A blessing in disguise: resolution of tardive dyskinesia with development of cervical myelitis.
Identifieur interne : 002F03 ( PubMed/Checkpoint ); précédent : 002F02; suivant : 002F04A blessing in disguise: resolution of tardive dyskinesia with development of cervical myelitis.
Auteurs : Erle Chuen-Hian Lim [Singapour] ; Einar P V. Wilder-Smith ; Raymond Chee-Seong SeetSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Adult, Antipsychotic Agents (adverse effects), Antipsychotic Agents (therapeutic use), Bipolar Disorder (drug therapy), Cervical Vertebrae, Dyskinesia, Drug-Induced (diagnosis), Follow-Up Studies, Haloperidol (adverse effects), Haloperidol (therapeutic use), Humans, Male, Myelitis (diagnosis), Myelitis (rehabilitation), Neurologic Examination (drug effects), Osteomyelitis (diagnosis), Osteomyelitis (rehabilitation), Quadriplegia (diagnosis), Quadriplegia (rehabilitation), Remission, Spontaneous.
- MESH :
- chemical , adverse effects : Antipsychotic Agents, Haloperidol.
- chemical , therapeutic use : Antipsychotic Agents, Haloperidol.
- diagnosis : Dyskinesia, Drug-Induced, Myelitis, Osteomyelitis, Quadriplegia.
- drug effects : Neurologic Examination.
- drug therapy : Bipolar Disorder.
- rehabilitation : Myelitis, Osteomyelitis, Quadriplegia.
- Adult, Cervical Vertebrae, Follow-Up Studies, Humans, Male, Remission, Spontaneous.
Abstract
Tardive dyskinesia (TD), which is frequently seen in patients treated with dopamine receptor blocking agents, is difficult to manage. We report on a young Chinese man with bipolar disorder who developed TD after haloperidol treatment, involving the trunk, limbs, and orofacial area. TD persisted despite switching to atypical antipsychotic agents and treatment with valproate, benzodiazepines, and tetrabenazine. Resolution only occurred years later when he developed quadriplegia arising from infective myelitis of the cervical cord (C4-5). He had concomitant vertebral osteomyelitis, which was successfully treated with intravenous antibiotics. With intensive rehabilitation, he recovered the use of his limbs, but had no recurrence of TD. We attribute the resolution of orofacial dyskinesias with a cervical lesion to the interconnections between the orofacial area and cervical spine via the trigeminal nucleus (which has fibers descending as far caudally as C6), as well as to resetting of cortical maps.
DOI: 10.1002/mds.20715
PubMed: 16211620
Affiliations:
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Wilder-Smith</name></author><author><name sortKey="Seet, Raymond Chee Seong" sort="Seet, Raymond Chee Seong" uniqKey="Seet R" first="Raymond Chee-Seong" last="Seet">Raymond Chee-Seong Seet</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="doi">10.1002/mds.20715</idno><idno type="RBID">pubmed:16211620</idno><idno type="pmid">16211620</idno><idno type="wicri:Area/PubMed/Corpus">002E35</idno><idno type="wicri:Area/PubMed/Curation">002E35</idno><idno type="wicri:Area/PubMed/Checkpoint">002F03</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A blessing in disguise: resolution of tardive dyskinesia with development of cervical myelitis.</title><author><name sortKey="Lim, Erle Chuen Hian" sort="Lim, Erle Chuen Hian" uniqKey="Lim E" first="Erle Chuen-Hian" last="Lim">Erle Chuen-Hian Lim</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology, National University Hospital, Singapore. mdcelch@nus.edu.sg</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Division of Neurology, National University Hospital</wicri:regionArea><wicri:noRegion>National University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Wilder Smith, Einar P V" sort="Wilder Smith, Einar P V" uniqKey="Wilder Smith E" first="Einar P V" last="Wilder-Smith">Einar P V. Wilder-Smith</name></author><author><name sortKey="Seet, Raymond Chee Seong" sort="Seet, Raymond Chee Seong" uniqKey="Seet R" first="Raymond Chee-Seong" last="Seet">Raymond Chee-Seong Seet</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antipsychotic Agents (adverse effects)</term><term>Antipsychotic Agents (therapeutic use)</term><term>Bipolar Disorder (drug therapy)</term><term>Cervical Vertebrae</term><term>Dyskinesia, Drug-Induced (diagnosis)</term><term>Follow-Up Studies</term><term>Haloperidol (adverse effects)</term><term>Haloperidol (therapeutic use)</term><term>Humans</term><term>Male</term><term>Myelitis (diagnosis)</term><term>Myelitis (rehabilitation)</term><term>Neurologic Examination (drug effects)</term><term>Osteomyelitis (diagnosis)</term><term>Osteomyelitis (rehabilitation)</term><term>Quadriplegia (diagnosis)</term><term>Quadriplegia (rehabilitation)</term><term>Remission, Spontaneous</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antipsychotic Agents</term><term>Haloperidol</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antipsychotic Agents</term><term>Haloperidol</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dyskinesia, Drug-Induced</term><term>Myelitis</term><term>Osteomyelitis</term><term>Quadriplegia</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Neurologic Examination</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Bipolar Disorder</term></keywords><keywords scheme="MESH" qualifier="rehabilitation" xml:lang="en"><term>Myelitis</term><term>Osteomyelitis</term><term>Quadriplegia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cervical Vertebrae</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Remission, Spontaneous</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Tardive dyskinesia (TD), which is frequently seen in patients treated with dopamine receptor blocking agents, is difficult to manage. We report on a young Chinese man with bipolar disorder who developed TD after haloperidol treatment, involving the trunk, limbs, and orofacial area. TD persisted despite switching to atypical antipsychotic agents and treatment with valproate, benzodiazepines, and tetrabenazine. Resolution only occurred years later when he developed quadriplegia arising from infective myelitis of the cervical cord (C4-5). He had concomitant vertebral osteomyelitis, which was successfully treated with intravenous antibiotics. With intensive rehabilitation, he recovered the use of his limbs, but had no recurrence of TD. We attribute the resolution of orofacial dyskinesias with a cervical lesion to the interconnections between the orofacial area and cervical spine via the trigeminal nucleus (which has fibers descending as far caudally as C6), as well as to resetting of cortical maps.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">16211620</PMID><DateCreated><Year>2006</Year><Month>01</Month><Day>19</Day></DateCreated><DateCompleted><Year>2006</Year><Month>07</Month><Day>03</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>21</Volume><Issue>1</Issue><PubDate><Year>2006</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>A blessing in disguise: resolution of tardive dyskinesia with development of cervical myelitis.</ArticleTitle><Pagination><MedlinePgn>120-2</MedlinePgn></Pagination><Abstract><AbstractText>Tardive dyskinesia (TD), which is frequently seen in patients treated with dopamine receptor blocking agents, is difficult to manage. We report on a young Chinese man with bipolar disorder who developed TD after haloperidol treatment, involving the trunk, limbs, and orofacial area. TD persisted despite switching to atypical antipsychotic agents and treatment with valproate, benzodiazepines, and tetrabenazine. Resolution only occurred years later when he developed quadriplegia arising from infective myelitis of the cervical cord (C4-5). He had concomitant vertebral osteomyelitis, which was successfully treated with intravenous antibiotics. With intensive rehabilitation, he recovered the use of his limbs, but had no recurrence of TD. We attribute the resolution of orofacial dyskinesias with a cervical lesion to the interconnections between the orofacial area and cervical spine via the trigeminal nucleus (which has fibers descending as far caudally as C6), as well as to resetting of cortical maps.</AbstractText><CopyrightInformation>Copyright (c) 2005 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lim</LastName><ForeName>Erle Chuen-Hian</ForeName><Initials>EC</Initials><AffiliationInfo><Affiliation>Division of Neurology, National University Hospital, Singapore. mdcelch@nus.edu.sg</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wilder-Smith</LastName><ForeName>Einar P V</ForeName><Initials>EP</Initials></Author><Author ValidYN="Y"><LastName>Seet</LastName><ForeName>Raymond Chee-Seong</ForeName><Initials>RC</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case 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MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009187">Myelitis</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000534">rehabilitation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009460">Neurologic Examination</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010019">Osteomyelitis</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000534">rehabilitation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011782">Quadriplegia</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000534">rehabilitation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012075">Remission, Spontaneous</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>10</Month><Day>8</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>7</Month><Day>4</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>10</Month><Day>8</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.20715</ArticleId><ArticleId IdType="pubmed">16211620</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Singapour</li></country></list><tree><noCountry><name sortKey="Seet, Raymond Chee Seong" sort="Seet, Raymond Chee Seong" uniqKey="Seet R" first="Raymond Chee-Seong" last="Seet">Raymond Chee-Seong Seet</name><name sortKey="Wilder Smith, Einar P V" sort="Wilder Smith, Einar P V" uniqKey="Wilder Smith E" first="Einar P V" last="Wilder-Smith">Einar P V. Wilder-Smith</name></noCountry><country name="Singapour"><noRegion><name sortKey="Lim, Erle Chuen Hian" sort="Lim, Erle Chuen Hian" uniqKey="Lim E" first="Erle Chuen-Hian" last="Lim">Erle Chuen-Hian Lim</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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