Fetal neural grafts for Huntington's disease: a prospective view.
Identifieur interne : 003A88 ( PubMed/Checkpoint ); précédent : 003A87; suivant : 003A89Fetal neural grafts for Huntington's disease: a prospective view.
Auteurs : Anne-Catherine Bachoud-Lévi ; Philippe Hantraye ; Marc PeschanskiSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2002.
English descriptors
- KwdEn :
- MESH :
- embryology : Nerve Tissue.
- surgery : Huntington Disease.
- transplantation : Corpus Striatum.
- Animals, Brain Tissue Transplantation, Clinical Trials as Topic, Female, Fetal Tissue Transplantation, Humans, Pregnancy, Treatment Outcome.
Abstract
Intrastriatal transplantation of striatal neuroblasts from human fetuses is a promising approach for treatment of Huntington's disease, on the basis of many experimental animal studies and, most recently, pilot clinical trials. Technically, several issues remain to be resolved (e.g., the precise site of dissection of the fetal tissue; the number and location of the fetal striatal implants; or the use of immunosuppressive therapy), and await larger-scale trials and purposely designed protocols. Further clinical data must also be obtained, and preliminary promising results must be replicated in a patient group large enough to provide conclusive results. It is important to establish (1) the amount of clinical benefit provided to the patient by the grafted cells; (2) the anticipated duration of clinical benefits; and (3) the secondary rate of decline after the benefit of the graft has been overbalanced. Evaluation of these parameters will require very long-term follow-up of the patients involved, over several years after grafting, before the technique can eventually be proposed widely to patients.
DOI: 10.1002/mds.10117
PubMed: 12112189
Affiliations:
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pubmed:12112189Le document en format XML
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<author><name sortKey="Bachoud Levi, Anne Catherine" sort="Bachoud Levi, Anne Catherine" uniqKey="Bachoud Levi A" first="Anne-Catherine" last="Bachoud-Lévi">Anne-Catherine Bachoud-Lévi</name>
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<author><name sortKey="Hantraye, Philippe" sort="Hantraye, Philippe" uniqKey="Hantraye P" first="Philippe" last="Hantraye">Philippe Hantraye</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Brain Tissue Transplantation</term>
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<term>Female</term>
<term>Fetal Tissue Transplantation</term>
<term>Humans</term>
<term>Huntington Disease (surgery)</term>
<term>Nerve Tissue (embryology)</term>
<term>Pregnancy</term>
<term>Treatment Outcome</term>
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<keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Nerve Tissue</term>
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<keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Corpus Striatum</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Brain Tissue Transplantation</term>
<term>Clinical Trials as Topic</term>
<term>Female</term>
<term>Fetal Tissue Transplantation</term>
<term>Humans</term>
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<front><div type="abstract" xml:lang="en">Intrastriatal transplantation of striatal neuroblasts from human fetuses is a promising approach for treatment of Huntington's disease, on the basis of many experimental animal studies and, most recently, pilot clinical trials. Technically, several issues remain to be resolved (e.g., the precise site of dissection of the fetal tissue; the number and location of the fetal striatal implants; or the use of immunosuppressive therapy), and await larger-scale trials and purposely designed protocols. Further clinical data must also be obtained, and preliminary promising results must be replicated in a patient group large enough to provide conclusive results. It is important to establish (1) the amount of clinical benefit provided to the patient by the grafted cells; (2) the anticipated duration of clinical benefits; and (3) the secondary rate of decline after the benefit of the graft has been overbalanced. Evaluation of these parameters will require very long-term follow-up of the patients involved, over several years after grafting, before the technique can eventually be proposed widely to patients.</div>
</front>
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<DateCreated><Year>2002</Year>
<Month>07</Month>
<Day>11</Day>
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<DateCompleted><Year>2002</Year>
<Month>09</Month>
<Day>16</Day>
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<DateRevised><Year>2007</Year>
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<JournalIssue CitedMedium="Print"><Volume>17</Volume>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
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<ArticleTitle>Fetal neural grafts for Huntington's disease: a prospective view.</ArticleTitle>
<Pagination><MedlinePgn>439-44</MedlinePgn>
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<Abstract><AbstractText>Intrastriatal transplantation of striatal neuroblasts from human fetuses is a promising approach for treatment of Huntington's disease, on the basis of many experimental animal studies and, most recently, pilot clinical trials. Technically, several issues remain to be resolved (e.g., the precise site of dissection of the fetal tissue; the number and location of the fetal striatal implants; or the use of immunosuppressive therapy), and await larger-scale trials and purposely designed protocols. Further clinical data must also be obtained, and preliminary promising results must be replicated in a patient group large enough to provide conclusive results. It is important to establish (1) the amount of clinical benefit provided to the patient by the grafted cells; (2) the anticipated duration of clinical benefits; and (3) the secondary rate of decline after the benefit of the graft has been overbalanced. Evaluation of these parameters will require very long-term follow-up of the patients involved, over several years after grafting, before the technique can eventually be proposed widely to patients.</AbstractText>
<CopyrightInformation>Copyright 2002 Movement Disorder Society</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bachoud-Lévi</LastName>
<ForeName>Anne-Catherine</ForeName>
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<ForeName>Philippe</ForeName>
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<MeshHeading><DescriptorName MajorTopicYN="Y" UI="D016332">Fetal Tissue Transplantation</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D006816">Huntington Disease</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D009417">Nerve Tissue</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D016896">Treatment Outcome</DescriptorName>
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<name sortKey="Hantraye, Philippe" sort="Hantraye, Philippe" uniqKey="Hantraye P" first="Philippe" last="Hantraye">Philippe Hantraye</name>
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