123I-Ioflupane SPECT in the diagnosis of suspected psychogenic Parkinsonism.
Identifieur interne : 002F05 ( PubMed/Checkpoint ); précédent : 002F04; suivant : 002F06123I-Ioflupane SPECT in the diagnosis of suspected psychogenic Parkinsonism.
Auteurs : Carles Gaig [Espagne] ; Maria José Martí ; Eduardo Tolosa ; Francesc Valldeoriola ; Pilar Paredes ; Francisco Juan Lome A ; Fernando NakamaeSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Adult, Aged, Female, Humans, Iodine Radioisotopes (diagnostic use), Iodine Radioisotopes (pharmacokinetics), Male, Middle Aged, Parkinsonian Disorders (diagnosis), Parkinsonian Disorders (etiology), Parkinsonian Disorders (radionuclide imaging), Psychotic Disorders (complications), Tomography, Emission-Computed, Single-Photon, Tropanes (diagnostic use), Tropanes (pharmacokinetics).
- MESH :
- chemical , diagnostic use : Iodine Radioisotopes, Tropanes.
- chemical , pharmacokinetics : Iodine Radioisotopes, Tropanes.
- complications : Psychotic Disorders.
- diagnosis : Parkinsonian Disorders.
- etiology : Parkinsonian Disorders.
- radionuclide imaging : Parkinsonian Disorders.
- Adult, Aged, Female, Humans, Male, Middle Aged, Tomography, Emission-Computed, Single-Photon.
Abstract
Psychogenic Parkinsonism (PsyP) can be clinically difficult to differentiate from Parkinson's disease (PD). Striatal dopamine transporter (DAT) imaging could be helpful in differentiating them. We performed (123)I-Ioflupane single-photon emission computed tomography (SPECT) in 9 patients with suspected PsyP. In 1 patient, (123)I-Ioflupane SPECT disclosed bilateral decrease of striatal tracer uptake that indicated nigrostriatal degeneration. In this patient, a parkin gene mutation was detected. In the other 8 patients, (123)I-Ioflupane SPECT was normal and supported the initial suspicion of PsyP. Normal DAT imaging supports the diagnosis of PsyP, whereas reduced striatal tracer uptake suggests an underlying neurodegenerative Parkinsonism and should encourage the search for additional causes for the syndrome.
DOI: 10.1002/mds.21062
PubMed: 16941463
Affiliations:
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pubmed:16941463Le document en format XML
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Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name></author><author><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name></author><author><name sortKey="Paredes, Pilar" sort="Paredes, Pilar" uniqKey="Paredes P" first="Pilar" last="Paredes">Pilar Paredes</name></author><author><name sortKey="Lome A, Francisco Juan" sort="Lome A, Francisco Juan" uniqKey="Lome A F" first="Francisco Juan" last="Lome A">Francisco Juan Lome A</name></author><author><name sortKey="Nakamae, Fernando" sort="Nakamae, Fernando" uniqKey="Nakamae F" first="Fernando" last="Nakamae">Fernando Nakamae</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="doi">10.1002/mds.21062</idno><idno type="RBID">pubmed:16941463</idno><idno type="pmid">16941463</idno><idno 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sortKey="Marti, Maria Jose" sort="Marti, Maria Jose" uniqKey="Marti M" first="Maria José" last="Martí">Maria José Martí</name></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name></author><author><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name></author><author><name sortKey="Paredes, Pilar" sort="Paredes, Pilar" uniqKey="Paredes P" first="Pilar" last="Paredes">Pilar Paredes</name></author><author><name sortKey="Lome A, Francisco Juan" sort="Lome A, Francisco Juan" uniqKey="Lome A F" first="Francisco Juan" last="Lome A">Francisco Juan Lome A</name></author><author><name sortKey="Nakamae, Fernando" sort="Nakamae, Fernando" uniqKey="Nakamae F" first="Fernando" last="Nakamae">Fernando Nakamae</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Iodine Radioisotopes (diagnostic use)</term><term>Iodine Radioisotopes (pharmacokinetics)</term><term>Male</term><term>Middle Aged</term><term>Parkinsonian Disorders (diagnosis)</term><term>Parkinsonian Disorders (etiology)</term><term>Parkinsonian Disorders (radionuclide imaging)</term><term>Psychotic Disorders (complications)</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Tropanes (diagnostic use)</term><term>Tropanes (pharmacokinetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Iodine Radioisotopes</term><term>Tropanes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Iodine Radioisotopes</term><term>Tropanes</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Psychotic Disorders</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Psychogenic Parkinsonism (PsyP) can be clinically difficult to differentiate from Parkinson's disease (PD). Striatal dopamine transporter (DAT) imaging could be helpful in differentiating them. We performed (123)I-Ioflupane single-photon emission computed tomography (SPECT) in 9 patients with suspected PsyP. In 1 patient, (123)I-Ioflupane SPECT disclosed bilateral decrease of striatal tracer uptake that indicated nigrostriatal degeneration. In this patient, a parkin gene mutation was detected. In the other 8 patients, (123)I-Ioflupane SPECT was normal and supported the initial suspicion of PsyP. Normal DAT imaging supports the diagnosis of PsyP, whereas reduced striatal tracer uptake suggests an underlying neurodegenerative Parkinsonism and should encourage the search for additional causes for the syndrome.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">16941463</PMID><DateCreated><Year>2006</Year><Month>12</Month><Day>05</Day></DateCreated><DateCompleted><Year>2007</Year><Month>02</Month><Day>20</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>21</Volume><Issue>11</Issue><PubDate><Year>2006</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>123I-Ioflupane SPECT in the diagnosis of suspected psychogenic Parkinsonism.</ArticleTitle><Pagination><MedlinePgn>1994-8</MedlinePgn></Pagination><Abstract><AbstractText>Psychogenic Parkinsonism (PsyP) can be clinically difficult to differentiate from Parkinson's disease (PD). Striatal dopamine transporter (DAT) imaging could be helpful in differentiating them. We performed (123)I-Ioflupane single-photon emission computed tomography (SPECT) in 9 patients with suspected PsyP. In 1 patient, (123)I-Ioflupane SPECT disclosed bilateral decrease of striatal tracer uptake that indicated nigrostriatal degeneration. In this patient, a parkin gene mutation was detected. In the other 8 patients, (123)I-Ioflupane SPECT was normal and supported the initial suspicion of PsyP. Normal DAT imaging supports the diagnosis of PsyP, whereas reduced striatal tracer uptake suggests an underlying neurodegenerative Parkinsonism and should encourage the search for additional causes for the syndrome.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gaig</LastName><ForeName>Carles</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic, University of Barcelona, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martí</LastName><ForeName>Maria José</ForeName><Initials>MJ</Initials></Author><Author ValidYN="Y"><LastName>Tolosa</LastName><ForeName>Eduardo</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Valldeoriola</LastName><ForeName>Francesc</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Paredes</LastName><ForeName>Pilar</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Lomeña</LastName><ForeName>Francisco Juan</ForeName><Initials>FJ</Initials></Author><Author ValidYN="Y"><LastName>Nakamae</LastName><ForeName>Fernando</ForeName><Initials>F</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007457">Iodine Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014326">Tropanes</NameOfSubstance></Chemical><Chemical><RegistryNumber>155797-99-2</RegistryNumber><NameOfSubstance UI="C087552">2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007457">Iodine Radioisotopes</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000176">diagnostic use</QualifierName><QualifierName MajorTopicYN="N" UI="Q000493">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020734">Parkinsonian Disorders</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000209">etiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000531">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011618">Psychotic Disorders</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000150">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D015899">Tomography, Emission-Computed, Single-Photon</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014326">Tropanes</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000176">diagnostic use</QualifierName><QualifierName MajorTopicYN="N" UI="Q000493">pharmacokinetics</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>8</Month><Day>31</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>2</Month><Day>21</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>8</Month><Day>31</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.21062</ArticleId><ArticleId IdType="pubmed">16941463</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country><region><li>Catalogne</li></region><settlement><li>Barcelone</li></settlement></list><tree><noCountry><name sortKey="Lome A, Francisco Juan" sort="Lome A, Francisco Juan" uniqKey="Lome A F" first="Francisco Juan" last="Lome A">Francisco Juan Lome A</name><name sortKey="Marti, Maria Jose" sort="Marti, Maria Jose" uniqKey="Marti M" first="Maria José" last="Martí">Maria José Martí</name><name sortKey="Nakamae, Fernando" sort="Nakamae, Fernando" uniqKey="Nakamae F" first="Fernando" last="Nakamae">Fernando Nakamae</name><name sortKey="Paredes, Pilar" sort="Paredes, Pilar" uniqKey="Paredes P" first="Pilar" last="Paredes">Pilar Paredes</name><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name></noCountry><country name="Espagne"><region name="Catalogne"><name sortKey="Gaig, Carles" sort="Gaig, Carles" uniqKey="Gaig C" first="Carles" last="Gaig">Carles Gaig</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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