Synchronized brain network associated with essential tremor as revealed by magnetoencephalography.
Identifieur interne : 001B53 ( PubMed/Checkpoint ); précédent : 001B52; suivant : 001B54Synchronized brain network associated with essential tremor as revealed by magnetoencephalography.
Auteurs : Alfons Schnitzler [Allemagne] ; Christian Münks ; Markus Butz ; Lars Timmermann ; Joachim GrossSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- Adult, Biological Clocks, Brain (physiopathology), Brain Mapping, Brain Stem (physiopathology), Cerebellum (physiopathology), Electromyography, Essential Tremor (physiopathology), Female, Forearm (physiopathology), Humans, Isometric Contraction, Magnetoencephalography, Male, Middle Aged, Motor Cortex (physiopathology), Muscle, Skeletal (innervation), Muscle, Skeletal (physiopathology), Nerve Net (physiopathology), Thalamus (physiopathology).
- MESH :
- innervation : Muscle, Skeletal.
- physiopathology : Brain, Brain Stem, Cerebellum, Essential Tremor, Forearm, Motor Cortex, Muscle, Skeletal, Nerve Net, Thalamus.
- Adult, Biological Clocks, Brain Mapping, Electromyography, Female, Humans, Isometric Contraction, Magnetoencephalography, Male, Middle Aged.
Abstract
Despite the fact that essential tremor (ET) is the most prevalent movement disorder, the underlying pathological mechanisms are not fully understood. There is accumulating evidence that this specific type of tremor is mainly of central origin, in particular involving inferior olive, cerebellum, thalamus, and primary motor cortex. We studied 8 patients with ET recording simultaneously neural activity with a whole-scalp neuromagnetometer and tremor activity with surface electromyography (EMG). Subjects performed an isometric contraction of the left forearm. Tremor frequency of 5 to 7 Hz and its first harmonic were clearly evident in power spectra of EMG recordings. We used the localization technique dynamic imaging of coherent sources (DICS) to identify cerebral areas coherent to the EMG signal at tremor frequency and its first harmonic. All subjects showed coherence to the contralateral primary motor cortex. In a further step, DICS was used to identify areas of significant cerebro-cerebral coherence. The analysis revealed a network of areas consisting of contralateral primary motor cortex, premotor cortex, thalamus, brainstem, and ipsilateral cerebellum. These results are consistent with the view that in ET, a network of cerebral areas including brainstem shows oscillatory interactions, which lead to a rhythmic modulation of muscle activity becoming apparent as tremor.
DOI: 10.1002/mds.22633
PubMed: 19514010
Affiliations:
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Münks</name></author><author><name sortKey="Butz, Markus" sort="Butz, Markus" uniqKey="Butz M" first="Markus" last="Butz">Markus Butz</name></author><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name></author><author><name sortKey="Gross, Joachim" sort="Gross, Joachim" uniqKey="Gross J" first="Joachim" last="Gross">Joachim Gross</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1002/mds.22633</idno><idno type="RBID">pubmed:19514010</idno><idno type="pmid">19514010</idno><idno type="wicri:Area/PubMed/Corpus">001C77</idno><idno type="wicri:Area/PubMed/Curation">001C77</idno><idno type="wicri:Area/PubMed/Checkpoint">001B53</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Synchronized brain network associated with essential tremor as revealed by magnetoencephalography.</title><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Neuroscience and Medical Psychology, Heinrich-Heine University, Düsseldorf, Germany. schnitza@uni-duesseldorf.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Clinical Neuroscience and Medical Psychology, Heinrich-Heine University, Düsseldorf</wicri:regionArea><wicri:noRegion>Düsseldorf</wicri:noRegion><wicri:noRegion>Düsseldorf</wicri:noRegion><wicri:noRegion>Düsseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Munks, Christian" sort="Munks, Christian" uniqKey="Munks C" first="Christian" last="Münks">Christian Münks</name></author><author><name sortKey="Butz, Markus" sort="Butz, Markus" uniqKey="Butz M" first="Markus" last="Butz">Markus Butz</name></author><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name></author><author><name sortKey="Gross, Joachim" sort="Gross, Joachim" uniqKey="Gross J" first="Joachim" last="Gross">Joachim Gross</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Biological Clocks</term><term>Brain (physiopathology)</term><term>Brain Mapping</term><term>Brain Stem (physiopathology)</term><term>Cerebellum (physiopathology)</term><term>Electromyography</term><term>Essential Tremor (physiopathology)</term><term>Female</term><term>Forearm (physiopathology)</term><term>Humans</term><term>Isometric Contraction</term><term>Magnetoencephalography</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (physiopathology)</term><term>Muscle, Skeletal (innervation)</term><term>Muscle, Skeletal (physiopathology)</term><term>Nerve Net (physiopathology)</term><term>Thalamus (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term><term>Brain Stem</term><term>Cerebellum</term><term>Essential Tremor</term><term>Forearm</term><term>Motor Cortex</term><term>Muscle, Skeletal</term><term>Nerve Net</term><term>Thalamus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Biological Clocks</term><term>Brain Mapping</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Isometric Contraction</term><term>Magnetoencephalography</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite the fact that essential tremor (ET) is the most prevalent movement disorder, the underlying pathological mechanisms are not fully understood. There is accumulating evidence that this specific type of tremor is mainly of central origin, in particular involving inferior olive, cerebellum, thalamus, and primary motor cortex. We studied 8 patients with ET recording simultaneously neural activity with a whole-scalp neuromagnetometer and tremor activity with surface electromyography (EMG). Subjects performed an isometric contraction of the left forearm. Tremor frequency of 5 to 7 Hz and its first harmonic were clearly evident in power spectra of EMG recordings. We used the localization technique dynamic imaging of coherent sources (DICS) to identify cerebral areas coherent to the EMG signal at tremor frequency and its first harmonic. All subjects showed coherence to the contralateral primary motor cortex. In a further step, DICS was used to identify areas of significant cerebro-cerebral coherence. The analysis revealed a network of areas consisting of contralateral primary motor cortex, premotor cortex, thalamus, brainstem, and ipsilateral cerebellum. These results are consistent with the view that in ET, a network of cerebral areas including brainstem shows oscillatory interactions, which lead to a rhythmic modulation of muscle activity becoming apparent as tremor.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">19514010</PMID><DateCreated><Year>2009</Year><Month>09</Month><Day>01</Day></DateCreated><DateCompleted><Year>2010</Year><Month>01</Month><Day>15</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>11</Issue><PubDate><Year>2009</Year><Month>Aug</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Synchronized brain network associated with essential tremor as revealed by magnetoencephalography.</ArticleTitle><Pagination><MedlinePgn>1629-35</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.22633</ELocationID><Abstract><AbstractText>Despite the fact that essential tremor (ET) is the most prevalent movement disorder, the underlying pathological mechanisms are not fully understood. There is accumulating evidence that this specific type of tremor is mainly of central origin, in particular involving inferior olive, cerebellum, thalamus, and primary motor cortex. We studied 8 patients with ET recording simultaneously neural activity with a whole-scalp neuromagnetometer and tremor activity with surface electromyography (EMG). Subjects performed an isometric contraction of the left forearm. Tremor frequency of 5 to 7 Hz and its first harmonic were clearly evident in power spectra of EMG recordings. We used the localization technique dynamic imaging of coherent sources (DICS) to identify cerebral areas coherent to the EMG signal at tremor frequency and its first harmonic. All subjects showed coherence to the contralateral primary motor cortex. In a further step, DICS was used to identify areas of significant cerebro-cerebral coherence. The analysis revealed a network of areas consisting of contralateral primary motor cortex, premotor cortex, thalamus, brainstem, and ipsilateral cerebellum. These results are consistent with the view that in ET, a network of cerebral areas including brainstem shows oscillatory interactions, which lead to a rhythmic modulation of muscle activity becoming apparent as tremor.</AbstractText><CopyrightInformation>2009 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schnitzler</LastName><ForeName>Alfons</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Clinical Neuroscience and Medical Psychology, Heinrich-Heine University, Düsseldorf, Germany. schnitza@uni-duesseldorf.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Münks</LastName><ForeName>Christian</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Butz</LastName><ForeName>Markus</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Timmermann</LastName><ForeName>Lars</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Gross</LastName><ForeName>Joachim</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001683">Biological Clocks</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001921">Brain</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D001931">Brain 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UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007537">Isometric Contraction</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015225">Magnetoencephalography</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009044">Motor Cortex</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018482">Muscle, Skeletal</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000294">innervation</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009415">Nerve Net</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013788">Thalamus</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>6</Month><Day>11</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>6</Month><Day>11</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>1</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.22633</ArticleId><ArticleId IdType="pubmed">19514010</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Butz, Markus" sort="Butz, Markus" uniqKey="Butz M" first="Markus" last="Butz">Markus Butz</name><name sortKey="Gross, Joachim" sort="Gross, Joachim" uniqKey="Gross J" first="Joachim" last="Gross">Joachim Gross</name><name sortKey="Munks, Christian" sort="Munks, Christian" uniqKey="Munks C" first="Christian" last="Münks">Christian Münks</name><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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