Striatal dopamine transporter imaging correlates with depressive symptoms and tower of London task performance in Parkinson's disease.
Identifieur interne : 002077 ( PubMed/Checkpoint ); précédent : 002076; suivant : 002078Striatal dopamine transporter imaging correlates with depressive symptoms and tower of London task performance in Parkinson's disease.
Auteurs : Irena Rektorova [République tchèque] ; Hana Srovnalova ; Radka Kubikova ; Jiri PrasekSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- Aged, Cognition (physiology), Corpus Striatum (metabolism), Corpus Striatum (radionuclide imaging), Depression (etiology), Depression (radionuclide imaging), Dopamine Plasma Membrane Transport Proteins (metabolism), Female, Humans, Iodine Radioisotopes (diagnostic use), Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (radionuclide imaging), Regression Analysis, Severity of Illness Index, Tomography, Emission-Computed, Single-Photon (methods), Tropanes (diagnostic use).
- MESH :
- chemical , diagnostic use : Iodine Radioisotopes, Tropanes.
- chemical , metabolism : Dopamine Plasma Membrane Transport Proteins.
- complications : Parkinson Disease.
- etiology : Depression.
- metabolism : Corpus Striatum.
- methods : Tomography, Emission-Computed, Single-Photon.
- physiology : Cognition.
- radionuclide imaging : Corpus Striatum, Depression, Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Regression Analysis, Severity of Illness Index.
Abstract
We studied whether the (123)I-FP-CIT uptake in the striatum correlates with depressive symptoms and cognitive performance in patients with Parkinson's disease (PD). Twenty patients with PD without major depression and/or dementia (mean age 61.7 +/- 12.7 years) underwent the (123)I-FP-CIT SPECT. Depressive symptoms and cognitive performance were assessed in the ON state. The ratios of striatal to occipital binding for the entire striatum, putamina, and putamen to the caudate (put/caud) index were calculated in the basal ganglia. The association between neuropsychiatric measures and dopamine transporter (DAT) availability was calculated; multiple regression analysis was used to assess association with age and disease duration. We found significant correlations between Montgomery and Asberg Depression Rating Scale (MARDS) and Tower of London (TOL) task scores and (123)I-FP-CIT uptake in various striatal ROIs. Multiple regression analysis confirmed the significant relationship between TOL performance and put/caud ratio (P = 0.001) and to age (P = 0.001), and between MADRS and left striatal (P = 0.005) and putaminal DAT availability (P = 0.003). Our pilot study results demonstrate that imaging with (123)I-FP-CIT SPECT appears to be sensitive for detecting dopaminergic deficit associated with mild depressive symptoms and specific cognitive dysfunction in patients with PD, yet without a current depressive episode and/or dementia.
DOI: 10.1002/mds.22158
PubMed: 18618663
Affiliations:
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Srovnalova</name></author><author><name sortKey="Kubikova, Radka" sort="Kubikova, Radka" uniqKey="Kubikova R" first="Radka" last="Kubikova">Radka Kubikova</name></author><author><name sortKey="Prasek, Jiri" sort="Prasek, Jiri" uniqKey="Prasek J" first="Jiri" last="Prasek">Jiri Prasek</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="doi">10.1002/mds.22158</idno><idno type="RBID">pubmed:18618663</idno><idno type="pmid">18618663</idno><idno type="wicri:Area/PubMed/Corpus">002158</idno><idno type="wicri:Area/PubMed/Curation">002158</idno><idno type="wicri:Area/PubMed/Checkpoint">002077</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Striatal dopamine transporter imaging correlates with depressive symptoms and tower of London task performance in Parkinson's disease.</title><author><name sortKey="Rektorova, Irena" sort="Rektorova, Irena" uniqKey="Rektorova I" first="Irena" last="Rektorova">Irena Rektorova</name><affiliation wicri:level="3"><nlm:affiliation>Movement Disorders Centre, First Department of Neurology, Masaryk University, St. Anne's Teaching Hospital, Brno, Czech Republic. irena.rektorova@fnusa.cz</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Movement Disorders Centre, First Department of Neurology, Masaryk University, St. Anne's Teaching Hospital, Brno</wicri:regionArea><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation></author><author><name sortKey="Srovnalova, Hana" sort="Srovnalova, Hana" uniqKey="Srovnalova H" first="Hana" last="Srovnalova">Hana Srovnalova</name></author><author><name sortKey="Kubikova, Radka" sort="Kubikova, Radka" uniqKey="Kubikova R" first="Radka" last="Kubikova">Radka Kubikova</name></author><author><name sortKey="Prasek, Jiri" sort="Prasek, Jiri" uniqKey="Prasek J" first="Jiri" last="Prasek">Jiri Prasek</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Cognition (physiology)</term><term>Corpus Striatum (metabolism)</term><term>Corpus Striatum (radionuclide imaging)</term><term>Depression (etiology)</term><term>Depression (radionuclide imaging)</term><term>Dopamine Plasma Membrane Transport Proteins (metabolism)</term><term>Female</term><term>Humans</term><term>Iodine Radioisotopes (diagnostic use)</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (radionuclide imaging)</term><term>Regression Analysis</term><term>Severity of Illness Index</term><term>Tomography, Emission-Computed, Single-Photon (methods)</term><term>Tropanes (diagnostic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Iodine Radioisotopes</term><term>Tropanes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine Plasma Membrane Transport Proteins</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Depression</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cognition</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Corpus Striatum</term><term>Depression</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Regression Analysis</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied whether the (123)I-FP-CIT uptake in the striatum correlates with depressive symptoms and cognitive performance in patients with Parkinson's disease (PD). Twenty patients with PD without major depression and/or dementia (mean age 61.7 +/- 12.7 years) underwent the (123)I-FP-CIT SPECT. Depressive symptoms and cognitive performance were assessed in the ON state. The ratios of striatal to occipital binding for the entire striatum, putamina, and putamen to the caudate (put/caud) index were calculated in the basal ganglia. The association between neuropsychiatric measures and dopamine transporter (DAT) availability was calculated; multiple regression analysis was used to assess association with age and disease duration. We found significant correlations between Montgomery and Asberg Depression Rating Scale (MARDS) and Tower of London (TOL) task scores and (123)I-FP-CIT uptake in various striatal ROIs. Multiple regression analysis confirmed the significant relationship between TOL performance and put/caud ratio (P = 0.001) and to age (P = 0.001), and between MADRS and left striatal (P = 0.005) and putaminal DAT availability (P = 0.003). Our pilot study results demonstrate that imaging with (123)I-FP-CIT SPECT appears to be sensitive for detecting dopaminergic deficit associated with mild depressive symptoms and specific cognitive dysfunction in patients with PD, yet without a current depressive episode and/or dementia.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">18618663</PMID><DateCreated><Year>2008</Year><Month>10</Month><Day>02</Day></DateCreated><DateCompleted><Year>2009</Year><Month>04</Month><Day>08</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><Issue>11</Issue><PubDate><Year>2008</Year><Month>Aug</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. 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The association between neuropsychiatric measures and dopamine transporter (DAT) availability was calculated; multiple regression analysis was used to assess association with age and disease duration. We found significant correlations between Montgomery and Asberg Depression Rating Scale (MARDS) and Tower of London (TOL) task scores and (123)I-FP-CIT uptake in various striatal ROIs. Multiple regression analysis confirmed the significant relationship between TOL performance and put/caud ratio (P = 0.001) and to age (P = 0.001), and between MADRS and left striatal (P = 0.005) and putaminal DAT availability (P = 0.003). Our pilot study results demonstrate that imaging with (123)I-FP-CIT SPECT appears to be sensitive for detecting dopaminergic deficit associated with mild depressive symptoms and specific cognitive dysfunction in patients with PD, yet without a current depressive episode and/or dementia.</AbstractText><CopyrightInformation>(c) 2008 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rektorova</LastName><ForeName>Irena</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Movement Disorders Centre, First Department of Neurology, Masaryk University, St. Anne's Teaching Hospital, Brno, Czech Republic. irena.rektorova@fnusa.cz</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Srovnalova</LastName><ForeName>Hana</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Kubikova</LastName><ForeName>Radka</ForeName><Initials>R</Initials></Author><Author 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PubStatus="medline"><Year>2009</Year><Month>4</Month><Day>9</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>7</Month><Day>12</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.22158</ArticleId><ArticleId IdType="pubmed">18618663</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République tchèque</li></country><region><li>Moravie</li></region><settlement><li>Brno</li></settlement></list><tree><noCountry><name sortKey="Kubikova, Radka" sort="Kubikova, Radka" uniqKey="Kubikova R" first="Radka" last="Kubikova">Radka Kubikova</name><name sortKey="Prasek, Jiri" sort="Prasek, Jiri" uniqKey="Prasek J" first="Jiri" last="Prasek">Jiri Prasek</name><name sortKey="Srovnalova, Hana" sort="Srovnalova, Hana" uniqKey="Srovnalova H" first="Hana" last="Srovnalova">Hana Srovnalova</name></noCountry><country name="République tchèque"><region name="Moravie"><name sortKey="Rektorova, Irena" sort="Rektorova, Irena" uniqKey="Rektorova I" first="Irena" last="Rektorova">Irena Rektorova</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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