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Alpha-synuclein dysfunction in Lewy body diseases.

Identifieur interne : 003242 ( PubMed/Checkpoint ); précédent : 003241; suivant : 003243

Alpha-synuclein dysfunction in Lewy body diseases.

Auteurs : George K. Tofaris [Royaume-Uni] ; Maria Grazia Spillantini

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.

RBID : pubmed:16092089

English descriptors

KwdEn :
- Animals, Chromosomes, Human, Pair 6 (genetics), Cytoskeleton (metabolism), Drosophila, Humans, In Vitro Techniques, Lewy Body Disease (genetics), Lewy Body Disease (metabolism), Lewy Body Disease (physiopathology), Mice, Parkinson Disease (genetics), Parkinson Disease (physiopathology), Phenotype, Phosphorylation, Point Mutation (genetics), alpha-Synuclein (genetics), alpha-Synuclein (metabolism).
MESH :
- chemical , genetics : alpha-Synuclein.
- genetics : Chromosomes, Human, Pair 6, Lewy Body Disease, Parkinson Disease, Point Mutation.
- metabolism : Cytoskeleton, Lewy Body Disease, alpha-Synuclein.
- physiopathology : Lewy Body Disease, Parkinson Disease.
- Animals, Drosophila, Humans, In Vitro Techniques, Mice, Phenotype, Phosphorylation.

Abstract

alpha-Synuclein belongs to a small group of natively unfolded proteins that can transiently bind to lipid membranes and acquire a partial alpha-helical conformation. Its relevance to Parkinson's disease (PD) is based on mutations found in familial cases of the disease and its presence in filaments of Lewy bodies (LB) and Lewy neurites (LN) in sporadic cases where it is packed in a beta-sheet configuration. This structural plasticity of alpha-synuclein has raised the possibility that neurodegeneration may be a consequence of abnormal protein folding. The extent to which abnormal folding and aggregation of neuronal proteins is directly toxic to the cell, an inert biochemical marker of an underlying harmful metabolic defect, or a protective reaction remains to be seen. We review the function of alpha-synuclein and recent studies that have shed light on the mechanisms by which it aggregates.

DOI: 10.1002/mds.20538
PubMed: 16092089

Affiliations:

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pubmed:16092089

Le document en format XML

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<author><name sortKey="Spillantini, Maria Grazia" sort="Spillantini, Maria Grazia" uniqKey="Spillantini M" first="Maria Grazia" last="Spillantini">Maria Grazia Spillantini</name>
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<front><div type="abstract" xml:lang="en">alpha-Synuclein belongs to a small group of natively unfolded proteins that can transiently bind to lipid membranes and acquire a partial alpha-helical conformation. Its relevance to Parkinson's disease (PD) is based on mutations found in familial cases of the disease and its presence in filaments of Lewy bodies (LB) and Lewy neurites (LN) in sporadic cases where it is packed in a beta-sheet configuration. This structural plasticity of alpha-synuclein has raised the possibility that neurodegeneration may be a consequence of abnormal protein folding. The extent to which abnormal folding and aggregation of neuronal proteins is directly toxic to the cell, an inert biochemical marker of an underlying harmful metabolic defect, or a protective reaction remains to be seen. We review the function of alpha-synuclein and recent studies that have shed light on the mechanisms by which it aggregates.</div>
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<Day>15</Day>
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<Month>12</Month>
<Day>13</Day>
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<Month>11</Month>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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<CopyrightInformation>Copyright 2005 Movement Disorder Society.</CopyrightInformation>
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<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Tofaris, George K" sort="Tofaris, George K" uniqKey="Tofaris G" first="George K" last="Tofaris">George K. Tofaris</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Alpha-synuclein dysfunction in Lewy body diseases.

Alpha-synuclein dysfunction in Lewy body diseases.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki