higher in the RLS group (P < 0.01).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Differences in CSF HVA concentrations were not found. The changes in 5-HIAA and BH4 are of unclear clinical significance and require further assessment with appropriate age-matched controls.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Earley</LastName><ForeName>C J</ForeName><Initials>CJ</Initials><AffiliationInfo><Affiliation>Department of Neurology, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hyland</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Allen</LastName><ForeName>R P</ForeName><Initials>RP</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>22150-76-1</RegistryNumber><NameOfSubstance UI="D001708">Biopterin</NameOfSubstance></Chemical><Chemical><RegistryNumber>333DO1RDJY</RegistryNumber><NameOfSubstance UI="D012701">Serotonin</NameOfSubstance></Chemical><Chemical><RegistryNumber>54-16-0</RegistryNumber><NameOfSubstance UI="D006897">Hydroxyindoleacetic Acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>670-65-5</RegistryNumber><NameOfSubstance UI="D019798">Neopterin</NameOfSubstance></Chemical><Chemical><RegistryNumber>EGX657432I</RegistryNumber><NameOfSubstance UI="C003402">sapropterin</NameOfSubstance></Chemical><Chemical><RegistryNumber>VTD58H1Z2X</RegistryNumber><NameOfSubstance UI="D004298">Dopamine</NameOfSubstance></Chemical><Chemical><RegistryNumber>X77S6GMS36</RegistryNumber><NameOfSubstance UI="D006719">Homovanillic Acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000367">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001708">Biopterin</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000031">analogs & derivatives</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000134">cerebrospinal fluid</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001921">Brain</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004298">Dopamine</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000134">cerebrospinal fluid</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006719">Homovanillic Acid</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000134">cerebrospinal fluid</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006897">Hydroxyindoleacetic Acid</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000134">cerebrospinal fluid</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019798">Neopterin</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000134">cerebrospinal fluid</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012148">Restless Legs Syndrome</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000134">cerebrospinal fluid</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012701">Serotonin</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000134">cerebrospinal fluid</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013116">Spinal Cord</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2001</Year><Month>2</Month><Day>24</Day><Hour>12</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2001</Year><Month>6</Month><Day>23</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2001</Year><Month>2</Month><Day>24</Day><Hour>12</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11215576</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Allen, R P" sort="Allen, R P" uniqKey="Allen R" first="R P" last="Allen">R P Allen</name><name sortKey="Hyland, K" sort="Hyland, K" uniqKey="Hyland K" first="K" last="Hyland">K. Hyland</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Earley, C J" sort="Earley, C J" uniqKey="Earley C" first="C J" last="Earley">C J Earley</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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