Cortical hypometabolism assessed by a metabolic ratio in Parkinson's disease primarily reflects cognitive deterioration-[18F]FDG-PET.
Identifieur interne : 001E77 ( PubMed/Checkpoint ); précédent : 001E76; suivant : 001E78Cortical hypometabolism assessed by a metabolic ratio in Parkinson's disease primarily reflects cognitive deterioration-[18F]FDG-PET.
Auteurs : Inga Liepelt [Allemagne] ; Matthias Reimold ; Walter Maetzler ; Jana Godau ; Gerald Reischl ; Alexandra Gaenslen ; Heinz Herbst ; Daniela BergSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Brain Mapping, Cerebral Cortex (pathology), Cerebral Cortex (radionuclide imaging), Chi-Square Distribution, Cognition Disorders (etiology), Cognition Disorders (pathology), Cognition Disorders (radionuclide imaging), Female, Fluorodeoxyglucose F18 (diagnostic use), Fluorodeoxyglucose F18 (metabolism), Humans, Male, Middle Aged, Multivariate Analysis, Neurologic Examination (methods), Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (radionuclide imaging), Positron-Emission Tomography, Severity of Illness Index, Statistics, Nonparametric.
- MESH :
- chemical , diagnostic use : Fluorodeoxyglucose F18.
- complications : Parkinson Disease.
- etiology : Cognition Disorders.
- chemical , metabolism : Fluorodeoxyglucose F18.
- methods : Neurologic Examination.
- pathology : Cerebral Cortex, Cognition Disorders.
- radionuclide imaging : Cerebral Cortex, Cognition Disorders, Parkinson Disease.
- Aged, Aged, 80 and over, Brain Mapping, Chi-Square Distribution, Female, Humans, Male, Middle Aged, Multivariate Analysis, Neuropsychological Tests, Positron-Emission Tomography, Severity of Illness Index, Statistics, Nonparametric.
Abstract
In Parkinson's disease patients with cognitive deterioration, regional cortical hypometabolism has been observed with [(18)F]fluorodeoxyglucose-positron emission tomography (FDG-PET). Our aim was to develop a robust method to subsume the overall degree of metabolic deterioration in Parkinson's disease by means of a single index and to investigate which of the clinical features correlates best with hypometabolism. Twenty-two Parkinson's patients (10 demented) and seven controls underwent FDG-PET. A metabolic index (mean relative uptake in typically affected regions) was calculated for each patient and compared with scores for cognition [Minimental State Examination (MMSE)], motor performance [Unified Parkinson's Disease Rating Scale (UPDRS III)" and behavior (Neuropsychiatric Inventory). In stepwise linear regression analysis, MMSE (P < 0.001) score showed the only significant effect. Estimated sensitivity and specificity for DSM-IV diagnosis of dementia were high for the metabolic index (MI), with 91 and 100%. Taken together, the presented data indicate that cerebral hypometabolism in Parkinson's disease is primarily associated with cognitive impairment.
DOI: 10.1002/mds.22662
PubMed: 19489069
Affiliations:
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Matthias" uniqKey="Reimold M" first="Matthias" last="Reimold">Matthias Reimold</name></author><author><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name></author><author><name sortKey="Godau, Jana" sort="Godau, Jana" uniqKey="Godau J" first="Jana" last="Godau">Jana Godau</name></author><author><name sortKey="Reischl, Gerald" sort="Reischl, Gerald" uniqKey="Reischl G" first="Gerald" last="Reischl">Gerald Reischl</name></author><author><name sortKey="Gaenslen, Alexandra" sort="Gaenslen, Alexandra" uniqKey="Gaenslen A" first="Alexandra" last="Gaenslen">Alexandra Gaenslen</name></author><author><name sortKey="Herbst, Heinz" sort="Herbst, Heinz" uniqKey="Herbst H" first="Heinz" last="Herbst">Heinz Herbst</name></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1002/mds.22662</idno><idno type="RBID">pubmed:19489069</idno><idno type="pmid">19489069</idno><idno type="wicri:Area/PubMed/Corpus">001C81</idno><idno type="wicri:Area/PubMed/Curation">001C81</idno><idno type="wicri:Area/PubMed/Checkpoint">001E77</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cortical hypometabolism assessed by a metabolic ratio in Parkinson's disease primarily reflects cognitive deterioration-[18F]FDG-PET.</title><author><name sortKey="Liepelt, Inga" sort="Liepelt, Inga" uniqKey="Liepelt I" first="Inga" last="Liepelt">Inga Liepelt</name><affiliation wicri:level="3"><nlm:affiliation>Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tuebingen, Tuebingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Reimold, Matthias" sort="Reimold, Matthias" uniqKey="Reimold M" first="Matthias" last="Reimold">Matthias Reimold</name></author><author><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name></author><author><name sortKey="Godau, Jana" sort="Godau, Jana" uniqKey="Godau J" first="Jana" last="Godau">Jana Godau</name></author><author><name sortKey="Reischl, Gerald" sort="Reischl, Gerald" uniqKey="Reischl G" first="Gerald" last="Reischl">Gerald Reischl</name></author><author><name sortKey="Gaenslen, Alexandra" sort="Gaenslen, Alexandra" uniqKey="Gaenslen A" first="Alexandra" last="Gaenslen">Alexandra Gaenslen</name></author><author><name sortKey="Herbst, Heinz" sort="Herbst, Heinz" uniqKey="Herbst H" first="Heinz" last="Herbst">Heinz Herbst</name></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Brain Mapping</term><term>Cerebral Cortex (pathology)</term><term>Cerebral Cortex (radionuclide imaging)</term><term>Chi-Square Distribution</term><term>Cognition Disorders (etiology)</term><term>Cognition Disorders (pathology)</term><term>Cognition Disorders (radionuclide imaging)</term><term>Female</term><term>Fluorodeoxyglucose F18 (diagnostic use)</term><term>Fluorodeoxyglucose F18 (metabolism)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Neurologic Examination (methods)</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (radionuclide imaging)</term><term>Positron-Emission Tomography</term><term>Severity of Illness Index</term><term>Statistics, Nonparametric</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Fluorodeoxyglucose F18</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fluorodeoxyglucose F18</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Neurologic Examination</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cerebral Cortex</term><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Cerebral Cortex</term><term>Cognition Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Brain Mapping</term><term>Chi-Square Distribution</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Neuropsychological Tests</term><term>Positron-Emission Tomography</term><term>Severity of Illness Index</term><term>Statistics, Nonparametric</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In Parkinson's disease patients with cognitive deterioration, regional cortical hypometabolism has been observed with [(18)F]fluorodeoxyglucose-positron emission tomography (FDG-PET). Our aim was to develop a robust method to subsume the overall degree of metabolic deterioration in Parkinson's disease by means of a single index and to investigate which of the clinical features correlates best with hypometabolism. Twenty-two Parkinson's patients (10 demented) and seven controls underwent FDG-PET. A metabolic index (mean relative uptake in typically affected regions) was calculated for each patient and compared with scores for cognition [Minimental State Examination (MMSE)], motor performance [Unified Parkinson's Disease Rating Scale (UPDRS III)" and behavior (Neuropsychiatric Inventory). In stepwise linear regression analysis, MMSE (P < 0.001) score showed the only significant effect. Estimated sensitivity and specificity for DSM-IV diagnosis of dementia were high for the metabolic index (MI), with 91 and 100%. Taken together, the presented data indicate that cerebral hypometabolism in Parkinson's disease is primarily associated with cognitive impairment.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">19489069</PMID><DateCreated><Year>2009</Year><Month>08</Month><Day>03</Day></DateCreated><DateCompleted><Year>2009</Year><Month>10</Month><Day>22</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>10</Issue><PubDate><Year>2009</Year><Month>Jul</Month><Day>30</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Cortical hypometabolism assessed by a metabolic ratio in Parkinson's disease primarily reflects cognitive deterioration-[18F]FDG-PET.</ArticleTitle><Pagination><MedlinePgn>1504-11</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.22662</ELocationID><Abstract><AbstractText>In Parkinson's disease patients with cognitive deterioration, regional cortical hypometabolism has been observed with [(18)F]fluorodeoxyglucose-positron emission tomography (FDG-PET). Our aim was to develop a robust method to subsume the overall degree of metabolic deterioration in Parkinson's disease by means of a single index and to investigate which of the clinical features correlates best with hypometabolism. Twenty-two Parkinson's patients (10 demented) and seven controls underwent FDG-PET. A metabolic index (mean relative uptake in typically affected regions) was calculated for each patient and compared with scores for cognition [Minimental State Examination (MMSE)], motor performance [Unified Parkinson's Disease Rating Scale (UPDRS III)" and behavior (Neuropsychiatric Inventory). In stepwise linear regression analysis, MMSE (P < 0.001) score showed the only significant effect. Estimated sensitivity and specificity for DSM-IV diagnosis of dementia were high for the metabolic index (MI), with 91 and 100%. Taken together, the presented data indicate that cerebral hypometabolism in Parkinson's disease is primarily associated with cognitive impairment.</AbstractText><CopyrightInformation>Copyright 2009 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liepelt</LastName><ForeName>Inga</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reimold</LastName><ForeName>Matthias</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Maetzler</LastName><ForeName>Walter</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Godau</LastName><ForeName>Jana</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Reischl</LastName><ForeName>Gerald</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Gaenslen</LastName><ForeName>Alexandra</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Herbst</LastName><ForeName>Heinz</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Berg</LastName><ForeName>Daniela</ForeName><Initials>D</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0Z5B2CJX4D</RegistryNumber><NameOfSubstance UI="D019788">Fluorodeoxyglucose 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PubStatus="entrez"><Year>2009</Year><Month>6</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>6</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>10</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.22662</ArticleId><ArticleId IdType="pubmed">19489069</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>District de Tübingen</li></region><settlement><li>Tübingen</li></settlement></list><tree><noCountry><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><name sortKey="Gaenslen, Alexandra" sort="Gaenslen, Alexandra" uniqKey="Gaenslen A" first="Alexandra" last="Gaenslen">Alexandra Gaenslen</name><name sortKey="Godau, Jana" sort="Godau, Jana" uniqKey="Godau J" first="Jana" last="Godau">Jana Godau</name><name sortKey="Herbst, Heinz" sort="Herbst, Heinz" uniqKey="Herbst H" first="Heinz" last="Herbst">Heinz Herbst</name><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name><name sortKey="Reimold, Matthias" sort="Reimold, Matthias" uniqKey="Reimold M" first="Matthias" last="Reimold">Matthias Reimold</name><name sortKey="Reischl, Gerald" sort="Reischl, Gerald" uniqKey="Reischl G" first="Gerald" last="Reischl">Gerald Reischl</name></noCountry><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Liepelt, Inga" sort="Liepelt, Inga" uniqKey="Liepelt I" first="Inga" last="Liepelt">Inga Liepelt</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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