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Progressive supranuclear palsy: phenotypic sex differences in a clinical cohort.

Identifieur interne : 002B39 ( PubMed/Checkpoint ); précédent : 002B38; suivant : 002B40

Progressive supranuclear palsy: phenotypic sex differences in a clinical cohort.

Auteurs : Yasuhiko Baba [États-Unis] ; John D. Putzke ; Nathaniel R. Whaley ; Zbigniew K. Wszolek ; Ryan J. Uitti

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.

RBID : pubmed:16342256

English descriptors

KwdEn :
- Adult, Age of Onset, Aged, Aged, 80 and over, Body Mass Index, Cohort Studies, Female, Humans, Male, Middle Aged, Phenotype, Retrospective Studies, Severity of Illness Index, Sex Characteristics, Supranuclear Palsy, Progressive (epidemiology), Supranuclear Palsy, Progressive (physiopathology).
MESH :
- epidemiology : Supranuclear Palsy, Progressive.
- physiopathology : Supranuclear Palsy, Progressive.
- Adult, Age of Onset, Aged, Aged, 80 and over, Body Mass Index, Cohort Studies, Female, Humans, Male, Middle Aged, Phenotype, Retrospective Studies, Severity of Illness Index, Sex Characteristics.

Abstract

We examined sex-based differences in phenotypic expression among a consecutive clinical series of 121 individuals diagnosed with probable progressive supranuclear palsy (PSP). For both men (44%) and women (56%), the age at symptomatic onset (66.2 and 68.5 years, respectively) and disease duration (4.6 and 4.3 years, respectively) were similar. The overwhelming majority of sex-based comparisons showed no significant difference on a variety of demographic, historical, and clinical characteristics, as well as measures of disease progression. The only differences observed were that men had significantly worse tremor as measured by the Unified Parkinson's Disease Rating Scale tremor subscore (0.9 for men and 0.3 for women, P<0.01) and men had a significantly higher mean body mass index (BMI; 28.2 for men and 25.1 for women, P=0.01), although these differences were not significant after Bonferroni correction. In general, the disease phenotype was similar between men and women, suggesting that sex may have little or no influence on the development, expression, or progression of the PSP phenotype.

DOI: 10.1002/mds.20769
PubMed: 16342256

Affiliations:

États-Unis

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Le document en format XML

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<author><name sortKey="Baba, Yasuhiko" sort="Baba, Yasuhiko" uniqKey="Baba Y" first="Yasuhiko" last="Baba">Yasuhiko Baba</name>
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<author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K" last="Wszolek">Zbigniew K. Wszolek</name>
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<front><div type="abstract" xml:lang="en">We examined sex-based differences in phenotypic expression among a consecutive clinical series of 121 individuals diagnosed with probable progressive supranuclear palsy (PSP). For both men (44%) and women (56%), the age at symptomatic onset (66.2 and 68.5 years, respectively) and disease duration (4.6 and 4.3 years, respectively) were similar. The overwhelming majority of sex-based comparisons showed no significant difference on a variety of demographic, historical, and clinical characteristics, as well as measures of disease progression. The only differences observed were that men had significantly worse tremor as measured by the Unified Parkinson's Disease Rating Scale tremor subscore (0.9 for men and 0.3 for women, P<0.01) and men had a significantly higher mean body mass index (BMI; 28.2 for men and 25.1 for women, P=0.01), although these differences were not significant after Bonferroni correction. In general, the disease phenotype was similar between men and women, suggesting that sex may have little or no influence on the development, expression, or progression of the PSP phenotype.</div>
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<Abstract><AbstractText>We examined sex-based differences in phenotypic expression among a consecutive clinical series of 121 individuals diagnosed with probable progressive supranuclear palsy (PSP). For both men (44%) and women (56%), the age at symptomatic onset (66.2 and 68.5 years, respectively) and disease duration (4.6 and 4.3 years, respectively) were similar. The overwhelming majority of sex-based comparisons showed no significant difference on a variety of demographic, historical, and clinical characteristics, as well as measures of disease progression. The only differences observed were that men had significantly worse tremor as measured by the Unified Parkinson's Disease Rating Scale tremor subscore (0.9 for men and 0.3 for women, P<0.01) and men had a significantly higher mean body mass index (BMI; 28.2 for men and 25.1 for women, P=0.01), although these differences were not significant after Bonferroni correction. In general, the disease phenotype was similar between men and women, suggesting that sex may have little or no influence on the development, expression, or progression of the PSP phenotype.</AbstractText>
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Movement Disorders (revue)

Progressive supranuclear palsy: phenotypic sex differences in a clinical cohort.

Progressive supranuclear palsy: phenotypic sex differences in a clinical cohort.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki