Melanized nigral neuronal numbers in Nigerian and British individuals.
Identifieur interne : 002C38 ( PubMed/Checkpoint ); précédent : 002C37; suivant : 002C39Melanized nigral neuronal numbers in Nigerian and British individuals.
Auteurs : Uday B. Muthane [Inde] ; Yasha T. Chickabasaviah ; Jasmine Henderson ; Ann E. Kingsbury ; Linda Kilford ; Susarla K. Shankar ; D K Subbakrishna ; Andrew J. LeesSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
Descripteurs français
- Wicri :
- geographic : Nigeria.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Melanins, alpha-Synuclein.
- geographic : Great Britain, Nigeria.
- cytology : Neurons, Substantia Nigra.
- metabolism : Neurons, Parkinson Disease, Substantia Nigra.
- pathology : Parkinson Disease.
- Cell Count, Humans, Reference Values.
Abstract
The role of genetic and environmental factors in etiopathogenesis of Parkinson's disease (PD) is debated. The prevalence of PD is higher among white than nonwhite populations, yet it is five times higher in nonwhites living in the United States than in Nigeria. We compare counts of melanized nigral neurons between neurologically normal Nigerians and British brains. Neuronal counts were estimated in an age-matched sample of 23 Nigerian and 7 British brains from neurologically normal individuals who had no Lewy bodies and Lewy neurites on alpha-synuclein immunostaining. Two investigators blind to age and ethnicity performed counts of melanized neurons in a single 7-mum hemisections showing the substantia nigra pars compacta. No significant difference exits in the number of neurons between the Nigerian and the British subjects (P = 0.1, NS). Differences in melanized nigral neuronal numbers may not explain differences in the prevalence of PD between white and nonwhite populations, suggesting factors other than neuronal numbers contribute to differential susceptibility of black vs. white races to PD.
DOI: 10.1002/mds.20917
PubMed: 16673400
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Melanized nigral neuronal numbers in Nigerian and British individuals.</title><author><name sortKey="Muthane, Uday B" sort="Muthane, Uday B" uniqKey="Muthane U" first="Uday B" last="Muthane">Uday B. Muthane</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India. umuthane@usa.net</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore</wicri:regionArea><wicri:noRegion>Bangalore</wicri:noRegion></affiliation></author><author><name sortKey="Chickabasaviah, Yasha T" sort="Chickabasaviah, Yasha T" uniqKey="Chickabasaviah Y" first="Yasha T" last="Chickabasaviah">Yasha T. Chickabasaviah</name></author><author><name sortKey="Henderson, Jasmine" sort="Henderson, Jasmine" uniqKey="Henderson J" first="Jasmine" last="Henderson">Jasmine Henderson</name></author><author><name sortKey="Kingsbury, Ann E" sort="Kingsbury, Ann E" uniqKey="Kingsbury A" first="Ann E" last="Kingsbury">Ann E. Kingsbury</name></author><author><name sortKey="Kilford, Linda" sort="Kilford, Linda" uniqKey="Kilford L" first="Linda" last="Kilford">Linda Kilford</name></author><author><name sortKey="Shankar, Susarla K" sort="Shankar, Susarla K" uniqKey="Shankar S" first="Susarla K" last="Shankar">Susarla K. Shankar</name></author><author><name sortKey="Subbakrishna, D K" sort="Subbakrishna, D K" uniqKey="Subbakrishna D" first="D K" last="Subbakrishna">D K Subbakrishna</name></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew J. Lees</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="doi">10.1002/mds.20917</idno><idno type="RBID">pubmed:16673400</idno><idno type="pmid">16673400</idno><idno type="wicri:Area/PubMed/Corpus">002C61</idno><idno type="wicri:Area/PubMed/Curation">002C61</idno><idno type="wicri:Area/PubMed/Checkpoint">002C38</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Melanized nigral neuronal numbers in Nigerian and British individuals.</title><author><name sortKey="Muthane, Uday B" sort="Muthane, Uday B" uniqKey="Muthane U" first="Uday B" last="Muthane">Uday B. 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Kingsbury</name></author><author><name sortKey="Kilford, Linda" sort="Kilford, Linda" uniqKey="Kilford L" first="Linda" last="Kilford">Linda Kilford</name></author><author><name sortKey="Shankar, Susarla K" sort="Shankar, Susarla K" uniqKey="Shankar S" first="Susarla K" last="Shankar">Susarla K. Shankar</name></author><author><name sortKey="Subbakrishna, D K" sort="Subbakrishna, D K" uniqKey="Subbakrishna D" first="D K" last="Subbakrishna">D K Subbakrishna</name></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew J. Lees</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Count</term><term>Great Britain</term><term>Humans</term><term>Melanins (metabolism)</term><term>Neurons (cytology)</term><term>Neurons (metabolism)</term><term>Nigeria</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (pathology)</term><term>Reference Values</term><term>Substantia Nigra (cytology)</term><term>Substantia Nigra (metabolism)</term><term>alpha-Synuclein (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Melanins</term><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Great Britain</term><term>Nigeria</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Neurons</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Neurons</term><term>Parkinson Disease</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Count</term><term>Humans</term><term>Reference Values</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Nigeria</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The role of genetic and environmental factors in etiopathogenesis of Parkinson's disease (PD) is debated. The prevalence of PD is higher among white than nonwhite populations, yet it is five times higher in nonwhites living in the United States than in Nigeria. We compare counts of melanized nigral neurons between neurologically normal Nigerians and British brains. Neuronal counts were estimated in an age-matched sample of 23 Nigerian and 7 British brains from neurologically normal individuals who had no Lewy bodies and Lewy neurites on alpha-synuclein immunostaining. Two investigators blind to age and ethnicity performed counts of melanized neurons in a single 7-mum hemisections showing the substantia nigra pars compacta. No significant difference exits in the number of neurons between the Nigerian and the British subjects (P = 0.1, NS). Differences in melanized nigral neuronal numbers may not explain differences in the prevalence of PD between white and nonwhite populations, suggesting factors other than neuronal numbers contribute to differential susceptibility of black vs. white races to PD.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">16673400</PMID><DateCreated><Year>2006</Year><Month>08</Month><Day>30</Day></DateCreated><DateCompleted><Year>2007</Year><Month>01</Month><Day>04</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>21</Volume><Issue>8</Issue><PubDate><Year>2006</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Melanized nigral neuronal numbers in Nigerian and British individuals.</ArticleTitle><Pagination><MedlinePgn>1239-41</MedlinePgn></Pagination><Abstract><AbstractText>The role of genetic and environmental factors in etiopathogenesis of Parkinson's disease (PD) is debated. The prevalence of PD is higher among white than nonwhite populations, yet it is five times higher in nonwhites living in the United States than in Nigeria. We compare counts of melanized nigral neurons between neurologically normal Nigerians and British brains. Neuronal counts were estimated in an age-matched sample of 23 Nigerian and 7 British brains from neurologically normal individuals who had no Lewy bodies and Lewy neurites on alpha-synuclein immunostaining. Two investigators blind to age and ethnicity performed counts of melanized neurons in a single 7-mum hemisections showing the substantia nigra pars compacta. No significant difference exits in the number of neurons between the Nigerian and the British subjects (P = 0.1, NS). Differences in melanized nigral neuronal numbers may not explain differences in the prevalence of PD between white and nonwhite populations, suggesting factors other than neuronal numbers contribute to differential susceptibility of black vs. white races to PD.</AbstractText><CopyrightInformation>(c) 2006 Movement Disorder Society</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Muthane</LastName><ForeName>Uday B</ForeName><Initials>UB</Initials><AffiliationInfo><Affiliation>Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India. umuthane@usa.net</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chickabasaviah</LastName><ForeName>Yasha T</ForeName><Initials>YT</Initials></Author><Author ValidYN="Y"><LastName>Henderson</LastName><ForeName>Jasmine</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Kingsbury</LastName><ForeName>Ann E</ForeName><Initials>AE</Initials></Author><Author ValidYN="Y"><LastName>Kilford</LastName><ForeName>Linda</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Shankar</LastName><ForeName>Susarla K</ForeName><Initials>SK</Initials></Author><Author ValidYN="Y"><LastName>Subbakrishna</LastName><ForeName>D K</ForeName><Initials>DK</Initials></Author><Author ValidYN="Y"><LastName>Lees</LastName><ForeName>Andrew J</ForeName><Initials>AJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008543">Melanins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051844">alpha-Synuclein</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002452">Cell Count</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" Type="Geographic" UI="D006113">Great Britain</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008543">Melanins</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009474">Neurons</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000166">cytology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" Type="Geographic" UI="D009549">Nigeria</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012016">Reference Values</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013378">Substantia Nigra</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000166">cytology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D051844">alpha-Synuclein</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>5</Month><Day>5</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>1</Month><Day>5</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>5</Month><Day>5</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.20917</ArticleId><ArticleId IdType="pubmed">16673400</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Chickabasaviah, Yasha T" sort="Chickabasaviah, Yasha T" uniqKey="Chickabasaviah Y" first="Yasha T" last="Chickabasaviah">Yasha T. Chickabasaviah</name><name sortKey="Henderson, Jasmine" sort="Henderson, Jasmine" uniqKey="Henderson J" first="Jasmine" last="Henderson">Jasmine Henderson</name><name sortKey="Kilford, Linda" sort="Kilford, Linda" uniqKey="Kilford L" first="Linda" last="Kilford">Linda Kilford</name><name sortKey="Kingsbury, Ann E" sort="Kingsbury, Ann E" uniqKey="Kingsbury A" first="Ann E" last="Kingsbury">Ann E. Kingsbury</name><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew J. Lees</name><name sortKey="Shankar, Susarla K" sort="Shankar, Susarla K" uniqKey="Shankar S" first="Susarla K" last="Shankar">Susarla K. Shankar</name><name sortKey="Subbakrishna, D K" sort="Subbakrishna, D K" uniqKey="Subbakrishna D" first="D K" last="Subbakrishna">D K Subbakrishna</name></noCountry><country name="Inde"><noRegion><name sortKey="Muthane, Uday B" sort="Muthane, Uday B" uniqKey="Muthane U" first="Uday B" last="Muthane">Uday B. 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