Staging of alpha-synuclein in the olfactory bulb in a model of Parkinson's disease: cell types involved.
Identifieur interne : 001598 ( PubMed/Checkpoint ); précédent : 001597; suivant : 001599Staging of alpha-synuclein in the olfactory bulb in a model of Parkinson's disease: cell types involved.
Auteurs : Isabel Ubeda-Ba On [Espagne] ; Daniel Saiz-Sanchez ; Carlos De La Rosa-Prieto ; Alicia Mohedano-Moriano ; Noelia Fradejas ; Soledad Calvo ; Lucia Argando A-Palacios ; Susana Garcia-Mu Ozguren ; Alino Martinez-MarcosSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Animals, Disease Models, Animal, Gene Expression Regulation (genetics), Humans, Mice, Mice, Transgenic, Mutation (genetics), Neurons (classification), Neurons (metabolism), Olfactory Bulb (metabolism), Olfactory Bulb (pathology), Parkinson Disease (genetics), Parkinson Disease (pathology), Parvalbumins (metabolism), Tyrosine 3-Monooxygenase (metabolism), Ubiquitins (metabolism), alpha-Synuclein (genetics), alpha-Synuclein (metabolism).
- MESH :
- chemical , genetics : alpha-Synuclein.
- chemical , metabolism : Parvalbumins, Tyrosine 3-Monooxygenase, Ubiquitins, alpha-Synuclein.
- classification : Neurons.
- genetics : Gene Expression Regulation, Mutation, Parkinson Disease.
- metabolism : Neurons, Olfactory Bulb.
- pathology : Olfactory Bulb, Parkinson Disease.
- Animals, Disease Models, Animal, Humans, Mice, Mice, Transgenic.
Abstract
Impaired olfaction is an early symptom of Parkinson's disease. The underlying neuropathology likely includes alpha-synucleinopathy in the olfactory bulb at an earlier stage (Braak's stage1) than pathology in the substantia nigra, which is not observed until stage 3. In this report, we investigated the distribution and cell types affected by alpha-synuclein in the olfactory bulb of transgenic mice (2-8 months of age) expressing the human A53T variant of alpha-synuclein. alpha-Synuclein immunostaining progressively affects interneurons and mitral cells. Double labeling studies demonstrate that dopaminergic cells are hardly involved, whereas glutamatergic- and calcium binding protein-positive cells are severely affected. This temporal evolution and the cell types expressing alpha-synuclein are reminiscent of idiopathic Parkinson's disease and support the usefulness of this model to address specific topics in the premotor phase of the disease.
DOI: 10.1002/mds.23197
PubMed: 20574962
Affiliations:
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last="Ubeda-Ba On">Isabel Ubeda-Ba On</name><affiliation wicri:level="1"><nlm:affiliation>Laboratorio de Neuroanatomía Humana, Departamento de Ciencias Médicas, Facultad de Medicina, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Laboratorio de Neuroanatomía Humana, Departamento de Ciencias Médicas, Facultad de Medicina, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha</wicri:regionArea><wicri:noRegion>Universidad de Castilla-La Mancha</wicri:noRegion></affiliation></author><author><name sortKey="Saiz Sanchez, Daniel" sort="Saiz Sanchez, Daniel" uniqKey="Saiz Sanchez D" first="Daniel" last="Saiz-Sanchez">Daniel Saiz-Sanchez</name></author><author><name sortKey="De La Rosa Prieto, Carlos" sort="De La Rosa Prieto, Carlos" uniqKey="De La Rosa Prieto C" first="Carlos" last="De La Rosa-Prieto">Carlos De La 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first="Alino" last="Martinez-Marcos">Alino Martinez-Marcos</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Gene Expression Regulation (genetics)</term><term>Humans</term><term>Mice</term><term>Mice, Transgenic</term><term>Mutation (genetics)</term><term>Neurons (classification)</term><term>Neurons (metabolism)</term><term>Olfactory Bulb (metabolism)</term><term>Olfactory Bulb (pathology)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (pathology)</term><term>Parvalbumins (metabolism)</term><term>Tyrosine 3-Monooxygenase (metabolism)</term><term>Ubiquitins (metabolism)</term><term>alpha-Synuclein 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Animal</term><term>Humans</term><term>Mice</term><term>Mice, Transgenic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Impaired olfaction is an early symptom of Parkinson's disease. The underlying neuropathology likely includes alpha-synucleinopathy in the olfactory bulb at an earlier stage (Braak's stage1) than pathology in the substantia nigra, which is not observed until stage 3. In this report, we investigated the distribution and cell types affected by alpha-synuclein in the olfactory bulb of transgenic mice (2-8 months of age) expressing the human A53T variant of alpha-synuclein. alpha-Synuclein immunostaining progressively affects interneurons and mitral cells. Double labeling studies demonstrate that dopaminergic cells are hardly involved, whereas glutamatergic- and calcium binding protein-positive cells are severely affected. 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Double labeling studies demonstrate that dopaminergic cells are hardly involved, whereas glutamatergic- and calcium binding protein-positive cells are severely affected. This temporal evolution and the cell types expressing alpha-synuclein are reminiscent of idiopathic Parkinson's disease and support the usefulness of this model to address specific topics in the premotor phase of the disease.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ubeda-Bañon</LastName><ForeName>Isabel</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Laboratorio de Neuroanatomía Humana, Departamento de Ciencias Médicas, Facultad de Medicina, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saiz-Sanchez</LastName><ForeName>Daniel</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>de la Rosa-Prieto</LastName><ForeName>Carlos</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Mohedano-Moriano</LastName><ForeName>Alicia</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Fradejas</LastName><ForeName>Noelia</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Calvo</LastName><ForeName>Soledad</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Argandoña-Palacios</LastName><ForeName>Lucia</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Garcia-Muñozguren</LastName><ForeName>Susana</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Martinez-Marcos</LastName><ForeName>Alino</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov 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UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010320">Parvalbumins</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014446">Tyrosine 3-Monooxygenase</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014452">Ubiquitins</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D051844">alpha-Synuclein</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>6</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>6</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>12</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.23197</ArticleId><ArticleId IdType="pubmed">20574962</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country></list><tree><noCountry><name sortKey="Argando A Palacios, Lucia" sort="Argando A Palacios, Lucia" uniqKey="Argando A Palacios L" first="Lucia" last="Argando A-Palacios">Lucia Argando A-Palacios</name><name sortKey="Calvo, Soledad" sort="Calvo, Soledad" uniqKey="Calvo S" first="Soledad" last="Calvo">Soledad Calvo</name><name sortKey="De La Rosa Prieto, Carlos" sort="De La Rosa Prieto, Carlos" uniqKey="De La Rosa Prieto C" first="Carlos" last="De La Rosa-Prieto">Carlos De La Rosa-Prieto</name><name sortKey="Fradejas, Noelia" sort="Fradejas, Noelia" uniqKey="Fradejas N" first="Noelia" last="Fradejas">Noelia Fradejas</name><name sortKey="Garcia Mu Ozguren, Susana" sort="Garcia Mu Ozguren, Susana" uniqKey="Garcia Mu Ozguren S" first="Susana" last="Garcia-Mu Ozguren">Susana Garcia-Mu Ozguren</name><name sortKey="Martinez Marcos, Alino" sort="Martinez Marcos, Alino" uniqKey="Martinez Marcos A" first="Alino" last="Martinez-Marcos">Alino Martinez-Marcos</name><name sortKey="Mohedano Moriano, Alicia" sort="Mohedano Moriano, Alicia" uniqKey="Mohedano Moriano A" first="Alicia" last="Mohedano-Moriano">Alicia Mohedano-Moriano</name><name sortKey="Saiz Sanchez, Daniel" sort="Saiz Sanchez, Daniel" uniqKey="Saiz Sanchez D" first="Daniel" last="Saiz-Sanchez">Daniel Saiz-Sanchez</name></noCountry><country name="Espagne"><noRegion><name sortKey="Ubeda Ba On, Isabel" sort="Ubeda Ba On, Isabel" uniqKey="Ubeda Ba On I" first="Isabel" last="Ubeda-Ba On">Isabel Ubeda-Ba On</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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