Movement Disorders (revue)

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

A comparison of treatment thresholds in two large Parkinson's disease clinical trial cohorts.

Identifieur interne : 001F86 ( PubMed/Checkpoint ); précédent : 001F85; suivant : 001F87

A comparison of treatment thresholds in two large Parkinson's disease clinical trial cohorts.

Auteurs : Connie Marras [Canada] ; Anthony E. Lang ; Shirley W. Eberly ; David Oakes ; Stanley Fahn ; Steven R. Schwid ; Christopher Hyson ; Ira Shoulson

Source :

RBID : pubmed:19908310

English descriptors

Abstract

Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism (DATATOP) and Parkinson Research Examination of CEP-1347 Trial (PRECEPT) were two clinical trials of potential disease-modifying agents for Parkinson's disease that used the time to reaching disability sufficient to require dopaminergic therapy as the primary endpoint. To compare the thresholds for initiating dopaminergic treatment for Parkinson's disease between the two studies, conducted fifteen years apart. Baseline and 12-month endpoint characteristics for subjects in the placebo arms of the two studies were compared. DATATOP placebo subjects had slightly higher total Unified Parkinson's Disease Rating Scale (UPDRS) scores at baseline than PRECEPT placebo subjects (26.1 vs. 23.6, P = 0.03). Time to endpoint was not significantly different. Mean total UPDRS scores at endpoint among those subjects reaching endpoint by 12 months were 48.4 in DATATOP and 37.5 in PRECEPT (P < 0.0001). Baseline disease severity and time to disability requiring dopaminergic therapy were similar in the DATATOP and PRECEPT trials. The threshold for starting dopaminergic treatment was lower in PRECEPT than in the earlier DATATOP study. This may relate to changes in philosophies with respect to starting treatment for Parkinson's disease, but the factors underlying this change remain to be elucidated.

DOI: 10.1002/mds.22828
PubMed: 19908310


Affiliations:


Links toward previous steps (curation, corpus...)


Links to Exploration step

pubmed:19908310

Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">A comparison of treatment thresholds in two large Parkinson's disease clinical trial cohorts.</title>
<author>
<name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name>
<affiliation wicri:level="1">
<nlm:affiliation>Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, Toronto, Ontario, Canada. connie.marras@utoronto.ca</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name>
</author>
<author>
<name sortKey="Eberly, Shirley W" sort="Eberly, Shirley W" uniqKey="Eberly S" first="Shirley W" last="Eberly">Shirley W. Eberly</name>
</author>
<author>
<name sortKey="Oakes, David" sort="Oakes, David" uniqKey="Oakes D" first="David" last="Oakes">David Oakes</name>
</author>
<author>
<name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name>
</author>
<author>
<name sortKey="Schwid, Steven R" sort="Schwid, Steven R" uniqKey="Schwid S" first="Steven R" last="Schwid">Steven R. Schwid</name>
</author>
<author>
<name sortKey="Hyson, Christopher" sort="Hyson, Christopher" uniqKey="Hyson C" first="Christopher" last="Hyson">Christopher Hyson</name>
</author>
<author>
<name sortKey="Shoulson, Ira" sort="Shoulson, Ira" uniqKey="Shoulson I" first="Ira" last="Shoulson">Ira Shoulson</name>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PubMed</idno>
<date when="2009">2009</date>
<idno type="doi">10.1002/mds.22828</idno>
<idno type="RBID">pubmed:19908310</idno>
<idno type="pmid">19908310</idno>
<idno type="wicri:Area/PubMed/Corpus">001A91</idno>
<idno type="wicri:Area/PubMed/Curation">001A91</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001F86</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en">A comparison of treatment thresholds in two large Parkinson's disease clinical trial cohorts.</title>
<author>
<name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name>
<affiliation wicri:level="1">
<nlm:affiliation>Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, Toronto, Ontario, Canada. connie.marras@utoronto.ca</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name>
</author>
<author>
<name sortKey="Eberly, Shirley W" sort="Eberly, Shirley W" uniqKey="Eberly S" first="Shirley W" last="Eberly">Shirley W. Eberly</name>
</author>
<author>
<name sortKey="Oakes, David" sort="Oakes, David" uniqKey="Oakes D" first="David" last="Oakes">David Oakes</name>
</author>
<author>
<name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name>
</author>
<author>
<name sortKey="Schwid, Steven R" sort="Schwid, Steven R" uniqKey="Schwid S" first="Steven R" last="Schwid">Steven R. Schwid</name>
</author>
<author>
<name sortKey="Hyson, Christopher" sort="Hyson, Christopher" uniqKey="Hyson C" first="Christopher" last="Hyson">Christopher Hyson</name>
</author>
<author>
<name sortKey="Shoulson, Ira" sort="Shoulson, Ira" uniqKey="Shoulson I" first="Ira" last="Shoulson">Ira Shoulson</name>
</author>
</analytic>
<series>
<title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint>
<date when="2009" type="published">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Aged</term>
<term>Antioxidants (therapeutic use)</term>
<term>Cohort Studies</term>
<term>Disability Evaluation</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Retrospective Studies</term>
<term>Selegiline (therapeutic use)</term>
<term>Tocopherols (therapeutic use)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en">
<term>Antioxidants</term>
<term>Selegiline</term>
<term>Tocopherols</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en">
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Aged</term>
<term>Cohort Studies</term>
<term>Disability Evaluation</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Retrospective Studies</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism (DATATOP) and Parkinson Research Examination of CEP-1347 Trial (PRECEPT) were two clinical trials of potential disease-modifying agents for Parkinson's disease that used the time to reaching disability sufficient to require dopaminergic therapy as the primary endpoint. To compare the thresholds for initiating dopaminergic treatment for Parkinson's disease between the two studies, conducted fifteen years apart. Baseline and 12-month endpoint characteristics for subjects in the placebo arms of the two studies were compared. DATATOP placebo subjects had slightly higher total Unified Parkinson's Disease Rating Scale (UPDRS) scores at baseline than PRECEPT placebo subjects (26.1 vs. 23.6, P = 0.03). Time to endpoint was not significantly different. Mean total UPDRS scores at endpoint among those subjects reaching endpoint by 12 months were 48.4 in DATATOP and 37.5 in PRECEPT (P < 0.0001). Baseline disease severity and time to disability requiring dopaminergic therapy were similar in the DATATOP and PRECEPT trials. The threshold for starting dopaminergic treatment was lower in PRECEPT than in the earlier DATATOP study. This may relate to changes in philosophies with respect to starting treatment for Parkinson's disease, but the factors underlying this change remain to be elucidated.</div>
</front>
</TEI>
<pubmed>
<MedlineCitation Owner="NLM" Status="MEDLINE">
<PMID Version="1">19908310</PMID>
<DateCreated>
<Year>2009</Year>
<Month>12</Month>
<Day>28</Day>
</DateCreated>
<DateCompleted>
<Year>2010</Year>
<Month>03</Month>
<Day>04</Day>
</DateCompleted>
<Article PubModel="Print">
<Journal>
<ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>24</Volume>
<Issue>16</Issue>
<PubDate>
<Year>2009</Year>
<Month>Dec</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>A comparison of treatment thresholds in two large Parkinson's disease clinical trial cohorts.</ArticleTitle>
<Pagination>
<MedlinePgn>2370-8</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.22828</ELocationID>
<Abstract>
<AbstractText>Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism (DATATOP) and Parkinson Research Examination of CEP-1347 Trial (PRECEPT) were two clinical trials of potential disease-modifying agents for Parkinson's disease that used the time to reaching disability sufficient to require dopaminergic therapy as the primary endpoint. To compare the thresholds for initiating dopaminergic treatment for Parkinson's disease between the two studies, conducted fifteen years apart. Baseline and 12-month endpoint characteristics for subjects in the placebo arms of the two studies were compared. DATATOP placebo subjects had slightly higher total Unified Parkinson's Disease Rating Scale (UPDRS) scores at baseline than PRECEPT placebo subjects (26.1 vs. 23.6, P = 0.03). Time to endpoint was not significantly different. Mean total UPDRS scores at endpoint among those subjects reaching endpoint by 12 months were 48.4 in DATATOP and 37.5 in PRECEPT (P < 0.0001). Baseline disease severity and time to disability requiring dopaminergic therapy were similar in the DATATOP and PRECEPT trials. The threshold for starting dopaminergic treatment was lower in PRECEPT than in the earlier DATATOP study. This may relate to changes in philosophies with respect to starting treatment for Parkinson's disease, but the factors underlying this change remain to be elucidated.</AbstractText>
<CopyrightInformation>(c) 2009 Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Marras</LastName>
<ForeName>Connie</ForeName>
<Initials>C</Initials>
<AffiliationInfo>
<Affiliation>Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, Toronto, Ontario, Canada. connie.marras@utoronto.ca</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Lang</LastName>
<ForeName>Anthony E</ForeName>
<Initials>AE</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Eberly</LastName>
<ForeName>Shirley W</ForeName>
<Initials>SW</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Oakes</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Fahn</LastName>
<ForeName>Stanley</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Schwid</LastName>
<ForeName>Steven R</ForeName>
<Initials>SR</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Hyson</LastName>
<ForeName>Christopher</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Shoulson</LastName>
<ForeName>Ira</ForeName>
<Initials>I</Initials>
</Author>
<Author ValidYN="Y">
<CollectiveName>Parkinson Study Group DATATOP and PRECEPT investigators</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y">
<Grant>
<GrantID>NS24778</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant>
<GrantID>UL1 RR 025005</GrantID>
<Acronym>RR</Acronym>
<Agency>NCRR NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList>
<PublicationType UI="D016430">Clinical Trial</PublicationType>
<PublicationType UI="D003160">Comparative Study</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016448">Multicenter Study</PublicationType>
<PublicationType UI="D016449">Randomized Controlled Trial</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo>
<Country>United States</Country>
<MedlineTA>Mov Disord</MedlineTA>
<NlmUniqueID>8610688</NlmUniqueID>
<ISSNLinking>0885-3185</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList>
<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>1406-66-2</RegistryNumber>
<NameOfSubstance UI="D024505">Tocopherols</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>14611-51-9</RegistryNumber>
<NameOfSubstance UI="D012642">Selegiline</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D000975">Antioxidants</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000627">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D015331">Cohort Studies</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D004185">Disability Evaluation</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D004311">Double-Blind Method</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000188">drug therapy</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D012189">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D012642">Selegiline</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000627">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D024505">Tocopherols</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000627">therapeutic use</QualifierName>
</MeshHeading>
</MeshHeadingList>
<InvestigatorList>
<Investigator ValidYN="Y">
<LastName>Shoulson</LastName>
<ForeName>Ira</ForeName>
<Initials>I</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Oakes</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Fahn</LastName>
<ForeName>Stanley</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Lang</LastName>
<ForeName>Anthony</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Langston</LastName>
<ForeName>J William</ForeName>
<Initials>JW</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>LeWitt</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Olanow</LastName>
<ForeName>C Warren</ForeName>
<Initials>CW</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Penney</LastName>
<ForeName>John B</ForeName>
<Initials>JB</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Tanner</LastName>
<ForeName>Caroline</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Kieburtz</LastName>
<ForeName>Karl</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Koller</LastName>
<ForeName>William</ForeName>
<Initials>W</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Olanow</LastName>
<ForeName>C Warren</ForeName>
<Initials>CW</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Rodnitzky</LastName>
<ForeName>Robert</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Fink</LastName>
<ForeName>J Stephen</ForeName>
<Initials>JS</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Growdon</LastName>
<ForeName>John H</ForeName>
<Initials>JH</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Paulson</LastName>
<ForeName>George</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Kurlan</LastName>
<ForeName>Roger</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Friedman</LastName>
<ForeName>Joseph H</ForeName>
<Initials>JH</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Gancher</LastName>
<ForeName>Stephen</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Nutt</LastName>
<ForeName>John</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Rajput</LastName>
<ForeName>Ali H</ForeName>
<Initials>AH</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Bennett</LastName>
<ForeName>James B</ForeName>
<Initials>JB</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Wooten</LastName>
<ForeName>G Frederick</ForeName>
<Initials>GF</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>LeWitt</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Goetz</LastName>
<ForeName>Christopher</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Tanner</LastName>
<ForeName>Caroline</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Shannon</LastName>
<ForeName>Kathleen</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Suchowersky</LastName>
<ForeName>Oksana</ForeName>
<Initials>O</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Brin</LastName>
<ForeName>Mitchell F</ForeName>
<Initials>MF</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Bressman</LastName>
<ForeName>Susan B</ForeName>
<Initials>SB</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Weiner</LastName>
<ForeName>William J</ForeName>
<Initials>WJ</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Sanchez-Ramos</LastName>
<ForeName>Juan</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Jankovic</LastName>
<ForeName>Joseph</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Penney</LastName>
<ForeName>John B</ForeName>
<Initials>JB</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Lang</LastName>
<ForeName>Anthony</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Hoehn</LastName>
<ForeName>Margaret</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Tetrud</LastName>
<ForeName>James</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Grimes</LastName>
<ForeName>J David</ForeName>
<Initials>JD</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Pfeiffer</LastName>
<ForeName>Ronald</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Shults</LastName>
<ForeName>Cliff</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Thal</LastName>
<ForeName>Leon</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Gauthier</LastName>
<ForeName>Serge</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Golbe</LastName>
<ForeName>Lawrence I</ForeName>
<Initials>LI</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Perlmutter</LastName>
<ForeName>Joel S</ForeName>
<Initials>JS</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Moses</LastName>
<ForeName>Hamilton</ForeName>
<Initials>H</Initials>
<Suffix>3rd</Suffix>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Reich</LastName>
<ForeName>Stephen G</ForeName>
<Initials>SG</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Hurtig</LastName>
<ForeName>Howard I</ForeName>
<Initials>HI</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Stern</LastName>
<ForeName>Matthew</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Barter</LastName>
<ForeName>Ruth</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Vetere-Overfiel</LastName>
<ForeName>Bridget</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Gauger</LastName>
<ForeName>Lisa</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Malapira</LastName>
<ForeName>Teresita</ForeName>
<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Dobson</LastName>
<ForeName>Judith</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Atamian</LastName>
<ForeName>Susan</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Tennis</LastName>
<ForeName>Marsha</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Cohen</LastName>
<ForeName>Jennifer B</ForeName>
<Initials>JB</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Desclos</LastName>
<ForeName>Gena</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Hoffman</LastName>
<ForeName>Elizabeth</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Graefe</LastName>
<ForeName>Karen</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Burke</LastName>
<ForeName>Catherine</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Marcus</LastName>
<ForeName>Ari</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Denio</LastName>
<ForeName>Lena</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Huber</LastName>
<ForeName>Steven</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Woike</LastName>
<ForeName>Teresa</ForeName>
<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Zoog</LastName>
<ForeName>Kimberly</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Mendell</LastName>
<ForeName>Rebecca</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Dudte</LastName>
<ForeName>Kimberly</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Behr</LastName>
<ForeName>Jill</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Gardiner</LastName>
<ForeName>Irenita Flynn</ForeName>
<Initials>IF</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Lannon</LastName>
<ForeName>Margaret</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Carter</LastName>
<ForeName>Julie</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Northrup</LastName>
<ForeName>Susanne</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Kanigan</LastName>
<ForeName>Bernice</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Turk</LastName>
<ForeName>Margaret</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Landow</LastName>
<ForeName>Elke</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Schlick</LastName>
<ForeName>Patricia</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Mistura</LastName>
<ForeName>Kathie</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Carroll</LastName>
<ForeName>Susan</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Thelen</LastName>
<ForeName>Jean A</ForeName>
<Initials>JA</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Demong</LastName>
<ForeName>Carol</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Winfield</LastName>
<ForeName>Linda</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Moskowitz</LastName>
<ForeName>Carol</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Ingenito</LastName>
<ForeName>Angela</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Sheldon</LastName>
<ForeName>Carol</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Cornelius</LastName>
<ForeName>Lisa</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Heiberg</LastName>
<ForeName>Dorothy</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Dunne</LastName>
<ForeName>Cathleen</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Brady</LastName>
<ForeName>Jan</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Kierans</LastName>
<ForeName>Catherine</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Belle-Scantlebury</LastName>
<ForeName>Loretta</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Duff</LastName>
<ForeName>Jan</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Weber</LastName>
<ForeName>Helena</ForeName>
<Initials>H</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Savioni</LastName>
<ForeName>Deborah</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Lewis</LastName>
<ForeName>Paula</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Kutner</LastName>
<ForeName>S Jerome</ForeName>
<Initials>SJ</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Gray</LastName>
<ForeName>Peggy</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Glaeske</LastName>
<ForeName>Carolyn</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Hofman</LastName>
<ForeName>Ruth</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Pay</LastName>
<ForeName>Mary Margaret</ForeName>
<Initials>MM</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Salmon</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>McFaul</LastName>
<ForeName>Frances</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Amyot</LastName>
<ForeName>Donna</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Bergen</LastName>
<ForeName>Mary</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>McGee-Minnich</LastName>
<ForeName>Lori</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Donnell</LastName>
<ForeName>Patricia O</ForeName>
<Initials>PO</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Ferrise</LastName>
<ForeName>Susie</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Shallow</LastName>
<ForeName>Kathy</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Axtell</LastName>
<ForeName>Catherine</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Baker</LastName>
<ForeName>Deborah</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Casaceli</LastName>
<ForeName>Cynthia</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Eberly</LastName>
<ForeName>Shirley</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>McDermott</LastName>
<ForeName>Michael</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Marshall</LastName>
<ForeName>Frederick</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Nobel</LastName>
<ForeName>Ruth</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Orme</LastName>
<ForeName>Constance</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Pelusio</LastName>
<ForeName>Rita M</ForeName>
<Initials>RM</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Plumb</LastName>
<ForeName>Sandra</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Rudolph</LastName>
<ForeName>Alice</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Randolph</LastName>
<ForeName>Heidi</ForeName>
<Initials>H</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Sotack</LastName>
<ForeName>Jenny</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Watts</LastName>
<ForeName>Arthur</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Seeberger</LastName>
<ForeName>Lauren</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Kumar</LastName>
<ForeName>Rajeev</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Jog</LastName>
<ForeName>Mandar</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Horn</LastName>
<ForeName>Cheryl</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Shannon</LastName>
<ForeName>Kathleen</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Blasucci</LastName>
<ForeName>Lucia</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Leehey</LastName>
<ForeName>Maureen</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Derian</LastName>
<ForeName>Teresa</ForeName>
<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Grimes</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Mortensen</LastName>
<ForeName>Melodie</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Haas</LastName>
<ForeName>Keely</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Tuite</LastName>
<ForeName>Paul</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Rolandelli</LastName>
<ForeName>Susan</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Hermanowicz</LastName>
<ForeName>Neal</ForeName>
<Initials>N</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Niswonger</LastName>
<ForeName>Shari</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Kurlan</LastName>
<ForeName>Roger</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Gardiner</LastName>
<ForeName>Irenita</ForeName>
<Initials>I</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Miyasaki</LastName>
<ForeName>Janis</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Johnston</LastName>
<ForeName>Lisa</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Tetrud</LastName>
<ForeName>James</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Stewart</LastName>
<ForeName>Tracy</ForeName>
<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Friedman</LastName>
<ForeName>Joseph</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Fernandez</LastName>
<ForeName>Hubert</ForeName>
<Initials>H</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Lannon</LastName>
<ForeName>Margaret</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Rodnitzky</LastName>
<ForeName>Robert</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Dobson</LastName>
<ForeName>Judith</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Evidente</LastName>
<ForeName>Virgilio</ForeName>
<Initials>V</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Lind</LastName>
<ForeName>Marlene</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Panisset</LastName>
<ForeName>Michel</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Hall</LastName>
<ForeName>Jean</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Racette</LastName>
<ForeName>Brad</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Deppen</LastName>
<ForeName>Patricia</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Jankovic</LastName>
<ForeName>Joseph</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Hunter</LastName>
<ForeName>Christine</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Jennings</LastName>
<ForeName>Dana</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Fussell</LastName>
<ForeName>Barbara</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Stavris</LastName>
<ForeName>Karen</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Molho</LastName>
<ForeName>Eric</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Factor</LastName>
<ForeName>Stewart</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Wojcieszek</LastName>
<ForeName>Joanne</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Belden</LastName>
<ForeName>JoAnn</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Zhang</LastName>
<ForeName>Lin</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Wilson</LastName>
<ForeName>Lisa</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Campbell</LastName>
<ForeName>Patricia</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Tempkin</LastName>
<ForeName>Teresa</ForeName>
<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Scott</LastName>
<ForeName>Burton</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Field</LastName>
<ForeName>Joanne</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Subramanian</LastName>
<ForeName>Thyagarajan</ForeName>
<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Kolb</LastName>
<ForeName>Ruth</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Siderowf</LastName>
<ForeName>Andrew</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Colcher</LastName>
<ForeName>Amy</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Maccarone</LastName>
<ForeName>Heather</ForeName>
<Initials>H</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Hauser</LastName>
<ForeName>Robert</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Delaney</LastName>
<ForeName>Diana</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Nemeth</LastName>
<ForeName>Joanne</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Savitt</LastName>
<ForeName>Joseph</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Biglan</LastName>
<ForeName>Kevin</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Gerstenhaber</LastName>
<ForeName>Melissa</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Sahay</LastName>
<ForeName>Alok</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Dalvi</LastName>
<ForeName>Arif</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Gartner</LastName>
<ForeName>Maureen</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Schwieterman</LastName>
<ForeName>Donna</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Uitti</LastName>
<ForeName>Ryan</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Turk</LastName>
<ForeName>Margaret</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Rivest</LastName>
<ForeName>Jean</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Soucy</LastName>
<ForeName>Daniel</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Wooten</LastName>
<ForeName>Frederick</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Rost-Ruffner</LastName>
<ForeName>Elke</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Schwarzschild</LastName>
<ForeName>Michael</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Tennis</LastName>
<ForeName>Marsha</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Sethi</LastName>
<ForeName>Kapil</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Hatch</LastName>
<ForeName>Lisa</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Didonato</LastName>
<ForeName>Caroline</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Pfeiffer</LastName>
<ForeName>Ronald</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Pfeiffer</LastName>
<ForeName>Brenda</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Feigin</LastName>
<ForeName>Andrew</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Ayan</LastName>
<ForeName>Jean</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Shannon</LastName>
<ForeName>Barbara</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Simuni</LastName>
<ForeName>Tanya</ForeName>
<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Williams</LastName>
<ForeName>Karen</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Wolff</LastName>
<ForeName>Michele</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Elmer</LastName>
<ForeName>Lawrence</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Davis</LastName>
<ForeName>Kathy</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>deMarcaida</LastName>
<ForeName>Antonelle</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Thurlow</LastName>
<ForeName>Sheila</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Chouinard</LastName>
<ForeName>Sylvain</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Poiffaut</LastName>
<ForeName>Hubert</ForeName>
<Initials>H</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Shill</LastName>
<ForeName>Holly</ForeName>
<Initials>H</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Stacy</LastName>
<ForeName>Mark</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Marlor</LastName>
<ForeName>Lynn</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Danielson</LastName>
<ForeName>Jill</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Zweig</LastName>
<ForeName>Richard</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Feldt</LastName>
<ForeName>Rhonda</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Waters</LastName>
<ForeName>Cheryl</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Figueroa</LastName>
<ForeName>Angel</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Tam</LastName>
<ForeName>Anne</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Pahwa</LastName>
<ForeName>Rajesh</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Parsons</LastName>
<ForeName>Amy</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Hui</LastName>
<ForeName>Jennifer</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Wu</LastName>
<ForeName>Allan</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Kawai</LastName>
<ForeName>Connie</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Camicioli</LastName>
<ForeName>Richard</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>King</LastName>
<ForeName>Pamela</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Dalvi</LastName>
<ForeName>Arif</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Kang</LastName>
<ForeName>Un Jung</ForeName>
<Initials>UJ</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Shaviers</LastName>
<ForeName>Elizabeth</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Harding-Clay</LastName>
<ForeName>Barbara</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Reich</LastName>
<ForeName>Stephen</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Shulman</LastName>
<ForeName>Lisa</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Dignon</LastName>
<ForeName>Carol</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Dustin</LastName>
<ForeName>Kelly</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Mark</LastName>
<ForeName>Margery</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Caputo</LastName>
<ForeName>Deborah</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Rajput</LastName>
<ForeName>Ali</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Novak</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Thomas</LastName>
<ForeName>Cathi-Ann</ForeName>
<Initials>CA</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Sutton</LastName>
<ForeName>James</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Young</LastName>
<ForeName>Juanita</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Song</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Fontaine</LastName>
<ForeName>Deborah</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Bertoni</LastName>
<ForeName>John M</ForeName>
<Initials>JM</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Peterson</LastName>
<ForeName>Carolyn</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Blindauer</LastName>
<ForeName>Karen</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Petit</LastName>
<ForeName>Jeanine</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>LeWitt</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>DeAngelis</LastName>
<ForeName>Maryan</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Ranawaya</LastName>
<ForeName>Ranjit</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Suchowersky</LastName>
<ForeName>Oksana</ForeName>
<Initials>O</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Pantella</LastName>
<ForeName>Carol</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Tarsy</LastName>
<ForeName>Daniel</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Paul</LastName>
<ForeName>Linda</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Scollins</LastName>
<ForeName>Lisa</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Gordon</LastName>
<ForeName>Mark Forrest</ForeName>
<Initials>MF</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Bressman</LastName>
<ForeName>Susan</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>DiRocco</LastName>
<ForeName>Alessandro</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Boyar</LastName>
<ForeName>Karyn</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Bronte-Stewart</LastName>
<ForeName>Helen</ForeName>
<Initials>H</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Andrzejewski</LastName>
<ForeName>Amy</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Podskalny</LastName>
<ForeName>Gerald</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Fogle</LastName>
<ForeName>Marcia</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Galvez-Jimenez</LastName>
<ForeName>Nestor</ForeName>
<Initials>N</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Alvarez</LastName>
<ForeName>Jose</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Harik</LastName>
<ForeName>Sami</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Tabbal</LastName>
<ForeName>Samer</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Patterson</LastName>
<ForeName>Jana</ForeName>
<Initials>J</Initials>
</Investigator>
</InvestigatorList>
</MedlineCitation>
<PubmedData>
<History>
<PubMedPubDate PubStatus="entrez">
<Year>2009</Year>
<Month>11</Month>
<Day>13</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed">
<Year>2009</Year>
<Month>11</Month>
<Day>13</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline">
<Year>2010</Year>
<Month>3</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList>
<ArticleId IdType="doi">10.1002/mds.22828</ArticleId>
<ArticleId IdType="pubmed">19908310</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations>
<list>
<country>
<li>Canada</li>
</country>
</list>
<tree>
<noCountry>
<name sortKey="Eberly, Shirley W" sort="Eberly, Shirley W" uniqKey="Eberly S" first="Shirley W" last="Eberly">Shirley W. Eberly</name>
<name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name>
<name sortKey="Hyson, Christopher" sort="Hyson, Christopher" uniqKey="Hyson C" first="Christopher" last="Hyson">Christopher Hyson</name>
<name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name>
<name sortKey="Oakes, David" sort="Oakes, David" uniqKey="Oakes D" first="David" last="Oakes">David Oakes</name>
<name sortKey="Schwid, Steven R" sort="Schwid, Steven R" uniqKey="Schwid S" first="Steven R" last="Schwid">Steven R. Schwid</name>
<name sortKey="Shoulson, Ira" sort="Shoulson, Ira" uniqKey="Shoulson I" first="Ira" last="Shoulson">Ira Shoulson</name>
</noCountry>
<country name="Canada">
<noRegion>
<name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001F86 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 001F86 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    PubMed
   |étape=   Checkpoint
   |type=    RBID
   |clé=     pubmed:19908310
   |texte=   A comparison of treatment thresholds in two large Parkinson's disease clinical trial cohorts.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i   -Sk "pubmed:19908310" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a MovDisordV3 

Wicri

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024