Adverse effects of dopamine potentiation by long-term treatment with selegiline.
Identifieur interne : 003572 ( PubMed/Checkpoint ); précédent : 003571; suivant : 003573Adverse effects of dopamine potentiation by long-term treatment with selegiline.
Auteurs : Susan Hollán [Hongrie] ; Lászl Vécsei ; Kálmán MagyarSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2004.
English descriptors
- KwdEn :
- Adolescent, Adult, Anemia, Hemolytic, Congenital (enzymology), Anemia, Hemolytic, Congenital (genetics), Antiparkinson Agents (adverse effects), Antiparkinson Agents (therapeutic use), Baclofen (adverse effects), Baclofen (therapeutic use), Basal Ganglia (drug effects), Basal Ganglia Diseases (drug therapy), Basal Ganglia Diseases (enzymology), Basal Ganglia Diseases (genetics), Blood Platelets (enzymology), Drug Therapy, Combination, Dyskinesia, Drug-Induced (diagnosis), Dyskinesia, Drug-Induced (etiology), Dystonia Musculorum Deformans (drug therapy), Dystonia Musculorum Deformans (enzymology), Dystonia Musculorum Deformans (genetics), Female, Genotype, Glyceraldehyde-3-Phosphate Dehydrogenases (deficiency), Glyceraldehyde-3-Phosphate Dehydrogenases (genetics), Heterozygote Detection, Humans, Long-Term Care, Male, Middle Aged, Monoamine Oxidase (blood), Monoamine Oxidase (genetics), Monoamine Oxidase Inhibitors (adverse effects), Monoamine Oxidase Inhibitors (therapeutic use), Nerve Tissue Proteins (genetics), Neurologic Examination (drug effects), Neuroprotective Agents (adverse effects), Neuroprotective Agents (therapeutic use), Nuclear Proteins (genetics), Polymerase Chain Reaction, Proteins (genetics), Psychoses, Substance-Induced (diagnosis), Psychoses, Substance-Induced (etiology), Reference Values, Selegiline (adverse effects), Selegiline (therapeutic use), Trinucleotide Repeats.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Baclofen, Monoamine Oxidase Inhibitors, Neuroprotective Agents, Selegiline.
- chemical , blood : Monoamine Oxidase.
- chemical , deficiency : Glyceraldehyde-3-Phosphate Dehydrogenases.
- diagnosis : Dyskinesia, Drug-Induced, Psychoses, Substance-Induced.
- drug effects : Basal Ganglia, Neurologic Examination.
- drug therapy : Basal Ganglia Diseases, Dystonia Musculorum Deformans.
- enzymology : Anemia, Hemolytic, Congenital, Basal Ganglia Diseases, Blood Platelets, Dystonia Musculorum Deformans.
- etiology : Dyskinesia, Drug-Induced, Psychoses, Substance-Induced.
- genetics : Anemia, Hemolytic, Congenital, Basal Ganglia Diseases, Dystonia Musculorum Deformans, Glyceraldehyde-3-Phosphate Dehydrogenases, Monoamine Oxidase, Nerve Tissue Proteins, Nuclear Proteins, Proteins.
- chemical , therapeutic use : Antiparkinson Agents, Baclofen, Monoamine Oxidase Inhibitors, Neuroprotective Agents, Selegiline.
- Adolescent, Adult, Drug Therapy, Combination, Female, Genotype, Heterozygote Detection, Humans, Long-Term Care, Male, Middle Aged, Polymerase Chain Reaction, Reference Values, Trinucleotide Repeats.
Abstract
A patient with triosephosphate isomerase (TPI) deficiency exhibited worsening of abnormal involuntary movements of the dystonic type and developed psychiatric symptoms while on selegiline. When selegiline was stopped after 9 years of treatment, abnormal involuntary movements improved to pretreatment level and psychiatric behaviour returned to normal. Monoamine oxidase-B platelet activity was low in this patient.
DOI: 10.1002/mds.10641
PubMed: 14743370
Affiliations:
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pubmed:14743370Le document en format XML
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<term>Antiparkinson Agents (adverse effects)</term>
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<term>Glyceraldehyde-3-Phosphate Dehydrogenases (deficiency)</term>
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<term>Heterozygote Detection</term>
<term>Humans</term>
<term>Long-Term Care</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Monoamine Oxidase (blood)</term>
<term>Monoamine Oxidase (genetics)</term>
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<term>Trinucleotide Repeats</term>
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<front><div type="abstract" xml:lang="en">A patient with triosephosphate isomerase (TPI) deficiency exhibited worsening of abnormal involuntary movements of the dystonic type and developed psychiatric symptoms while on selegiline. When selegiline was stopped after 9 years of treatment, abnormal involuntary movements improved to pretreatment level and psychiatric behaviour returned to normal. Monoamine oxidase-B platelet activity was low in this patient.</div>
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<Abstract><AbstractText>A patient with triosephosphate isomerase (TPI) deficiency exhibited worsening of abnormal involuntary movements of the dystonic type and developed psychiatric symptoms while on selegiline. When selegiline was stopped after 9 years of treatment, abnormal involuntary movements improved to pretreatment level and psychiatric behaviour returned to normal. Monoamine oxidase-B platelet activity was low in this patient.</AbstractText>
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