Whole-brain atrophy as a measure of progression in premanifest and early Huntington's disease.
Identifieur interne : 001A95 ( PubMed/Checkpoint ); précédent : 001A94; suivant : 001A96Whole-brain atrophy as a measure of progression in premanifest and early Huntington's disease.
Auteurs : Susie M D. Henley [Royaume-Uni] ; Edward J. Wild ; Nicola Z. Hobbs ; Chris Frost ; David G. Macmanus ; Roger A. Barker ; Nick C. Fox ; Sarah J. TabriziSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- MESH :
- complications : Huntington Disease.
- etiology : Atrophy.
- methods : Magnetic Resonance Imaging.
- pathology : Atrophy, Brain, Huntington Disease.
- Adult, Brain Mapping, Disease Progression, Humans, Middle Aged, Severity of Illness Index.
Abstract
Therapeutic trials in Huntington's disease (HD) are challenging as clinical progression is slow and variable and reliable biomarkers are lacking. We used magnetic resonance imaging and the brain boundary shift integral to quantify whole-brain atrophy rates over 1 year in early and premanifest HD subjects, and controls. Early HD subjects had statistically significantly (P = 0.007) increased (threefold higher) rates of whole-brain atrophy compared with controls. Higher atrophy rates were associated with longer CAG repeat length. MRI-based measures of whole-brain atrophy may have potential as a measure of progression in HD.
DOI: 10.1002/mds.22485
PubMed: 19243073
Affiliations:
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pubmed:19243073Le document en format XML
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<term>Atrophy (pathology)</term>
<term>Brain (pathology)</term>
<term>Brain Mapping</term>
<term>Disease Progression</term>
<term>Humans</term>
<term>Huntington Disease (complications)</term>
<term>Huntington Disease (pathology)</term>
<term>Magnetic Resonance Imaging (methods)</term>
<term>Middle Aged</term>
<term>Severity of Illness Index</term>
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<front><div type="abstract" xml:lang="en">Therapeutic trials in Huntington's disease (HD) are challenging as clinical progression is slow and variable and reliable biomarkers are lacking. We used magnetic resonance imaging and the brain boundary shift integral to quantify whole-brain atrophy rates over 1 year in early and premanifest HD subjects, and controls. Early HD subjects had statistically significantly (P = 0.007) increased (threefold higher) rates of whole-brain atrophy compared with controls. Higher atrophy rates were associated with longer CAG repeat length. MRI-based measures of whole-brain atrophy may have potential as a measure of progression in HD.</div>
</front>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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<Abstract><AbstractText>Therapeutic trials in Huntington's disease (HD) are challenging as clinical progression is slow and variable and reliable biomarkers are lacking. We used magnetic resonance imaging and the brain boundary shift integral to quantify whole-brain atrophy rates over 1 year in early and premanifest HD subjects, and controls. Early HD subjects had statistically significantly (P = 0.007) increased (threefold higher) rates of whole-brain atrophy compared with controls. Higher atrophy rates were associated with longer CAG repeat length. MRI-based measures of whole-brain atrophy may have potential as a measure of progression in HD.</AbstractText>
<CopyrightInformation>(c) 2009 Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Henley</LastName>
<ForeName>Susie M D</ForeName>
<Initials>SM</Initials>
<AffiliationInfo><Affiliation>Dementia Research Centre, Institute of Neurology, National Hospital for Neurology and Neurosurgery, University College London, Queen Square, London, United Kingdom. shenley@drc.ion.ucl.ac.uk</Affiliation>
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<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Henley, Susie M D" sort="Henley, Susie M D" uniqKey="Henley S" first="Susie M D" last="Henley">Susie M D. Henley</name>
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