Movement Disorders (revue)

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Long-term effect of unilateral pallidotomy on levodopa-induced dyskinesia.

Identifieur interne : 001797 ( PubMed/Checkpoint ); précédent : 001796; suivant : 001798

Long-term effect of unilateral pallidotomy on levodopa-induced dyskinesia.

Auteurs : Galit Kleiner-Fisman [Canada] ; Andres Lozano ; Elena Moro ; Yu-Yan Poon ; Anthony E. Lang

Source :

RBID : pubmed:20568091

English descriptors

Abstract

Unilateral pallidotomy has been effectively used to treat parkinsonism and reduce levodopa induced dyskinesia (LID). We sought to determine the long-term effects of pallidotomy on LID in 10 patients who had initial benefit from pallidotomy but went on to require DBS surgery for symptom progression. The Dyskinesia Rating Scale (DRS) was used to rate and quantify LID in a blinded fashion. Though sample size was small, there was a trend towards a reduction in LID lasting up to 12 years suggesting that posteroventral pallidotomy may provide sustained benefit in reducing LID.

DOI: 10.1002/mds.23155
PubMed: 20568091


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pubmed:20568091

Le document en format XML

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<nlm:affiliation>Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada. gkleinerfisman@yahoo.com</nlm:affiliation>
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<term>Deep Brain Stimulation (methods)</term>
<term>Dyskinesia, Drug-Induced (surgery)</term>
<term>Female</term>
<term>Functional Laterality (physiology)</term>
<term>Humans</term>
<term>Levodopa (adverse effects)</term>
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<div type="abstract" xml:lang="en">Unilateral pallidotomy has been effectively used to treat parkinsonism and reduce levodopa induced dyskinesia (LID). We sought to determine the long-term effects of pallidotomy on LID in 10 patients who had initial benefit from pallidotomy but went on to require DBS surgery for symptom progression. The Dyskinesia Rating Scale (DRS) was used to rate and quantify LID in a blinded fashion. Though sample size was small, there was a trend towards a reduction in LID lasting up to 12 years suggesting that posteroventral pallidotomy may provide sustained benefit in reducing LID.</div>
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