Health-related quality of life in multiple system atrophy.
Identifieur interne : 002D03 ( PubMed/Checkpoint ); précédent : 002D02; suivant : 002D04Health-related quality of life in multiple system atrophy.
Auteurs : Anette Schrag [Royaume-Uni] ; Felix Geser ; Michaela Stampfer-Kountchev ; Klaus Seppi ; Martin Sawires ; Martin Köllensperger ; Christoph Scherfler ; Niall Quinn ; Maria T. Pellecchia ; Paolo Barone ; Francesca Del Sorbo ; Alberto Albanese ; Karen Ostergaard ; Erik Dupont ; Adriana Cardozo ; Eduardo Tolosa ; Christer F. Nilsson ; H Kan Widner ; Olle Lindvall ; Nir Giladi ; Tanya Gurevich ; Christine Daniels ; Günther Deuschl ; Miguel Coelho ; Cristina Sampaio ; Michael Abele ; Thomas Klockgether ; Nicole Schimke ; Karla M. Eggert ; Wolfgang Oertel ; Ruth Djaldetti ; Carlo Colosimo ; Giuseppe Meco ; Werner Poewe [Autriche] ; Gregor K. WenningSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Anxiety (epidemiology), Cohort Studies, Depression (epidemiology), Disability Evaluation, Europe, European Continental Ancestry Group, Health Status, Humans, Motor Activity, Multiple System Atrophy (physiopathology), Multiple System Atrophy (psychology), Pain, Parkinson Disease (physiopathology), Parkinson Disease (psychology), Quality of Life, Questionnaires, Self Care.
- MESH :
- geographic : Europe.
- epidemiology : Anxiety, Depression.
- physiopathology : Multiple System Atrophy, Parkinson Disease.
- psychology : Multiple System Atrophy, Parkinson Disease.
- Cohort Studies, Disability Evaluation, European Continental Ancestry Group, Health Status, Humans, Motor Activity, Pain, Quality of Life, Questionnaires, Self Care.
Abstract
Although multiple system atrophy (MSA) is a neurodegenerative disorder leading to progressive disability and decreased life expectancy, little is known about patients' own evaluation of their illness and factors associated with poor health-related quality of life (Hr-QoL). We, therefore, assessed Hr-QoL and its determinants in MSA. The following scales were applied to 115 patients in the European MSA-Study Group (EMSA-SG) Natural History Study: Medical Outcome Study Short Form (SF-36), EQ-5D, Beck Depression Inventory (BDI), Mini-Mental state examination (MMSE), Unified MSA Rating Scale (UMSARS), Hoehn & Yahr (H&Y) Parkinson's disease staging scale, Composite Autonomic Symptom Scale (COMPASS), and Parkinson's Disease Sleep Scale (PDSS). Forty-six percent of patients had moderate to severe depression (BDI > or = 17); Hr-QoL scores on the SF-36 and EQ-5D were significantly impaired. Pain, the only domain with similar scores in MSA and published PD patients, was reported more frequently in patients with MSA-P (predominantly parkinsonian motor subtype) than MSA-C (predominantly cerebellar motor subtype; 76% vs. 50%; P = 0.005). Hr-QoL scores correlated most strongly with UMSARS motor, COMPASS, and BDI scores but not with MMSE scores, age at onset, or disease duration. The COMPASS and UMSARS activities of daily living scores were moderate-to-strong predictors for the SF-36 physical summary score and the BDI and UMSARS motor scores for the SF-36 mental summary score. This report is the first study to show that Hr-QoL is significantly impaired in MSA. Although not all possible factors related to impaired Hr-QoL in MSA could be assessed, autonomic dysfunction, motor impairment, and depression were most closely associated with poor Hr-QoL, and therapeutic management, therefore, should concentrate upon these aspects of the disease.
DOI: 10.1002/mds.20808
PubMed: 16502399
Affiliations:
- Autriche, Royaume-Uni
- Angleterre, Grand Londres, Tyrol (Land)
- Innsbruck, Londres
- Université de médecine d'Innsbruck
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pubmed:16502399Le document en format XML
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<author><name sortKey="Abele, Michael" sort="Abele, Michael" uniqKey="Abele M" first="Michael" last="Abele">Michael Abele</name>
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<front><div type="abstract" xml:lang="en">Although multiple system atrophy (MSA) is a neurodegenerative disorder leading to progressive disability and decreased life expectancy, little is known about patients' own evaluation of their illness and factors associated with poor health-related quality of life (Hr-QoL). We, therefore, assessed Hr-QoL and its determinants in MSA. The following scales were applied to 115 patients in the European MSA-Study Group (EMSA-SG) Natural History Study: Medical Outcome Study Short Form (SF-36), EQ-5D, Beck Depression Inventory (BDI), Mini-Mental state examination (MMSE), Unified MSA Rating Scale (UMSARS), Hoehn & Yahr (H&Y) Parkinson's disease staging scale, Composite Autonomic Symptom Scale (COMPASS), and Parkinson's Disease Sleep Scale (PDSS). Forty-six percent of patients had moderate to severe depression (BDI > or = 17); Hr-QoL scores on the SF-36 and EQ-5D were significantly impaired. Pain, the only domain with similar scores in MSA and published PD patients, was reported more frequently in patients with MSA-P (predominantly parkinsonian motor subtype) than MSA-C (predominantly cerebellar motor subtype; 76% vs. 50%; P = 0.005). Hr-QoL scores correlated most strongly with UMSARS motor, COMPASS, and BDI scores but not with MMSE scores, age at onset, or disease duration. The COMPASS and UMSARS activities of daily living scores were moderate-to-strong predictors for the SF-36 physical summary score and the BDI and UMSARS motor scores for the SF-36 mental summary score. This report is the first study to show that Hr-QoL is significantly impaired in MSA. Although not all possible factors related to impaired Hr-QoL in MSA could be assessed, autonomic dysfunction, motor impairment, and depression were most closely associated with poor Hr-QoL, and therapeutic management, therefore, should concentrate upon these aspects of the disease.</div>
</front>
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<DateCreated><Year>2006</Year>
<Month>06</Month>
<Day>13</Day>
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<DateCompleted><Year>2006</Year>
<Month>11</Month>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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<ArticleTitle>Health-related quality of life in multiple system atrophy.</ArticleTitle>
<Pagination><MedlinePgn>809-15</MedlinePgn>
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<Abstract><AbstractText>Although multiple system atrophy (MSA) is a neurodegenerative disorder leading to progressive disability and decreased life expectancy, little is known about patients' own evaluation of their illness and factors associated with poor health-related quality of life (Hr-QoL). We, therefore, assessed Hr-QoL and its determinants in MSA. The following scales were applied to 115 patients in the European MSA-Study Group (EMSA-SG) Natural History Study: Medical Outcome Study Short Form (SF-36), EQ-5D, Beck Depression Inventory (BDI), Mini-Mental state examination (MMSE), Unified MSA Rating Scale (UMSARS), Hoehn & Yahr (H&Y) Parkinson's disease staging scale, Composite Autonomic Symptom Scale (COMPASS), and Parkinson's Disease Sleep Scale (PDSS). Forty-six percent of patients had moderate to severe depression (BDI > or = 17); Hr-QoL scores on the SF-36 and EQ-5D were significantly impaired. Pain, the only domain with similar scores in MSA and published PD patients, was reported more frequently in patients with MSA-P (predominantly parkinsonian motor subtype) than MSA-C (predominantly cerebellar motor subtype; 76% vs. 50%; P = 0.005). Hr-QoL scores correlated most strongly with UMSARS motor, COMPASS, and BDI scores but not with MMSE scores, age at onset, or disease duration. The COMPASS and UMSARS activities of daily living scores were moderate-to-strong predictors for the SF-36 physical summary score and the BDI and UMSARS motor scores for the SF-36 mental summary score. This report is the first study to show that Hr-QoL is significantly impaired in MSA. Although not all possible factors related to impaired Hr-QoL in MSA could be assessed, autonomic dysfunction, motor impairment, and depression were most closely associated with poor Hr-QoL, and therapeutic management, therefore, should concentrate upon these aspects of the disease.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schrag</LastName>
<ForeName>Anette</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Neurosciences, Royal Free & University College Medical School, London, United Kingdom.</Affiliation>
</AffiliationInfo>
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<ForeName>Michaela</ForeName>
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<Author ValidYN="Y"><LastName>Seppi</LastName>
<ForeName>Klaus</ForeName>
<Initials>K</Initials>
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<Author ValidYN="Y"><LastName>Sawires</LastName>
<ForeName>Martin</ForeName>
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<ForeName>Martin</ForeName>
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<Author ValidYN="Y"><LastName>Scherfler</LastName>
<ForeName>Christoph</ForeName>
<Initials>C</Initials>
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<Author ValidYN="Y"><LastName>Quinn</LastName>
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<Initials>N</Initials>
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<ForeName>Adriana</ForeName>
<Initials>A</Initials>
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<Initials>E</Initials>
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<ForeName>Christer F</ForeName>
<Initials>CF</Initials>
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<ForeName>Håkan</ForeName>
<Initials>H</Initials>
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<ForeName>Olle</ForeName>
<Initials>O</Initials>
</Author>
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<ForeName>Nir</ForeName>
<Initials>N</Initials>
</Author>
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<ForeName>Tanya</ForeName>
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<Initials>C</Initials>
</Author>
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<ForeName>Günther</ForeName>
<Initials>G</Initials>
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<ForeName>Michael</ForeName>
<Initials>M</Initials>
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<ForeName>Thomas</ForeName>
<Initials>T</Initials>
</Author>
<Author ValidYN="Y"><LastName>Schimke</LastName>
<ForeName>Nicole</ForeName>
<Initials>N</Initials>
</Author>
<Author ValidYN="Y"><LastName>Eggert</LastName>
<ForeName>Karla M</ForeName>
<Initials>KM</Initials>
</Author>
<Author ValidYN="Y"><LastName>Oertel</LastName>
<ForeName>Wolfgang</ForeName>
<Initials>W</Initials>
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<ForeName>Ruth</ForeName>
<Initials>R</Initials>
</Author>
<Author ValidYN="Y"><LastName>Colosimo</LastName>
<ForeName>Carlo</ForeName>
<Initials>C</Initials>
</Author>
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<ForeName>Giuseppe</ForeName>
<Initials>G</Initials>
</Author>
<Author ValidYN="Y"><LastName>Poewe</LastName>
<ForeName>Werner</ForeName>
<Initials>W</Initials>
</Author>
<Author ValidYN="Y"><LastName>Wenning</LastName>
<ForeName>Gregor K</ForeName>
<Initials>GK</Initials>
</Author>
<Author ValidYN="Y"><CollectiveName>European MSA-Study Group</CollectiveName>
</Author>
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<Language>eng</Language>
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<MedlineTA>Mov Disord</MedlineTA>
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<ISSNLinking>0885-3185</ISSNLinking>
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<QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D004185">Disability Evaluation</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D044465">European Continental Ancestry Group</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="Y" UI="D006304">Health Status</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D009043">Motor Activity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D019578">Multiple System Atrophy</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D010146">Pain</DescriptorName>
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<QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="Y" UI="D011788">Quality of Life</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D011795">Questionnaires</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D012648">Self Care</DescriptorName>
</MeshHeading>
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<Month>2</Month>
<Day>28</Day>
<Hour>9</Hour>
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<PubMedPubDate PubStatus="medline"><Year>2006</Year>
<Month>11</Month>
<Day>15</Day>
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<ArticleIdList><ArticleId IdType="doi">10.1002/mds.20808</ArticleId>
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<li>Royaume-Uni</li>
</country>
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<li>Grand Londres</li>
<li>Tyrol (Land)</li>
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<settlement><li>Innsbruck</li>
<li>Londres</li>
</settlement>
<orgName><li>Université de médecine d'Innsbruck</li>
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