Frontotemporal dementia: pathology of gait?
Identifieur interne : 001872 ( PubMed/Checkpoint ); précédent : 001871; suivant : 001873Frontotemporal dementia: pathology of gait?
Auteurs : Gilles Allali [Suisse] ; Bruno Dubois ; Frederic Assal ; Elise Lallart ; Leonardo C. De Souza ; Maxime Bertoux ; Cédric Annweiler ; Francois R. Herrmann ; Richard Levy ; Olivier BeauchetSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Alzheimer Disease (complications), Alzheimer Disease (diagnosis), Disability Evaluation, Executive Function (physiology), Female, Frontotemporal Dementia (complications), Frontotemporal Dementia (diagnosis), Gait Disorders, Neurologic (etiology), Gait Disorders, Neurologic (pathology), Humans, Male, Models, Statistical, Neuropsychological Tests, Postural Balance (physiology), Psychomotor Performance (physiology).
- MESH :
- complications : Alzheimer Disease, Frontotemporal Dementia.
- diagnosis : Alzheimer Disease, Frontotemporal Dementia.
- etiology : Gait Disorders, Neurologic.
- pathology : Gait Disorders, Neurologic.
- physiology : Executive Function, Postural Balance, Psychomotor Performance.
- Aged, Aged, 80 and over, Disability Evaluation, Female, Humans, Male, Models, Statistical, Neuropsychological Tests.
Abstract
The main diagnostic criteria of the behavioural variant of frontotemporal degeneration (bvFTD) include neurobehavioral and dysexecutive syndromes, but not specific gait characteristics although strong relationship between gait and prefrontal functions are increasingly recognized. Accordingly, we tested the hypothesis that patients with bvFTD would have more gait changes than older healthy controls and demented patients with Alzheimer's disease (AD). Sixty subjects were included in the study: 19 with bvFTD, 19 with AD and 22 healthy controls. Mean values and coefficients of variation (CV) of stride time while just walking (i.e., single tasking) and while walking with backward counting (i.e., dual tasking) were measured using the SMTEC-footswitch system. Stride time, mean value, and CV were significantly increased in both patient groups compared with healthy controls during single task or walking alone (P < 0.001) and during dual tasking (P < 0.001). After adjusting for age, Mini-mental examination, psychoactive drugs, gender, and history of previous fall, only the patients with bvFTD group was associated with an increase of CV of stride time during single walking (P < 0.001) and dual tasking (P < 0.001). These data suggest that gait instability during single and dual tasking could represent a supportive argument for bvFTD. In clinical practice, such a diagnosis should be at least considered in any demented patient with gait instability.
DOI: 10.1002/mds.22927
PubMed: 20175202
Affiliations:
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De Souza</name></author><author><name sortKey="Bertoux, Maxime" sort="Bertoux, Maxime" uniqKey="Bertoux M" first="Maxime" last="Bertoux">Maxime Bertoux</name></author><author><name sortKey="Annweiler, Cedric" sort="Annweiler, Cedric" uniqKey="Annweiler C" first="Cédric" last="Annweiler">Cédric Annweiler</name></author><author><name sortKey="Herrmann, Francois R" sort="Herrmann, Francois R" uniqKey="Herrmann F" first="Francois R" last="Herrmann">Francois R. Herrmann</name></author><author><name sortKey="Levy, Richard" sort="Levy, Richard" uniqKey="Levy R" first="Richard" last="Levy">Richard Levy</name></author><author><name sortKey="Beauchet, Olivier" sort="Beauchet, Olivier" uniqKey="Beauchet O" first="Olivier" last="Beauchet">Olivier Beauchet</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1002/mds.22927</idno><idno type="RBID">pubmed:20175202</idno><idno type="pmid">20175202</idno><idno type="wicri:Area/PubMed/Corpus">001962</idno><idno type="wicri:Area/PubMed/Curation">001962</idno><idno type="wicri:Area/PubMed/Checkpoint">001872</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Frontotemporal dementia: pathology of gait?</title><author><name sortKey="Allali, Gilles" sort="Allali, Gilles" uniqKey="Allali G" first="Gilles" last="Allali">Gilles Allali</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Geneva University Hospitals and University of Geneva, Geneva, Switzerland. gilles.allali@hcuge.ch</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurology, Geneva University Hospitals and University of Geneva, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name></author><author><name sortKey="Assal, Frederic" sort="Assal, Frederic" uniqKey="Assal F" first="Frederic" last="Assal">Frederic Assal</name></author><author><name sortKey="Lallart, Elise" sort="Lallart, Elise" uniqKey="Lallart E" first="Elise" last="Lallart">Elise Lallart</name></author><author><name sortKey="De Souza, Leonardo C" sort="De Souza, Leonardo C" uniqKey="De Souza L" first="Leonardo C" last="De Souza">Leonardo C. De Souza</name></author><author><name sortKey="Bertoux, Maxime" sort="Bertoux, Maxime" uniqKey="Bertoux M" first="Maxime" last="Bertoux">Maxime Bertoux</name></author><author><name sortKey="Annweiler, Cedric" sort="Annweiler, Cedric" uniqKey="Annweiler C" first="Cédric" last="Annweiler">Cédric Annweiler</name></author><author><name sortKey="Herrmann, Francois R" sort="Herrmann, Francois R" uniqKey="Herrmann F" first="Francois R" last="Herrmann">Francois R. Herrmann</name></author><author><name sortKey="Levy, Richard" sort="Levy, Richard" uniqKey="Levy R" first="Richard" last="Levy">Richard Levy</name></author><author><name sortKey="Beauchet, Olivier" sort="Beauchet, Olivier" uniqKey="Beauchet O" first="Olivier" last="Beauchet">Olivier Beauchet</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Alzheimer Disease (complications)</term><term>Alzheimer Disease (diagnosis)</term><term>Disability Evaluation</term><term>Executive Function (physiology)</term><term>Female</term><term>Frontotemporal Dementia (complications)</term><term>Frontotemporal Dementia (diagnosis)</term><term>Gait Disorders, Neurologic (etiology)</term><term>Gait Disorders, Neurologic (pathology)</term><term>Humans</term><term>Male</term><term>Models, Statistical</term><term>Neuropsychological Tests</term><term>Postural Balance (physiology)</term><term>Psychomotor Performance (physiology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Alzheimer Disease</term><term>Frontotemporal Dementia</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Alzheimer Disease</term><term>Frontotemporal Dementia</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Gait Disorders, Neurologic</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Gait Disorders, Neurologic</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Executive Function</term><term>Postural Balance</term><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Disability Evaluation</term><term>Female</term><term>Humans</term><term>Male</term><term>Models, Statistical</term><term>Neuropsychological Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The main diagnostic criteria of the behavioural variant of frontotemporal degeneration (bvFTD) include neurobehavioral and dysexecutive syndromes, but not specific gait characteristics although strong relationship between gait and prefrontal functions are increasingly recognized. Accordingly, we tested the hypothesis that patients with bvFTD would have more gait changes than older healthy controls and demented patients with Alzheimer's disease (AD). Sixty subjects were included in the study: 19 with bvFTD, 19 with AD and 22 healthy controls. Mean values and coefficients of variation (CV) of stride time while just walking (i.e., single tasking) and while walking with backward counting (i.e., dual tasking) were measured using the SMTEC-footswitch system. Stride time, mean value, and CV were significantly increased in both patient groups compared with healthy controls during single task or walking alone (P < 0.001) and during dual tasking (P < 0.001). After adjusting for age, Mini-mental examination, psychoactive drugs, gender, and history of previous fall, only the patients with bvFTD group was associated with an increase of CV of stride time during single walking (P < 0.001) and dual tasking (P < 0.001). These data suggest that gait instability during single and dual tasking could represent a supportive argument for bvFTD. In clinical practice, such a diagnosis should be at least considered in any demented patient with gait instability.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20175202</PMID><DateCreated><Year>2010</Year><Month>05</Month><Day>03</Day></DateCreated><DateCompleted><Year>2010</Year><Month>07</Month><Day>28</Day></DateCompleted><DateRevised><Year>2011</Year><Month>07</Month><Day>18</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>6</Issue><PubDate><Year>2010</Year><Month>Apr</Month><Day>30</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Frontotemporal dementia: pathology of gait?</ArticleTitle><Pagination><MedlinePgn>731-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.22927</ELocationID><Abstract><AbstractText>The main diagnostic criteria of the behavioural variant of frontotemporal degeneration (bvFTD) include neurobehavioral and dysexecutive syndromes, but not specific gait characteristics although strong relationship between gait and prefrontal functions are increasingly recognized. Accordingly, we tested the hypothesis that patients with bvFTD would have more gait changes than older healthy controls and demented patients with Alzheimer's disease (AD). Sixty subjects were included in the study: 19 with bvFTD, 19 with AD and 22 healthy controls. Mean values and coefficients of variation (CV) of stride time while just walking (i.e., single tasking) and while walking with backward counting (i.e., dual tasking) were measured using the SMTEC-footswitch system. Stride time, mean value, and CV were significantly increased in both patient groups compared with healthy controls during single task or walking alone (P < 0.001) and during dual tasking (P < 0.001). After adjusting for age, Mini-mental examination, psychoactive drugs, gender, and history of previous fall, only the patients with bvFTD group was associated with an increase of CV of stride time during single walking (P < 0.001) and dual tasking (P < 0.001). These data suggest that gait instability during single and dual tasking could represent a supportive argument for bvFTD. In clinical practice, such a diagnosis should be at least considered in any demented patient with gait instability.</AbstractText><CopyrightInformation>2010 Movement Disorder Society</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Allali</LastName><ForeName>Gilles</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Neurology, Geneva University Hospitals and University of Geneva, Geneva, Switzerland. gilles.allali@hcuge.ch</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dubois</LastName><ForeName>Bruno</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Assal</LastName><ForeName>Frederic</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Lallart</LastName><ForeName>Elise</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>de Souza</LastName><ForeName>Leonardo C</ForeName><Initials>LC</Initials></Author><Author ValidYN="Y"><LastName>Bertoux</LastName><ForeName>Maxime</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Annweiler</LastName><ForeName>Cédric</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Herrmann</LastName><ForeName>Francois R</ForeName><Initials>FR</Initials></Author><Author ValidYN="Y"><LastName>Levy</LastName><ForeName>Richard</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Beauchet</LastName><ForeName>Olivier</ForeName><Initials>O</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000544">Alzheimer Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004185">Disability Evaluation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D056344">Executive Function</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D057180">Frontotemporal Dementia</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020233">Gait Disorders, Neurologic</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000209">etiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015233">Models, Statistical</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009483">Neuropsychological Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004856">Postural Balance</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011597">Psychomotor Performance</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>2</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>2</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>7</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.22927</ArticleId><ArticleId IdType="pubmed">20175202</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Suisse</li></country></list><tree><noCountry><name sortKey="Annweiler, Cedric" sort="Annweiler, Cedric" uniqKey="Annweiler C" first="Cédric" last="Annweiler">Cédric Annweiler</name><name sortKey="Assal, Frederic" sort="Assal, Frederic" uniqKey="Assal F" first="Frederic" last="Assal">Frederic Assal</name><name sortKey="Beauchet, Olivier" sort="Beauchet, Olivier" uniqKey="Beauchet O" first="Olivier" last="Beauchet">Olivier Beauchet</name><name sortKey="Bertoux, Maxime" sort="Bertoux, Maxime" uniqKey="Bertoux M" first="Maxime" last="Bertoux">Maxime Bertoux</name><name sortKey="De Souza, Leonardo C" sort="De Souza, Leonardo C" uniqKey="De Souza L" first="Leonardo C" last="De Souza">Leonardo C. De Souza</name><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name><name sortKey="Herrmann, Francois R" sort="Herrmann, Francois R" uniqKey="Herrmann F" first="Francois R" last="Herrmann">Francois R. Herrmann</name><name sortKey="Lallart, Elise" sort="Lallart, Elise" uniqKey="Lallart E" first="Elise" last="Lallart">Elise Lallart</name><name sortKey="Levy, Richard" sort="Levy, Richard" uniqKey="Levy R" first="Richard" last="Levy">Richard Levy</name></noCountry><country name="Suisse"><noRegion><name sortKey="Allali, Gilles" sort="Allali, Gilles" uniqKey="Allali G" first="Gilles" last="Allali">Gilles Allali</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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