Somatosensory disinhibition in dystonia.
Identifieur interne : 003C41 ( PubMed/Checkpoint ); précédent : 003C40; suivant : 003C42Somatosensory disinhibition in dystonia.
Auteurs : E. Frasson [Italie] ; A. Priori ; L. Bertolasi ; F. Mauguière ; A. Fiaschi ; M. TinazziSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2001.
English descriptors
- KwdEn :
- Adult, Brain Stem (physiopathology), Dystonia (physiopathology), Electric Stimulation, Evoked Potentials, Somatosensory (physiology), Feedback (physiology), Female, Frontal Lobe (physiopathology), Humans, Male, Median Nerve (physiopathology), Middle Aged, Motor Neurons (physiology), Neural Inhibition (physiology), Parietal Lobe (physiopathology), Spinal Cord (physiopathology).
- MESH :
- physiology : Evoked Potentials, Somatosensory, Feedback, Motor Neurons, Neural Inhibition.
- physiopathology : Brain Stem, Dystonia, Frontal Lobe, Median Nerve, Parietal Lobe, Spinal Cord.
- Adult, Electric Stimulation, Female, Humans, Male, Middle Aged.
Abstract
Despite the fact that somatosensory processing is inherently dependent on inhibitory functions, only excitatory aspects of the somatosensory feedback have so far been assessed in dystonic patients. We studied the recovery functions of spinal N13, brainstem P14, parietal N20, P27, and frontal N30 somatosensory evoked potentials (SEPs) after paired median nerve stimulation in 10 patients with dystonia and in 10 normal subjects. The recovery functions were assessed (conditioning stimulus: S1; test stimulus: S2) at interstimuls intervals (ISIs) of 5, 20, and 40 ms. SEPs evoked by S2 were calculated by subtracting the SEPs of the S1 only response from the SEPs of the response to the paired stimuli (S1 + S2), and their amplitudes were compared with those of the control response (S1) at each ISI considered. This ratio, (S2/S1)*100, investigates changes in the excitability of the somatosensory system. No significant difference was found in SEP amplitudes for single stimulus (S1) between dystonic patients and normal subjects. The (S2/S1)*100 ratio at the ISI of 5 ms did not significantly differ between dystonic patients and normal subjects, but at ISIs of 20 and 40 ms, this ratio was significantly higher in patients than in normals for spinal N13 and cortical N20, P27, N30 SEPs. These findings suggest that in dystonia there is an impaired inhibition at spinal and cortical levels of the somatosensory system which would lead to an abnormal sensory assistance to the ongoing motor programs, ultimately resulting in the motor abnormalities present in this disease.
PubMed: 11481691
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Somatosensory disinhibition in dystonia.</title><author><name sortKey="Frasson, E" sort="Frasson, E" uniqKey="Frasson E" first="E" last="Frasson">E. Frasson</name><affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Scienze Neurologiche e Della Visione, Sez. di Neurologia e Sez. di Neurologia Riabilitativa, Verona, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Neurologiche e Della Visione, Sez. di Neurologia e Sez. di Neurologia Riabilitativa, Verona</wicri:regionArea><wicri:noRegion>Verona</wicri:noRegion></affiliation></author><author><name sortKey="Priori, A" sort="Priori, A" uniqKey="Priori A" first="A" last="Priori">A. Priori</name></author><author><name sortKey="Bertolasi, L" sort="Bertolasi, L" uniqKey="Bertolasi L" first="L" last="Bertolasi">L. Bertolasi</name></author><author><name sortKey="Mauguiere, F" sort="Mauguiere, F" uniqKey="Mauguiere F" first="F" last="Mauguière">F. Mauguière</name></author><author><name sortKey="Fiaschi, A" sort="Fiaschi, A" uniqKey="Fiaschi A" first="A" last="Fiaschi">A. Fiaschi</name></author><author><name sortKey="Tinazzi, M" sort="Tinazzi, M" uniqKey="Tinazzi M" first="M" last="Tinazzi">M. Tinazzi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2001">2001</date><idno type="RBID">pubmed:11481691</idno><idno type="pmid">11481691</idno><idno type="wicri:Area/PubMed/Corpus">003D08</idno><idno type="wicri:Area/PubMed/Curation">003D08</idno><idno type="wicri:Area/PubMed/Checkpoint">003C41</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Somatosensory disinhibition in dystonia.</title><author><name sortKey="Frasson, E" sort="Frasson, E" uniqKey="Frasson E" first="E" last="Frasson">E. Frasson</name><affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Scienze Neurologiche e Della Visione, Sez. di Neurologia e Sez. di Neurologia Riabilitativa, Verona, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Neurologiche e Della Visione, Sez. di Neurologia e Sez. di Neurologia Riabilitativa, Verona</wicri:regionArea><wicri:noRegion>Verona</wicri:noRegion></affiliation></author><author><name sortKey="Priori, A" sort="Priori, A" uniqKey="Priori A" first="A" last="Priori">A. Priori</name></author><author><name sortKey="Bertolasi, L" sort="Bertolasi, L" uniqKey="Bertolasi L" first="L" last="Bertolasi">L. Bertolasi</name></author><author><name sortKey="Mauguiere, F" sort="Mauguiere, F" uniqKey="Mauguiere F" first="F" last="Mauguière">F. Mauguière</name></author><author><name sortKey="Fiaschi, A" sort="Fiaschi, A" uniqKey="Fiaschi A" first="A" last="Fiaschi">A. Fiaschi</name></author><author><name sortKey="Tinazzi, M" sort="Tinazzi, M" uniqKey="Tinazzi M" first="M" last="Tinazzi">M. Tinazzi</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Brain Stem (physiopathology)</term><term>Dystonia (physiopathology)</term><term>Electric Stimulation</term><term>Evoked Potentials, Somatosensory (physiology)</term><term>Feedback (physiology)</term><term>Female</term><term>Frontal Lobe (physiopathology)</term><term>Humans</term><term>Male</term><term>Median Nerve (physiopathology)</term><term>Middle Aged</term><term>Motor Neurons (physiology)</term><term>Neural Inhibition (physiology)</term><term>Parietal Lobe (physiopathology)</term><term>Spinal Cord (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials, Somatosensory</term><term>Feedback</term><term>Motor Neurons</term><term>Neural Inhibition</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain Stem</term><term>Dystonia</term><term>Frontal Lobe</term><term>Median Nerve</term><term>Parietal Lobe</term><term>Spinal Cord</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Electric Stimulation</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite the fact that somatosensory processing is inherently dependent on inhibitory functions, only excitatory aspects of the somatosensory feedback have so far been assessed in dystonic patients. We studied the recovery functions of spinal N13, brainstem P14, parietal N20, P27, and frontal N30 somatosensory evoked potentials (SEPs) after paired median nerve stimulation in 10 patients with dystonia and in 10 normal subjects. The recovery functions were assessed (conditioning stimulus: S1; test stimulus: S2) at interstimuls intervals (ISIs) of 5, 20, and 40 ms. SEPs evoked by S2 were calculated by subtracting the SEPs of the S1 only response from the SEPs of the response to the paired stimuli (S1 + S2), and their amplitudes were compared with those of the control response (S1) at each ISI considered. This ratio, (S2/S1)*100, investigates changes in the excitability of the somatosensory system. No significant difference was found in SEP amplitudes for single stimulus (S1) between dystonic patients and normal subjects. The (S2/S1)*100 ratio at the ISI of 5 ms did not significantly differ between dystonic patients and normal subjects, but at ISIs of 20 and 40 ms, this ratio was significantly higher in patients than in normals for spinal N13 and cortical N20, P27, N30 SEPs. These findings suggest that in dystonia there is an impaired inhibition at spinal and cortical levels of the somatosensory system which would lead to an abnormal sensory assistance to the ongoing motor programs, ultimately resulting in the motor abnormalities present in this disease.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">11481691</PMID><DateCreated><Year>2001</Year><Month>08</Month><Day>01</Day></DateCreated><DateCompleted><Year>2001</Year><Month>10</Month><Day>18</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>16</Volume><Issue>4</Issue><PubDate><Year>2001</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Somatosensory disinhibition in dystonia.</ArticleTitle><Pagination><MedlinePgn>674-82</MedlinePgn></Pagination><Abstract><AbstractText>Despite the fact that somatosensory processing is inherently dependent on inhibitory functions, only excitatory aspects of the somatosensory feedback have so far been assessed in dystonic patients. We studied the recovery functions of spinal N13, brainstem P14, parietal N20, P27, and frontal N30 somatosensory evoked potentials (SEPs) after paired median nerve stimulation in 10 patients with dystonia and in 10 normal subjects. The recovery functions were assessed (conditioning stimulus: S1; test stimulus: S2) at interstimuls intervals (ISIs) of 5, 20, and 40 ms. SEPs evoked by S2 were calculated by subtracting the SEPs of the S1 only response from the SEPs of the response to the paired stimuli (S1 + S2), and their amplitudes were compared with those of the control response (S1) at each ISI considered. This ratio, (S2/S1)*100, investigates changes in the excitability of the somatosensory system. No significant difference was found in SEP amplitudes for single stimulus (S1) between dystonic patients and normal subjects. The (S2/S1)*100 ratio at the ISI of 5 ms did not significantly differ between dystonic patients and normal subjects, but at ISIs of 20 and 40 ms, this ratio was significantly higher in patients than in normals for spinal N13 and cortical N20, P27, N30 SEPs. These findings suggest that in dystonia there is an impaired inhibition at spinal and cortical levels of the somatosensory system which would lead to an abnormal sensory assistance to the ongoing motor programs, ultimately resulting in the motor abnormalities present in this disease.</AbstractText><CopyrightInformation>Copyright 2001 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Frasson</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Dipartimento di Scienze Neurologiche e Della Visione, Sez. di Neurologia e Sez. di Neurologia Riabilitativa, Verona, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Priori</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Bertolasi</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Mauguière</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Fiaschi</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Tinazzi</LastName><ForeName>M</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Mov Disord. 2001 Jul;16(4):593-4</RefSource><PMID 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UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005625">Frontal Lobe</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008475">Median Nerve</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009046">Motor Neurons</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009433">Neural Inhibition</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010296">Parietal Lobe</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013116">Spinal Cord</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2001</Year><Month>8</Month><Day>2</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2001</Year><Month>10</Month><Day>19</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2001</Year><Month>8</Month><Day>2</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11481691</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Bertolasi, L" sort="Bertolasi, L" uniqKey="Bertolasi L" first="L" last="Bertolasi">L. Bertolasi</name><name sortKey="Fiaschi, A" sort="Fiaschi, A" uniqKey="Fiaschi A" first="A" last="Fiaschi">A. Fiaschi</name><name sortKey="Mauguiere, F" sort="Mauguiere, F" uniqKey="Mauguiere F" first="F" last="Mauguière">F. Mauguière</name><name sortKey="Priori, A" sort="Priori, A" uniqKey="Priori A" first="A" last="Priori">A. Priori</name><name sortKey="Tinazzi, M" sort="Tinazzi, M" uniqKey="Tinazzi M" first="M" last="Tinazzi">M. Tinazzi</name></noCountry><country name="Italie"><noRegion><name sortKey="Frasson, E" sort="Frasson, E" uniqKey="Frasson E" first="E" last="Frasson">E. Frasson</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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