UPDRS activity of daily living score as a marker of Parkinson's disease progression.
Identifieur interne : 001B16 ( PubMed/Checkpoint ); précédent : 001B15; suivant : 001B17UPDRS activity of daily living score as a marker of Parkinson's disease progression.
Auteurs : Madaline B. Harrison [États-Unis] ; Scott A. Wylie ; Robert C. Frysinger ; James T. Patrie ; Diane S. Huss ; Lillian J. Currie ; G Frederick WootenSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- Activities of Daily Living, Adult, Aged, Aged, 80 and over, Antiparkinson Agents (therapeutic use), Cross-Sectional Studies, Disease Progression, Female, Follow-Up Studies, Humans, Levodopa (therapeutic use), Male, Middle Aged, Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Psychomotor Performance, Treatment Outcome.
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- drug therapy : Parkinson Disease.
- physiopathology : Parkinson Disease.
- Activities of Daily Living, Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Disease Progression, Female, Follow-Up Studies, Humans, Male, Middle Aged, Psychomotor Performance, Treatment Outcome.
Abstract
The activities of daily living (ADL) subscore of the Unified Parkinson's Disease Rating Scale (UPDRS) captures the impact of Parkinson's disease (PD) on daily function and may be less affected than other subsections by variability associated with drug cycle and motor fluctuations. We examined UPDRS mentation, ADL and motor subscores in 888 patients with idiopathic PD. Multiple linear regression analyses determined the association between disease duration and UPDRS subscores as a function of medication status at examination and in a subset of patients with multiple examinations. Independent of medication status and across cross-sectional and longitudinal analyses, ADL subscores showed a stronger and more stable association with disease duration than other UPDRS subscores after adjusting for age of disease onset. The association between disease duration and the motor subscore depended on medication status. The strong association between ADL subscore and disease duration in PD suggests that this measure may serve as a better marker of disease progression than signs and symptoms assessed in other UPDRS sections.
DOI: 10.1002/mds.22335
PubMed: 18951537
Affiliations:
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pubmed:18951537Le document en format XML
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<author><name sortKey="Harrison, Madaline B" sort="Harrison, Madaline B" uniqKey="Harrison M" first="Madaline B" last="Harrison">Madaline B. Harrison</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of Virginia, Charlottesville, Virginia 22903, USA. mbh3y@virginia.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Virginia, Charlottesville, Virginia 22903</wicri:regionArea>
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<author><name sortKey="Wylie, Scott A" sort="Wylie, Scott A" uniqKey="Wylie S" first="Scott A" last="Wylie">Scott A. Wylie</name>
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<author><name sortKey="Frysinger, Robert C" sort="Frysinger, Robert C" uniqKey="Frysinger R" first="Robert C" last="Frysinger">Robert C. Frysinger</name>
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<author><name sortKey="Patrie, James T" sort="Patrie, James T" uniqKey="Patrie J" first="James T" last="Patrie">James T. Patrie</name>
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<author><name sortKey="Huss, Diane S" sort="Huss, Diane S" uniqKey="Huss D" first="Diane S" last="Huss">Diane S. Huss</name>
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<author><name sortKey="Currie, Lillian J" sort="Currie, Lillian J" uniqKey="Currie L" first="Lillian J" last="Currie">Lillian J. Currie</name>
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<author><name sortKey="Wooten, G Frederick" sort="Wooten, G Frederick" uniqKey="Wooten G" first="G Frederick" last="Wooten">G Frederick Wooten</name>
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<author><name sortKey="Patrie, James T" sort="Patrie, James T" uniqKey="Patrie J" first="James T" last="Patrie">James T. Patrie</name>
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<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Antiparkinson Agents (therapeutic use)</term>
<term>Cross-Sectional Studies</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Levodopa (therapeutic use)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Psychomotor Performance</term>
<term>Treatment Outcome</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Levodopa</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" xml:lang="en"><term>Activities of Daily Living</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Cross-Sectional Studies</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en">The activities of daily living (ADL) subscore of the Unified Parkinson's Disease Rating Scale (UPDRS) captures the impact of Parkinson's disease (PD) on daily function and may be less affected than other subsections by variability associated with drug cycle and motor fluctuations. We examined UPDRS mentation, ADL and motor subscores in 888 patients with idiopathic PD. Multiple linear regression analyses determined the association between disease duration and UPDRS subscores as a function of medication status at examination and in a subset of patients with multiple examinations. Independent of medication status and across cross-sectional and longitudinal analyses, ADL subscores showed a stronger and more stable association with disease duration than other UPDRS subscores after adjusting for age of disease onset. The association between disease duration and the motor subscore depended on medication status. The strong association between ADL subscore and disease duration in PD suggests that this measure may serve as a better marker of disease progression than signs and symptoms assessed in other UPDRS sections.</div>
</front>
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<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2001 Oct;58(10):1611-5</RefSource>
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<CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2002 Mar;17(2):283-8</RefSource>
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<name sortKey="Huss, Diane S" sort="Huss, Diane S" uniqKey="Huss D" first="Diane S" last="Huss">Diane S. Huss</name>
<name sortKey="Patrie, James T" sort="Patrie, James T" uniqKey="Patrie J" first="James T" last="Patrie">James T. Patrie</name>
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