Influence of target size on vertical gaze palsy in a pathologically proven case of progressive supranuclear palsy.
Identifieur interne : 003753 ( PubMed/Checkpoint ); précédent : 003752; suivant : 003754Influence of target size on vertical gaze palsy in a pathologically proven case of progressive supranuclear palsy.
Auteurs : Barry M. Seemungal [Royaume-Uni] ; Mary Faldon ; Tamas Revesz ; Andrew J. Lees ; David S. Zee ; Adolfo M. BronsteinSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2003.
English descriptors
- KwdEn :
- Aged, Atrophy, Brain (pathology), Brain (physiopathology), Brain Stem (pathology), Brain Stem (physiopathology), Electronystagmography, Electrooculography, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Pursuit, Smooth (physiology), Reflex, Vestibulo-Ocular (physiology), Saccades (physiology), Size Perception (physiology), Supranuclear Palsy, Progressive (diagnosis), Supranuclear Palsy, Progressive (physiopathology), Tauopathies (diagnosis), Tauopathies (physiopathology), Video Recording, tau Proteins (analysis).
- MESH :
- chemical , analysis : tau Proteins.
- diagnosis : Supranuclear Palsy, Progressive, Tauopathies.
- pathology : Brain, Brain Stem.
- physiology : Pursuit, Smooth, Reflex, Vestibulo-Ocular, Saccades, Size Perception.
- physiopathology : Brain, Brain Stem, Supranuclear Palsy, Progressive, Tauopathies.
- Aged, Atrophy, Electronystagmography, Electrooculography, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Video Recording.
Abstract
We document a new oculomotor phenomenon in a patient with pathologically proven progressive supranuclear gaze palsy (PSP), namely that vertical gaze excursion improves with larger pursuit targets. We used computerised video-oculography during vertical smooth pursuit eye movements (SPEM) of circular targets of diameter 0.16 degrees and 16 degrees, sinusoidally oscillating at 0.08 Hz (peak-to-peak amplitude 49 degrees). Increasing target size improved vertical gaze excursion from 10 degrees to 25 degrees. There was no concomitant increase in slow phase eye velocity. The findings could be explained by a potentiation of the position control mechanism of pursuit by target size due to increased activation of brainstem pursuit-optokinetic pathways and to higher order attentional mechanisms. This observation may be useful in the clinical assessment of PSP patients with severe neck rigidity in whom the doll's head-eye manoeuvre cannot be performed by comparing the degree of vertical gaze palsy during smooth pursuit testing between at least two differently sized targets and observing whether there is a larger excursion in response to a large target such as a newspaper.
DOI: 10.1002/mds.10434
PubMed: 12815662
Affiliations:
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Seemungal</name><affiliation wicri:level="3"><nlm:affiliation>The Academic Department of Neuro-Otology, Division of Neurosciences and Psychological Medicine, Imperial College Faculty of Medicine, Charing Cross Hospital, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Academic Department of Neuro-Otology, Division of Neurosciences and Psychological Medicine, Imperial College Faculty of Medicine, Charing Cross Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Faldon, Mary" sort="Faldon, Mary" uniqKey="Faldon M" first="Mary" last="Faldon">Mary Faldon</name></author><author><name sortKey="Revesz, Tamas" sort="Revesz, Tamas" uniqKey="Revesz T" first="Tamas" last="Revesz">Tamas Revesz</name></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew J. Lees</name></author><author><name sortKey="Zee, David S" sort="Zee, David S" uniqKey="Zee D" first="David S" last="Zee">David S. Zee</name></author><author><name sortKey="Bronstein, Adolfo M" sort="Bronstein, Adolfo M" uniqKey="Bronstein A" first="Adolfo M" last="Bronstein">Adolfo M. 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Seemungal</name><affiliation wicri:level="3"><nlm:affiliation>The Academic Department of Neuro-Otology, Division of Neurosciences and Psychological Medicine, Imperial College Faculty of Medicine, Charing Cross Hospital, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Academic Department of Neuro-Otology, Division of Neurosciences and Psychological Medicine, Imperial College Faculty of Medicine, Charing Cross Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Faldon, Mary" sort="Faldon, Mary" uniqKey="Faldon M" first="Mary" last="Faldon">Mary Faldon</name></author><author><name sortKey="Revesz, Tamas" sort="Revesz, Tamas" uniqKey="Revesz T" first="Tamas" last="Revesz">Tamas Revesz</name></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew J. 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We used computerised video-oculography during vertical smooth pursuit eye movements (SPEM) of circular targets of diameter 0.16 degrees and 16 degrees, sinusoidally oscillating at 0.08 Hz (peak-to-peak amplitude 49 degrees). Increasing target size improved vertical gaze excursion from 10 degrees to 25 degrees. There was no concomitant increase in slow phase eye velocity. The findings could be explained by a potentiation of the position control mechanism of pursuit by target size due to increased activation of brainstem pursuit-optokinetic pathways and to higher order attentional mechanisms. This observation may be useful in the clinical assessment of PSP patients with severe neck rigidity in whom the doll's head-eye manoeuvre cannot be performed by comparing the degree of vertical gaze palsy during smooth pursuit testing between at least two differently sized targets and observing whether there is a larger excursion in response to a large target such as a newspaper.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">12815662</PMID><DateCreated><Year>2003</Year><Month>06</Month><Day>19</Day></DateCreated><DateCompleted><Year>2004</Year><Month>01</Month><Day>28</Day></DateCompleted><DateRevised><Year>2014</Year><Month>02</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>18</Volume><Issue>7</Issue><PubDate><Year>2003</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Influence of target size on vertical gaze palsy in a pathologically proven case of progressive supranuclear palsy.</ArticleTitle><Pagination><MedlinePgn>818-22</MedlinePgn></Pagination><Abstract><AbstractText>We document a new oculomotor phenomenon in a patient with pathologically proven progressive supranuclear gaze palsy (PSP), namely that vertical gaze excursion improves with larger pursuit targets. We used computerised video-oculography during vertical smooth pursuit eye movements (SPEM) of circular targets of diameter 0.16 degrees and 16 degrees, sinusoidally oscillating at 0.08 Hz (peak-to-peak amplitude 49 degrees). Increasing target size improved vertical gaze excursion from 10 degrees to 25 degrees. There was no concomitant increase in slow phase eye velocity. The findings could be explained by a potentiation of the position control mechanism of pursuit by target size due to increased activation of brainstem pursuit-optokinetic pathways and to higher order attentional mechanisms. This observation may be useful in the clinical assessment of PSP patients with severe neck rigidity in whom the doll's head-eye manoeuvre cannot be performed by comparing the degree of vertical gaze palsy during smooth pursuit testing between at least two differently sized targets and observing whether there is a larger excursion in response to a large target such as a newspaper.</AbstractText><CopyrightInformation>Copyright 2003 Movement Disorder Society</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Seemungal</LastName><ForeName>Barry M</ForeName><Initials>BM</Initials><AffiliationInfo><Affiliation>The Academic Department of Neuro-Otology, Division of Neurosciences and Psychological Medicine, Imperial College Faculty of Medicine, Charing Cross Hospital, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Faldon</LastName><ForeName>Mary</ForeName><Initials>M</Initials></Author><Author 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Londres</li></region><settlement><li>Londres</li></settlement></list><tree><noCountry><name sortKey="Bronstein, Adolfo M" sort="Bronstein, Adolfo M" uniqKey="Bronstein A" first="Adolfo M" last="Bronstein">Adolfo M. Bronstein</name><name sortKey="Faldon, Mary" sort="Faldon, Mary" uniqKey="Faldon M" first="Mary" last="Faldon">Mary Faldon</name><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew J. Lees</name><name sortKey="Revesz, Tamas" sort="Revesz, Tamas" uniqKey="Revesz T" first="Tamas" last="Revesz">Tamas Revesz</name><name sortKey="Zee, David S" sort="Zee, David S" uniqKey="Zee D" first="David S" last="Zee">David S. Zee</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Seemungal, Barry M" sort="Seemungal, Barry M" uniqKey="Seemungal B" first="Barry M" last="Seemungal">Barry M. Seemungal</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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