Photophobia in essential blepharospasm--a positron emission tomographic study.
Identifieur interne : 001702 ( PubMed/Checkpoint ); précédent : 001701; suivant : 001703Photophobia in essential blepharospasm--a positron emission tomographic study.
Auteurs : Hirofumi Emoto [Japon] ; Yukihisa Suzuki ; Masato Wakakura ; Chiharu Horie ; Motohiro Kiyosawa ; Manabu Mochizuki ; Keiichi Kawasaki ; Keiichi Oda ; Kiichi Ishiwata ; Kenji IshiiSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Adult, Blepharospasm (psychology), Female, Fluorodeoxyglucose F18 (diagnostic use), Humans, Male, Middle Aged, Nerve Net (physiopathology), Neural Pathways (physiopathology), Occipital Lobe (physiopathology), Photophobia (diagnosis), Photophobia (etiology), Photophobia (physiopathology), Positron-Emission Tomography, Radiopharmaceuticals (diagnostic use), Thalamus (physiopathology), Trigeminal Nerve (physiopathology).
- MESH :
- chemical , diagnostic use : Fluorodeoxyglucose F18, Radiopharmaceuticals.
- diagnosis : Photophobia.
- etiology : Photophobia.
- physiopathology : Nerve Net, Neural Pathways, Occipital Lobe, Photophobia, Thalamus, Trigeminal Nerve.
- psychology : Blepharospasm.
- Adult, Female, Humans, Male, Middle Aged, Positron-Emission Tomography.
Abstract
To localize regional alterations in cerebral glucose metabolism in essential blepharospasm (EB) patients with photophobia. We have studied 22 EB patients by performing positron emission tomography and [(18)F]-fluorodeoxyglucose analysis. The patients were classified into two subgroups, namely, EB with photophobia (P group) and EB without photophobia (NP group), and compared with a healthy control group (n = 44). There were no significant differences between the two patient groups with respect to the severity of motor symptoms or the duration for which the condition persisted. The FDG-PET images were analyzed using the statistical parametric mapping software. As compared to the control group, the P group exhibited significant hypermetabolism in the thalamus (P = 0.002), while the NP group exhibited significant hypometabolism in the dorsal midbrain, especially, in the superior colliculus (P = 0.005). The P group exhibited significant hypermetabolism in the thalamus and the dorsal midbrain as compared to the NP group (P < 0.001). These findings suggest that photophobia in EB patients may be associated with abnormal hyperactivity in the thalamus. Either hyperactivity of the thalamus or hypoactivity of the superior colliculus, or both may be associated with excessive blinking in these patients.
DOI: 10.1002/mds.22916
PubMed: 20014062
Affiliations:
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Wakakura</name></author><author><name sortKey="Horie, Chiharu" sort="Horie, Chiharu" uniqKey="Horie C" first="Chiharu" last="Horie">Chiharu Horie</name></author><author><name sortKey="Kiyosawa, Motohiro" sort="Kiyosawa, Motohiro" uniqKey="Kiyosawa M" first="Motohiro" last="Kiyosawa">Motohiro Kiyosawa</name></author><author><name sortKey="Mochizuki, Manabu" sort="Mochizuki, Manabu" uniqKey="Mochizuki M" first="Manabu" last="Mochizuki">Manabu Mochizuki</name></author><author><name sortKey="Kawasaki, Keiichi" sort="Kawasaki, Keiichi" uniqKey="Kawasaki K" first="Keiichi" last="Kawasaki">Keiichi Kawasaki</name></author><author><name sortKey="Oda, Keiichi" sort="Oda, Keiichi" uniqKey="Oda K" first="Keiichi" last="Oda">Keiichi Oda</name></author><author><name sortKey="Ishiwata, Kiichi" sort="Ishiwata, Kiichi" uniqKey="Ishiwata K" first="Kiichi" last="Ishiwata">Kiichi Ishiwata</name></author><author><name sortKey="Ishii, Kenji" sort="Ishii, Kenji" uniqKey="Ishii K" first="Kenji" last="Ishii">Kenji Ishii</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1002/mds.22916</idno><idno type="RBID">pubmed:20014062</idno><idno type="pmid">20014062</idno><idno type="wicri:Area/PubMed/Corpus">001A64</idno><idno type="wicri:Area/PubMed/Curation">001A64</idno><idno type="wicri:Area/PubMed/Checkpoint">001702</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Photophobia in essential blepharospasm--a positron emission tomographic study.</title><author><name sortKey="Emoto, Hirofumi" sort="Emoto, Hirofumi" uniqKey="Emoto H" first="Hirofumi" last="Emoto">Hirofumi Emoto</name><affiliation wicri:level="3"><nlm:affiliation>Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Suzuki, Yukihisa" sort="Suzuki, Yukihisa" uniqKey="Suzuki Y" first="Yukihisa" last="Suzuki">Yukihisa Suzuki</name></author><author><name sortKey="Wakakura, Masato" sort="Wakakura, Masato" uniqKey="Wakakura M" first="Masato" last="Wakakura">Masato Wakakura</name></author><author><name sortKey="Horie, Chiharu" sort="Horie, Chiharu" uniqKey="Horie C" first="Chiharu" last="Horie">Chiharu Horie</name></author><author><name sortKey="Kiyosawa, Motohiro" sort="Kiyosawa, Motohiro" uniqKey="Kiyosawa M" first="Motohiro" last="Kiyosawa">Motohiro Kiyosawa</name></author><author><name sortKey="Mochizuki, Manabu" sort="Mochizuki, Manabu" uniqKey="Mochizuki M" first="Manabu" last="Mochizuki">Manabu Mochizuki</name></author><author><name sortKey="Kawasaki, Keiichi" sort="Kawasaki, Keiichi" uniqKey="Kawasaki K" first="Keiichi" last="Kawasaki">Keiichi Kawasaki</name></author><author><name sortKey="Oda, Keiichi" sort="Oda, Keiichi" uniqKey="Oda K" first="Keiichi" last="Oda">Keiichi Oda</name></author><author><name sortKey="Ishiwata, Kiichi" sort="Ishiwata, Kiichi" uniqKey="Ishiwata K" first="Kiichi" last="Ishiwata">Kiichi Ishiwata</name></author><author><name sortKey="Ishii, Kenji" sort="Ishii, Kenji" uniqKey="Ishii K" first="Kenji" last="Ishii">Kenji Ishii</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Blepharospasm (psychology)</term><term>Female</term><term>Fluorodeoxyglucose F18 (diagnostic use)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nerve Net (physiopathology)</term><term>Neural Pathways (physiopathology)</term><term>Occipital Lobe (physiopathology)</term><term>Photophobia (diagnosis)</term><term>Photophobia (etiology)</term><term>Photophobia (physiopathology)</term><term>Positron-Emission Tomography</term><term>Radiopharmaceuticals (diagnostic use)</term><term>Thalamus (physiopathology)</term><term>Trigeminal Nerve (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Fluorodeoxyglucose F18</term><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Photophobia</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Photophobia</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Nerve Net</term><term>Neural Pathways</term><term>Occipital Lobe</term><term>Photophobia</term><term>Thalamus</term><term>Trigeminal Nerve</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Blepharospasm</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Positron-Emission Tomography</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To localize regional alterations in cerebral glucose metabolism in essential blepharospasm (EB) patients with photophobia. We have studied 22 EB patients by performing positron emission tomography and [(18)F]-fluorodeoxyglucose analysis. The patients were classified into two subgroups, namely, EB with photophobia (P group) and EB without photophobia (NP group), and compared with a healthy control group (n = 44). There were no significant differences between the two patient groups with respect to the severity of motor symptoms or the duration for which the condition persisted. The FDG-PET images were analyzed using the statistical parametric mapping software. As compared to the control group, the P group exhibited significant hypermetabolism in the thalamus (P = 0.002), while the NP group exhibited significant hypometabolism in the dorsal midbrain, especially, in the superior colliculus (P = 0.005). The P group exhibited significant hypermetabolism in the thalamus and the dorsal midbrain as compared to the NP group (P < 0.001). These findings suggest that photophobia in EB patients may be associated with abnormal hyperactivity in the thalamus. Either hyperactivity of the thalamus or hypoactivity of the superior colliculus, or both may be associated with excessive blinking in these patients.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20014062</PMID><DateCreated><Year>2010</Year><Month>03</Month><Day>23</Day></DateCreated><DateCompleted><Year>2010</Year><Month>08</Month><Day>10</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>4</Issue><PubDate><Year>2010</Year><Month>Mar</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Photophobia in essential blepharospasm--a positron emission tomographic study.</ArticleTitle><Pagination><MedlinePgn>433-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.22916</ELocationID><Abstract><AbstractText>To localize regional alterations in cerebral glucose metabolism in essential blepharospasm (EB) patients with photophobia. We have studied 22 EB patients by performing positron emission tomography and [(18)F]-fluorodeoxyglucose analysis. The patients were classified into two subgroups, namely, EB with photophobia (P group) and EB without photophobia (NP group), and compared with a healthy control group (n = 44). There were no significant differences between the two patient groups with respect to the severity of motor symptoms or the duration for which the condition persisted. The FDG-PET images were analyzed using the statistical parametric mapping software. As compared to the control group, the P group exhibited significant hypermetabolism in the thalamus (P = 0.002), while the NP group exhibited significant hypometabolism in the dorsal midbrain, especially, in the superior colliculus (P = 0.005). The P group exhibited significant hypermetabolism in the thalamus and the dorsal midbrain as compared to the NP group (P < 0.001). These findings suggest that photophobia in EB patients may be associated with abnormal hyperactivity in the thalamus. Either hyperactivity of the thalamus or hypoactivity of the superior colliculus, or both may be associated with excessive blinking in these patients.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Emoto</LastName><ForeName>Hirofumi</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Suzuki</LastName><ForeName>Yukihisa</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Wakakura</LastName><ForeName>Masato</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Horie</LastName><ForeName>Chiharu</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Kiyosawa</LastName><ForeName>Motohiro</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Mochizuki</LastName><ForeName>Manabu</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Kawasaki</LastName><ForeName>Keiichi</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Oda</LastName><ForeName>Keiichi</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Ishiwata</LastName><ForeName>Kiichi</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Ishii</LastName><ForeName>Kenji</ForeName><Initials>K</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov 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use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009415">Nerve Net</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009434">Neural Pathways</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009778">Occipital Lobe</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020795">Photophobia</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000209">etiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D049268">Positron-Emission Tomography</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019275">Radiopharmaceuticals</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000176">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013788">Thalamus</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014276">Trigeminal Nerve</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>12</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>12</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>8</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.22916</ArticleId><ArticleId IdType="pubmed">20014062</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country><settlement><li>Tokyo</li></settlement></list><tree><noCountry><name sortKey="Horie, Chiharu" sort="Horie, Chiharu" uniqKey="Horie C" first="Chiharu" last="Horie">Chiharu Horie</name><name sortKey="Ishii, Kenji" sort="Ishii, Kenji" uniqKey="Ishii K" first="Kenji" last="Ishii">Kenji Ishii</name><name sortKey="Ishiwata, Kiichi" sort="Ishiwata, Kiichi" uniqKey="Ishiwata K" first="Kiichi" last="Ishiwata">Kiichi Ishiwata</name><name sortKey="Kawasaki, Keiichi" sort="Kawasaki, Keiichi" uniqKey="Kawasaki K" first="Keiichi" last="Kawasaki">Keiichi Kawasaki</name><name sortKey="Kiyosawa, Motohiro" sort="Kiyosawa, Motohiro" uniqKey="Kiyosawa M" first="Motohiro" last="Kiyosawa">Motohiro Kiyosawa</name><name sortKey="Mochizuki, Manabu" sort="Mochizuki, Manabu" uniqKey="Mochizuki M" first="Manabu" last="Mochizuki">Manabu Mochizuki</name><name sortKey="Oda, Keiichi" sort="Oda, Keiichi" uniqKey="Oda K" first="Keiichi" last="Oda">Keiichi Oda</name><name sortKey="Suzuki, Yukihisa" sort="Suzuki, Yukihisa" uniqKey="Suzuki Y" first="Yukihisa" last="Suzuki">Yukihisa Suzuki</name><name sortKey="Wakakura, Masato" sort="Wakakura, Masato" uniqKey="Wakakura M" first="Masato" last="Wakakura">Masato Wakakura</name></noCountry><country name="Japon"><noRegion><name sortKey="Emoto, Hirofumi" sort="Emoto, Hirofumi" uniqKey="Emoto H" first="Hirofumi" 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