ELAVL4, PARK10, and the Celts.
Identifieur interne : 002847 ( PubMed/Checkpoint ); précédent : 002846; suivant : 002848ELAVL4, PARK10, and the Celts.
Auteurs : Kristoffer Haugarvoll [États-Unis] ; Mathias Toft ; Owen A. Ross ; Jeremy T. Stone ; Michael G. Heckman ; Linda R. White ; Timothy Lynch ; John Mark Gibson ; Zbigniew K. Wszolek ; Ryan J. Uitti ; Jan O. Aasly ; Matthew J. FarrerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
Descripteurs français
- Wicri :
- geographic : Norvège.
English descriptors
- KwdEn :
- Adult, Age Factors, Aged, Aged, 80 and over, Alleles, Female, Genetic Linkage (genetics), Genetic Markers, Genetic Predisposition to Disease, Hu Paraneoplastic Encephalomyelitis Antigens (genetics), Humans, Male, Middle Aged, Norway (ethnology), Parkinson Disease (ethnology), Parkinson Disease (genetics), Point Mutation (genetics), Protein-Serine-Threonine Kinases (genetics), Ubiquitin-Protein Ligases (genetics), United States.
- MESH :
- chemical , genetics : Hu Paraneoplastic Encephalomyelitis Antigens, Protein-Serine-Threonine Kinases, Ubiquitin-Protein Ligases.
- chemical : Genetic Markers.
- geographic , ethnology : Norway.
- ethnology : Parkinson Disease.
- genetics : Genetic Linkage, Parkinson Disease, Point Mutation.
- Adult, Age Factors, Aged, Aged, 80 and over, Alleles, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, United States.
Abstract
Genetic variability in ELAVL4 located in the PARK10 locus was recently associated with age-at-onset (AAO) in a series of Parkinson's disease (PD) patients originating from the United States. We examined five markers spanning ELAVL4 in Norwegian, United States, and Irish PD case-control samples. No association was found between the examined markers and AAO or PD in Norwegian or US samples. However, ELAVL4 markers (rs967582 and rs3902720) were significantly associated with susceptibility to PD in our Irish series. Our data suggest that the association between ELAVL4 and PD previously observed might be explained by a Celtic-founder effect.
DOI: 10.1002/mds.21336
PubMed: 17230446
Affiliations:
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Links to Exploration step
pubmed:17230446Le document en format XML
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<term>Genetic Linkage (genetics)</term>
<term>Genetic Markers</term>
<term>Genetic Predisposition to Disease</term>
<term>Hu Paraneoplastic Encephalomyelitis Antigens (genetics)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Norway (ethnology)</term>
<term>Parkinson Disease (ethnology)</term>
<term>Parkinson Disease (genetics)</term>
<term>Point Mutation (genetics)</term>
<term>Protein-Serine-Threonine Kinases (genetics)</term>
<term>Ubiquitin-Protein Ligases (genetics)</term>
<term>United States</term>
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<term>Ubiquitin-Protein Ligases</term>
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<front><div type="abstract" xml:lang="en">Genetic variability in ELAVL4 located in the PARK10 locus was recently associated with age-at-onset (AAO) in a series of Parkinson's disease (PD) patients originating from the United States. We examined five markers spanning ELAVL4 in Norwegian, United States, and Irish PD case-control samples. No association was found between the examined markers and AAO or PD in Norwegian or US samples. However, ELAVL4 markers (rs967582 and rs3902720) were significantly associated with susceptibility to PD in our Irish series. Our data suggest that the association between ELAVL4 and PD previously observed might be explained by a Celtic-founder effect.</div>
</front>
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<Month>04</Month>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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<ArticleTitle>ELAVL4, PARK10, and the Celts.</ArticleTitle>
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<Abstract><AbstractText>Genetic variability in ELAVL4 located in the PARK10 locus was recently associated with age-at-onset (AAO) in a series of Parkinson's disease (PD) patients originating from the United States. We examined five markers spanning ELAVL4 in Norwegian, United States, and Irish PD case-control samples. No association was found between the examined markers and AAO or PD in Norwegian or US samples. However, ELAVL4 markers (rs967582 and rs3902720) were significantly associated with susceptibility to PD in our Irish series. Our data suggest that the association between ELAVL4 and PD previously observed might be explained by a Celtic-founder effect.</AbstractText>
<CopyrightInformation>(c) 2006 Movement Disorder Society.</CopyrightInformation>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
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<Chemical><RegistryNumber>EC 6.3.2.19</RegistryNumber>
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